K E A Lundin

Summary

Affiliation: Rikshospitalet University Hospital
Country: Norway

Publications

  1. ncbi request reprint [Coeliac disease--new clinical findings and diagnostic tools]
    Knut E A Lundin
    Medisinsk avdeling, Rikshospitlet, Oslo
    Tidsskr Nor Laegeforen 123:3226-9. 2003
  2. doi request reprint No induction of anti-avenin IgA by oats in adult, diet-treated coeliac disease
    Vigdis Guttormsen
    Akershus University College, Lillestrøm, Norway
    Scand J Gastroenterol 43:161-5. 2008
  3. ncbi request reprint [Cardiology as an engine for internal medicine]
    Knut E A Lundin
    Tidsskr Nor Laegeforen 124:1139. 2004
  4. pmc Oats induced villous atrophy in coeliac disease
    K E A Lundin
    Department of Medicine, Rikshospitalet, Oslo, Norway
    Gut 52:1649-52. 2003
  5. pmc HLA-DQ8 as an Ir gene in coeliac disease
    K E A Lundin
    Department of Medicine and Institute of Immunology, Rikshospitalet, N 0027 Oslo, Norway
    Gut 52:7-8. 2003
  6. pmc Gliadin peptide specific intestinal T cells in coeliac disease
    K E A Lundin
    Department of Medicine and Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Gut 52:162. 2003
  7. doi request reprint Plasmacytoid dendritic cells are scarcely represented in the human gut mucosa and are not recruited to the celiac lesion
    M Raki
    Centre for Immune Regulation and Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Mucosal Immunol 6:985-92. 2013
  8. pmc The effects of atorvastatin on gluten-induced intestinal T cell responses in coeliac disease
    M Raki
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Norway
    Clin Exp Immunol 142:333-40. 2005
  9. doi request reprint HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22
    M Bodd
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Mucosal Immunol 3:594-601. 2010
  10. doi request reprint Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesion
    A C R Beitnes
    Centre for Immune Regulation, Institute of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Scand J Immunol 74:186-94. 2011

Collaborators

Detail Information

Publications29

  1. ncbi request reprint [Coeliac disease--new clinical findings and diagnostic tools]
    Knut E A Lundin
    Medisinsk avdeling, Rikshospitlet, Oslo
    Tidsskr Nor Laegeforen 123:3226-9. 2003
    ..Coeliac disease can also exist with a normal serology. The trend in many countries is to require less pronounced mucosal abnormalities than previously for the diagnosis...
  2. doi request reprint No induction of anti-avenin IgA by oats in adult, diet-treated coeliac disease
    Vigdis Guttormsen
    Akershus University College, Lillestrøm, Norway
    Scand J Gastroenterol 43:161-5. 2008
    ..The objective of this study was to investigate whether levels of IgA against oats were increased in treated, adult coeliac disease patients...
  3. ncbi request reprint [Cardiology as an engine for internal medicine]
    Knut E A Lundin
    Tidsskr Nor Laegeforen 124:1139. 2004
  4. pmc Oats induced villous atrophy in coeliac disease
    K E A Lundin
    Department of Medicine, Rikshospitalet, Oslo, Norway
    Gut 52:1649-52. 2003
    ..Five of the patients showed positive levels of interferon gamma mRNA after challenge. Some concerns therefore remain with respect to the safety of oats for coeliacs...
  5. pmc HLA-DQ8 as an Ir gene in coeliac disease
    K E A Lundin
    Department of Medicine and Institute of Immunology, Rikshospitalet, N 0027 Oslo, Norway
    Gut 52:7-8. 2003
    ..HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in this disease..
  6. pmc Gliadin peptide specific intestinal T cells in coeliac disease
    K E A Lundin
    Department of Medicine and Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Gut 52:162. 2003
  7. doi request reprint Plasmacytoid dendritic cells are scarcely represented in the human gut mucosa and are not recruited to the celiac lesion
    M Raki
    Centre for Immune Regulation and Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Mucosal Immunol 6:985-92. 2013
    ..IFN-λ, a type III IFN important in intestinal antiviral defense, was produced mainly by APCs, but its expression was not increased in the celiac lesion...
  8. pmc The effects of atorvastatin on gluten-induced intestinal T cell responses in coeliac disease
    M Raki
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Norway
    Clin Exp Immunol 142:333-40. 2005
    ..In conclusion, atorvastatin has specific effects on isolated gluten-reactive T cells and dendritic cells, but does not shut down the gluten-induced production of proinflammatory cytokines in intestinal biopsies...
  9. doi request reprint HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22
    M Bodd
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Mucosal Immunol 3:594-601. 2010
    ..We conclude that gluten-reactive T cells produce IL-21 and IFN-γ, but not IL-17. Their production of IL-21 suggests a role for this cytokine in the pathogenesis of celiac disease...
  10. doi request reprint Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesion
    A C R Beitnes
    Centre for Immune Regulation, Institute of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Scand J Immunol 74:186-94. 2011
    ....
  11. doi request reprint Diagnosis and treatment of celiac disease
    L M Sollid
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, Oslo, Norway
    Mucosal Immunol 2:3-7. 2009
    ..Here we discuss how the new insight in the pathogenesis has lead to development of new diagnostics and nourished research into novel treatments...
  12. ncbi request reprint Coeliac disease--all questions answered?
    K E A Lundin
    Department of Medicine and Institute of Immunology, Rikshospitalet and University of Oslo, Norway
    Dig Liver Dis 34:238-42. 2002
    ..Moreover, the role for autoimmune phenomena and the mechanism of breaking of immunological tolerance remain elusive...
  13. pmc Gastrointestinal intraepithelial lymphocytes and T cell lymphomas
    I N Farstad
    Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Gut 52:163-4. 2003
  14. ncbi request reprint Interferon-gamma-secreting T cells localize to the epithelium in coeliac disease
    R W Olaussen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Scand J Immunol 56:652-64. 2002
    ..We conclude that isolated T cells spontaneously secreting IFN-gamma localize preferentially in the epithelium of patients with classical and refractory CD...
  15. ncbi request reprint [Dietary treatment of coeliac disease and dermatitis herpetiformis]
    Astrid Løvik
    Enhet for klinisk ernaering, Madisinsk avdeling, Rikshospitalet, Oslo
    Tidsskr Nor Laegeforen 123:3237-40. 2003
    ..The physician making the diagnosis has a duty to see to it that all coeliac patients get adequate dietary counselling and management...
  16. ncbi request reprint Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues
    Helene Arentz-Hansen
    Institute of Immunology and Department of Medicine, Rikshopitalet, University of Oslo, Oslo, Norway
    Gastroenterology 123:803-9. 2002
    ..Only a few gliadin T-cell epitopes have been identified by earlier work. The aim of this study was to perform a systematic characterization of DQ2-restricted T-cell epitopes in alpha- and gamma-gliadins...
  17. doi request reprint The INSPIRE study: are different personality traits related to disease-specific quality of life (IBDQ) in distressed patients with ulcerative colitis and Crohn's disease?
    Birgitte Boye
    Institute of Psychiatry, University of Oslo, Norway
    Inflamm Bowel Dis 14:680-6. 2008
    ....
  18. ncbi request reprint Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation
    Richard W Olaussen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Oslo, Norway
    Gastroenterology 132:2371-82. 2007
    ..Because CCR9 expression appears to be activation dependent, we examined CCR9 on duodenal T cells from untreated and treated (gluten-free diet) patients with celiac disease and healthy controls...
  19. pmc Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients
    Melinda Raki
    Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
    Proc Natl Acad Sci U S A 104:2831-6. 2007
    ..Most of the cells had a memory phenotype, but many other phenotypic markers showed a heterogeneous pattern. Tetramer staining of gluten-specific T cells has the potential to be used for diagnosis of celiac disease...
  20. ncbi request reprint A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells
    Melinda Raki
    Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Gastroenterology 131:428-38. 2006
    ..The aim of this study was to identify the antigen-presenting cells that are responsible for the activation of gluten-reactive T cells in the celiac lesion...
  21. pmc HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease
    Stig Tollefsen
    Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    J Clin Invest 116:2226-36. 2006
    ..Peptides combining the DQ2 and DQ8 signatures could be presented by DQ2, DQ8, and trans-encoded DQ heterodimers. Our findings shed light on the basis for the HLA associations in celiac disease and type 1 diabetes...
  22. ncbi request reprint Effect of elemental diet on mucosal immunopathology and clinical symptoms in type 1 refractory celiac disease
    Richard Willfred Olaussen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Oslo, Norway
    Clin Gastroenterol Hepatol 3:875-85. 2005
    ..Both conditions are difficult to treat. Here we describe the effects of a nonimmunogenic elemental diet on clinical symptoms and mucosal immunopathology in type 1 RCD...
  23. ncbi request reprint Intestinal T-cell responses to high-molecular-weight glutenins in celiac disease
    Øyvind Molberg
    Institute of Immunology, Rikshospitalet, University of Oslo, N 0027, Oslo, Norway
    Gastroenterology 125:337-44. 2003
    ....
  24. ncbi request reprint Commentary: transient coeliac disease back on stage again?
    Knut E A Lundin
    Scand J Gastroenterol 40:1137-9. 2005
  25. ncbi request reprint [Disease mechanisms in coeliac disease]
    Ludvig M Sollid
    Immunologisk institutt, Rikshospitlet, Oslo
    Tidsskr Nor Laegeforen 123:3230-3. 2003
    ..In recent years we have gained new knowledge of the molecular basis of this disorder; this paper gives an overview of the current understanding of the pathogenesis of coeliac disease...
  26. ncbi request reprint Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease
    Oyvind Molberg
    Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
    Gastroenterology 128:393-401. 2005
    ....
  27. pmc The molecular basis for oat intolerance in patients with celiac disease
    Helene Arentz-Hansen
    Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    PLoS Med 1:e1. 2004
    ..This study aimed to investigate whether oat intolerance exists in celiac disease and to characterize the cells and processes underlying this intolerance...
  28. ncbi request reprint [New Swedish specialty structure]
    Knut E A Lundin
    Tidsskr Nor Laegeforen 126:1594. 2006
  29. ncbi request reprint Gluten-free diet--what is toxic?
    Paul J Ciclitira
    Gastroenterology, Rayne Institute KCL St Thomas Hospital, Lambeth Palace Road, SE1 7EH London, UK
    Best Pract Res Clin Gastroenterol 19:359-71. 2005
    ..Future efforts may lead to better understanding of the disease processes as well as possible new therapeutic options...