Ola Dale

Summary

Affiliation: Pain and Palliation Research Group
Country: Norway

Publications

  1. ncbi request reprint Long term methadone for chronic pain: a pilot study of pharmacokinetic aspects
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Pain 11:599-604. 2007
  2. ncbi request reprint Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: A prospective 9-month follow-up study
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Institute of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 32:180-5. 2006
  3. ncbi request reprint Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Institute of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim
    Palliat Med 20:35-41. 2006
  4. pmc Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Faculty of Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7489, Trondheim, Norway
    Eur J Clin Pharmacol 68:55-64. 2012
  5. pmc Longitudinal associations between exercise and pain in the general population--the HUNT pain study
    Tormod Landmark
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    PLoS ONE 8:e65279. 2013
  6. doi request reprint Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain
    Kristin Moksnes
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Eur J Clin Pharmacol 68:1147-56. 2012
  7. doi request reprint Is oxycodone efficacy reflected in serum concentrations? A multicenter, cross-sectional study in 456 adult cancer patients
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 43:694-705. 2012
  8. pmc Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study
    Pål Klepstad
    Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    BMC Clin Pharmacol 4:7. 2004
  9. ncbi request reprint Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients
    Pål Klepstad
    Department of Anaesthesia and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 17:679-87. 2003
  10. doi request reprint A double-blind, randomized, crossover comparison between single-dose and double-dose immediate-release oral morphine at bedtime in cancer patients
    Ola Dale
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 37:68-76. 2009

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Long term methadone for chronic pain: a pilot study of pharmacokinetic aspects
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Pain 11:599-604. 2007
    ..Our findings contradict that autoinduction of methadone metabolism takes place during long term treatment and supports that a 3-day opioid switch from morphine to methadone followed by a one week titration seems pharmacologically sound...
  2. ncbi request reprint Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: A prospective 9-month follow-up study
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Institute of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 32:180-5. 2006
    ..We observed no episodes of arrhythmias...
  3. ncbi request reprint Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Institute of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim
    Palliat Med 20:35-41. 2006
    ..This study brings novel information on the long-term consequences for pain control, health-related quality of life and cognitive functioning with a switch from morphine to methadone in the treatment of chronic non-malignant pain...
  4. pmc Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Faculty of Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7489, Trondheim, Norway
    Eur J Clin Pharmacol 68:55-64. 2012
    ....
  5. pmc Longitudinal associations between exercise and pain in the general population--the HUNT pain study
    Tormod Landmark
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    PLoS ONE 8:e65279. 2013
    ..The aim of the current study was to investigate the association between exercise and pain longitudinally and to use within subjects analyses to remove between subjects confounding...
  6. doi request reprint Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain
    Kristin Moksnes
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Eur J Clin Pharmacol 68:1147-56. 2012
    ....
  7. doi request reprint Is oxycodone efficacy reflected in serum concentrations? A multicenter, cross-sectional study in 456 adult cancer patients
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 43:694-705. 2012
    ..The relationship between oxycodone and metabolite serum concentrations and clinical effects has not previously been investigated in cancer pain patients...
  8. pmc Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study
    Pål Klepstad
    Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    BMC Clin Pharmacol 4:7. 2004
    ..One important factor relevant to drug monitoring is to what extent morphine, M6G and M3G serum concentrations fluctuate during stable morphine treatment...
  9. ncbi request reprint Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients
    Pål Klepstad
    Department of Anaesthesia and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 17:679-87. 2003
    ..This result suggests that therapeutic drug monitoring as a routine tool during chronic morphine treatment has limited value for clinical decision making...
  10. doi request reprint A double-blind, randomized, crossover comparison between single-dose and double-dose immediate-release oral morphine at bedtime in cancer patients
    Ola Dale
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 37:68-76. 2009
    ..50 has little clinical significance, and the two procedures are, therefore, clinically equivalent. It is speculated whether the initial higher exposure to morphine-6-glucuronide may have clinical significance...
  11. doi request reprint Effects of hypothermia on the disposition of morphine, midazolam, fentanyl, and propofol in intensive care unit patients
    Thor Wilhelm Bjelland
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Drug Metab Dispos 41:214-23. 2013
    ..CL(tot) was lower during TH for morphine, fentanyl, and propofol but not for midazolam. Reducing the infusion rates of morphine, fentanyl, and propofol during TH is encouraged...
  12. doi request reprint Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with pain
    Torill Fladvad
    Department of Cancer Research and Molecular Medicine, European Palliative Care Research Center, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway
    Pharmacogenet Genomics 23:117-26. 2013
    ....
  13. ncbi request reprint The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients
    Trude Teoline Rakvåg
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, N 7489 Trondheim, Norway
    Pain 116:73-8. 2005
    ..These results suggest that genetic variation in the COMT gene may contribute to variability in the efficacy of morphine in cancer pain treatment...
  14. doi request reprint European Palliative Care Research Collaborative pain guidelines: opioid switching to improve analgesia or reduce side effects. A systematic review
    Ola Dale
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway
    Palliat Med 25:494-503. 2011
    ..Due to serious design limitations, the level of evidence was low (D). Randomized trials, with standardization of cohort classification, use of outcomes and analysis are warranted to establish the practice of opioid switching...
  15. doi request reprint Assessment and classification of cancer breakthrough pain: a systematic literature review
    Dagny Faksvåg Haugen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Pain 149:476-82. 2010
    ....
  16. doi request reprint Estimating the prevalence of chronic pain: validation of recall against longitudinal reporting (the HUNT pain study)
    Tormod Landmark
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Pain 153:1368-73. 2012
    ..Thus pain reporting in the general population is stable and cross-sectional measures may give valid prevalence estimates of chronic pain...
  17. doi request reprint Associations between recreational exercise and chronic pain in the general population: evidence from the HUNT 3 study
    Tormod Landmark
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Pain 152:2241-7. 2011
    ....
  18. doi request reprint A systematic review of oxymorphone in the management of chronic pain
    Fadia Mayyas
    Pain and Palliation Research Group, Norwegian University of Science and Technology, 7489Trondheim, Norway
    J Pain Symptom Manage 39:296-308. 2010
    ..No significant differences between oxymorphone and oxycodone at equipotent doses were found. In conclusion, oxymorphone is superior to placebo. There is no evidence that the efficacy of oxymorphone differs from other opioids...
  19. doi request reprint Early pharmacokinetics of nasal fentanyl: is there a significant arterio-venous difference?
    Kristin Moksnes
    Department of Circulation and Medical Imaging, Pain and Palliation Research Group, Norwegian University of Science and Technology, St Olav University Hospital, Kreftbygget, 5th Floor, Olav Kyrres gate 17, 7006, Trondheim, Norway
    Eur J Clin Pharmacol 64:497-502. 2008
    ..We have investigated the arterio-venous difference in the pharmacokinetics of 50 microg fentanyl during the first hour following nasal administration and documented its tolerability in opioid-naïve middle-aged to elderly patients...
  20. doi request reprint Propofol and remifentanil versus midazolam and fentanyl for sedation during therapeutic hypothermia after cardiac arrest: a randomised trial
    Thor W Bjelland
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
    Intensive Care Med 38:959-67. 2012
    ..Secondary outcomes were blood pressure, heart rate, use of vasopressors and inotropic drugs, pneumonia and neurological outcome...
  21. pmc Influences on the pharmacokinetics of oxycodone: a multicentre cross-sectional study in 439 adult cancer patients
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Clin Pharmacol 67:493-506. 2011
    ..The aim of this study was to explore the relationships between ordinary patient characteristics and serum concentrations of oxycodone and the ratios noroxycodone or oxymorphone/oxycodone in cancer patients...
  22. doi request reprint Which variables are associated with pain intensity and treatment response in advanced cancer patients?--Implications for a future classification system for cancer pain
    Anne Kari Knudsen
    European Palliative Care Research Centre, Faculty of Medicine, NTNU, NO 7006 Trondheim, Norway
    Eur J Pain 15:320-7. 2011
    ..A confirmative and explorative approach was applied to investigate which of the variables identified in the literature, by experts and patients that are associated with pain...
  23. ncbi request reprint Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy
    Monica Holthe
    Institute of Cancer Research and Molecular Biology, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Eur J Clin Pharmacol 58:353-6. 2002
    ..Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma ratios among cancer patients undergoing analgesic therapy with morphine...
  24. doi request reprint Depression assessment and classification in palliative cancer patients: a systematic literature review
    Elisabet Wasteson
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, N 7006 Trondheim, Norway
    Palliat Med 23:739-53. 2009
    ..Few studies classified depression by referring to a diagnostic system or by using cut-off scores. Evidently, there is a need for a consensus on how to assess and conceptualize depression and related conditions in palliative care...
  25. ncbi request reprint Intranasal midazolam: a comparison of two delivery devices in human volunteers
    Ola Dale
    Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    J Pharm Pharmacol 58:1311-8. 2006
    ..We cannot disregard that only the traditional spray caused less sedation than intravenous administration. This finding needs to be confirmed in trials designed for this purpose...
  26. doi request reprint Associations between physical activity and physical and mental health--a HUNT 3 study
    Gro F Bertheussen
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology and Department of Physical Medicine and Rehabilitation, St Olav University Hospital, Trondheim, Norway
    Med Sci Sports Exerc 43:1220-8. 2011
    ..We assessed how frequency, duration, and intensity of PA were related to HRQoL in younger (<65 yr) and older (≥65 yr) females and males...
  27. ncbi request reprint Transepithelial transport of morphine and mannitol in Caco-2 cells: the influence of chitosans of different molecular weights and degrees of acetylation
    Ola Dale
    Pain and Palliation Research Group, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    J Pharm Pharmacol 58:909-15. 2006
    ..43/170 induced a high and stable transport rate. Chitosans may enhance transepithelial transport of morphine by the same mechanism as for mannitol. Chitosans with F(A) of 0.3-0.4 and MW of approx. 200 kD seem favourable in this respect...
  28. doi request reprint Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrest
    Thor Wilhelm Bjelland
    Department of Circulation and Medical Imaging, Medical Faculty, Norwegian University of Science and Technology, 7006 Trondheim, Norway
    Resuscitation 81:1627-31. 2010
    ..To investigate the net platelet inhibition of clopidogrel, we have measured the platelet reactivity index in patients treated with therapeutic hypothermia...
  29. ncbi request reprint Heparin resistance and increased platelet activation in coronary surgery patients treated with enoxaparin preoperatively
    Hilde Pleym
    Department of Cardiothoracic Anesthesia and Intensive Care, St Olav University Hospital, Trondheim, Norway
    Eur J Cardiothorac Surg 29:933-40. 2006
    ..The aim of this study was to explore and describe the perioperative hemostatic process in patients with unstable coronary artery disease undergoing coronary artery bypass grafting...
  30. pmc Bioavailabilities of rectal and oral methadone in healthy subjects
    Ola Dale
    Department of Anaesthesiology, University of Washington, Seattle, USA
    Br J Clin Pharmacol 58:156-62. 2004
    ..The aim of this study was to compare the absolute rectal bioavailability of methadone with its oral bioavailability in healthy humans...
  31. ncbi request reprint [Genetic variation-- important for the clinical effect of opioids?]
    Pål Klepstad
    Avdeling for anestesi og akuttmedisin, St Olavs Hospital, 7006 Trondheim
    Tidsskr Nor Laegeforen 125:2655-8. 2005
    ..Results obtained so far strongly suggest that opioid efficacy is partly related to inborn properties caused by genetic variability...
  32. ncbi request reprint Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes
    Theresa Mariero Klees
    Department of Anesthesiology, Box 356540, University of Washington, 1959 NE Pacific, RR 442, Seattle, WA 98195, USA
    Drug Metab Dispos 33:303-11. 2005
    ..Alfentanil is one of the few CYP3A substrates that is metabolized in vitro as avidly by both CYP3A4 and 3A5. Polymorphic CYP3A5 expression may contribute to inter-individual variability in alfentanil metabolism...
  33. ncbi request reprint Disposition of nasal, intravenous, and oral methadone in healthy volunteers
    Ola Dale
    Department of Anesthesiology, University of Washington, Seattle, USA
    Clin Pharmacol Ther 72:536-45. 2002
    ..Nasal administration of many opioids demonstrates rapid uptake and fast onset of action. Nasal administration may be an alternative to intravenous and oral administration of methadone and was therefore studied in human volunteers...