Research Topics
Species | Ola DaleSummaryAffiliation: Pain and Palliation Research Group Country: Norway Publications
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Detail Information
Publications
Long term methadone for chronic pain: a pilot study of pharmacokinetic aspectsOlav Magnus S Fredheim
Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Eur J Pain 11:599-604. 2007..Our findings contradict that autoinduction of methadone metabolism takes place during long term treatment and supports that a 3-day opioid switch from morphine to methadone followed by a one week titration seems pharmacologically sound...- Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: A prospective 9-month follow-up studyOlav Magnus S Fredheim
Pain and Palliation Research Group, Institute of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
J Pain Symptom Manage 32:180-5. 2006..We observed no episodes of arrhythmias... - Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up studyOlav Magnus S Fredheim
Pain and Palliation Research Group, Institute of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim
Palliat Med 20:35-41. 2006..This study brings novel information on the long-term consequences for pain control, health-related quality of life and cognitive functioning with a switch from morphine to methadone in the treatment of chronic non-malignant pain... 
Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre studyTrine Naalsund Andreassen
Pain and Palliation Research Group, Faculty of Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7489, Trondheim, Norway
Eur J Clin Pharmacol 68:55-64. 2012....
Serum concentrations of opioids when comparing two switching strategies to methadone for cancer painKristin Moksnes
Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
Eur J Clin Pharmacol 68:1147-56. 2012....- Is oxycodone efficacy reflected in serum concentrations? A multicenter, cross-sectional study in 456 adult cancer patientsTrine Naalsund Andreassen
Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
J Pain Symptom Manage 43:694-705. 2012..The relationship between oxycodone and metabolite serum concentrations and clinical effects has not previously been investigated in cancer pain patients... - A double-blind, randomized, crossover comparison between single-dose and double-dose immediate-release oral morphine at bedtime in cancer patientsOla Dale
Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
J Pain Symptom Manage 37:68-76. 2009..50 has little clinical significance, and the two procedures are, therefore, clinically equivalent. It is speculated whether the initial higher exposure to morphine-6-glucuronide may have clinical significance... - Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational studyPål Klepstad
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
BMC Clin Pharmacol 4:7. 2004..One important factor relevant to drug monitoring is to what extent morphine, M6G and M3G serum concentrations fluctuate during stable morphine treatment... - Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patientsPål Klepstad
Department of Anaesthesia and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
Palliat Med 17:679-87. 2003..This result suggests that therapeutic drug monitoring as a routine tool during chronic morphine treatment has limited value for clinical decision making... - The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patientsTrude Teoline Rakvåg
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, N 7489 Trondheim, Norway
Pain 116:73-8. 2005..These results suggest that genetic variation in the COMT gene may contribute to variability in the efficacy of morphine in cancer pain treatment... - European Palliative Care Research Collaborative pain guidelines: opioid switching to improve analgesia or reduce side effects. A systematic reviewOla Dale
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway
Palliat Med 25:494-503. 2011..Due to serious design limitations, the level of evidence was low (D). Randomized trials, with standardization of cohort classification, use of outcomes and analysis are warranted to establish the practice of opioid switching... - Assessment and classification of cancer breakthrough pain: a systematic literature reviewDagny Faksvåg Haugen
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
Pain 149:476-82. 2010.... - Estimating the prevalence of chronic pain: validation of recall against longitudinal reporting (the HUNT pain study)Tormod Landmark
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Pain 153:1368-73. 2012..Thus pain reporting in the general population is stable and cross-sectional measures may give valid prevalence estimates of chronic pain... - Associations between recreational exercise and chronic pain in the general population: evidence from the HUNT 3 studyTormod Landmark
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Pain 152:2241-7. 2011.... - Early pharmacokinetics of nasal fentanyl: is there a significant arterio-venous difference?Kristin Moksnes
Department of Circulation and Medical Imaging, Pain and Palliation Research Group, Norwegian University of Science and Technology, St Olav University Hospital, Kreftbygget, 5th Floor, Olav Kyrres gate 17, 7006, Trondheim, Norway
Eur J Clin Pharmacol 64:497-502. 2008..We have investigated the arterio-venous difference in the pharmacokinetics of 50 microg fentanyl during the first hour following nasal administration and documented its tolerability in opioid-naïve middle-aged to elderly patients... - A systematic review of oxymorphone in the management of chronic painFadia Mayyas
Pain and Palliation Research Group, Norwegian University of Science and Technology, 7489Trondheim, Norway
J Pain Symptom Manage 39:296-308. 2010..No significant differences between oxymorphone and oxycodone at equipotent doses were found. In conclusion, oxymorphone is superior to placebo. There is no evidence that the efficacy of oxymorphone differs from other opioids... - Propofol and remifentanil versus midazolam and fentanyl for sedation during therapeutic hypothermia after cardiac arrest: a randomised trialThor W Bjelland
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
Intensive Care Med 38:959-67. 2012..Secondary outcomes were blood pressure, heart rate, use of vasopressors and inotropic drugs, pneumonia and neurological outcome... - Influences on the pharmacokinetics of oxycodone: a multicentre cross-sectional study in 439 adult cancer patientsTrine Naalsund Andreassen
Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Eur J Clin Pharmacol 67:493-506. 2011..The aim of this study was to explore the relationships between ordinary patient characteristics and serum concentrations of oxycodone and the ratios noroxycodone or oxymorphone/oxycodone in cancer patients... - Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapyMonica Holthe
Institute of Cancer Research and Molecular Biology, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
Eur J Clin Pharmacol 58:353-6. 2002..Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma ratios among cancer patients undergoing analgesic therapy with morphine... - Which variables are associated with pain intensity and treatment response in advanced cancer patients?--Implications for a future classification system for cancer painAnne Kari Knudsen
European Palliative Care Research Centre, Faculty of Medicine, NTNU, NO 7006 Trondheim, Norway
Eur J Pain 15:320-7. 2011..A confirmative and explorative approach was applied to investigate which of the variables identified in the literature, by experts and patients that are associated with pain... - Effects of hypothermia on the disposition of morphine, midazolam, fentanyl, and propofol in intensive care unit patientsThor Wilhelm Bjelland
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Drug Metab Dispos 41:214-23. 2013..CL(tot) was lower during TH for morphine, fentanyl, and propofol but not for midazolam. Reducing the infusion rates of morphine, fentanyl, and propofol during TH is encouraged... - Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with painTorill Fladvad
Department of Cancer Research and Molecular Medicine, European Palliative Care Research Center, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway
Pharmacogenet Genomics 23:117-26. 2013.... - Depression assessment and classification in palliative cancer patients: a systematic literature reviewElisabet Wasteson
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, N 7006 Trondheim, Norway
Palliat Med 23:739-53. 2009..Few studies classified depression by referring to a diagnostic system or by using cut-off scores. Evidently, there is a need for a consensus on how to assess and conceptualize depression and related conditions in palliative care... - Intranasal midazolam: a comparison of two delivery devices in human volunteersOla Dale
Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7489 Trondheim, Norway
J Pharm Pharmacol 58:1311-8. 2006..We cannot disregard that only the traditional spray caused less sedation than intravenous administration. This finding needs to be confirmed in trials designed for this purpose... - Associations between physical activity and physical and mental health--a HUNT 3 studyGro F Bertheussen
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology and Department of Physical Medicine and Rehabilitation, St Olav University Hospital, Trondheim, Norway
Med Sci Sports Exerc 43:1220-8. 2011..We assessed how frequency, duration, and intensity of PA were related to HRQoL in younger (<65 yr) and older (≥65 yr) females and males... - Transepithelial transport of morphine and mannitol in Caco-2 cells: the influence of chitosans of different molecular weights and degrees of acetylationOla Dale
Pain and Palliation Research Group, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
J Pharm Pharmacol 58:909-15. 2006..43/170 induced a high and stable transport rate. Chitosans may enhance transepithelial transport of morphine by the same mechanism as for mannitol. Chitosans with F(A) of 0.3-0.4 and MW of approx. 200 kD seem favourable in this respect... - Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrestThor Wilhelm Bjelland
Department of Circulation and Medical Imaging, Medical Faculty, Norwegian University of Science and Technology, 7006 Trondheim, Norway
Resuscitation 81:1627-31. 2010..To investigate the net platelet inhibition of clopidogrel, we have measured the platelet reactivity index in patients treated with therapeutic hypothermia... - Heparin resistance and increased platelet activation in coronary surgery patients treated with enoxaparin preoperativelyHilde Pleym
Department of Cardiothoracic Anesthesia and Intensive Care, St Olav University Hospital, Trondheim, Norway
Eur J Cardiothorac Surg 29:933-40. 2006..The aim of this study was to explore and describe the perioperative hemostatic process in patients with unstable coronary artery disease undergoing coronary artery bypass grafting... - Bioavailabilities of rectal and oral methadone in healthy subjectsOla Dale
Department of Anaesthesiology, University of Washington, Seattle, USA
Br J Clin Pharmacol 58:156-62. 2004..The aim of this study was to compare the absolute rectal bioavailability of methadone with its oral bioavailability in healthy humans... - [Genetic variation-- important for the clinical effect of opioids?]Pål Klepstad
Avdeling for anestesi og akuttmedisin, St Olavs Hospital, 7006 Trondheim
Tidsskr Nor Laegeforen 125:2655-8. 2005..Results obtained so far strongly suggest that opioid efficacy is partly related to inborn properties caused by genetic variability... - Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymesTheresa Mariero Klees
Department of Anesthesiology, Box 356540, University of Washington, 1959 NE Pacific, RR-442, Seattle, WA 98195, USA
Drug Metab Dispos 33:303-11. 2005..Alfentanil is one of the few CYP3A substrates that is metabolized in vitro as avidly by both CYP3A4 and 3A5. Polymorphic CYP3A5 expression may contribute to inter-individual variability in alfentanil metabolism... - Disposition of nasal, intravenous, and oral methadone in healthy volunteersOla Dale
Department of Anesthesiology, University of Washington, Seattle, USA
Clin Pharmacol Ther 72:536-45. 2002..Nasal administration of many opioids demonstrates rapid uptake and fast onset of action. Nasal administration may be an alternative to intravenous and oral administration of methadone and was therefore studied in human volunteers...