Research Topics
Genomes and Genes | A K StorsetSummaryAffiliation: Norwegian School of Veterinary Science Country: Norway Publications
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Publications
NKp46 defines ovine cells that have characteristics corresponding to NK cellsTimothy Connelley
The Roslin Institute, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, Edinburgh, Scotland, EH25 9RG, UK
Vet Res 42:37. 2011..Therefore we conclude that ovine NKp46+ cells represent a population that by phenotype, tissue distribution and function correspond to NK cells and that NKp46 is an activating receptor in sheep as in other species...- Bovine CD2-/NKp46+ cells are fully functional natural killer cells with a high activation statusPreben Boysen
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, P, O, Box 8146 Dep, N 0033 Oslo, Norway
BMC Immunol 7:10. 2006..NK cells are known as a heterogeneous cell group, and we here report the first functional study of bovine NK cell subsets, based on the expression of CD2... 
Evaluation of the gamma interferon test for diagnosis of paratuberculosis in goatsAnne K Storset
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, P O Box 8146 Dep, N 0033 Oslo, Norway
Vet Immunol Immunopathol 107:87-94. 2005..However, more information about the early gamma interferon responses of naturally infected goats and the presence of false negative samples are needed...- Detection of caprine arthritis--encephalitis virus RNA in macrophages by in situ hybridization using fluorescein-labelled single-stranded RNA probesA K Storset
Department of Pharmacology, Microbiology and Food Hygiene, Norwegian College of Veterinary Medicine, Oslo, Norway
Vet Microbiol 52:25-35. 1996..A few macrophages were positive for CAEV RNA 24 h post infection (p.i.) while most cells were positive 96 h p.i. The use of fluorescein-labelled RNA probes made this method feasible for kinetic in vitro studies of CAEV... - Immunology of Mycobacterium avium subsp. Paratuberculosis infection--immunodiagnostic methodsAnne K Storset
Department of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science, P.O. Box 8146, N-0033 Oslo, Norway
Acta Vet Scand 44:223-9. 2003 - NKp46 defines a subset of bovine leukocytes with natural killer cell characteristicsAnne K Storset
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway
Eur J Immunol 34:669-76. 2004..Together, these data indicate that bovine NKp46 is anactivating receptor and demonstrate the existence of a subset of leukocytes in cattle that, in terms of surface markers, morphology and function, represent NK cells... - Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifsAnne K Storset
Department of Pharmacology, Microbiology and Food Hygiene, Norwegian School of Veterinary Science, Oslo, Norway
Eur J Immunol 33:980-90. 2003..Thus, KIR multigene families with divergent signaling motifs do not only exist in primates. Based on sequence comparison, it appears that the primate and bovine KIR multigene families may have evolved independently... - Kinetics of IL-2 receptor expression on lymphocyte subsets from goats infected with Mycobacterium avium subsp. paratuberculosis after specific in vitro stimulationA K Storset
Department of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science, PO Box 8146, N 0033, Oslo, Norway
Vet Immunol Immunopathol 77:43-54. 2000..The proliferative responses differed between alphabeta and gammadelta-T cells; the IL-2R+ alphabeta T cell population mainly comprised proliferating cells, while the gammadelta+ population showed less expansion... - Subclinical paratuberculosis in goats following experimental infection. An immunological and microbiological studyA K Storset
Department of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science, P O Box 8146, N 0033 Oslo, Norway
Vet Immunol Immunopathol 80:271-87. 2001..a. paratuberculosis in the circulation were associated with disseminated lesions in the distal ileum and colon... - The use of interleukin-2 receptor expression as a marker of cell-mediated immunity in goats experimentally infected with Mycobacterium avium ssp. paratuberculosisS K Whist
Institute of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science, Postbox 8146 Dep, N 0033, Oslo, Norway
Vet Immunol Immunopathol 73:207-18. 2000..The risk of selecting subpopulations of lymphocytes during cell separation is avoided... - In vitro responses to purified protein derivate of caprine T lymphocytes following vaccination with live strains of Mycobacterium avium subsp paratuberculosisH J Hasvold
Department of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science, P O Box 8146 Dep, N 0033, Oslo, Norway
Vet Immunol Immunopathol 90:79-89. 2002..Insight into the in vitro recall responses of T cell subsets from animals vaccinated with live paratuberculosis vaccines is essential in the development of more efficient vaccines... - Localisation of CD25+ cells and MHCII+ cells in lymph nodes draining Mycobacterium avium subsp. paratuberculosis vaccination granuloma and the presence of a systemic immune responseM Valheim
Department of Morphology, Genetics and Aquatic Biology, Norwegian School of Veterinary Science, P O Box 8146 Dep N 0033 Oslo, Norway
Res Vet Sci 73:77-85. 2002.... - Modulation of leukocyte populations and immune responses in sheep experimentally infected with Anaplasma (formerly Ehrlichia) phagocytophilumS K Whist
Department of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science, PO Box 8146, N 0033, Oslo, Norway
Vet Immunol Immunopathol 94:163-75. 2003..Antibody responses to vaccines, lymphocyte in vitro proliferative responses to antigens and mitogens, and in vitro IFN-gamma responses to antigens were reduced up to 4 weeks after infection... - DNA injection in combination with electroporation: a novel method for vaccination of farmed ruminantsS Tollefsen
Immunological Institute, Rikshospitalet University of Oslo, Oslo, Norway
Scand J Immunol 57:229-38. 2003..In addition, we show that DNA vaccination in combination with electroporation can improve the primary immune responses to the encoded antigens... - Description of the infection status in a Norwegian cattle herd naturally infected by Mycobacterium avium subsp. paratuberculosisG Holstad
National Veterinary Institute, P.O. Box 8156 Dep, N-0033 Oslo, Norway
Acta Vet Scand 46:45-56. 2005..A cross-reaction with other mycobacteria might have caused some of the immunoreactions in these animals. It is also possible that the Norwegian red cattle breed is resistant to clinical infection with M. a. paratuberculosis... - Characterization of macrophages and occurrence of T cells in intestinal lesions of subclinical paratuberculosis in goatsM Valheim
Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
J Comp Pathol 131:221-32. 2004..No difference in the numbers of these cells was observed between the subclinically infected animals and control animals... - Innate IFN-gamma production in cattle in response to MPP14, a secreted protein from Mycobacterium avium subsp. ParatuberculosisI Olsen
National Veterinary Institute, Oslo, Norway
Scand J Immunol 54:306-13. 2001..This study showed that secreted proteins could induce innate IFN-gamma production that interferes with diagnostic testing using the IFN-gamma-test... - Reduced levels of total leukocytes and neutrophils in Norwegian cattle selected for decreased mastitis incidenceS Kulberg
Department of Pharmacology, Microbiology, and Food Hygiene, The Norwegian School of Veterinary Science, N 0033 Oslo
J Dairy Sci 85:3470-5. 2002.... - Cloning and sequencing of a cDNA encoding the bovine FcR gamma chainH C Morton
Laboratory of Immunohistochemistry and Immunopathology LIIPAT, Institute for Pathology, University of Oslo, Rikshospitalet, N 0027, Oslo, Norway
Vet Immunol Immunopathol 82:101-6. 2001..Cloning of a cDNA encoding, the bovine FcR gamma chain will allow for a better understanding of signal transduction processes triggered by bovine FcRs... - Functions of neutrophils in sheep experimentally infected with Ehrlichia phagocytophilaS K Whist
Department of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science, P O Box 8146, N 0033 Oslo, Norway
Vet Immunol Immunopathol 86:183-93. 2002..The population of cells showing phagocytic activity without respiratory burst was larger in the infected animals compared to controls up to Day 45 post-infection... - Bovine natural killer cells restrict the replication of Mycobacterium bovis in bovine macrophages and enhance IL-12 release by infected macrophagesMichel Denis
AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
Tuberculosis (Edinb) 87:53-62. 2007..bovis growth in infected macrophages by an unclear mechanism, and are potentially involved in innate resistance of cattle to tuberculosis... - Natural killer cells act as early responders in an experimental infection with Neospora caninum in calvesSiv Klevar
Department of Animal Health, National Veterinary Institute, P O Box, 8156 Dep, N 0033 Oslo, Norway
Int J Parasitol 37:329-39. 2007..caninum did not. We believe this is the first time NK cells have been demonstrated to be early responders in N. caninum infection in calves... 
Natural killer cells in lymph nodes of healthy calves express CD16 and show both cytotoxic and cytokine-producing propertiesPreben Boysen
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, P O Box 8146 Dep, N 0033 Oslo, Norway
Dev Comp Immunol 32:773-83. 2008..These findings suggest a cytotoxic role of lymph node residing NK cells, beyond the predominantly cytokine-producing role previously inferred from studies on human NK cells...- Bovine splenic NK cells synthesize IFN-gamma in response to IL-12-containing supernatants from Babesia bovis-exposed monocyte culturesWill L Goff
Animal Disease Research Unit, USDA ARS, Pullman, Washington, USA
Parasite Immunol 28:221-8. 2006..Finally, innate IFN-gamma production was induced in splenic NK cells in the presence of supernatants from B. bovis merozoite-exposed monocytes in an IL-12 pathway-dependent manner... - Genetic diversity of small-ruminant lentiviruses: characterization of Norwegian isolates of Caprine arthritis encephalitis virusBritt Gjerset
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Box 8146 Dep, N 0033 Oslo, Norway
J Gen Virol 87:573-80. 2006..The results described here reveal a distant genetic relationship between Norwegian CAEV and other SRLVs and demonstrate that there is more geographical heterogeneity among SRLVs than reported previously... - The protozoan Neospora caninum directly triggers bovine NK cells to produce gamma interferon and to kill infected fibroblastsPreben Boysen
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, P.O. Box 8146 Dep, N-0033 Oslo, Norway
Infect Immun 74:953-60. 2006.... - Bovine NK cells can produce gamma interferon in response to the secreted mycobacterial proteins ESAT-6 and MPP14 but not in response to MPB70Ingrid Olsen
National Veterinary Institute, P O Box 8156 Dep, 0033 Oslo, Norway
Infect Immun 73:5628-35. 2005.... - Cloning and characterization of equine CD89 and identification of the CD89 gene in chimpanzees and rhesus macaquesH Craig Morton
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet, University Hospital, Oslo, Norway
Immunology 115:74-84. 2005..The identification and characterization of CD89 in different species will contribute to a greater understanding of the biological role of IgA and CD89 in mucosal and systemic immunity throughout evolution... - Cloning and characterization of an immunoglobulin A Fc receptor from cattleH Craig Morton
Laboratory of Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
Immunology 111:204-11. 2004..Identification of the bFcalphaR will aid in the understanding of IgA-FcalphaR interactions, and may facilitate the isolation of FcalphaR from other species... - Reference values for relative numbers of natural killer cells in cattle bloodSiri Kulberg
Department of Food Safety and Infection Biology, The Norwegian School of Veterinary Science, P O Box 8146, Dep, Oslo 0033, Norway
Dev Comp Immunol 28:941-8. 2004..The present material provides a source for reference values for NK cells in cattle at various ages... - Lymphocyte subpopulations and neutrophil function in calves during the first 6 months of lifeAnnette H Kampen
Department of Animal Health, National Veterinary Institute, P O Box 8156 Dep, N 0033 Oslo, Norway
Vet Immunol Immunopathol 113:53-63. 2006..Furthermore, the results indicate that the neutrophilic granulocytes are functional and able to mount an effective response in young calves from the first week of life... - Bacillus cereus Nhe is a pore-forming toxin with structural and functional properties similar to the ClyA (HlyE, SheA) family of haemolysins, able to induce osmotic lysis in epitheliaAnnette Fagerlund
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
Microbiology 154:693-704. 2008..We propose that the common structural and functional properties indicate that the Hbl/Nhe and ClyA families of toxins constitute a superfamily of pore-forming cytotoxins...