Jan L Lyche

Summary

Affiliation: Norwegian School of Veterinary Science
Country: Norway

Publications

  1. ncbi request reprint Levels of PCB 126 and PCB 153 in plasma and tissues in goats exposed during gestation and lactation
    Jan L Lyche
    Department of Reproduction and Forensic Medicine, The Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
    Chemosphere 55:621-9. 2004
  2. doi request reprint Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling
    Jan L Lyche
    Dept Production Animal Clinical Science, Norwegian School of Veterinary Science, Oslo, Norway
    Aquat Toxicol 102:197-204. 2011
  3. ncbi request reprint Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish
    Jan L Lyche
    Department of Production Animal Clinical Science, Norwegian School of Veterinary Science, POB 8146 Dep, N 0033 Oslo, Norway
    J Toxicol Environ Health A 73:1032-57. 2010
  4. doi request reprint Reproductive and developmental toxicity of phthalates
    Jan L Lyche
    Department of Production Animal Clinical Science, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health B Crit Rev 12:225-49. 2009
  5. doi request reprint Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP)
    Rasoul Nourizadeh-Lillabadi
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health A 72:112-30. 2009
  6. doi request reprint Accumulation and effects of natural mixtures of persistent organic pollutants (POP) in Zebrafish after two generations of exposure
    Vidar Berg
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health A 74:407-23. 2011
  7. doi request reprint Altered stress-induced cortisol levels in goats exposed to polychlorinated biphenyls (PCB 126 and PCB 153) during fetal and postnatal development
    Karin E Zimmer
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health A 72:164-72. 2009
  8. doi request reprint Parental exposure to natural mixtures of POPs reduced embryo production and altered gene transcription in zebrafish embryos
    Jan L Lyche
    Dept Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway
    Aquat Toxicol 126:424-34. 2013
  9. doi request reprint Distribution of PCB 118 and PCB 153 and hydroxylated PCB metabolites (OH-CBs) in maternal, fetal and lamb tissues of sheep exposed during gestation and lactation
    Vidar Berg
    Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology, POB 8146 Dep, N 0033 Oslo, Norway
    Chemosphere 80:1144-50. 2010
  10. ncbi request reprint Endocrine disruption induced by organochlorines (OCs): field studies and experimental models
    Erik Ropstad
    Department of Production Animal Sciences, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health A 69:53-76. 2006

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Levels of PCB 126 and PCB 153 in plasma and tissues in goats exposed during gestation and lactation
    Jan L Lyche
    Department of Reproduction and Forensic Medicine, The Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
    Chemosphere 55:621-9. 2004
    ..For PCB 153, the body burden may provide the appropriate dose metric at steady state, but may give a minor underestimation of PCB 126 at low environmental exposure levels due to hepatic sequestration...
  2. doi request reprint Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling
    Jan L Lyche
    Dept Production Animal Clinical Science, Norwegian School of Veterinary Science, Oslo, Norway
    Aquat Toxicol 102:197-204. 2011
    ....
  3. ncbi request reprint Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish
    Jan L Lyche
    Department of Production Animal Clinical Science, Norwegian School of Veterinary Science, POB 8146 Dep, N 0033 Oslo, Norway
    J Toxicol Environ Health A 73:1032-57. 2010
    ..The effects observed in the experimental zebrafish model raise the question whether chemical pollution represents a risk to reproductive health of wild fish inhabitating the freshwater system...
  4. doi request reprint Reproductive and developmental toxicity of phthalates
    Jan L Lyche
    Department of Production Animal Clinical Science, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health B Crit Rev 12:225-49. 2009
    ..Thus, it is concluded that it is important to improve the knowledge of toxic interactions among the different chemicals and to develop measures for combined exposure to various groups of phthalates...
  5. doi request reprint Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP)
    Rasoul Nourizadeh-Lillabadi
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health A 72:112-30. 2009
    ..The effects observed in the experimental zebrafish model raise the question of whether chemical pollution represents a risk to the reproductive health of wild fish inhabiting the freshwater system...
  6. doi request reprint Accumulation and effects of natural mixtures of persistent organic pollutants (POP) in Zebrafish after two generations of exposure
    Vidar Berg
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health A 74:407-23. 2011
    ..Zebrafish exposed to relatively low quantities of POP showed a significant induction of biomarkers (EROD and Vtg), while fish exposed to higher exposure doses did not demonstrate induction...
  7. doi request reprint Altered stress-induced cortisol levels in goats exposed to polychlorinated biphenyls (PCB 126 and PCB 153) during fetal and postnatal development
    Karin E Zimmer
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health A 72:164-72. 2009
    ..Neither the basal maternal cortisol plasma level nor goat kid adrenal masses were affected by PCB exposure...
  8. doi request reprint Parental exposure to natural mixtures of POPs reduced embryo production and altered gene transcription in zebrafish embryos
    Jan L Lyche
    Dept Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway
    Aquat Toxicol 126:424-34. 2013
    ..The results suggest that relative low concentrations of the natural mixtures of POPs used in the present study might pose a threat to wild freshwater fish living in the lakes from which the POPs mixtures originated...
  9. doi request reprint Distribution of PCB 118 and PCB 153 and hydroxylated PCB metabolites (OH-CBs) in maternal, fetal and lamb tissues of sheep exposed during gestation and lactation
    Vidar Berg
    Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology, POB 8146 Dep, N 0033 Oslo, Norway
    Chemosphere 80:1144-50. 2010
    ..The present study demonstrate that high levels of PCB 118 and PCB 153 cross the placenta and accumulate in the fetal adipose tissue and brain thus exposing the fetus during vulnerable periods of extensive development...
  10. ncbi request reprint Endocrine disruption induced by organochlorines (OCs): field studies and experimental models
    Erik Ropstad
    Department of Production Animal Sciences, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health A 69:53-76. 2006
    ....
  11. ncbi request reprint Effects of long-term maternal exposure to low doses of PCB126 and PCB153 on the reproductive system and related hormones of young male goats
    Irma C Oskam
    Department of Production Animal Clinical Science, The Norwegian School of Veterinary Science, Oslo, Norway
    Reproduction 130:731-42. 2005
    ..The effects observed in male kids after a long-term maternal exposure to PCB153 support the concept that exposure to endocrine-disrupting compounds during foetal development may lead to adverse reproductive effects in adult life...
  12. doi request reprint High prevalence of infections and pathological changes in burbot (Lota lota) from a polluted lake (Lake Mjøsa, Norway)
    Vidar Berg
    Norwegian School of Veterinary Science, Oslo, Norway
    Chemosphere 90:1711-8. 2013
    ..The results of the present study suggest that the high level of contamination in Lake Mjøsa could have a negative impact on the health status of wild fish inhabiting the lake...
  13. doi request reprint Natural mixtures of persistent organic pollutants (POPs) suppress ovarian follicle development, liver vitellogenin immunostaining and hepatocyte proliferation in female zebrafish (Danio rerio)
    Marianne Kraugerud
    Dept of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, POB 8146 Dep, 0033 Oslo, Norway
    Aquat Toxicol 116:16-23. 2012
    ....
  14. ncbi request reprint Effects of gestational and lactational exposure to low doses of PCBs 126 and 153 on anterior pituitary and gonadal hormones and on puberty in female goats
    Jan L Lyche
    Department of Production Animal Clinical Sciences, The Norwegian School of Veterinary Science, P O Box 8146 Dep, NO 0033 Oslo, Norway
    Reprod Toxicol 19:87-95. 2004
    ..PCB 126 did not produce any effects at the exposure level tested in this study. In conclusion, perinatal exposure to PCB 153 affected the reproductive function and the puberty maturation in goats...
  15. ncbi request reprint Perinatal exposure to low doses of PCB 153 and PCB 126 affects maternal and neonatal immunity in goat kids
    Jan L Lyche
    Department of Production Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo
    J Toxicol Environ Health A 69:139-58. 2006
    ..The observation that the effects produced by PCB 153 resembled those produced by DES raises the question of whether this congener may modulate immunity by estrogenic mechanisms...
  16. ncbi request reprint Perinatal exposure to PCB 153, but not PCB 126, alters bone tissue composition in female goat offspring
    Rebecca Lundberg
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Toxicology 228:33-40. 2006
    ..In conclusion, perinatal exposure to PCB 153, but not PCB 126, resulted in altered bone composition in female goat offspring...