Vessela N Kristensen

Summary

Affiliation: Norwegian Radium Hospital
Country: Norway

Publications

  1. ncbi request reprint High-throughput methods for detection of genetic variation
    V N Kristensen
    Institute for Cancer Research, Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    Biotechniques 30:318-22, 324, 326 passim. 2001
  2. ncbi request reprint Genetic susceptibility and environmental estrogen-like compounds
    V N Kristensen
    Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    Mutat Res 482:77-82. 2001
  3. pmc Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer
    Noriko Yoshimura
    Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake, Japan
    Breast Cancer Res 6:R46-55. 2004
  4. ncbi request reprint Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer
    Vessela Nedelcheva Kristensen
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    J Steroid Biochem Mol Biol 95:105-11. 2005
  5. ncbi request reprint Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications
    Vessela N Kristensen
    Department of Genetics, Institute of Cancer Research, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Clin Cancer Res 11:878s-83s. 2005
  6. ncbi request reprint Single tube multiplex polymerase chain reaction genotype analysis of GSTM1, GSTT1 and GSTP1: relation of genotypes to TP53 tumor status and clinicopathological variables in breast cancer patients
    V Nedelcheva Kristensen
    Department of Genetics, Institute of Cancer Research, Norwegian Radium Hospital, Montebello
    Pharmacogenetics 8:441-7. 1998
  7. ncbi request reprint CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1
    V Nedelcheva Kristensen
    Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, University Clinic, Oslo
    Cancer Res 59:2825-8. 1999
  8. doi request reprint Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival
    Silje H Nordgard
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    Int J Cancer 123:577-85. 2008
  9. pmc Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features
    Vilde D Haakensen
    Dept of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Norway
    BMC Med Genomics 4:77. 2011
  10. pmc Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
    Vessela N Kristensen
    Department of Genetics, Institute for Cancer Research, and Cancer Clinic, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 109:2802-7. 2012

Collaborators

Detail Information

Publications37

  1. ncbi request reprint High-throughput methods for detection of genetic variation
    V N Kristensen
    Institute for Cancer Research, Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    Biotechniques 30:318-22, 324, 326 passim. 2001
    ..The most frequently used techniques and instrumental settings applied in different combinations are described, and other methods that are less broadly used but have interesting potentials are discussed...
  2. ncbi request reprint Genetic susceptibility and environmental estrogen-like compounds
    V N Kristensen
    Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    Mutat Res 482:77-82. 2001
    ..Polymorphisms in these enzymes may have a possible role in the link between environmental estrogens and hormone-like substances and the interindividual risk of breast cancer...
  3. pmc Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer
    Noriko Yoshimura
    Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake, Japan
    Breast Cancer Res 6:R46-55. 2004
    ..The expression of mRNA transcripts of members of the oestradiol metabolic and signalling pathways including the ER was studied in detail...
  4. ncbi request reprint Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer
    Vessela Nedelcheva Kristensen
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    J Steroid Biochem Mol Biol 95:105-11. 2005
    ..Using significance analysis of microarrays (SAM), we identified 298 genes significantly differently expressed between the partial response and progressive disease groups...
  5. ncbi request reprint Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications
    Vessela N Kristensen
    Department of Genetics, Institute of Cancer Research, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Clin Cancer Res 11:878s-83s. 2005
    ..Using significance analysis of microarrays, we identified 298 genes significantly differently expressed between partial response and progressive disease groups...
  6. ncbi request reprint Single tube multiplex polymerase chain reaction genotype analysis of GSTM1, GSTT1 and GSTP1: relation of genotypes to TP53 tumor status and clinicopathological variables in breast cancer patients
    V Nedelcheva Kristensen
    Department of Genetics, Institute of Cancer Research, Norwegian Radium Hospital, Montebello
    Pharmacogenetics 8:441-7. 1998
    ..05). Patients who were homozygous for the deleted GSTM1 allele were found to have a significantly shorter overall survival (P = 0.036)...
  7. ncbi request reprint CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1
    V Nedelcheva Kristensen
    Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, University Clinic, Oslo
    Cancer Res 59:2825-8. 1999
    ..Age at onset, tumor grade, lymph node status and distant metastases, stage, and estrogen and progesterone receptor status were not associated with the CYP17 genotype...
  8. doi request reprint Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival
    Silje H Nordgard
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    Int J Cancer 123:577-85. 2008
    ..These data suggest that 3 copies of the TYMS 5'UTR repeat may give a treatment specific reduced survival in breast cancer patients, and that TP53 may have a direct, allele specific, role in 5-FU mediated response...
  9. pmc Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features
    Vilde D Haakensen
    Dept of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Norway
    BMC Med Genomics 4:77. 2011
    ..Increased understanding of the variability in normal breast biology will enable us to identify mechanisms of breast cancer initiation and the origin of different subtypes, and to better predict breast cancer risk...
  10. pmc Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
    Vessela N Kristensen
    Department of Genetics, Institute for Cancer Research, and Cancer Clinic, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 109:2802-7. 2012
    ..In conclusion, by means of a pathway-based modeling methodology (PARADIGM) integrating different layers of molecular data from whole-tumor samples, we demonstrate that we can stratify immune signatures that predict patient survival...
  11. ncbi request reprint Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients
    Thomas Fleischer
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway The K G Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway
    Int J Cancer 134:2615-25. 2014
    ..Our study provides evidence for the promise of DNA methylation alterations for clinical applications...
  12. ncbi request reprint Principles and methods of integrative genomic analyses in cancer
    Vessela N Kristensen
    1 Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway 2 K G Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway 3 Department of Clinical Molecular Oncology, Division of Medicine, Akershus University Hospital, 1478 Ahus, Norway
    Nat Rev Cancer 14:299-313. 2014
    ..The objectives, methods and computational tools of integrative genomics that are available to date are reviewed here, as is their implementation in cancer research. ..
  13. doi request reprint Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients
    Silje H Nordgard
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 47:680-96. 2008
    ..The genes where these SNPs reside encode proteins involved in the extracellular matrix (CHST3 and SPOCK2), in regulation of the cell cycle (JMY, PTPRN2, and Cwf19L2) and chromosome stability (KPNB1)...
  14. pmc Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas
    Vilde D Haakensen
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    BMC Cancer 11:332. 2011
    ..High serum levels of estradiol are associated with increased risk of postmenopausal breast cancer. Little is known about the gene expression in normal breast tissue in relation to levels of circulating serum estradiol...
  15. pmc Combining gene signatures improves prediction of breast cancer survival
    Xi Zhao
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    PLoS ONE 6:e17845. 2011
    ..Gene sets from eleven previously published gene signatures are included in the study...
  16. ncbi request reprint Germline glutathione S-transferase variants in breast cancer: relation to diagnosis and cutaneous long-term adverse effects after two fractionation patterns of radiotherapy
    Hege Edvardsen
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Int J Radiat Oncol Biol Phys 67:1163-71. 2007
    ..To explore whether certain glutathione S-transferase (GST) polymorphisms are associated with an increased risk of breast cancer or the level of radiation-induced adverse effects after two fractionation patterns of adjuvant radiotherapy...
  17. pmc Genetic variation in putative regulatory loci controlling gene expression in breast cancer
    Vessela N Kristensen
    Department of Genetics, Institute of Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 103:7735-40. 2006
    ..It provides the statistical framework for further genotype expression correlation studies in cancer data sets...
  18. doi request reprint GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas
    Jo Anders Rønneberg
    Department of Genetics, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Cancer Res 68:5562-71. 2008
    ..GSTP1 expression was moderately but significantly (P = 0.01) reduced after siRNA-mediated knockdown of c-Myb. Our results indicate that haplotype structure of a promoter is important for the extent of DNA methylation...
  19. pmc Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer
    Aslaug Aa Muggerud
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, Oslo, N 0310, Norway
    Breast Cancer Res 12:R3. 2010
    ....
  20. doi request reprint Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway
    Kristin V Reinertsen
    National Resource Center for Late Effects, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Montebello, 0310 Oslo, Norway
    Brain Behav Immun 25:1376-83. 2011
    ..In a large cohort of BCSs the investigated SNPs in inflammation-related genes were not associated with fatigue, though subset analyses indicated an association between the CRP SNP (rs3091244) and serum hsCRP...
  21. pmc Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes
    Silje H Nordgard
    Department of Genetics, Institute of Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Montebello, N 0310 Oslo, Norway
    Breast Cancer Res 9:113. 2007
    ....
  22. pmc Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer
    Hiroko K Solvang
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Montebello, and Department of Biostatistics, Institute of Basic Medical Science, University of Oslo, 0310 Oslo, Norway
    BMC Bioinformatics 12:197. 2011
    ..Here, we propose a statistical approach to investigate and distinguish between linear and nonlinear dependences between DNA copy number alteration and mRNA expression...
  23. ncbi request reprint ABCB1 and GST polymorphisms associated with TP53 status in breast cancer
    Silje H Nordgard
    Department of Genetics, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Pharmacogenet Genomics 17:127-36. 2007
    ..The goal of this study was to characterize the genetic variation in the ABCB1, GSTM1, GSTT1 and GSTP1 genes, as well as the haplotype structure in the ABCB1 gene...
  24. doi request reprint Functional glutathione S-transferase genotypes among testicular germ cell tumor survivors: associations with primary and post-chemotherapy tumor histology
    Sigrid M Kraggerud
    Department of Cancer Prevention, Centre for Cancer Biomedicine, The Norwegian Radium Hospital, Drammen, Norway
    Pharmacogenet Genomics 19:751-9. 2009
    ....
  25. doi request reprint SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling
    Hege Edvardsen
    Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo, Norway
    Int J Radiat Oncol Biol Phys 86:791-9. 2013
    ..Reactive oxygen species (ROS) are generated after irradiation, and genetic variation in genes related to ROS metabolism might influence the level of radiation-induced adverse effects (AEs)...
  26. pmc Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data
    Miriam Ragle Aure
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    PLoS ONE 8:e53014. 2013
    ..Validation in an independent data set supports the conclusion that the method identifies genes implicated in cancer...
  27. ncbi request reprint Experimental validation of data mined single nucleotide polymorphisms from several databases and consecutive dbSNP builds
    Hege Edvardsen
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Faculty Division of the University of Oslo, Oslo, Norway
    Pharmacogenet Genomics 16:207-17. 2006
    ..The selected genotypes represent a valuable set of verified candidate SNPs for pharmacogenetic studies in Caucasian populations...
  28. pmc Multilocus analysis of SNP and metabolic data within a given pathway
    Vessela N Kristensen
    Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
    BMC Genomics 7:5. 2006
    ..One of the greatest challenges facing human geneticists is the identification and characterization of susceptibility genes for common multifactorial diseases and their association to different quantitative phenotypic traits...
  29. pmc Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status
    Xi Zhao
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello 0310 Oslo, Norway
    BMC Cancer 14:211. 2014
    ....
  30. doi request reprint Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression
    Ivan O Potapenko
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Mol Oncol 4:98-118. 2010
    ....
  31. pmc Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density
    Vilde D Haakensen
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Montebello, NO 0310, Norway
    Breast Cancer Res 12:R65. 2010
    ..However, the biologic correlates of density are little known...
  32. pmc Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density
    Margarethe Biong
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello 0310, Oslo, Norway
    BMC Med Genomics 3:9. 2010
    ..The associations between genetic polymorphisms in genes from the IGF pathway on mammographic density and circulating levels of IGF1, its binding protein IGFBP3, and their ratio in postmenopausal women are reported here...
  33. ncbi request reprint The genetics and epigenetics of fatigue
    Hege Landmark-Høyvik
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Montebello, Norway
    PM R 2:456-65. 2010
    ....
  34. pmc Allele-specific copy number analysis of tumors
    Peter Van Loo
    Department of Genetics, Institute for Cancer Research, Clinic for Cancer and Surgery, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 107:16910-5. 2010
    ..We hypothesize that these alternative alleles have a different influence on breast carcinoma development...
  35. pmc miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors
    Espen Enerly
    Division of Surgery and Cancer, Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    PLoS ONE 6:e16915. 2011
    ..In this study we present and analyze data derived from expression profiling of 799 miRNAs in 101 primary human breast tumors, along with genome-wide mRNA profiles and extensive clinical information...
  36. ncbi request reprint BUB1 infrequently mutated in human breast carcinomas
    Anita Langerød
    Dep of Genetics, Inst for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Hum Mutat 22:420. 2003
    ..No somatic mutations were detected. These results indicate that genomic instability scored as copy number alterations by CGH in TP53 wild type breast carcinomas is not caused by somatic mutations in the BUB1 gene...
  37. ncbi request reprint Interaction between smoking, GSTM1 deletion and colorectal cancer: results from the GSEC study
    K M Smits
    University of Maastricht, Maastricht, The Netherlands
    Biomarkers 8:299-310. 2003
    ..007, p=0.97). Our findings do not support an association between the GSTM1 null genotype and colorectal cancer. In addition, we did not find any modification of the smoking-induced colorectal cancer risk by GSTM1 genotype..