Pål Klepstad

Summary

Affiliation: Norwegian University of Science and Technology
Country: Norway

Publications

  1. doi The importance and pitfalls of correlational science in palliative care research
    Pål Klepstad
    Department of Anesthesiology and Acute Medicine, St Olavs University Hospital, Trondheim, Norway
    Curr Opin Support Palliat Care 6:508-13. 2012
  2. pmc Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S--Scandinavian Starch for Severe Sepsis/Septic Shock trial): study protocol, design and rationale for
    Anders Perner
    Department of Intensive Care, Centre of Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 12:24. 2011
  3. ncbi Pain and pain treatments in European palliative care units. A cross sectional survey from the European Association for Palliative Care Research Network
    Pål Klepstad
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 19:477-84. 2005
  4. doi Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients
    P Klepstad
    Pain and Palliation Research Group, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway
    Pain 152:1139-45. 2011
  5. doi Starting step III opioids for moderate to severe pain in cancer patients: dose titration: a systematic review
    Pål Klepstad
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 25:424-30. 2011
  6. ncbi [Genetic variation-- important for the clinical effect of opioids?]
    Pål Klepstad
    Avdeling for anestesi og akuttmedisin, St Olavs Hospital, 7006 Trondheim
    Tidsskr Nor Laegeforen 125:2655-8. 2005
  7. ncbi Genetic variability and clinical efficacy of morphine
    P Klepstad
    Department of Circulation and Medical Imaging, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway
    Acta Anaesthesiol Scand 49:902-8. 2005
  8. ncbi Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients
    Pål Klepstad
    Department of Anaesthesia and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 17:679-87. 2003
  9. pmc Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Faculty of Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7489, Trondheim, Norway
    Eur J Clin Pharmacol 68:55-64. 2012
  10. pmc Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study
    Pål Klepstad
    Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    BMC Clin Pharmacol 4:7. 2004

Detail Information

Publications63

  1. doi The importance and pitfalls of correlational science in palliative care research
    Pål Klepstad
    Department of Anesthesiology and Acute Medicine, St Olavs University Hospital, Trondheim, Norway
    Curr Opin Support Palliat Care 6:508-13. 2012
    ..The purpose of this review is to address the importance and potential pitfalls in correlational science...
  2. pmc Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S--Scandinavian Starch for Severe Sepsis/Septic Shock trial): study protocol, design and rationale for
    Anders Perner
    Department of Intensive Care, Centre of Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 12:24. 2011
    ..Now lower molecular weight HES 130/0.4 is the preferred colloid in Scandinavian intensive care units (ICUs) and 1st choice fluid for patients with severe sepsis. However, HES 130/0.4 is largely unstudied in patients with severe sepsis...
  3. ncbi Pain and pain treatments in European palliative care units. A cross sectional survey from the European Association for Palliative Care Research Network
    Pål Klepstad
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 19:477-84. 2005
    ..We observed large variations in the use of opioids across countries. Finally, we observed that only a minority of the patients who used morphine needed very high doses...
  4. doi Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients
    P Klepstad
    Pain and Palliation Research Group, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway
    Pain 152:1139-45. 2011
    ..To elicit knowledge about new genes that influence pain and the need for opioids, strategies other than the candidate gene approach is needed...
  5. doi Starting step III opioids for moderate to severe pain in cancer patients: dose titration: a systematic review
    Pål Klepstad
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 25:424-30. 2011
    ..Two randomized controlled trials were identified. One study compared starting opioid treatment with intravenous morphine versus IR oral morphine and one study compared IR oral morphine versus sustained release oral morphine...
  6. ncbi [Genetic variation-- important for the clinical effect of opioids?]
    Pål Klepstad
    Avdeling for anestesi og akuttmedisin, St Olavs Hospital, 7006 Trondheim
    Tidsskr Nor Laegeforen 125:2655-8. 2005
    ..Results obtained so far strongly suggest that opioid efficacy is partly related to inborn properties caused by genetic variability...
  7. ncbi Genetic variability and clinical efficacy of morphine
    P Klepstad
    Department of Circulation and Medical Imaging, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway
    Acta Anaesthesiol Scand 49:902-8. 2005
    ..Thus, results obtained so far strongly argue that opioid efficacy is partly related to inborn properties caused by genetic variability...
  8. ncbi Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients
    Pål Klepstad
    Department of Anaesthesia and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 17:679-87. 2003
    ..This result suggests that therapeutic drug monitoring as a routine tool during chronic morphine treatment has limited value for clinical decision making...
  9. pmc Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Faculty of Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7489, Trondheim, Norway
    Eur J Clin Pharmacol 68:55-64. 2012
    ....
  10. pmc Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study
    Pål Klepstad
    Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    BMC Clin Pharmacol 4:7. 2004
    ..One important factor relevant to drug monitoring is to what extent morphine, M6G and M3G serum concentrations fluctuate during stable morphine treatment...
  11. doi Is oxycodone efficacy reflected in serum concentrations? A multicenter, cross-sectional study in 456 adult cancer patients
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 43:694-705. 2012
    ..The relationship between oxycodone and metabolite serum concentrations and clinical effects has not previously been investigated in cancer pain patients...
  12. ncbi Intensity and treatment of symptoms in 3,030 palliative care patients: a cross-sectional survey of the EAPC Research Network
    Eivor Alette Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Opioid Manag 5:11-21. 2009
    ..This study aimed to describe intensity and treatment of symptoms other than pain in European palliative care units...
  13. doi Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with pain
    Torill Fladvad
    Department of Cancer Research and Molecular Medicine, European Palliative Care Research Center, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway
    Pharmacogenet Genomics 23:117-26. 2013
    ....
  14. doi A double-blind, randomized, crossover comparison between single-dose and double-dose immediate-release oral morphine at bedtime in cancer patients
    Ola Dale
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 37:68-76. 2009
    ..50 has little clinical significance, and the two procedures are, therefore, clinically equivalent. It is speculated whether the initial higher exposure to morphine-6-glucuronide may have clinical significance...
  15. ncbi [Use of opioids against severe cancer pain]
    Petter C Borchgrevink
    Senter for smerte og sammensatte lidelser, Anestesiavdelingen, St Olavs Hospital, 7006 Trondheim
    Tidsskr Nor Laegeforen 124:337-8. 2004
  16. doi Effects of hypothermia on the disposition of morphine, midazolam, fentanyl, and propofol in intensive care unit patients
    Thor Wilhelm Bjelland
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Drug Metab Dispos 41:214-23. 2013
    ..CL(tot) was lower during TH for morphine, fentanyl, and propofol but not for midazolam. Reducing the infusion rates of morphine, fentanyl, and propofol during TH is encouraged...
  17. ncbi Long term methadone for chronic pain: a pilot study of pharmacokinetic aspects
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Pain 11:599-604. 2007
    ..Our findings contradict that autoinduction of methadone metabolism takes place during long term treatment and supports that a 3-day opioid switch from morphine to methadone followed by a one week titration seems pharmacologically sound...
  18. ncbi Recovery patterns and health-related quality of life in older patients undergoing cardiac surgery: a prospective study
    Kari Hanne Gjeilo
    Department of Cardiothoracic Surgery, St Olav s Hospital, Trondheim University Hospital, Trondheim, Norway
    Eur J Cardiovasc Nurs 11:322-30. 2012
    ..Particularly in older age, HRQOL, rather than longevity, is the primary goal of treatment. However, prospective studies describing recovery and HRQOL are still scarce...
  19. ncbi Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: A prospective 9-month follow-up study
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Institute of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 32:180-5. 2006
    ..We observed no episodes of arrhythmias...
  20. ncbi Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy
    Monica Holthe
    Institute of Cancer Research and Molecular Biology, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Eur J Clin Pharmacol 58:353-6. 2002
    ..Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma ratios among cancer patients undergoing analgesic therapy with morphine...
  21. doi Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    Eur J Cancer 47:1682-91. 2011
    ..This study investigates whether demographical, disease-related and genetic factors contribute to inter-individual differences in nausea and vomiting among patients receiving opioids for cancer pain...
  22. ncbi The Norwegian brief pain inventory questionnaire: translation and validation in cancer pain patients
    Pål Klepstad
    Department of Anesthesiology and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 24:517-25. 2002
    ....
  23. doi Which domains should be included in a cancer pain classification system? Analyses of longitudinal data
    Anne Kari Knudsen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Pain 153:696-703. 2012
    ..Initial pain intensity emerged as the strongest predictor of pain outcome after 2 weeks, and incident pain was confirmed to be a relevant domain. The regression models explained only a minor part of the variability of pain outcomes...
  24. pmc Inadequate symptom control in advanced cancer patients across Europe
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Medisinsk teknisk forskningssenter, Olav Kyrres gate 9, 7489 Trondheim, Norway
    Support Care Cancer 19:2005-14. 2011
    ..The purpose of this study is to examine the adequacy of treatment for constipation, nausea, depression and poor sleep and the factors associated with inadequate symptom control in cancer patients receiving opioids...
  25. pmc Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain
    Trude T Rakvåg
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Mol Pain 4:64. 2008
    ..In this study we wanted to investigate if variability in other regions in the COMT gene also contributes to interindividual variability in morphine efficacy...
  26. doi The role of sex in health-related quality of life after cardiac surgery: a prospective study
    Kari Hanne Gjeilo
    Department of aCardiothoracic Surgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    Eur J Cardiovasc Prev Rehabil 15:448-52. 2008
    ..To assess health-related quality of life (HRQOL) in patients after cardiac surgery with emphasis on sex differences...
  27. ncbi Self-reports are not related to objective assessments of cognitive function and sedation in patients with cancer pain admitted to a palliative care unit
    Pål Klepstad
    Department of Anesthesia and Medical Imaging, Norwegian University of Science and Technology, Trondheim
    Palliat Med 16:513-9. 2002
    ..This finding illustrates the importance of differentiating between observations and patient self-reports. The results also question the validity of patient self-reports for measurements of cognitive failure and sedation...
  28. ncbi Survival and quality of life in an elderly cardiac surgery population: 5-year follow-up
    Kari Hanne Gjeilo
    Department of Cardiothoracic Surgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    Eur J Cardiothorac Surg 44:e182-8. 2013
    ..The purpose of this study was to explore HRQOL and survival in patients undergoing cardiac surgery after 5 years, emphasizing on older patients (≥75 years)...
  29. ncbi Expert conference on cancer pain assessment and classification--the need for international consensus: working proposals on international standards
    Stein Kaasa
    European Palliative Care Research Centre PRC, Faculty of Medicine, NTNU, Trondheim, Norway
    BMJ Support Palliat Care 1:281-7. 2011
    ..The proposed name for this international standard is Cancer Pain Assessment and Classification System (CPACS). ..
  30. pmc Health care providers underestimate symptom intensities of cancer patients: a multicenter European study
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Health Qual Life Outcomes 8:104. 2010
    ..The extent of agreement between patient and provider symptom assessments and the association of agreement with demographic- and disease-related factors was examined...
  31. ncbi Interviews with patients with advanced cancer--another step towards an international cancer pain classification system
    Anne Kari Knudsen
    European Palliative Care Research Centre, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, Trondheim University Hospital, Trondheim, Norway
    Support Care Cancer 20:2491-500. 2012
    ....
  32. doi Propofol and remifentanil versus midazolam and fentanyl for sedation during therapeutic hypothermia after cardiac arrest: a randomised trial
    Thor W Bjelland
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
    Intensive Care Med 38:959-67. 2012
    ..Secondary outcomes were blood pressure, heart rate, use of vasopressors and inotropic drugs, pneumonia and neurological outcome...
  33. doi Management of opioid-induced nausea and vomiting in cancer patients: systematic review and evidence-based recommendations
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Norway
    Palliat Med 25:442-53. 2011
    ..The evidence was also too limited to prioritize between symptomatic treatment and adjustment of the opioid treatment...
  34. pmc Influences on the pharmacokinetics of oxycodone: a multicentre cross-sectional study in 439 adult cancer patients
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Clin Pharmacol 67:493-506. 2011
    ..The aim of this study was to explore the relationships between ordinary patient characteristics and serum concentrations of oxycodone and the ratios noroxycodone or oxymorphone/oxycodone in cancer patients...
  35. ncbi Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Institute of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim
    Palliat Med 20:35-41. 2006
    ..This study brings novel information on the long-term consequences for pain control, health-related quality of life and cognitive functioning with a switch from morphine to methadone in the treatment of chronic non-malignant pain...
  36. doi Early pharmacokinetics of nasal fentanyl: is there a significant arterio-venous difference?
    Kristin Moksnes
    Department of Circulation and Medical Imaging, Pain and Palliation Research Group, Norwegian University of Science and Technology, St Olav University Hospital, Kreftbygget, 5th Floor, Olav Kyrres gate 17, 7006, Trondheim, Norway
    Eur J Clin Pharmacol 64:497-502. 2008
    ..We have investigated the arterio-venous difference in the pharmacokinetics of 50 microg fentanyl during the first hour following nasal administration and documented its tolerability in opioid-naïve middle-aged to elderly patients...
  37. doi The Brief Pain Inventory: pain's interference with functions is different in cancer pain compared with noncancer chronic pain
    Jacob C Hølen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Norway
    Clin J Pain 24:219-25. 2008
    ....
  38. ncbi Validation of the brief pain inventory in patients six months after cardiac surgery
    Kari Hanne Gjeilo
    Department of Cardiothoracic Surgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    J Pain Symptom Manage 34:648-56. 2007
    ..Validating pain measures for use in this population is an important part of establishing a foundation for future studies on chronic pain after cardiac surgery...
  39. ncbi A controlled comparison between single doses of intravenous and intramuscular morphine with respect to analgesic effects and patient safety
    T Tveita
    Department of Anaesthesiology, Institute of Clinical Medicine, Medical Faculty, University of Tromsø, Norway
    Acta Anaesthesiol Scand 52:920-5. 2008
    ..This study was carried out to compare patient safety and analgesic efficacy of a single and high dose of morphine given IM or IV for post-operative pain management...
  40. ncbi Start of oral morphine to cancer patients: effective serum morphine concentrations and contribution from morphine-6-glucuronide to the analgesia produced by morphine
    P Klepstad
    Department of Anaesthesiology, University Hospital of Trondheim, Norwegian University of Science and Technology, Trondheim N 7006, Norway
    Eur J Clin Pharmacol 55:713-9. 2000
    ....
  41. doi Patterns of smoking behaviour in patients following cardiac surgery. A prospective study
    Kari Hanne Gjeilo
    Department of Cardiothoracic Surgery, St Olav s Hospital, Trondheim University Hospital, Trondheim, Norway
    Scand Cardiovasc J 44:295-300. 2010
    ..To describe patterns of smoking behaviour in patients undergoing cardiac surgery...
  42. doi Lack of association between genetic variability and multiple pain-related outcomes in a large cohort of patients with advanced cancer: the European Pharmacogenetic Opioid Study (EPOS)
    Torill Fladvad
    European Palliative Care Research Center PRC, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    BMJ Support Palliat Care 2:351-5. 2012
    ....
  43. ncbi Health-related quality of life in long term-survivors of thoracoabdominal aortic aneurysm repair
    Trine M Olberg Eide
    Department of Surgery, University Hospital of Trondheim, Trondheim, Norway
    J Vasc Nurs 23:88-94; quiz 95. 2005
    ..When disease-specific questions were related to thoracoabdominal aneurysm surgery, most patients reported an acceptable HRQOL...
  44. doi Which variables are associated with pain intensity and treatment response in advanced cancer patients?--Implications for a future classification system for cancer pain
    Anne Kari Knudsen
    European Palliative Care Research Centre, Faculty of Medicine, NTNU, NO 7006 Trondheim, Norway
    Eur J Pain 15:320-7. 2011
    ..A confirmative and explorative approach was applied to investigate which of the variables identified in the literature, by experts and patients that are associated with pain...
  45. ncbi Immediate- or sustained-release morphine for dose finding during start of morphine to cancer patients: a randomized, double-blind trial
    P Klepstad
    Department of Anesthesiology, University Hospital of Trondheim, N 7006, Trondheim, Norway
    Pain 101:193-8. 2003
    ..Similar global satisfactions with the morphine treatments were reported. In conclusion, a simplified titration using sustained-release morphine once daily is equally effective as immediate-release morphine given 4-hourly...
  46. ncbi Pain intensity and side effects during titration of morphine to cancer patients using a fixed schedule dose escalation
    P Klepstad
    Department of Anesthesia and Medical Imaging, Norwegian University of Science and Technology, Trondheim
    Acta Anaesthesiol Scand 44:656-64. 2000
    ..However, to our knowledge, only one previous study has reported effective doses in morphine naive cancer patients and no prospective evaluation has compared symptoms before with symptoms during morphine titration...
  47. doi Classification of pain in cancer patients--a systematic literature review
    A K Knudsen
    Pain and Palliation Research Group and Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, Trondheim University Hospital, Trondheim, Norway
    Palliat Med 23:295-308. 2009
    ..This systematic review suggests a need for developing an international consensus on how to classify pain in cancer patients...
  48. ncbi Variable response to opioid treatment: any genetic predictors within sight?
    F Skorpen
    Department of Laboratory Medicine, Children s and Women s Health, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Palliat Med 22:310-27. 2008
    ..This reflects the general lack of studies performed in the context of palliative care, the lack of sufficiently scaled studies and the lack of international standards for the assessment of subjective symptoms...
  49. ncbi Serum and cerebrospinal fluid morphine pharmacokinetics after single doses of intravenous and intramuscular morphine after hip replacement surgery
    O Dale
    Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Clin Pharmacol 63:837-42. 2007
    ..To compare the time course of morphine and metabolite concentrations in serum and cerebrospinal fluid (CSF) after intravenous and intramuscular administration after surgery...
  50. ncbi The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease
    P Klepstad
    Institute of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Acta Anaesthesiol Scand 48:1232-9. 2004
    ..The purpose of the study was to investigate whether this and other genetic polymorphisms in OPRM1 influence the efficacy of morphine in cancer pain patients...
  51. ncbi Influences on serum concentrations of morphine, M6G and M3G during routine clinical drug monitoring: a prospective survey in 300 adult cancer patients
    P Klepstad
    Department of Anesthesia and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Acta Anaesthesiol Scand 47:725-31. 2003
    ..These factors, however, are not evaluated in studies with a sample size sufficient to explore predictive factors...
  52. pmc The systemic inflammatory response and its relationship to pain and other symptoms in advanced cancer
    Barry J Laird
    European Palliative Care Research Centre, Norwegian University of Science and Technology, Trondheim, Norway
    Oncologist 18:1050-5. 2013
    ..The aim of the present study was to examine the relationship between symptoms and systemic inflammation in a large cohort of patients with advanced cancer...
  53. pmc Is there a genetic cause of appetite loss?-an explorative study in 1,853 cancer patients
    Tora S Solheim
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, 7030, Trondheim, Norway
    J Cachexia Sarcopenia Muscle 3:191-8. 2012
    ....
  54. ncbi Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients
    M Holthe
    Institute of Cancer Research and Molecular Biology, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Pharmacogenomics J 3:17-26. 2003
    ..4-309.2; morphine 6-glucuronide/morphine: 0.5-72.8). Our results suggest that factors other than UGT2B7 polymorphism may be more deciding for the variability in morphine glucuronide to morphine serum ratios...
  55. ncbi Long-term treatment with ketamine in a 12-year-old girl with severe neuropathic pain caused by a cervical spinal tumor
    P Klepstad
    Pain Clinic, Department of Anesthesiology, University Hospital, Trondheim, Norway
    J Pediatr Hematol Oncol 23:616-9. 2001
    ..This patient also demonstrates the feasibility of long-term ketamine treatment in pediatric oncology and that such treatment can be administered in a home care setting...
  56. ncbi A cross-sectional study on prevalence of pain and breakthrough pain among an unselected group of outpatients in a tertiary cancer clinic
    Sunil X Raj
    European Palliative Care Research Centre, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Support Care Cancer 22:1965-71. 2014
    ....
  57. doi Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study
    Daniel T Barratt
    aDiscipline of Pharmacology, School of Medical Sciences bSchool of Mathematical Sciences, University of Adelaide cDepartment of Clinical Pharmacology, Royal Adelaide Hospital, Adelaide, Australia dDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark eDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology fDepartment of Cancer Research and Molecular Medicine, European Palliative Care Research Centre, Trondheim, Norway
    Pharmacogenet Genomics 24:185-94. 2014
    ..This study aimed to investigate whether CYP3A4/5 genetic variants, together with clinical and patient factors, influence serum fentanyl and norfentanyl concentrations and their ratio in cancer pain patients receiving transdermal fentanyl...
  58. ncbi [Biobank legislation stops research using critically ill patients]
    Ola Dale
    Klinikk for anestesi og akuttmedisin, St Olavs Hospital, og Institutt for sirkulasjon og bildediagnostikk, Norges Teknisk Naturvitenskapelige Universitet, 7006 Trondheim
    Tidsskr Nor Laegeforen 125:2524. 2005
  59. ncbi Intranasal midazolam: a comparison of two delivery devices in human volunteers
    Ola Dale
    Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    J Pharm Pharmacol 58:1311-8. 2006
    ..We cannot disregard that only the traditional spray caused less sedation than intravenous administration. This finding needs to be confirmed in trials designed for this purpose...
  60. ncbi Health-related quality of life three years after coronary surgery: a comparison with the general population
    Kari Hanne Gjeilo
    Department of Cardiothoracic Surgery, St Olavs HospitalTrondheim University Hospital, Trondheim, Norway
    Scand Cardiovasc J 40:29-36. 2006
    ..To assess health-related quality of life (HRQOL) in patients three years after coronary artery bypass grafting (CABG) compared to the general Norwegian population, with emphasis on age and gender-differences...
  61. doi Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrest
    Thor Wilhelm Bjelland
    Department of Circulation and Medical Imaging, Medical Faculty, Norwegian University of Science and Technology, 7006 Trondheim, Norway
    Resuscitation 81:1627-31. 2010
    ..To investigate the net platelet inhibition of clopidogrel, we have measured the platelet reactivity index in patients treated with therapeutic hypothermia...
  62. doi Direct transport versus interhospital transfer of patients with severe head injury in Norway
    Kent Gøran Moen
    Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Emerg Med 15:249-55. 2008
    ..This study compares injury severity and outcome of patients with severe head injury admitted directly to a neurosurgical department with those initially transferred to a local hospital...
  63. doi Chronic pain after cardiac surgery: a prospective study
    K H Gjeilo
    St Elisabeth Department of Cardiothoracic Surgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    Acta Anaesthesiol Scand 54:70-8. 2010
    ..The aim of the present study was to assess chronic pain and health-related quality of life (HRQOL) after cardiac surgery...