Research Topics

Genomes and Genes

Species

Trine Husøy

Summary

Affiliation: Norwegian Institute of Public Health
Country: Norway

Publications

  1. request reprint
    Høie A, Svendsen C, Rasmussen T, Alexander J, Husøy T. Intestinal Tumor Development in C57BL/6J-ApcMin/+ Mice Expressing Human Sulphotransferases 1A1 and 1A2 After Oral Exposure to 2,5-Dimethylfuran. Anticancer Res. 2016;36:545-53 pubmed
    ..Tumor development in Min mice was not affected. Overall, the tumorigenic potential of DMF in a metabolically competent mouse model was not convincing. ..
  2. Høie A, Monien B, Glatt H, Hjertholm H, Husøy T. DNA adducts induced by food mutagen PhIP in a mouse model expressing human sulfotransferases 1A1 and 1A2. Toxicol Lett. 2016;248:34-8 pubmed publisher
    ..The liver was the least affected organ in wild-type mice, whereas it was the most affected organ in hSULT mice with a 14-fold higher adduct level. ..
  3. von Goetz N, Pirow R, Hart A, Bradley E, Poças F, Arcella D, et al. Including non-dietary sources into an exposure assessment of the European Food Safety Authority: The challenge of multi-sector chemicals such as Bisphenol A. Regul Toxicol Pharmacol. 2017;85:70-78 pubmed publisher
    ....
  4. request reprint
    Husøy T, Cruciani V, Knutsen H, Mikalsen S, Ølstørn H, Alexander J. Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization. Carcinogenesis. 2003;24:643-50 pubmed
    ..Reduction in GJIC and Cx43 level in IMCE cells may be caused by reduced Cx43 transport as a result of alterations in microtubule function. ..
  5. request reprint
    Husøy T, Knutsen H, Cruciani V, Olstørn H, Mikalsen S, Løberg E, et al. Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts. Int J Cancer. 2005;116:351-8 pubmed
    ..We hypothesise that gap junctions may be of importance in the transfer of signals between epithelium and stroma. ..
  6. Huffman M, Høie A, Svendsen C, Brunborg G, Murkovic M, Glatt H, et al. An in vitro study on the genotoxic effect of substituted furans in cells transfected with human metabolizing enzymes: 2,5-dimethylfuran and furfuryl alcohol. Mutagenesis. 2016;31:597-602 pubmed publisher
    ..The results suggest that DNA damage in V79 cells from exposure to DMF detected by the alkaline SCGE assay is independent of human CYP2E1 and SULT1A1, and the genotoxic effect of FFA, as assessed by SCGE, is minimal in V79 cells. ..

Locale

Detail Information

Publications6

  1. request reprint
    Høie A, Svendsen C, Rasmussen T, Alexander J, Husøy T. Intestinal Tumor Development in C57BL/6J-ApcMin/+ Mice Expressing Human Sulphotransferases 1A1 and 1A2 After Oral Exposure to 2,5-Dimethylfuran. Anticancer Res. 2016;36:545-53 pubmed
    ..Tumor development in Min mice was not affected. Overall, the tumorigenic potential of DMF in a metabolically competent mouse model was not convincing. ..
  2. Høie A, Monien B, Glatt H, Hjertholm H, Husøy T. DNA adducts induced by food mutagen PhIP in a mouse model expressing human sulfotransferases 1A1 and 1A2. Toxicol Lett. 2016;248:34-8 pubmed publisher
    ..The liver was the least affected organ in wild-type mice, whereas it was the most affected organ in hSULT mice with a 14-fold higher adduct level. ..
  3. von Goetz N, Pirow R, Hart A, Bradley E, Poças F, Arcella D, et al. Including non-dietary sources into an exposure assessment of the European Food Safety Authority: The challenge of multi-sector chemicals such as Bisphenol A. Regul Toxicol Pharmacol. 2017;85:70-78 pubmed publisher
    ....
  4. request reprint
    Husøy T, Cruciani V, Knutsen H, Mikalsen S, Ølstørn H, Alexander J. Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization. Carcinogenesis. 2003;24:643-50 pubmed
    ..Reduction in GJIC and Cx43 level in IMCE cells may be caused by reduced Cx43 transport as a result of alterations in microtubule function. ..
  5. request reprint
    Husøy T, Knutsen H, Cruciani V, Olstørn H, Mikalsen S, Løberg E, et al. Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts. Int J Cancer. 2005;116:351-8 pubmed
    ..We hypothesise that gap junctions may be of importance in the transfer of signals between epithelium and stroma. ..
  6. Huffman M, Høie A, Svendsen C, Brunborg G, Murkovic M, Glatt H, et al. An in vitro study on the genotoxic effect of substituted furans in cells transfected with human metabolizing enzymes: 2,5-dimethylfuran and furfuryl alcohol. Mutagenesis. 2016;31:597-602 pubmed publisher
    ..The results suggest that DNA damage in V79 cells from exposure to DMF detected by the alkaline SCGE assay is independent of human CYP2E1 and SULT1A1, and the genotoxic effect of FFA, as assessed by SCGE, is minimal in V79 cells. ..