Gudrun Høiseth

Summary

Affiliation: Norwegian Institute of Public Health
Country: Norway

Publications

  1. ncbi request reprint Ethyl glucuronide concentrations in oral fluid, blood, and urine after volunteers drank 0.5 and 1.0 g/kg doses of ethanol
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Nydalen, Oslo, Norway
    J Anal Toxicol 34:319-24. 2010
  2. doi request reprint Less glucuronidation of morphine in the presence of ethanol in vivo
    Gudrun Høiseth
    Division of Forensic Medicine and Drug Abuse Research, Norwegian Institute of Public Health, Pb 4404 Nydalen, 0403 Oslo, Norway
    Eur J Clin Pharmacol 69:1683-7. 2013
  3. doi request reprint Higher levels of hair ethyl glucuronide in patients with decreased kidney function
    Gudrun Høiseth
    Division of Forensic Medicine and Drug Abuse Research, Norwegian Institute of Public Health, Oslo, Norway
    Alcohol Clin Exp Res 37:E14-6. 2013
  4. doi request reprint CYP2C19 genetics in fatal carisoprodol intoxications
    Gudrun Høiseth
    Center for Psychopharmacology, Diakonhjemmet Hospital, Forskningsveien 7, PB 85 Vinderen, 0319, Oslo, Norway
    Eur J Clin Pharmacol 68:1561-5. 2012
  5. doi request reprint Prolonged urinary detection times of EtG and EtS in patients with decreased renal function
    Gudrun Høiseth
    Division of Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, Oslo, Norway
    Alcohol Clin Exp Res 36:1148-51. 2012
  6. doi request reprint Blood kinetics of ethyl glucuronide and ethyl sulphate in heavy drinkers during alcohol detoxification
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway
    Forensic Sci Int 188:52-6. 2009
  7. ncbi request reprint Serum/whole blood concentration ratio for ethylglucuronide and ethyl sulfate
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Nydalen, Oslo, Norway
    J Anal Toxicol 33:208-11. 2009
  8. doi request reprint The effect of scheduling and withdrawal of carisoprodol on prevalence of intoxications with the drug
    Gudrun Høiseth
    Division of Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Basic Clin Pharmacol Toxicol 105:345-9. 2009
  9. doi request reprint Practical use of ethyl glucuronide and ethyl sulfate in postmortem cases as markers of antemortem alcohol ingestion
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Pb 4404 Nydalen, Oslo, Norway
    Int J Legal Med 124:143-8. 2010
  10. ncbi request reprint Levels of ethyl glucuronide and ethyl sulfate in oral fluid, blood, and urine after use of mouthwash and ingestion of nonalcoholic wine
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway
    J Anal Toxicol 34:84-8. 2010

Detail Information

Publications25

  1. ncbi request reprint Ethyl glucuronide concentrations in oral fluid, blood, and urine after volunteers drank 0.5 and 1.0 g/kg doses of ethanol
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Nydalen, Oslo, Norway
    J Anal Toxicol 34:319-24. 2010
    ..5 h (range 3.5-11.5 h) in oral fluid. According to this, the detection time for EtG in oral fluid is therefore only a few hours longer than for ethanol itself and represents limited additional value...
  2. doi request reprint Less glucuronidation of morphine in the presence of ethanol in vivo
    Gudrun Høiseth
    Division of Forensic Medicine and Drug Abuse Research, Norwegian Institute of Public Health, Pb 4404 Nydalen, 0403 Oslo, Norway
    Eur J Clin Pharmacol 69:1683-7. 2013
    ..The aim of this study was to compare the ratios between M6G and morphine and between M3G and morphine in blood samples from suspected drunk and drugged drivers, with and without presence of ethanol...
  3. doi request reprint Higher levels of hair ethyl glucuronide in patients with decreased kidney function
    Gudrun Høiseth
    Division of Forensic Medicine and Drug Abuse Research, Norwegian Institute of Public Health, Oslo, Norway
    Alcohol Clin Exp Res 37:E14-6. 2013
    ..The aim of this study was to compare hair EtG levels in patients with decreased kidney function to those seen in healthy volunteers...
  4. doi request reprint CYP2C19 genetics in fatal carisoprodol intoxications
    Gudrun Høiseth
    Center for Psychopharmacology, Diakonhjemmet Hospital, Forskningsveien 7, PB 85 Vinderen, 0319, Oslo, Norway
    Eur J Clin Pharmacol 68:1561-5. 2012
    ..The objective of this study was to investigate the role of CYP2C19 genetics in mortalities due to carisoprodol intoxication...
  5. doi request reprint Prolonged urinary detection times of EtG and EtS in patients with decreased renal function
    Gudrun Høiseth
    Division of Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, Oslo, Norway
    Alcohol Clin Exp Res 36:1148-51. 2012
    ....
  6. doi request reprint Blood kinetics of ethyl glucuronide and ethyl sulphate in heavy drinkers during alcohol detoxification
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway
    Forensic Sci Int 188:52-6. 2009
    ..In the present work, there was one exception to this, and we propose that this could be explained by the patient's renal disease, which would delay excretion of these conjugated metabolites...
  7. ncbi request reprint Serum/whole blood concentration ratio for ethylglucuronide and ethyl sulfate
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Nydalen, Oslo, Norway
    J Anal Toxicol 33:208-11. 2009
    ..001). The higher concentrations of EtG and EtS in serum than in whole blood have to be considered when whole blood results obtained from forensic toxicology are compared to serum or plasma results from clinical laboratories...
  8. doi request reprint The effect of scheduling and withdrawal of carisoprodol on prevalence of intoxications with the drug
    Gudrun Høiseth
    Division of Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Basic Clin Pharmacol Toxicol 105:345-9. 2009
    ..This, together with previous publications, indicates that the population reflected in our data uses regularly prescribed carisoprodol and, to a lesser degree, drug from an illegal street market...
  9. doi request reprint Practical use of ethyl glucuronide and ethyl sulfate in postmortem cases as markers of antemortem alcohol ingestion
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Pb 4404 Nydalen, Oslo, Norway
    Int J Legal Med 124:143-8. 2010
    ..In the last case, the interpretation was more difficult. One possible explanation would be postmortem degradation of EtG in blood...
  10. ncbi request reprint Levels of ethyl glucuronide and ethyl sulfate in oral fluid, blood, and urine after use of mouthwash and ingestion of nonalcoholic wine
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway
    J Anal Toxicol 34:84-8. 2010
    ..Finally, the study showed that a positive EtG or EtS result after accidental alcohol exposure is unlikely in blood and oral fluid...
  11. doi request reprint Ethyl glucuronide in hair compared with traditional alcohol biomarkers--a pilot study of heavy drinkers referred to an alcohol detoxification unit
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway
    Alcohol Clin Exp Res 33:812-6. 2009
    ..We also wanted to study the quantitative relation between alcohol intake and the different biomarkers...
  12. doi request reprint Comparison between the urinary alcohol markers EtG, EtS, and GTOL/5-HIAA in a controlled drinking experiment
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Pb 4404 Nydalen, N 0403 Oslo, Norway
    Alcohol Alcohol 43:187-91. 2008
    ..The aim of this controlled study was to compare the sensitivities and detection times of EtG, EtS, and GTOL/5-HIAA, after a single ingestion of ethanol...
  13. ncbi request reprint In vitro formation of ethanol in autopsy samples containing fluoride ions
    Gudrun Høiseth
    Division of Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, Pb 4404 Nydalen, 0403, Oslo, Norway
    Int J Legal Med 122:63-6. 2008
    ..Possible reasons for this unusual formation of ethanol were the abundant presence of bacteria, a high level of glucose and, possibly, an insufficient amount of fluoride added to the vials...
  14. ncbi request reprint Disappearance of ethyl glucuronide during heavy putrefaction
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Pb 4404 Nydalen, N 0403 Oslo, Norway
    Forensic Sci Int 176:147-51. 2008
    ..Further, we used the information from the in vitro study on real cases, to get an impression of the practical problem of degradation or formation of EtG...
  15. doi request reprint Divergent associations of drinking frequency and binge consumption of alcohol with mortality within the same cohort
    Sidsel Graff-Iversen
    Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway
    J Epidemiol Community Health 67:350-7. 2013
    ..The aim of this study was to assess the associations of alcohol use with mortality in a population with a hybrid of drinking patterns...
  16. ncbi request reprint A pharmacokinetic study of ethyl glucuronide in blood and urine: applications to forensic toxicology
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Nydalen, Oslo, Norway
    Forensic Sci Int 172:119-24. 2007
    ..For this purpose, two subsequent increasing EtG values and a high ethanol-to-EtG ratio in blood would support information of recent drinking...
  17. doi request reprint Is ADH1C genotype relevant for the cardioprotective effect of alcohol?
    Gudrun Høiseth
    Division of Forensic Medicine and Drug Abuse Research, Norwegian Institute of Public Health, Oslo, Norway
    Alcohol 47:81-4. 2013
    ..This study, which included the largest study group published so far, failed to find any link between the ADH1C genotype and the cardioprotective effects of alcohol...
  18. ncbi request reprint Carisoprodol intoxications: a retrospective study of forensic autopsy material from 1992-2003
    Gudrun Høiseth
    Division of Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, P O Box 4404, Nydalen, 0403 Oslo, Norway
    Int J Legal Med 121:403-9. 2007
    ..There were, however, only a small number of cases where the cause of death can be attributed to use of carisoprodol alone...
  19. ncbi request reprint A study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol
    Gudrun Høiseth
    Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Pb 4404 Nydalen, N 0403 Oslo, Norway
    Forensic Sci Int 165:41-5. 2007
    ..In conclusion, blood EtG determination seems to be a reliable marker of ante-mortem ingestion of alcohol, and it could be considered in forensic autopsy cases when post-mortem formation of ethanol is questioned...
  20. doi request reprint Acute intoxications with carisoprodol
    Gudrun Høiseth
    Division of Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, Oslo, Norway
    Clin Toxicol (Phila) 46:307-9. 2008
    ..Despite the potential weaknesses of the present material, this study gave an additional indication of a high toxicity of carisoprodol...
  21. ncbi request reprint Heroin-using drivers: importance of morphine and morphine-6-glucuronide on late clinical impairment
    Liliana Bachs
    Division for Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, P O Box 4404, Nydalen, 0403, Oslo, Norway
    Eur J Clin Pharmacol 62:905-12. 2006
    ..To evaluate the relationship between major heroin metabolites (morphine, morphine-6-glucoronide), pattern of drug use, and late impairment of psychomotor functions...
  22. ncbi request reprint [Phencyclidine--angel dust]
    Gudrun Høiseth
    Divisjon for rettstoksikologi og rusmiddelforskning, Nasjonalt folkehelseinstitutt, Postboks 4404 Nydalen, 0403 Oslo
    Tidsskr Nor Laegeforen 125:2775-6. 2005
    ..For the first time in ten years, phencyclidine (PCP) has been confiscated in Norway. Physicians should be aware of this substance when treating intoxications...
  23. ncbi request reprint [Psychiatric and cognitive long-term effects of ecstasy]
    Gudrun Høiseth
    Divisjon for rettstoksikologi og rusmiddelforskning, Nasjonalt folkehelseinstitutt, Postboks 4404 Nydalen, 0403 Oslo
    Tidsskr Nor Laegeforen 126:596-8. 2006
    ..We wanted to review human studies to find evidence for these side effects of ecstasy...
  24. ncbi request reprint [Ricin--a therapeutic agent and a biological weapon]
    Gudrun Høiseth
    Divisjon for rettstoksikologi og rusmiddelforskning, Nasjonalt folkehelseinstitutt, Postboks 4404 Nydalen, 0403 Oslo
    Tidsskr Nor Laegeforen 125:2477-9. 2005
    ..Ricin is a highly toxic plant protein that is lethal in small doses; it kills cells by inactivating ribosomes but has potential for medical use...
  25. doi request reprint Controlling for high-density lipoprotein cholesterol does not affect the magnitude of the relationship between alcohol and coronary heart disease
    Per Magnus
    Norwegian Institute of Public Health, Nydalen, Oslo, Norway
    Circulation 124:2296-302. 2011
    ..This study tested the hypothesis that moderate alcohol intake exerts its cardioprotective effect mainly through an increase in the serum level of high-density lipoprotein cholesterol...