Bent H Hellum

Summary

Affiliation: Norwegian University of Science and Technology
Country: Norway

Publications

  1. ncbi request reprint The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes
    Bent H Hellum
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Basic Clin Pharmacol Toxicol 100:23-30. 2007
  2. ncbi request reprint The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol
    Bent H Hellum
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Basic Clin Pharmacol Toxicol 101:350-8. 2007
  3. doi request reprint In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products
    Bent H Hellum
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Basic Clin Pharmacol Toxicol 102:466-75. 2008
  4. doi request reprint Trade herbal products and induction of CYP2C19 and CYP2E1 in cultured human hepatocytes
    Bent H Hellum
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Basic Clin Pharmacol Toxicol 105:58-63. 2009
  5. doi request reprint Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea
    Bent H Hellum
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Planta Med 76:331-8. 2010

Detail Information

Publications5

  1. ncbi request reprint The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes
    Bent H Hellum
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Basic Clin Pharmacol Toxicol 100:23-30. 2007
    ..biloba (highest concentration). An allosteric activation is suggested. From the data obtained, G. biloba, common valerian and St. John's wort are suggested as candidates for clinically significant CYP interactions in vivo...
  2. ncbi request reprint The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol
    Bent H Hellum
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Basic Clin Pharmacol Toxicol 101:350-8. 2007
    ..Common valerian was the only herb that showed a mechanistic inhibition of CYP2D6 activity and attention should be paid to a possible toxicity of this herb...
  3. doi request reprint In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products
    Bent H Hellum
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Basic Clin Pharmacol Toxicol 102:466-75. 2008
    ..Ginkgo biloba, horse chestnut and common sage, besides St. John's wort, are suggested candidates for in vivo intestinal herb-drug pharmacokinetic interactions...
  4. doi request reprint Trade herbal products and induction of CYP2C19 and CYP2E1 in cultured human hepatocytes
    Bent H Hellum
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Basic Clin Pharmacol Toxicol 105:58-63. 2009
    ..In addition to St John's wort, Gingko biloba and common sage should be considered as possible candidates for clinically relevant drug-herb interactions with selected CYP2C19 substrates...
  5. doi request reprint Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea
    Bent H Hellum
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Planta Med 76:331-8. 2010
    ..Other constituents might thus be responsible for the observed inhibitory properties. The place of origin seemed to be of minor importance for CYP3A4 or P-gp inhibition...