- Periodicity in tumor vasculature targeting kinetics of ligand-functionalized nanoparticles studied by dynamic contrast enhanced magnetic resonance imaging and intravital microscopySjoerd Hak
MI Lab, The Norwegian University of Science and Technology, Trondheim, Norway
Angiogenesis 17:93-107. 2014..Taken together, this demonstrates that our experimental approach provides new insights in in vivo nanoparticle targeting, which may proof useful for vascular targeting in general. ..
- The effect of nanoparticle polyethylene glycol surface density on ligand-directed tumor targeting studied in vivo by dual modality imagingSjoerd Hak
MI Lab and Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Trondheim, Norway
ACS Nano 6:5648-58. 2012..Counterintuitively, yet consistent with the PEG density conformation models, the highest specificity and targeting efficiency was observed at a low PEG surface density...
- Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticlesSjoerd Hak
Department of Circulation and Medical Imaging, The NTNU MR Center, The Norwegian University of Science and Technology, Ragnhildsgate 15, 7006, Trondheim, Norway
Angiogenesis 13:113-30. 2010..We conclude with a discussion of the potential value of intravital microscopy in window chambers in multimodality studies of tumor pathophysiology and nanoparticle dynamics...