Sjoerd Hak

Summary

Affiliation: Norwegian University of Science and Technology
Country: Norway

Publications

  1. doi request reprint The Effects of oil-in-Water Nanoemulsion Polyethylene Glycol Surface Density on Intracellular Stability, Pharmacokinetics, and Biodistribution in Tumor Bearing Mice
    Sjoerd Hak
    MI Lab and Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Trondheim, Norway
    Pharm Res 32:1475-85. 2015
  2. pmc Periodicity in tumor vasculature targeting kinetics of ligand-functionalized nanoparticles studied by dynamic contrast enhanced magnetic resonance imaging and intravital microscopy
    Sjoerd Hak
    MI Lab, The Norwegian University of Science and Technology, Trondheim, Norway
    Angiogenesis 17:93-107. 2014
  3. pmc The effect of nanoparticle polyethylene glycol surface density on ligand-directed tumor targeting studied in vivo by dual modality imaging
    Sjoerd Hak
    MI Lab and Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Trondheim, Norway
    ACS Nano 6:5648-58. 2012
  4. doi request reprint Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticles
    Sjoerd Hak
    Department of Circulation and Medical Imaging, The NTNU MR Center, The Norwegian University of Science and Technology, Ragnhildsgate 15, 7006, Trondheim, Norway
    Angiogenesis 13:113-30. 2010

Detail Information

Publications4

  1. doi request reprint The Effects of oil-in-Water Nanoemulsion Polyethylene Glycol Surface Density on Intracellular Stability, Pharmacokinetics, and Biodistribution in Tumor Bearing Mice
    Sjoerd Hak
    MI Lab and Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Trondheim, Norway
    Pharm Res 32:1475-85. 2015
    ..Until now, the effects of varying PEG surface density have been studied in a narrow and low range. Here, the effects of high and a broad range of PEG surface densities on the in vivo performance of lipid-based nanoparticles were studied...
  2. pmc Periodicity in tumor vasculature targeting kinetics of ligand-functionalized nanoparticles studied by dynamic contrast enhanced magnetic resonance imaging and intravital microscopy
    Sjoerd Hak
    MI Lab, The Norwegian University of Science and Technology, Trondheim, Norway
    Angiogenesis 17:93-107. 2014
    ..Taken together, this demonstrates that our experimental approach provides new insights in in vivo nanoparticle targeting, which may proof useful for vascular targeting in general. ..
  3. pmc The effect of nanoparticle polyethylene glycol surface density on ligand-directed tumor targeting studied in vivo by dual modality imaging
    Sjoerd Hak
    MI Lab and Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Trondheim, Norway
    ACS Nano 6:5648-58. 2012
    ..Counterintuitively, yet consistent with the PEG density conformation models, the highest specificity and targeting efficiency was observed at a low PEG surface density...
  4. doi request reprint Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticles
    Sjoerd Hak
    Department of Circulation and Medical Imaging, The NTNU MR Center, The Norwegian University of Science and Technology, Ragnhildsgate 15, 7006, Trondheim, Norway
    Angiogenesis 13:113-30. 2010
    ..We conclude with a discussion of the potential value of intravital microscopy in window chambers in multimodality studies of tumor pathophysiology and nanoparticle dynamics...