Research Topics
Genomes and Genes | Duan ChenSummaryAffiliation: Norwegian University of Science and Technology Country: Norway Publications
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Publications
Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer? Inadequate evidence in Mongolian gerbils and inbred miceDuan Chen
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
FEMS Immunol Med Microbiol 50:184-9. 2007..We therefore conclude that both Mongolian gerbils and inbred mice may be inadequate models for studying H. pylori infection-associated gastric cancer and that there is no animal model of H. pylori infection-induced duodenal ulcer...- Genetic dissection of the signaling pathways that control gastric acid secretionDuan Chen
Department of Surgery, University Hospital Trondheim, Olav Kyrres gate 17, 7006 Trondheim, Norway
Inflammopharmacology 13:201-7. 2005..The observations illustrate the complexity and plasticity of the acid regulatory mechanisms. It seems that one pathway may be suppressed or allowed to dominate over the others depending on the circumstances... - The possible existence of a gut-bone axis suggested by studies of genetically manipulated mouse models?Duan Chen
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Curr Pharm Des 17:1552-5. 2011..Moreover, pharmacological inhibition of serotonin synthesis prevented bone loss following ovariectomy in wild-type mice and rats, an observation that does not support the existence of Lrp5 pathway in the serotonin-bone axis... - Differentiation of the gastric mucosa. I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genesDuan Chen
Dept of Cancer Research and Molecular Medicine, Norwegian Univ of Science and Technology, Laboratory Centre, Erling Skjalgssons gate 1, NO 7006 Trondheim, Norway
Am J Physiol Gastrointest Liver Physiol 291:G539-44. 2006..Such analysis may provide insight into the functional significance of gastric histamine... - Genetically engineered mice: a new paradigm to study gastric physiologyDuan Chen
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Curr Opin Gastroenterol 23:602-6. 2007.... - Complexity of gastric acid secretion revealed by targeted gene disruption in miceDuan Chen
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Laboratory Centre 3rd Floor East Side, Erling Skjalgssons gate 1, NO 7006 Trondheim, Norway
Curr Pharm Des 16:1235-40. 2010..pylori infection. Taken together, phenotyping of a series of genetically engineered mouse models reveals a high degree of complexity of gastric acid secretion in both physiological and pathophysiological conditions... - Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron-microscopic studyChun Mei Zhao
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Cell Tissue Res 331:575-87. 2008..Thus, obestatin and ghrelin co-localize with an anticipated monoamine in A-like cells in the stomach, and obestatin is found in pancreatic islets... - Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant miceDuan Chen
Department of Cancer Research and Molecular Medicine, Norweigian University of Science and Technology, Trondheim, Norway
Gastroenterology 126:476-87. 2004..Mice lacking gastrin or both gastrin and CCK were examined to determine the role of the hormones... - Is gastrin partially responsible for body weight reduction after gastric bypass?Bjorn Stenstrom
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Eur Surg Res 38:94-101. 2006..Unlike ghrelin, gastrin is released in response to food intake. Here we studied the possible role of gastrin in the reduction of body weight after gastric bypass surgery... - Mechanism of gastric bypass-induced body weight loss: one-year follow-up after micro-gastric bypass in ratsBjorn Stenstrom
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
J Gastrointest Surg 10:1384-91. 2006.... 
Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathwaysChun Mei Zhao
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO 7006, Trondheim, Norway
Endocrinology 149:498-505. 2008..We suggest that there is a remodeling of the neuroendocrine mechanisms that regulate acid secretion in these mutant mice...
Regulated endocrine-specific protein 18 (RESP18) is localized to and regulated in A-like cells and G-cells in rat stomachSten Even Erlandsen
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, PB 8905, N 7491 Trondheim, Norway
Regul Pept 177:53-9. 2012..This suggests that Resp18 may indeed have a functional role in the synthesis or storage of these gastrointestinal peptides...- Chronic Helicobacter pylori infection results in gastric hypoacidity and hypergastrinemia in wild-type mice but vagally induced hypersecretion in gastrin-deficient miceChun Mei Zhao
Departments of Cancer Research and Molecular Medicine and Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Regul Pept 115:161-70. 2003..pylori infection results to impaired parietal-cell function (acid hyposecretion), hypergastrinemia and hyperplasia of ECL cells in wild-type mice but leads to vagally induced hypersecretion in gastrin-deficient mice... - Gastric phenotypic abnormality in cholecystokinin 2 receptor null miceDuan Chen
Institute of Intra abdominal Diseases, Norwegian University of Science and Technology, Trondheim, Norway
Pharmacol Toxicol 91:375-81. 2002..Thus, studies of CCK2 receptor null mice demonstrate the importance of the receptor in the regulation of gastric acid secretion and in the differentiation of ECL cells in the oxyntic mucosa of stomach... - Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of actionCarl Jørgen Arum
St Olavs University Hospital Trondheim, Department of Surgery, N 7006 Trondheim, Norway
J Biomed Opt 16:028001. 2011..We suggest that pathways of action of HAL-PDT may include, at least, activations of mitochondrial apoptosis and autophagy, breakdown of cancer stem cell niches, and importantly, enhancement of T-cell activation... - Gastric bypass surgery causes body weight loss without reducing food intake in ratsMarianne W Furnes
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Laboratory Centre, Erling Skjalgssons gate 1, 7006 Trondheim, Norway
Obes Surg 18:415-22. 2008..It is a common dogma that gastric bypass (GB) induces early satiety and consequent reductions in food intake and nutrient absorption. The aim of the present study was to analyze feeding behavioral and metabolic changes in rats after GB... - Experimental gastrocystoplasty in rats: risk of developing ECLomaReidar Alexander Vigen
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Erling Skjalgssons gate 1, NO 7006 Trondheim, Norway
J Pediatr Urol 8:209-13. 2012..There are no clinical reports on the risk of carcinoids in the gastric segment following gastrocystoplasty. The aim of the present study was to examine whether gastric carcinoids could develop in a rat model of gastrocystoplasty... - Immunohistochemical evidence for an impairment of autophagy in tumorigenesis of gastric carcinoids and adenocarcinomas in rodent models and patientsReidar Alexander Vigen
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Histol Histopathol 28:531-42. 2013..The aim of the present study was to examine autophagy-related markers by immunohistochemistry in gastric carcinoids and adenocarcinomas in rodent models and patients... - Gastric bypass surgery does not increase susceptibility to Helicobacter pylori infection in the stomach of rat or mouseBjorn Stenstrom
Department of Cancer Research and Molecular Medicine, University Hospital Trondheim, Olav Kyrres gate 17, 7006 Trondheim, Norway
Inflammopharmacology 13:229-34. 2005..While all the rats were H. pylori negative, 54% of gastric bypassed mice and 75% of controls were positive (P = 0.4). We conclude that susceptibility to H. pylori infection in the stomach is not increased by gastric bypass surgery... - Eating behavior in rats subjected to vagotomy, sleeve gastrectomy, and duodenal switchYosuke Kodama
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
J Gastrointest Surg 14:1502-10. 2010..Food intake, eating behavior, and metabolic parameters in rats that underwent bilateral truncal vagotomy, sleeve gastrectomy, and duodenal switch procedures were examined... - Swedish moist snuff accelerates gastric cancer development in Helicobacter pylori-infected wild-type and gastrin transgenic miceBjorn Stenstrom
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, NO 7006 Norway
Carcinogenesis 28:2041-6. 2007..We suggest that snus is a potential gastric carcinogen in mice. The development of CIS was associated with increased rates of the epithelial cell proliferation and apoptosis, common features of gastric carcinogenesis... - Topical application of acetic acid in cytoreduction of gastric cancer. A technical report using mouse modelSusumu Okabe
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
J Gastroenterol Hepatol 27:40-8. 2012..The aim of the present study was to apply it as a new cytoreductive approach in a mouse model of gastric cancer... - A rat model of intravesical delivery of small interfering RNA for studying urinary carcinomaCarl Jørgen Arum
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
World J Urol 28:479-85. 2010..The aims of the present study were (1) to establish rat models for in vivo delivery of siRNA to bladder cancer, and (2) to identify potential targets for siRNA... - Cancer immunoediting from immunosurveillance to tumor escape in microvillus-formed niche: a study of syngeneic orthotopic rat bladder cancer model in comparison with human bladder cancerCarl Jørgen Arum
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Neoplasia 12:434-42. 2010..We suggest that the microvillus-formed niche that harbors a few implanted cancer cells might be the compartment that prevents the tumor eradication by the host immune system... - Acid secretion in urinary bladder of rats subjected to gastrocystoplastyCarl Jørgen Arum
Department of Surgery, St Olav s Hospital, University Hospital Trondheim, Olav Kyrres gate 17, 7006 Trondheim, Norway
Inflammopharmacology 13:191-9. 2005.... - Development of obesity is associated with increased calories per meal rather than per day. A study of high-fat diet-induced obesity in young ratsMarianne W Furnes
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Laboratory Center, Erling Skjalgssons gate 1, 7006, Trondheim, Norway
Obes Surg 19:1430-8. 2009..We challenge the current belief that obesity is a result of overnutrition by studying a rodent model of human obesity... - Differentiation of gastric ECL cells is altered in CCK(2) receptor-deficient miceDuan Chen
Department of Intra abdominal Diseases and Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Gastroenterology 123:577-85. 2002..This report describes the effects of targeted disruption of the CCK(2) receptor gene on ECL cell morphology and function... - Dedifferentiation of enterochromaffin-like cells in gastric cancer of hypergastrinemic cotton ratsReidar Fossmark
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
APMIS 113:436-49. 2005..We suggest that ECL cells in hypergastrinemic cotton rats dedifferentiate with time and that the gastric carcinomas may develop from ECL cells... - Secretory organelles in ECL cells: effects of pharmacological blockade of the gastrin/CCK2 receptor versus its elimination by gene targetingChun Mei Zhao
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Inflammopharmacology 13:75-82. 2005..We suggest that the gastrin/CCK2 receptor is important for the proper differentiation of the ECL cells and for maintaining their characteristic ultrastructure... - Ultrastructure of ECL cells in Mastomys after long-term treatment with H2 receptor antagonist loxtidineReidar Alexander Vigen
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology NTNU, Erling Skjalgssons gate 1, NO 7006, Trondheim, Norway
Med Mol Morphol 45:80-5. 2012..We suggest that the ultrastructure of ECL cells in Mastomys after long-term treatment with loxtidine displayed an impaired formation of vacuoles and lipofuscin bodies, markers of the autophagic pathway... - Eating behavior and glucagon-like peptide-1-producing cells in interposed ileum and pancreatic islets in rats subjected to ileal interposition associated with sleeve gastrectomyHelene Johannessen
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Obes Surg 23:39-49. 2013..The aim of the present study was to test this hypothesis by studying the eating behavior, metabolic changes, and glucagon-like peptide-1 (GLP-1)-producing cells in rat models... - Gene expression profiling and pathway analysis of superficial bladder cancer in ratsCarl Jørgen Arum
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Urology 75:742-9. 2010..To reveal the gene expression profile and pathways involved in host-tumor interactions in a rat orthotopic syngeneic bladder cancer model... - Ciprofibrate stimulates the gastrin-producing cell by acting luminally on antral PPAR-alphaTom C Martinsen
Dept of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, St Olav s Hospital HF, Trondheim, Norway
Am J Physiol Gastrointest Liver Physiol 289:G1052-60. 2005..The results indicate that PPAR-alpha may have a role in the physiological regulation of gastrin release... - Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopyEivind L P Larsen
Norwegian University of Science and Technology, Department of Electronics and Telecommunications, N 7034 Trondheim, Norway
J Biomed Opt 13:044031. 2008..The most treatment-responsive animals had the highest PpIX fluorescence prior to light irradiation. Thus, optical spectroscopy can provide useful information for PDT. The model has proved to be very suitable for bladder cancer studies... - Role of bradykinin in gastric vasodilation caused by hypertonic saline and acid back diffusionAstrid Rydning
Department of Surgery, Norwegian University of Science and Technology, University Hospital Trondheim, St Olavs Hospital, N 7006 Trondheim, Norway
Regul Pept 119:139-48. 2004..We conclude that bradykinin is involved in gastric vasodilation caused by hypertonic injury alone via influence on mast cells, and by acid back diffusion via influence on both sensory neurons and mast cells... - Serum gastrin and gastric enterochromaffin-like cells during estrous cycle, pregnancy and lactation, and in response to estrogen-like agents in ratsR A Vigen
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
J Physiol Pharmacol 62:335-40. 2011..Possible gender-related factors behind the female preponderance of ECL-cell tumors remain unknown... - Cardioprotection of exogenous erythropoietin in mice with ligature-induced aortic stenosis: effects on maladaptive cardiac hypertrophyL Zheng
Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
J Physiol Pharmacol 61:13-20. 2010.... - Identification of a series of CCK-2 receptor nonpeptide agonists: sensitivity to stereochemistry and a receptor point mutationAlan S Kopin
Molecular Pharmacology Research Center, Department of Medicine, Tufts New England Medical Center, 750 Washington Street, Box 7703, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 100:5525-30. 2003..The results of this study highlight the potential of constitutively active receptors as drug screening tools and the interdependence of ligand stereochemistry and receptor conformation in defining drug efficacy... - Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout miceTakeshi Aihara
Departmentof Applied Pharmacology, Kyoto Pharmaceutical University, Yamashina, Japan
Gastroenterology 125:1774-84. 2003..In the present study, M(3) receptor knockout (KO) mice were used to elucidate the role of M(3) receptors in gastric acid secretion and gastric mucosal integrity... - TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injuryJames J Farrell
Massachusetts General Hospital, Gastrointestinal Unit, Boston, Massachusetts, USA
J Clin Invest 109:193-204. 2002..Taken together, these results suggest a physiologic role for TFF2 to promote mucosal healing through the stimulation of proliferation and downregulation of gastric acid secretion... - Overexpression of glycine-extended gastrin inhibits parietal cell loss and atrophy in the mouse stomachGuanglin Cui
Division of Gastroenterology, University of Massachusetts Medical School, Worcester, Massachusetts
Cancer Res 64:8160-6. 2004..The overexpression of G-gly seems to increase the susceptibility to peptic ulcer disease and delay the development of Helicobacter-mediated gastric preneoplasia in this model... - Hypothalamic gene expression following ghrelin therapy to gastrectomized rodentsEmil Egecioglu
Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, P O Box 434, SE 405 30 Goteborg, Sweden
Regul Pept 146:176-82. 2008..Thus, while predicted pro-obesity ghrelin signalling pathways were activated by ghrelin and ghrelin mimetics, these were largely unaffected by gastrectomy...