Duan Chen

Summary

Affiliation: Norwegian University of Science and Technology
Country: Norway

Publications

  1. pmc Eating behavior in rats subjected to vagotomy, sleeve gastrectomy, and duodenal switch
    Yosuke Kodama
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Gastrointest Surg 14:1502-10. 2010
  2. ncbi request reprint Complexity of gastric acid secretion revealed by targeted gene disruption in mice
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Laboratory Centre 3rd Floor East Side, Erling Skjalgssons gate 1, NO 7006 Trondheim, Norway
    Curr Pharm Des 16:1235-40. 2010
  3. ncbi request reprint Genetically engineered mice: a new paradigm to study gastric physiology
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Curr Opin Gastroenterol 23:602-6. 2007
  4. ncbi request reprint Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer? Inadequate evidence in Mongolian gerbils and inbred mice
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    FEMS Immunol Med Microbiol 50:184-9. 2007
  5. ncbi request reprint Differentiation of the gastric mucosa. I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genes
    Duan Chen
    Dept of Cancer Research and Molecular Medicine, Norwegian Univ of Science and Technology, Laboratory Centre, Erling Skjalgssons gate 1, NO 7006 Trondheim, Norway
    Am J Physiol Gastrointest Liver Physiol 291:G539-44. 2006
  6. ncbi request reprint Genetic dissection of the signaling pathways that control gastric acid secretion
    Duan Chen
    Department of Surgery, University Hospital Trondheim, Olav Kyrres gate 17, 7006 Trondheim, Norway
    Inflammopharmacology 13:201-7. 2005
  7. ncbi request reprint The possible existence of a gut-bone axis suggested by studies of genetically manipulated mouse models?
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Curr Pharm Des 17:1552-5. 2011
  8. ncbi request reprint Immunohistochemical evidence for an impairment of autophagy in tumorigenesis of gastric carcinoids and adenocarcinomas in rodent models and patients
    Reidar Alexander Vigen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Histol Histopathol 28:531-42. 2013
  9. ncbi request reprint Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron-microscopic study
    Chun Mei Zhao
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Cell Tissue Res 331:575-87. 2008
  10. ncbi request reprint Is gastrin partially responsible for body weight reduction after gastric bypass?
    Bjorn Stenstrom
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur Surg Res 38:94-101. 2006

Detail Information

Publications43

  1. pmc Eating behavior in rats subjected to vagotomy, sleeve gastrectomy, and duodenal switch
    Yosuke Kodama
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Gastrointest Surg 14:1502-10. 2010
    ..Food intake, eating behavior, and metabolic parameters in rats that underwent bilateral truncal vagotomy, sleeve gastrectomy, and duodenal switch procedures were examined...
  2. ncbi request reprint Complexity of gastric acid secretion revealed by targeted gene disruption in mice
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Laboratory Centre 3rd Floor East Side, Erling Skjalgssons gate 1, NO 7006 Trondheim, Norway
    Curr Pharm Des 16:1235-40. 2010
    ..pylori infection. Taken together, phenotyping of a series of genetically engineered mouse models reveals a high degree of complexity of gastric acid secretion in both physiological and pathophysiological conditions...
  3. ncbi request reprint Genetically engineered mice: a new paradigm to study gastric physiology
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Curr Opin Gastroenterol 23:602-6. 2007
    ....
  4. ncbi request reprint Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer? Inadequate evidence in Mongolian gerbils and inbred mice
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    FEMS Immunol Med Microbiol 50:184-9. 2007
    ..We therefore conclude that both Mongolian gerbils and inbred mice may be inadequate models for studying H. pylori infection-associated gastric cancer and that there is no animal model of H. pylori infection-induced duodenal ulcer...
  5. ncbi request reprint Differentiation of the gastric mucosa. I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genes
    Duan Chen
    Dept of Cancer Research and Molecular Medicine, Norwegian Univ of Science and Technology, Laboratory Centre, Erling Skjalgssons gate 1, NO 7006 Trondheim, Norway
    Am J Physiol Gastrointest Liver Physiol 291:G539-44. 2006
    ..Such analysis may provide insight into the functional significance of gastric histamine...
  6. ncbi request reprint Genetic dissection of the signaling pathways that control gastric acid secretion
    Duan Chen
    Department of Surgery, University Hospital Trondheim, Olav Kyrres gate 17, 7006 Trondheim, Norway
    Inflammopharmacology 13:201-7. 2005
    ..The observations illustrate the complexity and plasticity of the acid regulatory mechanisms. It seems that one pathway may be suppressed or allowed to dominate over the others depending on the circumstances...
  7. ncbi request reprint The possible existence of a gut-bone axis suggested by studies of genetically manipulated mouse models?
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Curr Pharm Des 17:1552-5. 2011
    ..Moreover, pharmacological inhibition of serotonin synthesis prevented bone loss following ovariectomy in wild-type mice and rats, an observation that does not support the existence of Lrp5 pathway in the serotonin-bone axis...
  8. ncbi request reprint Immunohistochemical evidence for an impairment of autophagy in tumorigenesis of gastric carcinoids and adenocarcinomas in rodent models and patients
    Reidar Alexander Vigen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Histol Histopathol 28:531-42. 2013
    ..The aim of the present study was to examine autophagy-related markers by immunohistochemistry in gastric carcinoids and adenocarcinomas in rodent models and patients...
  9. ncbi request reprint Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron-microscopic study
    Chun Mei Zhao
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Cell Tissue Res 331:575-87. 2008
    ..Thus, obestatin and ghrelin co-localize with an anticipated monoamine in A-like cells in the stomach, and obestatin is found in pancreatic islets...
  10. ncbi request reprint Is gastrin partially responsible for body weight reduction after gastric bypass?
    Bjorn Stenstrom
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur Surg Res 38:94-101. 2006
    ..Unlike ghrelin, gastrin is released in response to food intake. Here we studied the possible role of gastrin in the reduction of body weight after gastric bypass surgery...
  11. ncbi request reprint Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Norweigian University of Science and Technology, Trondheim, Norway
    Gastroenterology 126:476-87. 2004
    ..Mice lacking gastrin or both gastrin and CCK were examined to determine the role of the hormones...
  12. pmc Mechanistic comparison between gastric bypass vs. duodenal switch with sleeve gastrectomy in rat models
    Yosuke Kodama
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    PLoS ONE 8:e72896. 2013
    ..The aim of this study was to better understand the mechanisms leading to body weight loss by comparing these two procedures in experimental models of rats...
  13. pmc Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathways
    Chun Mei Zhao
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO 7006, Trondheim, Norway
    Endocrinology 149:498-505. 2008
    ..We suggest that there is a remodeling of the neuroendocrine mechanisms that regulate acid secretion in these mutant mice...
  14. doi request reprint Regulated endocrine-specific protein 18 (RESP18) is localized to and regulated in A-like cells and G-cells in rat stomach
    Sten Even Erlandsen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, PB 8905, N 7491 Trondheim, Norway
    Regul Pept 177:53-9. 2012
    ..This suggests that Resp18 may indeed have a functional role in the synthesis or storage of these gastrointestinal peptides...
  15. doi request reprint Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action
    Carl Jørgen Arum
    St Olavs University Hospital Trondheim, Department of Surgery, N 7006 Trondheim, Norway
    J Biomed Opt 16:028001. 2011
    ..We suggest that pathways of action of HAL-PDT may include, at least, activations of mitochondrial apoptosis and autophagy, breakdown of cancer stem cell niches, and importantly, enhancement of T-cell activation...
  16. ncbi request reprint Mechanism of gastric bypass-induced body weight loss: one-year follow-up after micro-gastric bypass in rats
    Bjorn Stenstrom
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Gastrointest Surg 10:1384-91. 2006
    ....
  17. ncbi request reprint Chronic Helicobacter pylori infection results in gastric hypoacidity and hypergastrinemia in wild-type mice but vagally induced hypersecretion in gastrin-deficient mice
    Chun Mei Zhao
    Departments of Cancer Research and Molecular Medicine and Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Regul Pept 115:161-70. 2003
    ..pylori infection results to impaired parietal-cell function (acid hyposecretion), hypergastrinemia and hyperplasia of ECL cells in wild-type mice but leads to vagally induced hypersecretion in gastrin-deficient mice...
  18. ncbi request reprint Gastric phenotypic abnormality in cholecystokinin 2 receptor null mice
    Duan Chen
    Institute of Intra abdominal Diseases, Norwegian University of Science and Technology, Trondheim, Norway
    Pharmacol Toxicol 91:375-81. 2002
    ..Thus, studies of CCK2 receptor null mice demonstrate the importance of the receptor in the regulation of gastric acid secretion and in the differentiation of ECL cells in the oxyntic mucosa of stomach...
  19. doi request reprint Experimental gastrocystoplasty in rats: risk of developing ECLoma
    Reidar Alexander Vigen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Erling Skjalgssons gate 1, NO 7006 Trondheim, Norway
    J Pediatr Urol 8:209-13. 2012
    ..There are no clinical reports on the risk of carcinoids in the gastric segment following gastrocystoplasty. The aim of the present study was to examine whether gastric carcinoids could develop in a rat model of gastrocystoplasty...
  20. doi request reprint Topical application of acetic acid in cytoreduction of gastric cancer. A technical report using mouse model
    Susumu Okabe
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Gastroenterol Hepatol 27:40-8. 2012
    ..The aim of the present study was to apply it as a new cytoreductive approach in a mouse model of gastric cancer...
  21. doi request reprint Gastric bypass surgery causes body weight loss without reducing food intake in rats
    Marianne W Furnes
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Laboratory Centre, Erling Skjalgssons gate 1, 7006 Trondheim, Norway
    Obes Surg 18:415-22. 2008
    ..It is a common dogma that gastric bypass (GB) induces early satiety and consequent reductions in food intake and nutrient absorption. The aim of the present study was to analyze feeding behavioral and metabolic changes in rats after GB...
  22. doi request reprint Eating behavior and glucagon-like peptide-1-producing cells in interposed ileum and pancreatic islets in rats subjected to ileal interposition associated with sleeve gastrectomy
    Helene Johannessen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Obes Surg 23:39-49. 2013
    ..The aim of the present study was to test this hypothesis by studying the eating behavior, metabolic changes, and glucagon-like peptide-1 (GLP-1)-producing cells in rat models...
  23. ncbi request reprint Swedish moist snuff accelerates gastric cancer development in Helicobacter pylori-infected wild-type and gastrin transgenic mice
    Bjorn Stenstrom
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, NO 7006 Norway
    Carcinogenesis 28:2041-6. 2007
    ..We suggest that snus is a potential gastric carcinogen in mice. The development of CIS was associated with increased rates of the epithelial cell proliferation and apoptosis, common features of gastric carcinogenesis...
  24. ncbi request reprint Gastric bypass surgery does not increase susceptibility to Helicobacter pylori infection in the stomach of rat or mouse
    Bjorn Stenstrom
    Department of Cancer Research and Molecular Medicine, University Hospital Trondheim, Olav Kyrres gate 17, 7006 Trondheim, Norway
    Inflammopharmacology 13:229-34. 2005
    ..While all the rats were H. pylori negative, 54% of gastric bypassed mice and 75% of controls were positive (P = 0.4). We conclude that susceptibility to H. pylori infection in the stomach is not increased by gastric bypass surgery...
  25. ncbi request reprint A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma
    Carl Jørgen Arum
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    World J Urol 28:479-85. 2010
    ..The aims of the present study were (1) to establish rat models for in vivo delivery of siRNA to bladder cancer, and (2) to identify potential targets for siRNA...
  26. pmc Cancer immunoediting from immunosurveillance to tumor escape in microvillus-formed niche: a study of syngeneic orthotopic rat bladder cancer model in comparison with human bladder cancer
    Carl Jørgen Arum
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Neoplasia 12:434-42. 2010
    ..We suggest that the microvillus-formed niche that harbors a few implanted cancer cells might be the compartment that prevents the tumor eradication by the host immune system...
  27. ncbi request reprint Development of obesity is associated with increased calories per meal rather than per day. A study of high-fat diet-induced obesity in young rats
    Marianne W Furnes
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Laboratory Center, Erling Skjalgssons gate 1, 7006, Trondheim, Norway
    Obes Surg 19:1430-8. 2009
    ..We challenge the current belief that obesity is a result of overnutrition by studying a rodent model of human obesity...
  28. ncbi request reprint Dedifferentiation of enterochromaffin-like cells in gastric cancer of hypergastrinemic cotton rats
    Reidar Fossmark
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    APMIS 113:436-49. 2005
    ..We suggest that ECL cells in hypergastrinemic cotton rats dedifferentiate with time and that the gastric carcinomas may develop from ECL cells...
  29. ncbi request reprint Differentiation of gastric ECL cells is altered in CCK(2) receptor-deficient mice
    Duan Chen
    Department of Intra abdominal Diseases and Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Gastroenterology 123:577-85. 2002
    ..This report describes the effects of targeted disruption of the CCK(2) receptor gene on ECL cell morphology and function...
  30. ncbi request reprint Acid secretion in urinary bladder of rats subjected to gastrocystoplasty
    Carl Jørgen Arum
    Department of Surgery, St Olav s Hospital, University Hospital Trondheim, Olav Kyrres gate 17, 7006 Trondheim, Norway
    Inflammopharmacology 13:191-9. 2005
    ....
  31. ncbi request reprint Secretory organelles in ECL cells: effects of pharmacological blockade of the gastrin/CCK2 receptor versus its elimination by gene targeting
    Chun Mei Zhao
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Inflammopharmacology 13:75-82. 2005
    ..We suggest that the gastrin/CCK2 receptor is important for the proper differentiation of the ECL cells and for maintaining their characteristic ultrastructure...
  32. doi request reprint Ultrastructure of ECL cells in Mastomys after long-term treatment with H2 receptor antagonist loxtidine
    Reidar Alexander Vigen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology NTNU, Erling Skjalgssons gate 1, NO 7006, Trondheim, Norway
    Med Mol Morphol 45:80-5. 2012
    ..We suggest that the ultrastructure of ECL cells in Mastomys after long-term treatment with loxtidine displayed an impaired formation of vacuoles and lipofuscin bodies, markers of the autophagic pathway...
  33. ncbi request reprint Ciprofibrate stimulates the gastrin-producing cell by acting luminally on antral PPAR-alpha
    Tom C Martinsen
    Dept of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, St Olav s Hospital HF, Trondheim, Norway
    Am J Physiol Gastrointest Liver Physiol 289:G1052-60. 2005
    ..The results indicate that PPAR-alpha may have a role in the physiological regulation of gastrin release...
  34. doi request reprint Gene expression profiling and pathway analysis of superficial bladder cancer in rats
    Carl Jørgen Arum
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Urology 75:742-9. 2010
    ..To reveal the gene expression profile and pathways involved in host-tumor interactions in a rat orthotopic syngeneic bladder cancer model...
  35. ncbi request reprint Role of bradykinin in gastric vasodilation caused by hypertonic saline and acid back diffusion
    Astrid Rydning
    Department of Surgery, Norwegian University of Science and Technology, University Hospital Trondheim, St Olavs Hospital, N 7006 Trondheim, Norway
    Regul Pept 119:139-48. 2004
    ..We conclude that bradykinin is involved in gastric vasodilation caused by hypertonic injury alone via influence on mast cells, and by acid back diffusion via influence on both sensory neurons and mast cells...
  36. doi request reprint Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopy
    Eivind L P Larsen
    Norwegian University of Science and Technology, Department of Electronics and Telecommunications, N 7034 Trondheim, Norway
    J Biomed Opt 13:044031. 2008
    ..The most treatment-responsive animals had the highest PpIX fluorescence prior to light irradiation. Thus, optical spectroscopy can provide useful information for PDT. The model has proved to be very suitable for bladder cancer studies...
  37. ncbi request reprint Serum gastrin and gastric enterochromaffin-like cells during estrous cycle, pregnancy and lactation, and in response to estrogen-like agents in rats
    R A Vigen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Physiol Pharmacol 62:335-40. 2011
    ..Possible gender-related factors behind the female preponderance of ECL-cell tumors remain unknown...
  38. ncbi request reprint Cardioprotection of exogenous erythropoietin in mice with ligature-induced aortic stenosis: effects on maladaptive cardiac hypertrophy
    L Zheng
    Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    J Physiol Pharmacol 61:13-20. 2010
    ....
  39. pmc Identification of a series of CCK-2 receptor nonpeptide agonists: sensitivity to stereochemistry and a receptor point mutation
    Alan S Kopin
    Molecular Pharmacology Research Center, Department of Medicine, Tufts New England Medical Center, 750 Washington Street, Box 7703, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 100:5525-30. 2003
    ..The results of this study highlight the potential of constitutively active receptors as drug screening tools and the interdependence of ligand stereochemistry and receptor conformation in defining drug efficacy...
  40. pmc TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury
    James J Farrell
    Massachusetts General Hospital, Gastrointestinal Unit, Boston, Massachusetts, USA
    J Clin Invest 109:193-204. 2002
    ..Taken together, these results suggest a physiologic role for TFF2 to promote mucosal healing through the stimulation of proliferation and downregulation of gastric acid secretion...
  41. ncbi request reprint Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice
    Takeshi Aihara
    Departmentof Applied Pharmacology, Kyoto Pharmaceutical University, Yamashina, Japan
    Gastroenterology 125:1774-84. 2003
    ..In the present study, M(3) receptor knockout (KO) mice were used to elucidate the role of M(3) receptors in gastric acid secretion and gastric mucosal integrity...
  42. ncbi request reprint Overexpression of glycine-extended gastrin inhibits parietal cell loss and atrophy in the mouse stomach
    Guanglin Cui
    Division of Gastroenterology, University of Massachusetts Medical School, Worcester, Massachusetts
    Cancer Res 64:8160-6. 2004
    ..The overexpression of G-gly seems to increase the susceptibility to peptic ulcer disease and delay the development of Helicobacter-mediated gastric preneoplasia in this model...
  43. ncbi request reprint Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents
    Emil Egecioglu
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, P O Box 434, SE 405 30 Goteborg, Sweden
    Regul Pept 146:176-82. 2008
    ..Thus, while predicted pro-obesity ghrelin signalling pathways were activated by ghrelin and ghrelin mimetics, these were largely unaffected by gastrectomy...