Affiliation: National Institute of Occupational Health
Jensen J, Aslesen R, Jebens E, Skrondal A. Adrenaline-mediated glycogen phosphorylase activation is enhanced in rat soleus muscle with increased glycogen content. Biochim Biophys Acta. 1999;1472:215-21 pubmed
..Glycogen phosphorylase activation during adrenaline stimulation was much higher in epitrochlearis than in soleus muscles with a similar content of glycogen. ..
Jensen J, Brennesvik E, Lai Y, Shepherd P. GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3. Cell Signal. 2007;19:204-10 pubmed
..Further, we hypothesise that each of these pools is involved in the control of different cellular processes. ..
Jensen J, Ruzzin J, Jebens E, Brennesvik E, Knardahl S. Improved insulin-stimulated glucose uptake and glycogen synthase activation in rat skeletal muscles after adrenaline infusion: role of glycogen content and PKB phosphorylation. Acta Physiol Scand. 2005;184:121-30 pubmed
..The mechanisms for the improved insulin sensitivity after adrenaline treatment deserve particular attention as they occur in conjunction with hyperglycaemia. ..
Jensen J, Jebens E, Brennesvik E, Ruzzin J, Soos M, Engebretsen E, et al
. Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling. Am J Physiol Endocrinol Metab. 2006;290:E154-E162 pubmed
..quot;Insulin resistance" is observed at the level of glycogen synthase, and the reduced glycogen synthesis leads to increased levels of glucose 6-phosphate, glycolytic flux, and accumulation of nonphosphorylated 2-deoxyglucose. ..
Jensen J, Lai Y. Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance. Arch Physiol Biochem. 2009;115:13-21 pubmed publisher
..In this paper we discuss the physiological regulation of glycogen synthase phosphorylation and how the phosphorylation pattern regulates glycogen synthase kinetic properties. ..
Jensen J, Grønning Wang L, Jebens E, Whitehead J, Zorec R, Shepherd P. Adrenaline potentiates insulin-stimulated PKB activation in the rat fast-twitch epitrochlearis muscle without affecting IRS-1-associated PI 3-kinase activity. Pflugers Arch. 2008;456:969-78 pubmed publisher
..These results indicate that the combination of adrenaline and insulin may activate novel signalling molecules rather than just summing up their effects on linear pathways. ..