Affiliation: Institute for Cancer Research
Solberg N, Melheim M, Strand M, Olsen P, Krauss S. MEK Inhibition Induces Canonical WNT Signaling through YAP in KRAS Mutated HCT-15 Cells, and a Cancer Preventive FOXO3/FOXM1 Ratio in Combination with TNKS Inhibition. Cancers (Basel). 2019;11: pubmed publisher
..RNA sequencing analysis suggests that combined TNKS/MEK inhibition induces metabolic stress responses in HCT-15 cells promoting a positive FOXO3/FOXM1 ratio to reduce antioxidative and cryoprotective systems. ..
Solberg N, Machon O, Krauss S. Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool. Dev Dyn. 2008;237:1799-811 pubmed publisher
..The lower number of progenitors in the dentate gyrus was not rescued after migration to the subgranular zone and thus the dentate gyrus lacked the entire internal blade and a part of the external blade from postnatal to adult stages. ..
Solberg N, Machon O, Krauss S. Characterization and functional analysis of the 5'-flanking promoter region of the mouse Tcf3 gene. Mol Cell Biochem. 2012;360:289-99 pubmed publisher
..In vivo analysis of a 4.5 kb promoter fragment (-4303/+211) driving, the expression of EGFP in mouse embryos highly resembled endogenous expression of mTcf3. ..
Solberg N, Machon O, Machonova O, Krauss S. Mouse Tcf3 represses canonical Wnt signaling by either competing for ?-catenin binding or through occupation of DNA-binding sites. Mol Cell Biochem. 2012;365:53-63 pubmed publisher
..A direct physical interaction between ?-catenin and Tcf3 in the nucleus was confirmed by co-immunoprecipitation studies. The inhibitory ?-catenin/Tcf3 interface was independent of the ability of Tcf3 to directly interact with DNA. ..
Solberg N, Waaler J, Lund K, Mygland L, Olsen P, Krauss S. TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting β-CATENIN and AKT Signaling in Colorectal Cancer. Mol Cancer Res. 2018;16:543-553 pubmed publisher
..b>Implications: Combining TNKS inhibitors with PI3K and EGFR inhibition may expand the therapeutic arsenal against colorectal cancers. Mol Cancer Res; 16(3); 543-53. ©2017 AACR. ..