Ola Didrik Saugstad

Summary

Affiliation: Institute for Cancer Research
Country: Norway

Publications

  1. doi request reprint Neurodevelopmental outcome of infants resuscitated with air or 100% oxygen: a systematic review and meta-analysis
    Ola Didrik Saugstad
    Department of Pediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway
    Neonatology 102:98-103. 2012
  2. ncbi request reprint Oxygenation of the newborn: a molecular approach
    Ola Didrik Saugstad
    Department of Pediatric Research, Women and Children s Division, Oslo University Hospital, University of Oslo, Oslo, Norway
    Neonatology 101:315-25. 2012
  3. doi request reprint Impact of antenatal glucocorticosteroids on whole-genome expression in preterm babies
    Ola Didrik Saugstad
    Department of Pediatric Research, Clinic of Women and Child Health, Oslo University Hospital, University of Oslo, Norway
    Acta Paediatr 102:349-55. 2013
  4. doi request reprint Hyperoxia in the term newborn: more evidence is still needed for optimal oxygen therapy
    Ola Didrik Saugstad
    Department of Pediatric Research, Clinic of Women and Child Health, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway
    Acta Paediatr Suppl 101:34-8. 2012
  5. doi request reprint In search of the optimal oxygen saturation for extremely low birth weight infants: a systematic review and meta-analysis
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet, Oslo University Hospital, University of Oslo, Oslo, Norway
    Neonatology 100:1-8. 2011
  6. doi request reprint New guidelines for newborn resuscitation--a critical evaluation
    O D Saugstad
    Department of Paediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway
    Acta Paediatr 100:1058-62. 2011
  7. doi request reprint Reducing global neonatal mortality is possible
    Ola Didrik Saugstad
    Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway
    Neonatology 99:250-7. 2011
  8. doi request reprint Resuscitation of newborn infants with 21% or 100% oxygen: an updated systematic review and meta-analysis
    Ola Didrik Saugstad
    Department of Paediatric Research, Rikshospitalet Medical Centre, University of Oslo, Oslo, Norway
    Neonatology 94:176-82. 2008
  9. doi request reprint Oxygen and oxidative stress in bronchopulmonary dysplasia
    Ola Didrik Saugstad
    Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, University of Oslo, Norway
    J Perinat Med 38:571-7. 2010
  10. ncbi request reprint Effect of interleukin-10 on newborn piglet brain following hypoxia-ischemia and endotoxin-induced inflammation
    Kristin Lyng
    Department of Pediatric Research, University of Oslo, Oslo, Norway
    Biol Neonate 87:207-16. 2005

Detail Information

Publications67

  1. doi request reprint Neurodevelopmental outcome of infants resuscitated with air or 100% oxygen: a systematic review and meta-analysis
    Ola Didrik Saugstad
    Department of Pediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway
    Neonatology 102:98-103. 2012
    ..The use of air for the initial resuscitation of newborn infants has been shown to reduce neonatal mortality. However, a precise estimate of the neurodevelopmental status upon follow-up of infants resuscitated in air is lacking...
  2. ncbi request reprint Oxygenation of the newborn: a molecular approach
    Ola Didrik Saugstad
    Department of Pediatric Research, Women and Children s Division, Oslo University Hospital, University of Oslo, Oslo, Norway
    Neonatology 101:315-25. 2012
    ..In the postnatal period the oxygen saturation should be targeted low <95%; however, saturations between 85 and 89% seem to increase mortality. The optimal oxygen saturation target for these infants postnatally is still unknown...
  3. doi request reprint Impact of antenatal glucocorticosteroids on whole-genome expression in preterm babies
    Ola Didrik Saugstad
    Department of Pediatric Research, Clinic of Women and Child Health, Oslo University Hospital, University of Oslo, Norway
    Acta Paediatr 102:349-55. 2013
    ..To study the impact that using antenatal steroid to treat threatened preterm delivery has on whole-genome expression...
  4. doi request reprint Hyperoxia in the term newborn: more evidence is still needed for optimal oxygen therapy
    Ola Didrik Saugstad
    Department of Pediatric Research, Clinic of Women and Child Health, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway
    Acta Paediatr Suppl 101:34-8. 2012
    ..There are still a number of unanswered questions related to oxygen therapy of the newborn infant. The newborn brain, lungs and other organs are susceptible to oxygen injury, and newborns still develop injury caused by hyperoxia...
  5. doi request reprint In search of the optimal oxygen saturation for extremely low birth weight infants: a systematic review and meta-analysis
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet, Oslo University Hospital, University of Oslo, Oslo, Norway
    Neonatology 100:1-8. 2011
    ..The optimal arterial oxygen saturation in the first weeks of life is unknown for immature newborn infants...
  6. doi request reprint New guidelines for newborn resuscitation--a critical evaluation
    O D Saugstad
    Department of Paediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway
    Acta Paediatr 100:1058-62. 2011
    ..As colour pink assessment and routine suctioning of airways are not recommended anymore, there is an urgent need to obtain international consensus and create a new and revised Apgar score without these two variables...
  7. doi request reprint Reducing global neonatal mortality is possible
    Ola Didrik Saugstad
    Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway
    Neonatology 99:250-7. 2011
    ..The decline in neonatal mortality has been slow and is a main reason the Millennium Development Goal 4 does not seem to have been reached...
  8. doi request reprint Resuscitation of newborn infants with 21% or 100% oxygen: an updated systematic review and meta-analysis
    Ola Didrik Saugstad
    Department of Paediatric Research, Rikshospitalet Medical Centre, University of Oslo, Oslo, Norway
    Neonatology 94:176-82. 2008
    ..The issue of whether 21% O(2) is more effective than 100% O(2) for resuscitation of newborn infants remains controversial...
  9. doi request reprint Oxygen and oxidative stress in bronchopulmonary dysplasia
    Ola Didrik Saugstad
    Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, University of Oslo, Norway
    J Perinat Med 38:571-7. 2010
    ..to summarize present knowledge regarding the relation between oxidative stress and development of bronchopulmonary dysplasia (BPD)...
  10. ncbi request reprint Effect of interleukin-10 on newborn piglet brain following hypoxia-ischemia and endotoxin-induced inflammation
    Kristin Lyng
    Department of Pediatric Research, University of Oslo, Oslo, Norway
    Biol Neonate 87:207-16. 2005
    ..We wanted to assess (1) whether IL-10 had a beneficial effect on brain metabolism and microcirculation in newborn piglets after an inflammatory, hypoxic and ischemic challenge, and (2) whether IL-10 had any harmful effects per se...
  11. pmc Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF
    Rønnaug Solberg
    Department of Paediatric Research, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway
    PLoS ONE 5:e14261. 2010
    ....
  12. ncbi request reprint Inflammation increases vulnerability to hypoxia in newborn piglets: effect of reoxygenation with 21% and 100% O2
    Kristin Lyng
    Department of Pediatric Research, Rikshospitalet University Hospital, Oslo, Norway
    Am J Obstet Gynecol 192:1172-8. 2005
    ..The purpose of this study was to assess whether inflammation increases vulnerability to hypoxia, and influences the effect of 100% O(2) and 21% O 2 reoxygenation on brain...
  13. ncbi request reprint Intratracheal albumin reduces interleukin-8 in tracheobronchial aspirates in piglets after meconium aspiration
    Per Arne Tølløfsrud
    Department of Pediatric Research, The National Hospital, Oslo, Norway
    J Perinat Med 32:78-83. 2004
    ..In conclusion, albumin significantly decreased interleukin-8 concentrations in tracheobronchial aspirates after meconium aspiration...
  14. ncbi request reprint Resuscitation with 21 or 100% oxygen in hypoxic nicotine-pretreated newborn piglets: possible neuroprotective effects of nicotine
    Jannicke H Andresen
    Department of Pediatric Research, Medical Faculty, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Neonatology 93:36-44. 2008
    ..Perinatal asphyxia is a major concern in perinatal medicine. Resuscitation and ways to prevent and minimize adverse outcomes after perinatal asphyxia are subject to extensive research...
  15. doi request reprint Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes
    Rønnaug Solberg
    Department of Paediatric Research, University of Oslo, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Pediatr Res 67:250-6. 2010
    ..MMP-, VEGF-, and TGFbeta-superfamily are vital for the development, growth, and functional integrity of most tissues and our data rise concern about both short- and long-term consequences of even a brief hyperoxic exposure...
  16. doi request reprint Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation
    Marit L Dalen
    Department of Paediatric Research, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway
    J Perinat Med 38:545-56. 2010
    ..Inflammatory response after the insult did not differ between groups. The results indicate an early protective effect of hypothermia which may vary with oxygen level used during reoxygenation...
  17. ncbi request reprint Resuscitation of hypoxic newborn piglets with oxygen induces a dose-dependent increase in markers of oxidation
    Rønnaug Solberg
    Department of Pediatric Research, Medical Faculty, University of Oslo Rikshospitalet Medical Centre, Oslo, N 0027, Norway
    Pediatr Res 62:559-63. 2007
    ..The increase in the hydroxyl attack may lead to a pro-oxidative status and risk for genetic instability...
  18. ncbi request reprint Comparison of short- and long-duration oxygen treatment after cerebral asphyxia in newborn piglets
    Anne Beate Solas
    Department of Pediatric Research, The National Hospital, Oslo, Norway
    Pediatr Res 56:125-31. 2004
    ..In conclusion, after experimental asphyxia, newborn piglets can be reoxygenated as efficiently with 100% O(2) for only 5 min as 100% O(2) for 20 min compared with room air...
  19. ncbi request reprint Detrimental effects of nicotine and endotoxin in the newborn piglet brain during severe hypoxemia
    J Frederik Frøen
    Department of Pediatric Research, The National Hospital, University of Oslo, Norway
    Biol Neonate 82:188-96. 2002
    ..02). These findings contribute in explaining how nicotine and inflammatory response to bacterial toxins could act as cofactors for hypoxic-ischemic neurologic injury in the immature brain...
  20. doi request reprint Effects of nicotine infusion on striatal glutamate and cortical non-protein-bound iron in hypoxic newborn piglets
    Jannicke Hanne Andresen
    Department of Pediatric Research, Medical Faculty, Institute for Surgical Research, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    Neonatology 94:284-92. 2008
    ..Nicotine's effects have further been shown to be dose-dependent, with lower doses showing neuroprotective, and higher doses showing neurotoxic effects...
  21. ncbi request reprint Fetal brain injury in experimental intrauterine asphyxia and inflammation in Göttingen minipigs
    Kristin Lyng
    Department of Obstetrics and Gynecology, Rikshospitalet University Hospital, Oslo, Norway
    J Perinat Med 34:226-34. 2006
    ..To examine fetal brain injury in the Göttingen minipig following intrauterine asphyxia and infection/inflammation induced at 3/4 of gestational length...
  22. doi request reprint Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets
    Jannicke Hanne Andresen
    Department of Pediatric Research, Institute of Surgical Research, Medical Faculty, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    J Perinat Med 37:553-60. 2009
    ..This might imply neuroprotective effects of nicotine in asphyxiated neonates...
  23. ncbi request reprint Acidosis has opposite effects on neuronal survival during hypoxia and reoxygenation
    Runar Almaas
    Department of Pediatric Research, Rikshospitalet, N 0027 Oslo, Norway
    J Neurochem 84:1018-27. 2003
    ..The effect of acidosis on neuronal survival depends on the timing of acidosis, as acidosis was protective during OGD and detrimental during reoxygenation...
  24. doi request reprint Nicotine in a small-to-moderate dose does not cause a significant increase in plasma catecholamine levels in newborn piglets
    Jannicke Hanne Andresen
    Department of Pediatric Research, Medical Faculty, Institute for Surgical Research, Rikshospitalet Medical Center, University of Oslo, Oslo, Norway
    Neonatology 94:279-83. 2008
    ..Recently, nicotine has been investigated in a piglet model of perinatal asphyxia, where the question has been raised whether nicotine's effect on the sympathetic nervous system can explain some of the positive effects...
  25. ncbi request reprint Hyperoxic resuscitation after hypoxia-ischemia induces cerebral inflammation that is attenuated by tempol in a reporter mouse model with very young mice
    Gaute Døhlen
    Department of Paediatric Research, University of Oslo and Oslo University Hospital, Oslo, Norway
    J Perinat Med 41:251-7. 2013
    ..Oxygen supplementation is still part of international resuscitation protocols for premature children. Mechanisms for tissue damage by hypoxia/ischemia in the extreme premature involve inflammation...
  26. doi request reprint Reduced expression of DNA glycosylases in post-hypoxic newborn pigs undergoing therapeutic hypothermia
    Marit Lunde Dalen
    Department of Paediatric Research, University of Oslo, Oslo University Hospital, N 0027 Oslo, Norway
    Brain Res 1363:198-205. 2010
    ..We confirm increased oxidative stress after hypoxia. DNA repair glycosylases were down-regulated by hypothermia but with no effect on accumulation of oxidative damage in genomic DNA...
  27. doi request reprint Impaired diastolic function and disruption of the force-frequency relationship in the right ventricle of newborn pigs resuscitated with 100% oxygen
    Hans Henrik Odland
    Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Neonatology 101:147-53. 2012
    ..Resuscitation with 100% oxygen increases oxidative stress and is detrimental for organ function...
  28. pmc Ejection time-corrected systolic velocity improves accuracy in the evaluation of myocardial dysfunction: a study in piglets
    Hans Henrik Odland
    Department of Pediatric Research, Oslo University Hospital and University of Oslo, Oslo, Norway
    Pediatr Cardiol 31:1070-8. 2010
    ..It is robust toward hemodynamic changes. This novel method has the potential of becoming a useful tool in clinical practice...
  29. ncbi request reprint Resuscitation of depressed newborn infants with ambient air or pure oxygen: a meta-analysis
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet, University of Oslo, Norway
    Biol Neonate 87:27-34. 2005
    ..It is discussed whether depressed newborn infants should be resuscitated with room air or 100% O2...
  30. ncbi request reprint Antioxidant activity in the newborn brain: a luciferase mouse model
    Gaute Dohlen
    Department of Pediatric Research, Rikshospitalet Medical Center, Oslo, Norway
    Neonatology 93:125-31. 2008
    ..The aim of this study is to present a model that can monitor genetic activity in vivo during pregnancy and the first 10 days of life...
  31. ncbi request reprint Hypoxia-reoxygenation affects whole-genome expression in the newborn eye
    Embjørg J Wollen
    Department of Pediatric Research, Clinic of Women and Child Health, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway
    Invest Ophthalmol Vis Sci 55:1393-401. 2014
    ..We wanted to assess transcriptional changes in ocular tissue after the acute use of oxygen in the delivery room in a hypoxia-reoxygenation model of the newborn mouse...
  32. doi request reprint Nicotine does not influence NF-κB activity in neonatal mice reoxygenated with room-air or 100% oxygen
    Jehan Mohamed Alsharnoubi
    Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    J Matern Fetal Neonatal Med 25:2102-5. 2012
    ..Nuclear factor kappa B (NF-κB) is considered an important mediator of inflammation, but is also important for developing organs and is constitutive active in neurons in the newborn brain...
  33. doi request reprint Myocardial longitudinal peak systolic acceleration (pSac): relationship to ejection phase, pressure, and contractility
    Hans Henrik Odland
    Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Echocardiography 29:541-53. 2012
    ..Indexed to EDV, pSac may represent a load independent noninvasive contractility parameter. We consider pSac a candidate marker of long-axis contractility which should be viewed upon as the long-axis contribution to dP/dt(max)...
  34. ncbi request reprint Oxygen for newborn resuscitation: how much is enough?
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet University Hospital, 0027 Oslo, Norway
    Pediatrics 118:789-92. 2006
  35. doi request reprint Post-hypoxic hypothermia is protective in human NT2-N neurons regardless of oxygen concentration during reoxygenation
    Marit Lunde Dalen
    Department of Paediatric Research, Rikshospitalet University Hospital and University of Oslo, N 0027, Norway
    Brain Res 1259:80-9. 2009
    ..We conclude that hypothermia protects isolated neurons after in vitro hypoxia, and that this protection is not affected by hyperoxic, normoxic or hypoxic reoxygenation...
  36. ncbi request reprint Comparison of pulmonary and inflammatory effects of lipid- and water-soluble components in meconium in newborn piglets
    Per Arne Tølløfsrud
    Department of Pediatric Research, National Hospital, Oslo, Oslo, Norway
    Biol Neonate 84:330-7. 2003
    ....
  37. doi request reprint Albumin lavage does not improve the outcome of meconium aspiration syndrome
    Bodil Salvesen
    Department of Pediatric Research, Medical Faculty, University of Oslo and Rikshospitalet University Hospital, Oslo, Norway
    J Matern Fetal Neonatal Med 21:719-25. 2008
    ..Lung compliance increased when albumin was instilled after meconium as a rescue. The aim of this study was to combine the effect of albumin and lavage...
  38. ncbi request reprint Resuscitation with supplementary oxygen induces oxidative injury in the cerebral cortex
    Rønnaug Solberg
    Department of Pediatric Research, University of Oslo, Oslo University Hospital, Rikshospitalet, N 0424 Oslo, Norway
    Free Radic Biol Med 53:1061-7. 2012
    ..These novel findings provide new knowledge regarding the relationships between oxidative brain injury and resuscitation with oxygen...
  39. doi request reprint Cerebral perfusion in perinatal hypoxia and resuscitation assessed by transcranial contrast-enhanced ultrasound and 3 T MRI in newborn pigs
    Charlotte de Lange
    Department of Paediatric Research, Oslo University Hospital, Oslo, Norway
    Invest Radiol 46:686-96. 2011
    ....
  40. ncbi request reprint Resuscitation of hypoxic piglets with 100% O2 increases pulmonary metalloproteinases and IL-8
    Berit Holthe Munkeby
    Department of Pediatric Research, Rikhospitalet University Hospital, Oslo, Norway
    Pediatr Res 58:542-8. 2005
    ..Altogether, these data strongly suggest that caution must be taken when applying pure O2 to the newborn infant...
  41. doi request reprint Atrioventricular valve annulus velocity and acceleration during global hypoxia in newborn pigs - assessment of myocardial function
    Hans Henrik Odland
    Department of Pediatric Research, Rikshospitalet University Hospital, Oslo, Norway
    Neonatology 97:100-7. 2010
    ..Global hypoxia may affect regions of the neonatal heart during systole and diastole differently...
  42. doi request reprint Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigs
    Charlotte de Lange
    Department of Paediatric Research, Oslo University Hospital, Rikshospitalet, PO Box 4950, Nydalen, 0424 Oslo, Norway
    Eur J Nucl Med Mol Imaging 39:792-9. 2012
    ..In this study dynamic ¹⁸F-FDG PET was used to evaluate cerebral glucose metabolism in piglets after global perinatal hypoxia and the impact of the resuscitation strategy using room air or hyperoxia...
  43. ncbi request reprint Room air resuscitation-two decades of neonatal research
    Ola Didrik Saugstad
    Department of Pediatric, Research Rikshospitalet, University of Oslo, 0027 Oslo, Norway
    Early Hum Dev 81:111-6. 2005
    ..Although the optimal oxygen concentration probably is not known for newborn infants in need of resuscitation, pure oxygen should be avoided. These data should be reflected in new guidelines that are under way...
  44. ncbi request reprint Interleukin-10 reverses acute detrimental effects of endotoxin-induced inflammation on perinatal cerebral hypoxia-ischemia
    J Frederik Frøen
    Department of Pediatric Research, The National Hospital, University of Oslo, N 0027 Oslo, Norway
    Brain Res 942:87-94. 2002
    ..Thus IL-10 counteracts acute effects of endotoxin on cerebral metabolism, microcirculation and oxygen tension during hypoxia-ischemia in the perinatal brain...
  45. ncbi request reprint Positive factors associated with promoting health in low-risk and high-risk populations of 15- and 16-year-old pupils in Oslo, Norway
    Ole Rikard Haavet
    Department of General Practice and Community Medicine, Section for General Practice, University of Oslo, Oslo, Norway
    Acta Paediatr 94:345-51. 2005
    ..To explore possible risk-reducing factors associated with the incidence of common illnesses and use of healthcare services among adolescents...
  46. ncbi request reprint Morphological and hemodynamic magnetic resonance assessment of early neonatal brain injury in a piglet model
    Berit H Munkeby
    Department of Pediatric Research, Rikshospitalet University Hospital, Oslo, Norway
    J Magn Reson Imaging 20:8-15. 2004
    ....
  47. ncbi request reprint Contrast-enhanced ultrasound identifies reduced overall and regional renal perfusion during global hypoxia in piglets
    Knut Brabrand
    From the Department of Radiology and Nuclear Medicine, The Intervention Centre, Department of Pathology, Department of Pediatric Research, and Department of Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Invest Radiol 49:540-6. 2014
    ..Various methods have been applied to evaluate renal perfusion in both experimental and clinical settings, including magnetic resonance imaging, computed tomography, laser Doppler, and contrast-enhanced ultrasound (CEUS)...
  48. ncbi request reprint Take a breath--but do not add oxygen (if not needed)
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet Medical Center, Faculty of Medicine, University of Oslo, Oslo, Norway
    Acta Paediatr 96:798-800. 2007
  49. ncbi request reprint The role of oxygen in neonatal resuscitation
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet University Hospital, University of Oslo, Oslo 0027, Norway
    Clin Perinatol 31:431-43. 2004
    ..Brain injury as assessed by glycerol augmentation, matrix injury, and neonatal mortality is less in infants given 21% versus 100% O2...
  50. ncbi request reprint Optimal oxygen therapy in the newborn period
    Ola Didrik Saugstad
    Department of Pediatric Research, National Hospital, University of Oslo, Oslo, Norway
    Pediatr Pulmonol Suppl 26:112-3. 2004
  51. ncbi request reprint Oxygen for newborns: how much is too much?
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet University Hospital, University of Oslo, Norway
    J Perinatol 25:S45-9; discussion S50. 2005
    ..The neonatologist would be well served to think of oxygen as a medication, and use it sparingly...
  52. ncbi request reprint Oxidative stress in the newborn--a 30-year perspective
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet Faculty Division, University of Oslo, Oslo, Norway
    Biol Neonate 88:228-36. 2005
    ..Inflammation and oxidative stress seem to be two sides of the same coin in newborn babies both contributing to injury partly through similar mechanisms...
  53. ncbi request reprint Bronchopulmonary dysplasia-oxidative stress and antioxidants
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet, University of Oslo, Norway
    Semin Neonatol 8:39-49. 2003
    ..So far, there has been no significant breakthrough regarding antioxidant therapies. Care should, however, be exercised in supplementing the preterm infant with antioxidants since this may affect growth and development...
  54. ncbi request reprint Chorioamnionitis as a risk factor for retinopathy of prematurity: a systematic review and meta-analysis
    Souvik Mitra
    Department of Paediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway
    Neonatology 105:189-99. 2014
    ..The role of chorioamnionitis (CA) in the development of retinopathy of prematurity (ROP) has not been well established...
  55. ncbi request reprint Systematic review and meta-analysis of optimal initial fraction of oxygen levels in the delivery room at ≤32 weeks
    Ola Didrik Saugstad
    Division of Women and Children s Health, Department of Pediatric Research, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway
    Acta Paediatr 103:744-51. 2014
    ..We aimed to study currently available information and provide guidelines regarding the iFiO2 levels needed to resuscitate/stabilise premature infants of ≤32 weeks' gestation...
  56. doi request reprint Effects of Natural versus Synthetic Surfactant with SP-B and SP-C Analogs in a Porcine Model of Meconium Aspiration Syndrome
    Bodil Salvesen
    Department of Pediatric Research, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway
    Neonatology 105:128-35. 2014
    ..A synthetic surfactant, CHF5633 containing SP-B and SP-C analogs, has been designed to act similarly to the natural surfactant poractant alfa...
  57. doi request reprint How does the duration of active pushing in labor affect neonatal outcomes?
    Branka M Yli
    Women and Children s Division, Oslo University Hospital Rikshospitalet and Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    J Perinat Med 40:171-8. 2012
    ..To assess the effect of time of active pushing (TAP) on neonatal outcome...
  58. ncbi request reprint Albumin mixed with meconium attenuates pulmonary dysfunction in a newborn piglet model with meconium aspiration
    Per Arne Tølløfsrud
    Department of Pediatric Research, National Hospital, NO 0027, Oslo, Norway
    Pediatr Res 52:545-53. 2002
    ..In conclusion, albumin given concurrently with meconium significantly reduced detrimental effects of meconium aspiration in the lungs of newborn piglets...
  59. ncbi request reprint Optimal oxygenation at birth and in the neonatal period
    Ola Didrik Saugstad
    Department of Pediatrics, Rikshospitalet Medical Center, Faculty of Medicine, University of Oslo, Oslo, Norway
    Neonatology 91:319-22. 2007
    ..In recent years it has become clear that even a brief exposure to high oxygen concentration at birth and an oxygen saturation (SaO(2)) >93-95% in extremely low birth weight (ELBW) infants is more toxic than previously believed...
  60. ncbi request reprint Maternal health in sudden intrauterine unexplained death: do urinary tract infections protect the fetus?
    J Frederik Frøen
    Department of Obstetrics and Gynecology, Rikshospitalet University Clinic, University of Oslo, Oslo, Norway
    Obstet Gynecol 100:909-15. 2002
    ..To study the impact of maternal health and obstetric complications on the risk for sudden intrauterine unexplained death...
  61. ncbi request reprint Physical activity and the risk of preeclampsia: a systematic review and meta-analysis
    Dagfinn Aune
    From the aDepartment of Preventive Cardiology, Oslo University Hospital Ulleval, Oslo, Norway bDepartment of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway cDepartment of Epidemiology and Biostatistics, Imperial College, London, United Kingdom dDepartment of Pediatric Research, Rikshospitalet, Oslo University Hospital, University of Oslo, Oslo, Norway eSection of obstetrics, Division of Obstetrics and Gynaecology, Rikshospitalet, Oslo University Hospital, Oslo, Norway and fDepartment of Health Promotion and Education, Loma Linda University, Loma Linda, CA
    Epidemiology 25:331-43. 2014
    ..Physical activity has been hypothesized to reduce the risk of preeclampsia, but epidemiologic studies have not shown consistent results. Therefore, we conducted a systematic review and dose-response meta-analysis of epidemiologic studies...
  62. doi request reprint Optimal oxygenation of extremely low birth weight infants: a meta-analysis and systematic review of the oxygen saturation target studies
    Ola Didrik Saugstad
    Department of Pediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway
    Neonatology 105:55-63. 2014
    ..The optimal oxygen saturation for extremely low birth weight infants in the postnatal period beyond the delivery room is not known...
  63. ncbi request reprint Prolonged apneas and hypoxia mediated by nicotine and endotoxin in piglets
    J Frederik Frøen
    Department of Pediatric Research, The National Hospital, University of Oslo, Norway
    Biol Neonate 81:119-25. 2002
    ..We investigated the acute effects of nicotine and endotoxin on repeated apnea by laryngeal reflex stimulation and the following autoresuscitation...
  64. ncbi request reprint New guidelines for newborn resuscitation
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet Faculty Division, University of Oslo, Oslo, Norway
    Acta Paediatr 96:333-7. 2007
    ..A number of gaps in newborn resuscitation have been identified and discussed...
  65. ncbi request reprint Reoxygenation of hypoxic mice with 100% oxygen induces brain nuclear factor-kappa B
    Gaute Døhlen
    Department of Pediatric Research, Rikshospitalet, University of Oslo, 0027 Oslo, Norway
    Pediatr Res 58:941-5. 2005
    ..However, when reoxygenation occurs with 21% O2 (room air), no elevation in NF-kappaB activity is observed. Thus, reoxygenation with room air may induce less brain inflammation than reoxygenation with pure oxygen...
  66. ncbi request reprint Do negative life experiences predict the health-care-seeking of adolescents? A study of 10th-year students in Oslo, Norway
    Ole Rikard Haavet
    Department of General Practice and Community Medicine, University of Oslo, Oslo, Norway
    J Adolesc Health 37:128-34. 2005
    ..To analyze associations among the negative life experiences and health-care-seeking of adolescents during the 12 months before the study...
  67. ncbi request reprint Neuronal formation of free radicals plays a minor role in hypoxic cell death in human NT2-N neurons
    Runar Almaas
    Department of Pediatric Research, National Hospital, Oslo, Norway
    Pediatr Res 51:136-43. 2002
    ..Thus in this model, mechanisms downstream of the N-methyl-D-aspartate-glutamate receptor other than free radicals and nitric oxide have to be invoked...