Ioannis Panagopoulos

Summary

Affiliation: Institute for Cancer Research
Country: Norway

Publications

  1. doi request reprint Fusion of the HMGA2 and C9orf92 genes in myolipoma with t(9;12)(p22;q14)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, P O Box 4953, Nydalen, NO 0424, Oslo, Norway
    Diagn Pathol 11:22. 2016
  2. doi request reprint LAMTOR1-PRKCD and NUMA1-SFMBT1 fusion genes identified by RNA sequencing in aneurysmal benign fibrous histiocytoma with t(3;11)(p21;q13)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Electronic address
    Cancer Genet 208:545-51. 2015
  3. doi request reprint Novel TNS3-MAP3K3 and ZFPM2-ELF5 fusion genes identified by RNA sequencing in multicystic mesothelioma with t(7;17)(p12;q23) and t(8;11)(q23;p13)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, PO Box 49534, Nydalen, NO 0424, Oslo 0310, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Electronic address
    Cancer Lett 357:502-9. 2015
  4. doi request reprint Sequential combination of karyotyping and RNA-sequencing in the search for cancer-specific fusion genes
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Electronic address
    Int J Biochem Cell Biol 53:462-5. 2014
  5. doi request reprint Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 52:610-8. 2013
  6. pmc Fusion of ZMYND8 and RELA genes in acute erythroid leukemia
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 8:e63663. 2013
  7. pmc Myeloid leukemia with t(7;21)(p22;q22) and 5q deletion
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncol Rep 30:1549-52. 2013
  8. doi request reprint A novel TCF3-HLF fusion transcript in acute lymphoblastic leukemia with a t(17;19)(q22;p13)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Cancer Genet 205:669-72. 2012
  9. pmc Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e39354. 2012
  10. doi request reprint RNA sequencing identifies fusion of the EWSR1 and YY1 genes in mesothelioma with t(14;22)(q32;q12)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 52:733-40. 2013

Collaborators

Detail Information

Publications35

  1. doi request reprint Fusion of the HMGA2 and C9orf92 genes in myolipoma with t(9;12)(p22;q14)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, P O Box 4953, Nydalen, NO 0424, Oslo, Norway
    Diagn Pathol 11:22. 2016
    ..It is found predominantly in women. The cytogenetic and molecular genetic features of myolipomas remain largely unexplored. Here we present the first cytogenetically analyzed myolipoma...
  2. doi request reprint LAMTOR1-PRKCD and NUMA1-SFMBT1 fusion genes identified by RNA sequencing in aneurysmal benign fibrous histiocytoma with t(3;11)(p21;q13)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Electronic address
    Cancer Genet 208:545-51. 2015
    ..The data support a neoplastic genesis of aneurysmal benign fibrous histiocytoma and indicate a pathogenetic role for LAMTOR1-PRKCD and NUMA1-SFMBT1. ..
  3. doi request reprint Novel TNS3-MAP3K3 and ZFPM2-ELF5 fusion genes identified by RNA sequencing in multicystic mesothelioma with t(7;17)(p12;q23) and t(8;11)(q23;p13)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, PO Box 49534, Nydalen, NO 0424, Oslo 0310, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Electronic address
    Cancer Lett 357:502-9. 2015
    ....
  4. doi request reprint Sequential combination of karyotyping and RNA-sequencing in the search for cancer-specific fusion genes
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Electronic address
    Int J Biochem Cell Biol 53:462-5. 2014
    ..This article is part of a Directed Issue entitled: Rare Cancers. ..
  5. doi request reprint Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 52:610-8. 2013
    ..Whether or not the (patho)genetic subsets JAZF1-SUZ12, PHF1 rearrangements, and ZC3H7B-BCOR correspond to any phenotypic, let alone clinically important, differences in ESS remain unknown...
  6. pmc Fusion of ZMYND8 and RELA genes in acute erythroid leukemia
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 8:e63663. 2013
    ....
  7. pmc Myeloid leukemia with t(7;21)(p22;q22) and 5q deletion
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncol Rep 30:1549-52. 2013
    ..The fact that t(7;21) and 5q- occur together much more often than chance would allow seems to be unquestionable, although the pathogenetic connection between the two aberrations remains unknown...
  8. doi request reprint A novel TCF3-HLF fusion transcript in acute lymphoblastic leukemia with a t(17;19)(q22;p13)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Cancer Genet 205:669-72. 2012
    ..Whether the type 3 chimeric transcript has the same DNA binding and transcriptional regulatory effect as type 1 and type 2 TCF3-HLF chimeras remains to be seen...
  9. pmc Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e39354. 2012
    ....
  10. doi request reprint RNA sequencing identifies fusion of the EWSR1 and YY1 genes in mesothelioma with t(14;22)(q32;q12)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 52:733-40. 2013
    ..This is the first study to detect a specific fusion gene in mesothelioma (the reason how frequent the EWSR1-YY1 fusion is remains uncertain) and also the first time that direct involvement of YY1 in oncogenesis has been demonstrated...
  11. doi request reprint t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 48:1051-6. 2009
    ..How the new fusion gene contributes to tumorigenesis is unknown, but the finding of an EWSR1 rearrangement suggests that this, possibly even the EWSR1-ZNF444, is a defining pathogenetic feature of at least a subset of these tumors...
  12. doi request reprint Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 47:558-64. 2008
    ..Based on the structure of the novel fusion gene detected, its transforming mechanism is thought to be the same as for other fusion genes involving EWSR1 or PBX1...
  13. doi request reprint MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway Electronic address
    Cancer Lett 347:75-8. 2014
    ..The transcript of both cases was an in-frame fusion between exon 5 of MEAF6 and exon 2 of PHF1. Both genes are involved in epigenetic modification, and this may well be their main pathogenetic theme also in ESS tumorigenesis. ..
  14. ncbi request reprint Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma
    Francesca Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo
    Cancer Res 66:107-12. 2006
    ..The PHF1 gene encodes a protein with two zinc finger motifs whose involvement in tumorigenesis and/or tumor progression has not been reported before, but its rearrangement clearly defines a new pathogenetic subgroup of ESS...
  15. pmc Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma
    Kaja B Nyquist
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e49705. 2012
    ..This demonstrates that genetic heterogeneity exists in mesenchymal chondrosarcoma...
  16. doi request reprint Genomic aberration patterns and expression profiles of squamous cell carcinomas of the vulva
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    Genes Chromosomes Cancer 52:551-63. 2013
    ..Notable among the downregulated genes were MAL (in 2q11), KRT4 (in 12q13), and OLFM4 (in 13q14), whereas upregulated genes included SPRR2G (in 1q21.3) and S100A7A (in 1q21.3)...
  17. ncbi request reprint Deregulation of HMGA2 in an aggressive angiomyxoma with t(11;12)(q23;q15)
    Francesca Micci
    Department of Medical Genetics, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Virchows Arch 448:838-42. 2006
    ..FISH analyses demonstrated no structural alteration of HMGA2 at the cytogenetic level; however, expression of the full-length gene was detected molecularly...
  18. pmc Cryptic FUS-ERG fusion identified by RNA-sequencing in childhood acute myeloid leukemia
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncol Rep 30:2587-92. 2013
    ..The clinical significance, if any, of the amino acid residues which are coded by the exons 8, 9 and 10 of ERG in the fusion FUS-ERG proteins, remains unclear. ..
  19. doi request reprint t(3;21)(q22;q22) leading to truncation of the RYK gene in atypical chronic myeloid leukemia
    Francesca Micci
    Department of Medical Genetics, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Cancer Lett 277:205-11. 2009
    ..The resulting fusion was not in frame, however, which is why we speculate that an abrogated RYK gene product rather than a chimeric protein might be the leukemogenic result...
  20. doi request reprint HMGA2 expression pattern and TERT mutations in tumors of the vulva
    Antonio Agostini
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncol Rep 33:2675-80. 2015
    ..Five of the 24 tumors (all SCC) showed the C228T mutation in the TERT promoter. Our results showed that HMGA2 and TERT may be of importance in the genesis and/or the progression of tumors of the vulva...
  21. doi request reprint Novel ZEB2-BCL11B Fusion Gene Identified by RNA-Sequencing in Acute Myeloid Leukemia with t(2;14)(q22;q32)
    Synne Torkildsen
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Hematology, Oslo University Hospital, Oslo, Norway
    PLoS ONE 10:e0132736. 2015
    ..All functional domains of BCL11B are retained in the chimeric protein. Abnormal expression of BCL11B coding regions subjected to control by the ZEB2 promoter seems to be the leukemogenic mechanism behind the translocation. ..
  22. doi request reprint Fusion of the TBL1XR1 and HMGA1 genes in splenic hemangioma with t(3;6)(q26;p21)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Int J Oncol 48:1242-50. 2016
    ..This is reminiscent of similar pathogenetic mechanisms involving high mobility genes in benign connective tissue tumors such as lipomas and leiomyomas. ..
  23. doi request reprint The recurrent chromosomal translocation t(12;18)(q14~15;q12~21) causes the fusion gene HMGA2-SETBP1 and HMGA2 expression in lipoma and osteochondrolipoma
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Int J Oncol 47:884-90. 2015
    ..The fact that the examined osteochondrolipoma had a t(12;18) and a HMGA2-SETBP1 fusion identical to the findings in the much more common ordinary lipomas, underscores the close developmental relationship between the two tumor types. ..
  24. pmc Several fusion genes identified by whole transcriptome sequencing in a spindle cell sarcoma with rearrangements of chromosome arm 12q and MDM2 amplification
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Int J Oncol 45:1829-36. 2014
    ..Which of them is pathogenetically primary remains unknown...
  25. pmc Comparison between karyotyping-FISH-reverse transcription PCR and RNA-sequencing-fusion gene identification programs in the detection of KAT6A-CREBBP in acute myeloid leukemia
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 9:e96570. 2014
    ....
  26. pmc Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Int J Oncol 44:1425-32. 2014
    ....
  27. pmc Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    PLoS Biol 12:e1001784. 2014
    ..At the very least, it seems clear that the said fusion cannot be a common pathogenetic event in this tumor type...
  28. ncbi request reprint Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17)
    Francesca Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Cancer Genet Cytogenet 144:119-24. 2003
    ..Evidently, karyotypic, and hence pathogenetic, heterogeneity exists for tumors classified as endometrial stromal sarcomas based on their phenotypic features...
  29. ncbi request reprint Molecular cytogenetic characterization of t(14;19)(q32;p13), a new recurrent translocation in B cell malignancies
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre Montebello, 0310, Oslo, Norway
    Virchows Arch 450:559-65. 2007
    ..Other pathogenetic possibilities could be deregulation of the neighboring NOTCH3 and/or ABHD9 genes, located distal to BRD4 in 19p13...
  30. doi request reprint Rearrangement of chromosome bands 12q14~15 causing HMGA2-SOX5 gene fusion and HMGA2 expression in extraskeletal osteochondroma
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncol Rep 34:577-84. 2015
    ..Our data therefore show that a subset of soft tissue osteochondromas shares pathogenetic involvement of HMGA2 with lipomas, leiomyomas and other benign connective tissue neoplasms...
  31. doi request reprint Fusion genes with ALK as recurrent partner in ependymoma-like gliomas: a new brain tumor entity?
    Thale Kristin Olsen
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway T K O, I P, F M, L G, J T, S H, P B Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway T K O, I P, F M, L G, J T, S H, P B Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway T K O, S H Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway T R M, B D T Department of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway M L I, B K Department of Radiology, WA 98104
    Neuro Oncol 17:1365-73. 2015
    ..We have previously characterized 19 ependymal tumors using Giemsa banding and high-resolution comparative genomic hybridization. The aim of this study was to analyze these tumors searching for fusion genes...
  32. pmc Fusion of the genes EWSR1 and PBX3 in retroperitoneal leiomyoma with t(9;22)(q33;q12)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 10:e0124288. 2015
    ..However, cytogenetic and molecular heterogeneity exists in these tumors and it is too early to tell how many and which different pathways lead to retroperitoneal leiomyomagenesis. ..
  33. pmc Novel KAT6B-KANSL1 fusion gene identified by RNA sequencing in retroperitoneal leiomyoma with t(10;17)(q22;q21)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 10:e0117010. 2015
    ..The tumor also expressed MED12 in the absence of exon 2 mutations. Overall, the data show that the examined retroperitoneal leiomyoma resembles a subset of uterine leiomyomas in terms of histology and genetics. ..
  34. pmc The "grep" command but not FusionMap, FusionFinder or ChimeraScan captures the CIC-DUX4 fusion gene from whole transcriptome sequencing data on a small round cell tumor with t(4;19)(q35;q13)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 9:e99439. 2014
    ..The "grep" command is an excellent tool to capture chimeric transcripts from RNA sequencing data when the pathological and/or cytogenetic information strongly indicates the presence of a specific fusion gene. ..
  35. pmc Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncol Rep 32:40-4. 2014
    ..The pathogenetic mechanisms behind this nonrandom involvement are unknown, but the presence on 8q of two genes, HEY1 and NCOA2, now known to be involved in mesenchymal chondrosarcoma tumorigenesis is, of course, suggestive...