Ioannis Panagopoulos

Summary

Affiliation: Institute for Cancer Research
Country: Norway

Publications

  1. doi request reprint Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 52:610-8. 2013
  2. pmc Myeloid leukemia with t(7;21)(p22;q22) and 5q deletion
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncol Rep 30:1549-52. 2013
  3. pmc Fusion of ZMYND8 and RELA genes in acute erythroid leukemia
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 8:e63663. 2013
  4. doi request reprint RNA sequencing identifies fusion of the EWSR1 and YY1 genes in mesothelioma with t(14;22)(q32;q12)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 52:733-40. 2013
  5. pmc Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e39354. 2012
  6. doi request reprint A novel TCF3-HLF fusion transcript in acute lymphoblastic leukemia with a t(17;19)(q22;p13)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Cancer Genet 205:669-72. 2012
  7. ncbi request reprint t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 48:1051-6. 2009
  8. doi request reprint Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 47:558-64. 2008
  9. ncbi request reprint MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway Electronic address
    Cancer Lett 347:75-8. 2014
  10. ncbi request reprint Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma
    Francesca Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo
    Cancer Res 66:107-12. 2006

Collaborators

Detail Information

Publications22

  1. doi request reprint Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 52:610-8. 2013
    ..Whether or not the (patho)genetic subsets JAZF1-SUZ12, PHF1 rearrangements, and ZC3H7B-BCOR correspond to any phenotypic, let alone clinically important, differences in ESS remain unknown...
  2. pmc Myeloid leukemia with t(7;21)(p22;q22) and 5q deletion
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncol Rep 30:1549-52. 2013
    ..The fact that t(7;21) and 5q- occur together much more often than chance would allow seems to be unquestionable, although the pathogenetic connection between the two aberrations remains unknown...
  3. pmc Fusion of ZMYND8 and RELA genes in acute erythroid leukemia
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 8:e63663. 2013
    ....
  4. doi request reprint RNA sequencing identifies fusion of the EWSR1 and YY1 genes in mesothelioma with t(14;22)(q32;q12)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 52:733-40. 2013
    ..This is the first study to detect a specific fusion gene in mesothelioma (the reason how frequent the EWSR1-YY1 fusion is remains uncertain) and also the first time that direct involvement of YY1 in oncogenesis has been demonstrated...
  5. pmc Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e39354. 2012
    ....
  6. doi request reprint A novel TCF3-HLF fusion transcript in acute lymphoblastic leukemia with a t(17;19)(q22;p13)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Cancer Genet 205:669-72. 2012
    ..Whether the type 3 chimeric transcript has the same DNA binding and transcriptional regulatory effect as type 1 and type 2 TCF3-HLF chimeras remains to be seen...
  7. ncbi request reprint t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 48:1051-6. 2009
    ..How the new fusion gene contributes to tumorigenesis is unknown, but the finding of an EWSR1 rearrangement suggests that this, possibly even the EWSR1-ZNF444, is a defining pathogenetic feature of at least a subset of these tumors...
  8. doi request reprint Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 47:558-64. 2008
    ..Based on the structure of the novel fusion gene detected, its transforming mechanism is thought to be the same as for other fusion genes involving EWSR1 or PBX1...
  9. ncbi request reprint MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway Electronic address
    Cancer Lett 347:75-8. 2014
    ..The transcript of both cases was an in-frame fusion between exon 5 of MEAF6 and exon 2 of PHF1. Both genes are involved in epigenetic modification, and this may well be their main pathogenetic theme also in ESS tumorigenesis. ..
  10. ncbi request reprint Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma
    Francesca Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo
    Cancer Res 66:107-12. 2006
    ..The PHF1 gene encodes a protein with two zinc finger motifs whose involvement in tumorigenesis and/or tumor progression has not been reported before, but its rearrangement clearly defines a new pathogenetic subgroup of ESS...
  11. pmc Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma
    Kaja B Nyquist
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e49705. 2012
    ..This demonstrates that genetic heterogeneity exists in mesenchymal chondrosarcoma...
  12. doi request reprint Genomic aberration patterns and expression profiles of squamous cell carcinomas of the vulva
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    Genes Chromosomes Cancer 52:551-63. 2013
    ..Notable among the downregulated genes were MAL (in 2q11), KRT4 (in 12q13), and OLFM4 (in 13q14), whereas upregulated genes included SPRR2G (in 1q21.3) and S100A7A (in 1q21.3)...
  13. ncbi request reprint Deregulation of HMGA2 in an aggressive angiomyxoma with t(11;12)(q23;q15)
    Francesca Micci
    Department of Medical Genetics, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Virchows Arch 448:838-42. 2006
    ..FISH analyses demonstrated no structural alteration of HMGA2 at the cytogenetic level; however, expression of the full-length gene was detected molecularly...
  14. pmc Cryptic FUS-ERG fusion identified by RNA-sequencing in childhood acute myeloid leukemia
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncol Rep 30:2587-92. 2013
    ..The clinical significance, if any, of the amino acid residues which are coded by the exons 8, 9 and 10 of ERG in the fusion FUS-ERG proteins, remains unclear. ..
  15. doi request reprint t(3;21)(q22;q22) leading to truncation of the RYK gene in atypical chronic myeloid leukemia
    Francesca Micci
    Department of Medical Genetics, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Cancer Lett 277:205-11. 2009
    ..The resulting fusion was not in frame, however, which is why we speculate that an abrogated RYK gene product rather than a chimeric protein might be the leukemogenic result...
  16. pmc Comparison between Karyotyping-FISH-Reverse Transcription PCR and RNA- Sequencing-Fusion Gene Identification Programs in the Detection of KAT6A-CREBBP in Acute Myeloid Leukemia
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 9:e96570. 2014
    ....
  17. pmc Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Int J Oncol 44:1425-32. 2014
    ....
  18. pmc Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    PLoS Biol 12:e1001784. 2014
    ..At the very least, it seems clear that the said fusion cannot be a common pathogenetic event in this tumor type...
  19. ncbi request reprint Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17)
    Francesca Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Cancer Genet Cytogenet 144:119-24. 2003
    ..Evidently, karyotypic, and hence pathogenetic, heterogeneity exists for tumors classified as endometrial stromal sarcomas based on their phenotypic features...
  20. ncbi request reprint Molecular cytogenetic characterization of t(14;19)(q32;p13), a new recurrent translocation in B cell malignancies
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre Montebello, 0310, Oslo, Norway
    Virchows Arch 450:559-65. 2007
    ..Other pathogenetic possibilities could be deregulation of the neighboring NOTCH3 and/or ABHD9 genes, located distal to BRD4 in 19p13...
  21. pmc Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncol Rep 32:40-4. 2014
    ..The pathogenetic mechanisms behind this nonrandom involvement are unknown, but the presence on 8q of two genes, HEY1 and NCOA2, now known to be involved in mesenchymal chondrosarcoma tumorigenesis is, of course, suggestive...
  22. pmc The "Grep" Command But Not FusionMap, FusionFinder or ChimeraScan Captures the CIC-DUX4 Fusion Gene from Whole Transcriptome Sequencing Data on a Small Round Cell Tumor with t(4;19)(q35;q13)
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 9:e99439. 2014
    ..The "grep" command is an excellent tool to capture chimeric transcripts from RNA sequencing data when the pathological and/or cytogenetic information strongly indicates the presence of a specific fusion gene. ..