Leonardo A Meza-Zepeda

Summary

Affiliation: Institute for Cancer Research
Country: Norway

Publications

  1. pmc Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    BMC Res Notes 3:223. 2010
  2. pmc Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e48262. 2012
  3. pmc Modulation of the osteosarcoma expression phenotype by microRNAs
    Heidi M Namløs
    The EuroBoNet Network of Excellence on Bone Tumours, Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e48086. 2012
  4. doi request reprint Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice
    Dag Henrik Reikvam
    Department of Pathology and Centre for Immune Regulation, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Eur J Immunol 42:2959-70. 2012
  5. ncbi request reprint Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas
    Leonardo A Meza-Zepeda
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Cancer Res 66:8984-93. 2006
  6. pmc Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model
    Tale Barøy
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Mol Cancer 13:93. 2014
  7. pmc DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH
    Stine H Kresse
    Department of Tumor Biology, Radiumhospitalet, Rikshospitalet, Oslo, Norway
    Mol Cancer 7:48. 2008
  8. pmc M-CGH: analysing microarray-based CGH experiments
    Junbai Wang
    Department of Tumor Biology, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    BMC Bioinformatics 5:74. 2004
  9. pmc DNA copy number changes in human malignant fibrous histiocytomas by array comparative genomic hybridisation
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 5:e15378. 2010
  10. ncbi request reprint Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21
    Leonardo A Meza-Zepeda
    Department of Tumour Biology, The Norwegian Radium Hospital, Montebello N 0310, Oslo, Norway
    Oncogene 21:2261-9. 2002

Collaborators

Detail Information

Publications28

  1. pmc Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    BMC Res Notes 3:223. 2010
    ..eu), we have evaluated four different commercial high-resolution microarray platforms in order to identify the most appropriate technology for mapping DNA copy number aberrations in such tumours...
  2. pmc Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e48262. 2012
    ..We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based on microarray technologies...
  3. pmc Modulation of the osteosarcoma expression phenotype by microRNAs
    Heidi M Namløs
    The EuroBoNet Network of Excellence on Bone Tumours, Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e48086. 2012
    ..In order to investigate the involvement of miRNAs in osteosarcoma development, global microarray analyses of a panel of 19 human osteosarcoma cell lines was performed...
  4. doi request reprint Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice
    Dag Henrik Reikvam
    Department of Pathology and Centre for Immune Regulation, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Eur J Immunol 42:2959-70. 2012
    ..Thus, in the absence of pIgR, the stability of the commensal microbiota is disturbed, gut homeostasis is compromised, and the outcome of colitis is significantly worsened...
  5. ncbi request reprint Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas
    Leonardo A Meza-Zepeda
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Cancer Res 66:8984-93. 2006
    ..Our results show the potential of using array comparative genomic hybridization to classify histologically similar tumors such as GISTs and leiomyosarcomas...
  6. pmc Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model
    Tale Barøy
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Mol Cancer 13:93. 2014
    ..We have identified LSAMP as the target gene for the deletion, and have studied the functional implications of LSAMP-reexpression...
  7. pmc DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH
    Stine H Kresse
    Department of Tumor Biology, Radiumhospitalet, Rikshospitalet, Oslo, Norway
    Mol Cancer 7:48. 2008
    ....
  8. pmc M-CGH: analysing microarray-based CGH experiments
    Junbai Wang
    Department of Tumor Biology, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    BMC Bioinformatics 5:74. 2004
    ..Dedicated tools are needed to analyse the results of such experiments, which include appropriate visualisation, and to take into consideration the physical relation in the genome between the probes on the array...
  9. pmc DNA copy number changes in human malignant fibrous histiocytomas by array comparative genomic hybridisation
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 5:e15378. 2010
    ....
  10. ncbi request reprint Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21
    Leonardo A Meza-Zepeda
    Department of Tumour Biology, The Norwegian Radium Hospital, Montebello N 0310, Oslo, Norway
    Oncogene 21:2261-9. 2002
    ..Quite likely, the different genes may give selective advantages to different subsets of tumours...
  11. pmc Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo, Norway
    Mol Cancer 4:39. 2005
    ..In this study we have mapped and characterized the amplicon in 1q23 in more detail...
  12. doi request reprint Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222
    Magne Skårn
    Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Stem Cells Dev 21:873-83. 2012
    ....
  13. doi request reprint Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma
    Hege O Ohnstad
    Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway
    Cancer 119:1013-22. 2013
    ..Relatively few sarcomas harbor TP53 (tumor protein p53) mutations, but in many cases, amplification of MDM2 (murine double minute 2) effectively inactivate p53. The p53 pathway activity can also be affected by normal genetic variation...
  14. pmc Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
    Susanne Lorenz
    Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway
    Oncotarget 7:5273-88. 2016
    ..For the first time the genomic chaos of osteosarcoma is characterized so thoroughly and delivered new insights in mechanisms involved in osteosarcoma development and may contribute to new diagnostic and therapeutic strategies. ..
  15. doi request reprint Preclinical xenograft models of human sarcoma show nonrandom loss of aberrations
    Stine H Kresse
    Department of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Cancer 118:558-70. 2012
    ..Human tumors transplanted into immunodeficient mice (xenografts) are good preclinical models, and it is important to identify possible systematic changes during establishment and passaging in mice...
  16. pmc Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells
    Jørn Henriksen
    CAST, Cancer Stem Cell Innovation Centre, Department of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital, N 0027 Oslo, Norway
    BMC Cancer 10:329. 2010
    ....
  17. pmc Performance comparison of four exome capture systems for deep sequencing
    Chandra Sekhar Reddy Chilamakuri
    Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, 0310 Oslo, Norway
    BMC Genomics 15:449. 2014
    ..0, Agilent's SureSelect v4.0, Illumina's TruSeq Exome, and Illumina's Nextera Exome, all applied to the same human tumor DNA sample...
  18. pmc Rapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program
    Su Qu
    Department of Biosciences, University of Oslo, Oslo, Norway
    PLoS ONE 8:e61910. 2013
    ..These data suggest that yoga and related practices result in rapid gene expression alterations which may be the basis for their longer term cell biological and higher level health effects...
  19. pmc High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence
    Leonardo A Meza-Zepeda
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    J Cell Mol Med 12:553-63. 2008
    ..Nonetheless, incidence of these aberrations seems to be negligible in the majority of long-term ASC cultures, at least under the culture conditions used here...
  20. pmc Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
    Pierre Chymkowitch
    Institute of Microbiology, Clinic for Diagnostics and Intervention, Oslo University Hospital, N 0027 Oslo, Norway University of Oslo, 0316 Oslo, Norway
    Genome Res 25:897-906. 2015
    ..Taken together, Sumo regulates the cellular translational capacity by promoting transcription of tRNA genes and RPGs. ..
  21. doi request reprint LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
    Stine H Kresse
    Department of Tumor Biology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 48:679-93. 2009
    ..4-p15.3 and low expression of LSAMP (both P = 0.011) were significantly associated with poor survival. Our results show that LSAMP is a novel candidate tumor suppressor gene in osteosarcomas...
  22. pmc Human ALKBH4 interacts with proteins associated with transcription
    Linn G Bjørnstad
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    PLoS ONE 7:e49045. 2012
    ..Although the molecular function of both proteins remains to be revealed, our findings suggest a role for ALKBH4 in regulation of gene expression or chromatin state...
  23. doi request reprint Multiple chromosomal monosomies are characteristic of giant cell ependymoma
    Hanne Sofie S Dahlback
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
    Hum Pathol 42:2042-6. 2011
    ..We were also able to analyze cytogenetically the subsequent recurrent tumor, phenotypically an anaplastic ependymoma, allowing a first insight into the genetic events involved in disease progression...
  24. pmc Translocational renal cell carcinoma (t(6;11)(p21;q12) with transcription factor EB (TFEB) amplification and an integrated precision approach: a case report
    Wolfgang Lilleby
    Department of Oncology, Oslo University Hospital, Nydalen, Postboks 4950, 0424, Oslo, Norway
    J Med Case Rep 9:281. 2015
    ....
  25. pmc Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA
    Anastassia Serguienko
    Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Oncotarget 6:2451-65. 2015
    ..We thus have demonstrated that let-7a plays a prominent role in regulating energy metabolism in cancer cells, further expanding its therapeutic potential. ..
  26. pmc Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing
    Torfinn Nome
    Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    Transl Oncol 6:546-53. 2013
    ..1-PSD2 as novel intrachromosomal fusion transcripts and the most highly recurring chimeric transcripts described for CRC to date. The functional and clinical relevance of these chimeric RNA molecules remains to be elucidated. ..
  27. pmc Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression
    Dag Henrik Reikvam
    Department of Pathology and Centre for Immune Regulation, University of Oslo, Oslo, Norway
    PLoS ONE 6:e17996. 2011
    ..We aimed at refining a protocol that in a robust manner would deplete the cultivable intestinal microbiota of conventionally raised mice and that would prove to have significant biologic validity...
  28. pmc Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma
    Geir Olav Hjortland
    Oslo University Hospital, Division for Cancer and Surgery, Department of Oncology, The Norwegian Radium Hospital, Nydalen, N 0424 Oslo, Norway
    BMC Cancer 11:455. 2011
    ....