Leonardo A Meza-Zepeda

Summary

Affiliation: Institute for Cancer Research
Country: Norway

Publications

  1. pmc Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e48262. 2012
  2. pmc DNA copy number changes in human malignant fibrous histiocytomas by array comparative genomic hybridisation
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 5:e15378. 2010
  3. pmc Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    BMC Res Notes 3:223. 2010
  4. doi request reprint LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
    Stine H Kresse
    Department of Tumor Biology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 48:679-93. 2009
  5. pmc Modulation of the osteosarcoma expression phenotype by microRNAs
    Heidi M Namløs
    The EuroBoNet Network of Excellence on Bone Tumours, Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e48086. 2012
  6. ncbi request reprint Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas
    Leonardo A Meza-Zepeda
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Cancer Res 66:8984-93. 2006
  7. doi request reprint Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice
    Dag Henrik Reikvam
    Department of Pathology and Centre for Immune Regulation, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Eur J Immunol 42:2959-70. 2012
  8. pmc DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH
    Stine H Kresse
    Department of Tumor Biology, Radiumhospitalet, Rikshospitalet, Oslo, Norway
    Mol Cancer 7:48. 2008
  9. pmc M-CGH: analysing microarray-based CGH experiments
    Junbai Wang
    Department of Tumor Biology, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    BMC Bioinformatics 5:74. 2004
  10. pmc Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model
    Tale Barøy
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Mol Cancer 13:93. 2014

Collaborators

Detail Information

Publications23

  1. pmc Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e48262. 2012
    ..We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based on microarray technologies...
  2. pmc DNA copy number changes in human malignant fibrous histiocytomas by array comparative genomic hybridisation
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 5:e15378. 2010
    ....
  3. pmc Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    BMC Res Notes 3:223. 2010
    ..eu), we have evaluated four different commercial high-resolution microarray platforms in order to identify the most appropriate technology for mapping DNA copy number aberrations in such tumours...
  4. doi request reprint LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
    Stine H Kresse
    Department of Tumor Biology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 48:679-93. 2009
    ..4-p15.3 and low expression of LSAMP (both P = 0.011) were significantly associated with poor survival. Our results show that LSAMP is a novel candidate tumor suppressor gene in osteosarcomas...
  5. pmc Modulation of the osteosarcoma expression phenotype by microRNAs
    Heidi M Namløs
    The EuroBoNet Network of Excellence on Bone Tumours, Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e48086. 2012
    ..In order to investigate the involvement of miRNAs in osteosarcoma development, global microarray analyses of a panel of 19 human osteosarcoma cell lines was performed...
  6. ncbi request reprint Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas
    Leonardo A Meza-Zepeda
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Cancer Res 66:8984-93. 2006
    ..Our results show the potential of using array comparative genomic hybridization to classify histologically similar tumors such as GISTs and leiomyosarcomas...
  7. doi request reprint Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice
    Dag Henrik Reikvam
    Department of Pathology and Centre for Immune Regulation, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Eur J Immunol 42:2959-70. 2012
    ..Thus, in the absence of pIgR, the stability of the commensal microbiota is disturbed, gut homeostasis is compromised, and the outcome of colitis is significantly worsened...
  8. pmc DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH
    Stine H Kresse
    Department of Tumor Biology, Radiumhospitalet, Rikshospitalet, Oslo, Norway
    Mol Cancer 7:48. 2008
    ....
  9. pmc M-CGH: analysing microarray-based CGH experiments
    Junbai Wang
    Department of Tumor Biology, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    BMC Bioinformatics 5:74. 2004
    ..Dedicated tools are needed to analyse the results of such experiments, which include appropriate visualisation, and to take into consideration the physical relation in the genome between the probes on the array...
  10. pmc Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model
    Tale Barøy
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Mol Cancer 13:93. 2014
    ..We have identified LSAMP as the target gene for the deletion, and have studied the functional implications of LSAMP-reexpression...
  11. pmc Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo, Norway
    Mol Cancer 4:39. 2005
    ..In this study we have mapped and characterized the amplicon in 1q23 in more detail...
  12. ncbi request reprint Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21
    Leonardo A Meza-Zepeda
    Department of Tumour Biology, The Norwegian Radium Hospital, Montebello N 0310, Oslo, Norway
    Oncogene 21:2261-9. 2002
    ..Quite likely, the different genes may give selective advantages to different subsets of tumours...
  13. doi request reprint Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222
    Magne Skårn
    Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Stem Cells Dev 21:873-83. 2012
    ....
  14. ncbi request reprint Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma
    Hege O Ohnstad
    Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway
    Cancer 119:1013-22. 2013
    ..Relatively few sarcomas harbor TP53 (tumor protein p53) mutations, but in many cases, amplification of MDM2 (murine double minute 2) effectively inactivate p53. The p53 pathway activity can also be affected by normal genetic variation...
  15. pmc Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells
    Jørn Henriksen
    CAST, Cancer Stem Cell Innovation Centre, Department of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital, N 0027 Oslo, Norway
    BMC Cancer 10:329. 2010
    ....
  16. doi request reprint Preclinical xenograft models of human sarcoma show nonrandom loss of aberrations
    Stine H Kresse
    Department of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Cancer 118:558-70. 2012
    ..Human tumors transplanted into immunodeficient mice (xenografts) are good preclinical models, and it is important to identify possible systematic changes during establishment and passaging in mice...
  17. ncbi request reprint Performance comparison of four exome capture systems for deep sequencing
    Chandra Sekhar Reddy Chilamakuri
    Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, 0310 Oslo, Norway
    BMC Genomics 15:449. 2014
    ..0, Agilent's SureSelect v4.0, Illumina's TruSeq Exome, and Illumina's Nextera Exome, all applied to the same human tumor DNA sample...
  18. pmc Rapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program
    Su Qu
    Department of Biosciences, University of Oslo, Oslo, Norway
    PLoS ONE 8:e61910. 2013
    ..These data suggest that yoga and related practices result in rapid gene expression alterations which may be the basis for their longer term cell biological and higher level health effects...
  19. doi request reprint High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence
    Leonardo A Meza-Zepeda
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    J Cell Mol Med 12:553-63. 2008
    ..Nonetheless, incidence of these aberrations seems to be negligible in the majority of long-term ASC cultures, at least under the culture conditions used here...
  20. pmc Human ALKBH4 interacts with proteins associated with transcription
    Linn G Bjørnstad
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    PLoS ONE 7:e49045. 2012
    ..Although the molecular function of both proteins remains to be revealed, our findings suggest a role for ALKBH4 in regulation of gene expression or chromatin state...
  21. doi request reprint Multiple chromosomal monosomies are characteristic of giant cell ependymoma
    Hanne Sofie S Dahlback
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
    Hum Pathol 42:2042-6. 2011
    ..We were also able to analyze cytogenetically the subsequent recurrent tumor, phenotypically an anaplastic ependymoma, allowing a first insight into the genetic events involved in disease progression...
  22. pmc Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma
    Geir Olav Hjortland
    Oslo University Hospital, Division for Cancer and Surgery, Department of Oncology, The Norwegian Radium Hospital, Nydalen, N 0424 Oslo, Norway
    BMC Cancer 11:455. 2011
    ....
  23. pmc Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression
    Dag Henrik Reikvam
    Department of Pathology and Centre for Immune Regulation, University of Oslo, Oslo, Norway
    PLoS ONE 6:e17996. 2011
    ..We aimed at refining a protocol that in a robust manner would deplete the cultivable intestinal microbiota of conventionally raised mice and that would prove to have significant biologic validity...