Research Topics
| Asta JuzenieneSummaryAffiliation: Institute for Cancer Research Country: Norway Publications
| Collaborators
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Detail Information
Publications
The effect of skin permeation enhancers on the formation of porphyrins in mouse skin during topical application of the methyl ester of 5-aminolevulinic acidAndrzej Bugaj
Department of Clinical Pharmacy and Biopharmacy, Karol Marcinkowski University of Medical Sciences, ul Marii Magdaleny 14, 61861 Poznań, Poland
J Photochem Photobiol B 83:94-7. 2006..This suggests that in 2-20% MAL creams HPE-101 may be substituted by Labrafac CC to reduce skin irritation induced by HPE-101 without impairing the porphyrin formation...
Malignant melanomas on head/neck and foot: differences in time and latitudinal trends in NorwayA Juzeniene
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello 0310 Oslo Institute of Physics, University of Oslo, Blindern 0316 Oslo, Norway
J Eur Acad Dermatol Venereol 26:821-7. 2012....- Development of different human skin colors: a review highlighting photobiological and photobiophysical aspectsAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
J Photochem Photobiol B 96:93-100. 2009..The genetical processes behind some of the changes of skin color will be also briefly reviewed... - The seasonality of pandemic and non-pandemic influenzas: the roles of solar radiation and vitamin DAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
Int J Infect Dis 14:e1099-105. 2010..Seasonal variations in ultraviolet B (UVB) radiation cause seasonal variations in vitamin D status. This may influence immune responses and play a role in the seasonality of influenza... - Milestones in the development of photodynamic therapy and fluorescence diagnosisAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, The Norwegian Radium Hospital, Montebello, N 0310, Oslo, Norway
Photochem Photobiol Sci 6:1234-45. 2007.... - Pilot study of folate status in healthy volunteers and in patients with psoriasis before and after UV exposureAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
J Photochem Photobiol B 101:111-6. 2010..Further studies, using proper, adequate 5-methyltetrahydrofolate methodology, are needed to clarify the influence of broadband phototherapy on folate degradation and the consequences of these on the health of psoriasis patients... - Changes in human skin after topical PDT with hexyl aminolevulinateAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway
Photodiagnosis Photodyn Ther 5:176-81. 2008..Photodynamic therapy (PDT) induces physiological changes in human skin, but details and kinetics are not known... - Topical applications of iron chelators in photosensitizationAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
Photochem Photobiol Sci 6:1268-74. 2007..Further studies are needed to evaluate the role of PpIX induced by iron chelators used, against photoaging and cancer prevention... - 5-Methyltetrahydrofolate can be photodegraded by endogenous photosensitizersAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
Free Radic Biol Med 47:1199-204. 2009..This study suggests that 5MTHF in blood can be photodegraded in the presence of the flavins and porphyrins, but protected by bilirubins. This may have health and evolutionary implications... - Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA estersJohan Moan
Department of Biophysics, The Norwegian Radium Hospital, Montebello, Oslo, Norway
Int J Cancer 103:132-5. 2003..The esters seem to penetrate less into the circulation than ALA, and PpIX formed by them in the skin is faster cleared than PpIX formed from ALA. This is also true after oral and i.p. administration of the drugs... - Immediate pigment darkening: its evolutionary roles may include protection against folate photosensitizationJohan Moan
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello 0310 Oslo, Norway
FASEB J 26:971-5. 2012..We here propose that the biological role of IPD is protection of folates against photodegradation, which would be of large evolutionary importance for early hominids... - Noninvasive fluorescence excitation spectroscopy during application of 5-aminolevulinic acid in vivoPetras Juzenas
Department of Biophysics, The Norwegian Radium Hospital, Oslo, Norway
Photochem Photobiol Sci 1:745-8. 2002..The fluorescence excitation spectra calculated for the depth 1.1 mm obtained the best fit with the experimentally measured spectra after topical application of ALA... - Effectiveness of different light sources for 5-aminolevulinic acid photodynamic therapyAsta Juzeniene
Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Montebello, Oslo, Norway
Lasers Med Sci 19:139-49. 2004..All these differences are related to difference in the spectra of the lamps. Thus, PDT light sources with emissions that are visually similar have significantly different photobiological properties... - The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinateLiwei Ma
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
Photochem Photobiol Sci 5:755-9. 2006..The present data seem to favour the latter mechanism. Folic acid may have a role as an adjuvant in photodynamic therapy with systemically administered ALA and its derivatives... - Fluorescence photobleaching of ALA and ALA-heptyl ester induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: a comparison of two light sources and different illumination schemesXiao Pudroma
Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
J Environ Pathol Toxicol Oncol 30:235-40. 2011..These have been suggested to allow reoxygenation of the irradiated tissue, with a consequent enhancement of singlet oxygen production in the second and subsequent fractions... - Biological activity of 5-aminolevulinic acid and its methyl ester after storage under different conditionsMiron Kaliszewski
Department of Radiation Biology, Institute for Cancer Research, 0310 Montebello, Oslo, Norway
J Photochem Photobiol B 87:67-72. 2007..Our work shows that solutions should be prepared immediately before use and stored at low temperatures. The pH of stock solutions should not exceed 5... - Photodegradation of 5-methyltetrahydrofolate in the presence of UroporphyrinTran Thi Thu Tam
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, N 0310 Oslo, Norway
J Photochem Photobiol B 94:201-4. 2009..Our results show that singlet oxygen is likely to be the main intermediate in the photodegradation of 5MTHF mediated by Uro. Our findings may be useful for further studies the evolution of human skin colours... - Influence of narrowband UVB phototherapy on vitamin D and folate statusEmanuela Cicarma
Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Exp Dermatol 19:e67-72. 2010..Such therapy leads to enhanced cutaneous vitamin D synthesis, which may be one of the mechanisms of action. Furthermore, another nutrient, folate, can probably also be influenced by UV radiation... - The influence of temperature on photodynamic cell killing in vitro with 5-aminolevulinic acidAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Montebello, Oslo, Norway
J Photochem Photobiol B 84:161-6. 2006..Thus, the photodynamic effect with 5-aminolevulinic acid may be enhanced by heating the tumour area before, and by cooling it immediately after the treatment... - Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapyPatrycja Mikolajewska
Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
Transl Res 152:128-33. 2008..Pretreatment with (R)L-sulforaphane before topical ALA-PDT may improve penetration of ALA through the stratum corneum, and, subsequently, increase PpIX synthesis... - 5-Methyltetrahydrofolate is photosensitive in the presence of riboflavinArnfinn Hykkerud Steindal
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310, Oslo, Norway
Photochem Photobiol Sci 7:814-8. 2008..Thus, a dark skin colour may be favourable for prevention of folate degradation under high solar fluence rates, such as in equatorial areas... - Deferoxamine photosensitizes cancer cells in vitroPetras Juzenas
Department of Radiation Biology, The Norwegian Radium Hospital, Oslo, Norway
Biochem Biophys Res Commun 332:388-91. 2005..In conclusion, the present study describes a novel approach of using iron chelating agents without 5-aminolevulinic acid (ALA) to photosensitize cancer cells... - The effect of sub-lethal ALA-PDT on the cytoskeleton and adhesion of cultured human cancer cellsAnatoly Uzdensky
Institute for Cancer Research, 0310 Montebello, Oslo, Norway
Biochim Biophys Acta 1722:43-50. 2005..Some signal transduction processes are suggested to be involved in ALA-PDT-induced changes in cytoskeleton, cell shape, and adhesion... - Photodynamic inhibition of enzymatic detachment of human cancer cells from a substratumAnatoly Uzdensky
Institute for Cancer Research, 0310 Montebello, Oslo, Norway
Biochim Biophys Acta 1670:1-11. 2004..Photodynamic inhibition of enzymatic cell detachment may be related to PDT-induced inhibition of tumour metastasis... - Temperature effect on accumulation of protoporphyrin IX after topical application of 5-aminolevulinic acid and its methylester and hexylester derivatives in normal mouse skinAsta Juzeniene
Department of Biophysics, The Norwegian Radium Hospital, Oslo
Photochem Photobiol 76:452-6. 2002.... - Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin modelAsta Juzeniene
Biophysics Department, The Norwegian Radium Hospital, Oslo
Photochem Photobiol 76:329-34. 2002..But for long application times and high concentrations, systemic effect of ALA applied topically on relatively large areas should be considered... - Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythemaPatrycja Mikolajewska
Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
Pharm Res 27:2213-20. 2010..To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as MN impact on pain sensations during light exposure and erythema after PDT... - The influence of light and darkness on cutaneous fluorescence in micePetras Juzenas
Department of Radiation Biology, The Norwegian Radium Hospital, N 310 Oslo, Norway
Luminescence 21:159-63. 2006..The presence of cutaneous PpIX together with ambient light may comprise a photosensitizing mechanism by which PpIX may be a photomessenger between ambient light and internal rhythms... - Bioimpedance for pain monitoring during cutaneous photodynamic therapy: Preliminary studyPatrycja Mikolajewska
Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
Photodiagnosis Photodyn Ther 8:307-13. 2011..Different methods for dealing with the pain have been developed over the past years, ranging from cooling with air or water to nerve blocking. However, the mechanisms responsible for the pain induction have not yet been fully understood... - Sun and sun beds: inducers of vitamin D and skin cancerEmanuela Cicarma
Department of Radiation Biology, Rikshospitalet Radiumhospitalet HF, Oslo, Norway
Anticancer Res 29:3495-500. 2009..Populations living at high latitudes would probably benefit from moderately increasing their exposure to UVB to provide a good vitamin D status... - Vitamin D, sun, sunbeds and healthJohan Moan
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Ullernchausseen 70, Montebello N 0310 Oslo, Norway
Public Health Nutr 15:711-5. 2012..To review the health effects of solar radiation, sunbeds and vitamin D... - UVA, UVB and incidence of cutaneous malignant melanoma in Norway and SwedenJohan Moan
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310, Oslo, Norway
Photochem Photobiol Sci 11:191-8. 2012..Also, UVB induction of vitamin D may be involved. CMM incidence rates among young people have decreased or been constant since about 1990 in Norway and Sweden. All reasons for UVA contributing to CMM will be discussed... - Reduction of cutaneous photosensitivity by application of ointment containing ferrous or cobaltous ions concomitant with the use of topical protoporphyrin IX precursorsPetras Juzenas
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
Photodiagnosis Photodyn Ther 7:152-7. 2010..The present study was carried out to investigate clearance of protoporphyrin IX (PpIX) in the presence of metal ions in the cream applied on healthy skin of mice in vivo... - Reflectance spectroscopy and fluorescein angiography applied to assess photodynamic response in healthy mouse skin treated with topical hexylaminolevulinateAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
Photodiagnosis Photodyn Ther 7:239-45. 2010..The aim of this study was to measure photosensitization responses in healthy mouse skin using non-invasive reflectance spectroscopy and fluorescein angiography... - Depth profile of protoporphyrin IX fluorescence in an amelanotic mouse melanoma modelPetras Juzenas
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
Photochem Photobiol 85:760-4. 2009..16 +/- 0.03 mm(2) h(-1)), MAL (0.045 +/- 0.005 mm(2) h(-1)) and HAL (0.037 +/- 0.003 mm(2) h(-1)), the behavior of the drugs after different application times could be estimated in this tumor model... - Application of 5-aminolevulinic acid and its derivatives for photodynamic therapy in vitro and in vivoAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
Methods Mol Biol 635:97-106. 2010..The content and distribution of ALA intracellularly and in tissues is difficult to measure, but PpIX content, on a relative scale, can be easily measured by fluorimetric assays... - Where the sun does not shine: is sunshine protective against melanoma of the vulva?Johan Moan
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
J Photochem Photobiol B 101:179-83. 2010.... - Latitude gradient for melanoma incidence by anatomic site and gender in Norway 1966-2007Emanuela Cicarma
Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
J Photochem Photobiol B 101:174-8. 2010..The leveling off of melanoma trend is probably associated with melanoma prevention campaigns and with increasing awareness, although vitamin D could play a role... - Photosensitizing effect of protoporphyrin IX in pigmented melanoma of micePetras Juzenas
Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, NO 0310 Montebello, Oslo, Norway
Biochem Biophys Res Commun 297:468-72. 2002..Topical application of ALA-Me followed by exposure with laser light (633nm) delayed the growth of the tumors slightly. Light alone also had a significant effect on the tumor growth... - Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapyMateusz Kwitniewski
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, 0310, Norway
Photochem Photobiol Sci 10:25-8. 2011..For the first time we present data showing that metabolic targeted therapy with dichloroacetate (DCA) may improve the outcome of photodynamic therapy. This treatment modality can be easily introduced into clinical practice guidelines... - Biophysical aspects of photodynamic therapyAsta Juzeniene
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, N-0310 Oslo, Norway
J Environ Pathol Toxicol Oncol 25:7-28. 2006..These are all important parameters for optimally effective PDT. The present review will give a brief, physically based, overview of PDT and then discuss some of the main biophysical aspects of this therapeutic modality... - Ultraviolet photodegradation of folic acidMorten Kristian Off
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
J Photochem Photobiol B 80:47-55. 2005..However, experiments performed in heavy water indicate that generation of singlet oxygen is probably not the explanation for the photosensitizing of folic acid... - Influence of light exposure on the kinetics of protoporphyrin IX formation in normal skin of hairless mice after application of 5-aminolevulinic acid methyl esterJohan Moan
Department of Radiation Biology, Institute for Cancer Research, Oslo, Norway
J Invest Dermatol 125:1039-44. 2005..The rate of elimination of PpIX from the volume of detection was faster after 420 nm light irradiation than that after 632 nm. These findings are discussed in view of penetration depths of light and ALA-Me, and diffusion of PpIX... - Erythrocytes-the 'house elves' of photodynamic therapyLars Kaestner
Institute for Cancer Research, Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
Photochem Photobiol Sci 3:981-9. 2004..Future aspects of applications of photosensitisation of red blood cells are discussed... - Photodegradation of 5-methyltetrahydrofolate: biophysical aspectsArnfinn Hykkerud Steindal
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
Photochem Photobiol 82:1651-5. 2006..5MTHF mainly absorbs, and is degraded by, UVB and UVC, radiation that does not penetrate the earth's atmosphere and the human skin well... - Spectroscopic evidence of monomeric aluminium phthalocyanine tetrasulphonate in aqueous solutionsPetras Juzenas
Institute for Cancer Research, Department of Radiation Biology, The Norwegian Radium Hospital, Oslo, Norway
J Photochem Photobiol B 75:107-10. 2004..In conclusion, the present spectroscopic results show that AlPcS(4) does not form aggregates and is a very stable compound in aqueous solutions... - Solar radiation, vitamin D and survival rate of colon cancer in NorwayJohan Moan
Avdeling for strålingsbiologi, Institutt for kreftforskning, Montebello, N 0310 Oslo, Norway
J Photochem Photobiol B 78:189-93. 2005..One possible interpretation of the present data is that, the level of calcidiol, or its derivative calcitriol (1alpha,25-dihydroxyvitamin D3, 1alpha,25-(OH)2D3), may act positively in concert with conventional therapies of colon cancer... - Superficial-spreading and nodular melanomas in Norway: a comparison by body site distribution and latitude gradientsEmanuela Micu
aDepartment of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital bFaculty of Medicine, University of Oslo cDepartment of Oncology, The Norwegian Radium Hospital dDepartment of Physics, University of Oslo, Oslo, Norway
Melanoma Res 22:460-5. 2012..Differences in sun exposure at northern latitudes have a major impact on different types of melanoma. It seems that NM is less sun-induced than SSM, for which other etiological and pathogenetic factors may play important roles... - In vitro and in vivo photosensitization by protoporphyrins possessing different lipophilicities and vertical localization in the membraneIrena Bronshteint
Department of Physics, Bar Ilan University, Ramat Gan, Israel
Photochem Photobiol 82:1319-25. 2006..Tumors in mice that were treated with PPIX-PDT grew more slowly than control tumors. However, tumors that were given PPIXC6 followed by light exposure showed a significant delay in their growth... - Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: potential for enhanced topical photodynamic therapyRyan F Donnelly
School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
J Control Release 129:154-62. 2008..As ALA is expensive and degrades rapidly via a second order reaction, reducing the required dose is also a notable advantage... - Choice of optimal wavelength for PDT: the significance of oxygen depletionKristian P Nielsen
Department of Physics and Technology, University of Bergen, N 5007 Bergen, Norway
Photochem Photobiol 81:1190-4. 2005..At 390 nm, the light penetration into a tumor does not depend on the oxygenation of the blood... - Photodegradation and phototransformation of 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (m-THPBC) in solutionHenri-Pierre Lassalle
Centre Alexis Vautrin, CRAN CNRS UMR 7039, Vandoeuvre-les-Nancy, France
Photochem Photobiol Sci 3:999-1005. 2004.... - Immunotherapy: a way to improve the therapeutic outcome of photodynamic therapy?Mateusz Kwitniewski
Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, ul Do Studzienki 38, 80 227, Gdansk, Poland
Photochem Photobiol Sci 7:1011-7. 2008..This review summarizes the current knowledge about different immunotherapeutic approaches which can be used to improve effectiveness and extend the applications of PDT in clinics... - Kinetics of protoporphyrin IX formation in rat oral mucosa and skin after application of 5-aminolevulinic acid and its methylesterStefan Kristiansson
Department of Otolaryngology, Orebro University Hospital, Orebro, Sweden
Photochem Photobiol 81:394-7. 2005..Maximal PpIX fluorescence appeared later after application of high concentrations of the drugs (around 8 h for 5% and 20% wt/wt) than after application of low concentrations (around 3-5 h for 1% and 2% wt/wt)... - On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formationSabine Collaud
School of Pharmacy Geneva-Lausanne, University of Geneva, 1211 Geneva, Switzerland
Curr Med Chem Anticancer Agents 4:301-16. 2004..Thereby, morphological, environmental, enzymatic, as well as cell-specific factors will be discussed... - Spectroscopic measurements of photoinduced processes in human skin after topical application of the hexyl ester of 5-aminolevulinic acidLu Zhao
Department of Physics and Technology, University of Bergen, , N-5007 Bergen, Norway
J Environ Pathol Toxicol Oncol 25:307-20. 2006..Using these methods we were able to quantify melanogenesis, O2 level, erythema, vasoconstriction, and vasodilatation...