Asta Juzeniene

Summary

Affiliation: Institute for Cancer Research
Country: Norway

Publications

  1. ncbi request reprint The effect of skin permeation enhancers on the formation of porphyrins in mouse skin during topical application of the methyl ester of 5-aminolevulinic acid
    Andrzej Bugaj
    Department of Clinical Pharmacy and Biopharmacy, Karol Marcinkowski University of Medical Sciences, ul Marii Magdaleny 14, 61861 Poznań, Poland
    J Photochem Photobiol B 83:94-7. 2006
  2. doi request reprint Malignant melanomas on head/neck and foot: differences in time and latitudinal trends in Norway
    A Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello 0310 Oslo Institute of Physics, University of Oslo, Blindern 0316 Oslo, Norway
    J Eur Acad Dermatol Venereol 26:821-7. 2012
  3. doi request reprint 5-Methyltetrahydrofolate can be photodegraded by endogenous photosensitizers
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Free Radic Biol Med 47:1199-204. 2009
  4. doi request reprint The seasonality of pandemic and non-pandemic influenzas: the roles of solar radiation and vitamin D
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Int J Infect Dis 14:e1099-105. 2010
  5. ncbi request reprint Milestones in the development of photodynamic therapy and fluorescence diagnosis
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, The Norwegian Radium Hospital, Montebello, N 0310, Oslo, Norway
    Photochem Photobiol Sci 6:1234-45. 2007
  6. doi request reprint Changes in human skin after topical PDT with hexyl aminolevulinate
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway
    Photodiagnosis Photodyn Ther 5:176-81. 2008
  7. ncbi request reprint Topical applications of iron chelators in photosensitization
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol Sci 6:1268-74. 2007
  8. doi request reprint Pilot study of folate status in healthy volunteers and in patients with psoriasis before and after UV exposure
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 101:111-6. 2010
  9. doi request reprint Development of different human skin colors: a review highlighting photobiological and photobiophysical aspects
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Photochem Photobiol B 96:93-100. 2009
  10. ncbi request reprint Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters
    Johan Moan
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Cancer 103:132-5. 2003

Collaborators

Detail Information

Publications63

  1. ncbi request reprint The effect of skin permeation enhancers on the formation of porphyrins in mouse skin during topical application of the methyl ester of 5-aminolevulinic acid
    Andrzej Bugaj
    Department of Clinical Pharmacy and Biopharmacy, Karol Marcinkowski University of Medical Sciences, ul Marii Magdaleny 14, 61861 Poznań, Poland
    J Photochem Photobiol B 83:94-7. 2006
    ..This suggests that in 2-20% MAL creams HPE-101 may be substituted by Labrafac CC to reduce skin irritation induced by HPE-101 without impairing the porphyrin formation...
  2. doi request reprint Malignant melanomas on head/neck and foot: differences in time and latitudinal trends in Norway
    A Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello 0310 Oslo Institute of Physics, University of Oslo, Blindern 0316 Oslo, Norway
    J Eur Acad Dermatol Venereol 26:821-7. 2012
    ....
  3. doi request reprint 5-Methyltetrahydrofolate can be photodegraded by endogenous photosensitizers
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Free Radic Biol Med 47:1199-204. 2009
    ..This study suggests that 5MTHF in blood can be photodegraded in the presence of the flavins and porphyrins, but protected by bilirubins. This may have health and evolutionary implications...
  4. doi request reprint The seasonality of pandemic and non-pandemic influenzas: the roles of solar radiation and vitamin D
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Int J Infect Dis 14:e1099-105. 2010
    ..Seasonal variations in ultraviolet B (UVB) radiation cause seasonal variations in vitamin D status. This may influence immune responses and play a role in the seasonality of influenza...
  5. ncbi request reprint Milestones in the development of photodynamic therapy and fluorescence diagnosis
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, The Norwegian Radium Hospital, Montebello, N 0310, Oslo, Norway
    Photochem Photobiol Sci 6:1234-45. 2007
    ....
  6. doi request reprint Changes in human skin after topical PDT with hexyl aminolevulinate
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway
    Photodiagnosis Photodyn Ther 5:176-81. 2008
    ..Photodynamic therapy (PDT) induces physiological changes in human skin, but details and kinetics are not known...
  7. ncbi request reprint Topical applications of iron chelators in photosensitization
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol Sci 6:1268-74. 2007
    ..Further studies are needed to evaluate the role of PpIX induced by iron chelators used, against photoaging and cancer prevention...
  8. doi request reprint Pilot study of folate status in healthy volunteers and in patients with psoriasis before and after UV exposure
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 101:111-6. 2010
    ..Further studies, using proper, adequate 5-methyltetrahydrofolate methodology, are needed to clarify the influence of broadband phototherapy on folate degradation and the consequences of these on the health of psoriasis patients...
  9. doi request reprint Development of different human skin colors: a review highlighting photobiological and photobiophysical aspects
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Photochem Photobiol B 96:93-100. 2009
    ..The genetical processes behind some of the changes of skin color will be also briefly reviewed...
  10. ncbi request reprint Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters
    Johan Moan
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Cancer 103:132-5. 2003
    ..The esters seem to penetrate less into the circulation than ALA, and PpIX formed by them in the skin is faster cleared than PpIX formed from ALA. This is also true after oral and i.p. administration of the drugs...
  11. doi request reprint Immediate pigment darkening: its evolutionary roles may include protection against folate photosensitization
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello 0310 Oslo, Norway
    FASEB J 26:971-5. 2012
    ..We here propose that the biological role of IPD is protection of folates against photodegradation, which would be of large evolutionary importance for early hominids...
  12. ncbi request reprint The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinate
    Liwei Ma
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol Sci 5:755-9. 2006
    ..The present data seem to favour the latter mechanism. Folic acid may have a role as an adjuvant in photodynamic therapy with systemically administered ALA and its derivatives...
  13. ncbi request reprint Noninvasive fluorescence excitation spectroscopy during application of 5-aminolevulinic acid in vivo
    Petras Juzenas
    Department of Biophysics, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol Sci 1:745-8. 2002
    ..The fluorescence excitation spectra calculated for the depth 1.1 mm obtained the best fit with the experimentally measured spectra after topical application of ALA...
  14. ncbi request reprint Effectiveness of different light sources for 5-aminolevulinic acid photodynamic therapy
    Asta Juzeniene
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Montebello, Oslo, Norway
    Lasers Med Sci 19:139-49. 2004
    ..All these differences are related to difference in the spectra of the lamps. Thus, PDT light sources with emissions that are visually similar have significantly different photobiological properties...
  15. ncbi request reprint Fluorescence photobleaching of ALA and ALA-heptyl ester induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: a comparison of two light sources and different illumination schemes
    Xiao Pudroma
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    J Environ Pathol Toxicol Oncol 30:235-40. 2011
    ..These have been suggested to allow reoxygenation of the irradiated tissue, with a consequent enhancement of singlet oxygen production in the second and subsequent fractions...
  16. ncbi request reprint Photodegradation of 5-methyltetrahydrofolate in the presence of Uroporphyrin
    Tran Thi Thu Tam
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 94:201-4. 2009
    ..Our results show that singlet oxygen is likely to be the main intermediate in the photodegradation of 5MTHF mediated by Uro. Our findings may be useful for further studies the evolution of human skin colours...
  17. ncbi request reprint Biological activity of 5-aminolevulinic acid and its methyl ester after storage under different conditions
    Miron Kaliszewski
    Department of Radiation Biology, Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    J Photochem Photobiol B 87:67-72. 2007
    ..Our work shows that solutions should be prepared immediately before use and stored at low temperatures. The pH of stock solutions should not exceed 5...
  18. ncbi request reprint Influence of narrowband UVB phototherapy on vitamin D and folate status
    Emanuela Cicarma
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Exp Dermatol 19:e67-72. 2010
    ..Such therapy leads to enhanced cutaneous vitamin D synthesis, which may be one of the mechanisms of action. Furthermore, another nutrient, folate, can probably also be influenced by UV radiation...
  19. doi request reprint 5-Methyltetrahydrofolate is photosensitive in the presence of riboflavin
    Arnfinn Hykkerud Steindal
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310, Oslo, Norway
    Photochem Photobiol Sci 7:814-8. 2008
    ..Thus, a dark skin colour may be favourable for prevention of folate degradation under high solar fluence rates, such as in equatorial areas...
  20. doi request reprint Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema
    Patrycja Mikolajewska
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Pharm Res 27:2213-20. 2010
    ..To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as MN impact on pain sensations during light exposure and erythema after PDT...
  21. ncbi request reprint Temperature effect on accumulation of protoporphyrin IX after topical application of 5-aminolevulinic acid and its methylester and hexylester derivatives in normal mouse skin
    Asta Juzeniene
    Department of Biophysics, The Norwegian Radium Hospital, Oslo
    Photochem Photobiol 76:452-6. 2002
    ....
  22. doi request reprint Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy
    Patrycja Mikolajewska
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    Transl Res 152:128-33. 2008
    ..Pretreatment with (R)L-sulforaphane before topical ALA-PDT may improve penetration of ALA through the stratum corneum, and, subsequently, increase PpIX synthesis...
  23. ncbi request reprint Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin model
    Asta Juzeniene
    Biophysics Department, The Norwegian Radium Hospital, Oslo
    Photochem Photobiol 76:329-34. 2002
    ..But for long application times and high concentrations, systemic effect of ALA applied topically on relatively large areas should be considered...
  24. ncbi request reprint Deferoxamine photosensitizes cancer cells in vitro
    Petras Juzenas
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo, Norway
    Biochem Biophys Res Commun 332:388-91. 2005
    ..In conclusion, the present study describes a novel approach of using iron chelating agents without 5-aminolevulinic acid (ALA) to photosensitize cancer cells...
  25. ncbi request reprint The effect of sub-lethal ALA-PDT on the cytoskeleton and adhesion of cultured human cancer cells
    Anatoly Uzdensky
    Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    Biochim Biophys Acta 1722:43-50. 2005
    ..Some signal transduction processes are suggested to be involved in ALA-PDT-induced changes in cytoskeleton, cell shape, and adhesion...
  26. ncbi request reprint The influence of temperature on photodynamic cell killing in vitro with 5-aminolevulinic acid
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Montebello, Oslo, Norway
    J Photochem Photobiol B 84:161-6. 2006
    ..Thus, the photodynamic effect with 5-aminolevulinic acid may be enhanced by heating the tumour area before, and by cooling it immediately after the treatment...
  27. ncbi request reprint The influence of light and darkness on cutaneous fluorescence in mice
    Petras Juzenas
    Department of Radiation Biology, The Norwegian Radium Hospital, N 310 Oslo, Norway
    Luminescence 21:159-63. 2006
    ..The presence of cutaneous PpIX together with ambient light may comprise a photosensitizing mechanism by which PpIX may be a photomessenger between ambient light and internal rhythms...
  28. doi request reprint The action spectrum for folic acid photodegradation in aqueous solutions
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 126:11-6. 2013
    ..The action spectrum demonstrated that UVB and UVA degrade folic acid. Protecting skin against UVB and UVA radiation by sunscreens may help to protect folic acid in human blood under intense solar radiation. ..
  29. doi request reprint Sunbed use and cutaneous melanoma in Norway
    Johan E Moan
    1Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Scand J Public Health 41:812-7. 2013
    ....
  30. ncbi request reprint Photodynamic inhibition of enzymatic detachment of human cancer cells from a substratum
    Anatoly Uzdensky
    Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    Biochim Biophys Acta 1670:1-11. 2004
    ..Photodynamic inhibition of enzymatic cell detachment may be related to PDT-induced inhibition of tumour metastasis...
  31. doi request reprint Bioimpedance for pain monitoring during cutaneous photodynamic therapy: Preliminary study
    Patrycja Mikolajewska
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Photodiagnosis Photodyn Ther 8:307-13. 2011
    ..Different methods for dealing with the pain have been developed over the past years, ranging from cooling with air or water to nerve blocking. However, the mechanisms responsible for the pain induction have not yet been fully understood...
  32. ncbi request reprint Sun and sun beds: inducers of vitamin D and skin cancer
    Emanuela Cicarma
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet HF, Oslo, Norway
    Anticancer Res 29:3495-500. 2009
    ..Populations living at high latitudes would probably benefit from moderately increasing their exposure to UVB to provide a good vitamin D status...
  33. doi request reprint Vitamin D, sun, sunbeds and health
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Ullernchausseen 70, Montebello N 0310 Oslo, Norway
    Public Health Nutr 15:711-5. 2012
    ..To review the health effects of solar radiation, sunbeds and vitamin D...
  34. doi request reprint UVA, UVB and incidence of cutaneous malignant melanoma in Norway and Sweden
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310, Oslo, Norway
    Photochem Photobiol Sci 11:191-8. 2012
    ..Also, UVB induction of vitamin D may be involved. CMM incidence rates among young people have decreased or been constant since about 1990 in Norway and Sweden. All reasons for UVA contributing to CMM will be discussed...
  35. ncbi request reprint Application of 5-aminolevulinic acid and its derivatives for photodynamic therapy in vitro and in vivo
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Methods Mol Biol 635:97-106. 2010
    ..The content and distribution of ALA intracellularly and in tissues is difficult to measure, but PpIX content, on a relative scale, can be easily measured by fluorimetric assays...
  36. doi request reprint Reduction of cutaneous photosensitivity by application of ointment containing ferrous or cobaltous ions concomitant with the use of topical protoporphyrin IX precursors
    Petras Juzenas
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Photodiagnosis Photodyn Ther 7:152-7. 2010
    ..The present study was carried out to investigate clearance of protoporphyrin IX (PpIX) in the presence of metal ions in the cream applied on healthy skin of mice in vivo...
  37. doi request reprint Depth profile of protoporphyrin IX fluorescence in an amelanotic mouse melanoma model
    Petras Juzenas
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Photochem Photobiol 85:760-4. 2009
    ..16 +/- 0.03 mm(2) h(-1)), MAL (0.045 +/- 0.005 mm(2) h(-1)) and HAL (0.037 +/- 0.003 mm(2) h(-1)), the behavior of the drugs after different application times could be estimated in this tumor model...
  38. doi request reprint Reflectance spectroscopy and fluorescein angiography applied to assess photodynamic response in healthy mouse skin treated with topical hexylaminolevulinate
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Photodiagnosis Photodyn Ther 7:239-45. 2010
    ..The aim of this study was to measure photosensitization responses in healthy mouse skin using non-invasive reflectance spectroscopy and fluorescein angiography...
  39. doi request reprint Cutaneous malignant melanoma incidence rates in Norway
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, Norway
    Scand J Public Health 41:336-9. 2013
    ..However, a decrease in incidence rates is observed in some countries. If the reason for this could be found, it might be useful to transfer the knowledge to other fields of medicine...
  40. doi request reprint Latitude gradient for melanoma incidence by anatomic site and gender in Norway 1966-2007
    Emanuela Cicarma
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 101:174-8. 2010
    ..The leveling off of melanoma trend is probably associated with melanoma prevention campaigns and with increasing awareness, although vitamin D could play a role...
  41. doi request reprint Where the sun does not shine: is sunshine protective against melanoma of the vulva?
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 101:179-83. 2010
    ....
  42. ncbi request reprint Photosensitizing effect of protoporphyrin IX in pigmented melanoma of mice
    Petras Juzenas
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, NO 0310 Montebello, Oslo, Norway
    Biochem Biophys Res Commun 297:468-72. 2002
    ..Topical application of ALA-Me followed by exposure with laser light (633nm) delayed the growth of the tumors slightly. Light alone also had a significant effect on the tumor growth...
  43. ncbi request reprint Influence of light exposure on the kinetics of protoporphyrin IX formation in normal skin of hairless mice after application of 5-aminolevulinic acid methyl ester
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Oslo, Norway
    J Invest Dermatol 125:1039-44. 2005
    ..The rate of elimination of PpIX from the volume of detection was faster after 420 nm light irradiation than that after 632 nm. These findings are discussed in view of penetration depths of light and ALA-Me, and diffusion of PpIX...
  44. doi request reprint Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy
    Mateusz Kwitniewski
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, 0310, Norway
    Photochem Photobiol Sci 10:25-8. 2011
    ..For the first time we present data showing that metabolic targeted therapy with dichloroacetate (DCA) may improve the outcome of photodynamic therapy. This treatment modality can be easily introduced into clinical practice guidelines...
  45. ncbi request reprint Ultraviolet photodegradation of folic acid
    Morten Kristian Off
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    J Photochem Photobiol B 80:47-55. 2005
    ..However, experiments performed in heavy water indicate that generation of singlet oxygen is probably not the explanation for the photosensitizing of folic acid...
  46. ncbi request reprint Biophysical aspects of photodynamic therapy
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Environ Pathol Toxicol Oncol 25:7-28. 2006
    ..These are all important parameters for optimally effective PDT. The present review will give a brief, physically based, overview of PDT and then discuss some of the main biophysical aspects of this therapeutic modality...
  47. ncbi request reprint Erythrocytes-the 'house elves' of photodynamic therapy
    Lars Kaestner
    Institute for Cancer Research, Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol Sci 3:981-9. 2004
    ..Future aspects of applications of photosensitisation of red blood cells are discussed...
  48. ncbi request reprint Photodegradation of 5-methyltetrahydrofolate: biophysical aspects
    Arnfinn Hykkerud Steindal
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Photochem Photobiol 82:1651-5. 2006
    ..5MTHF mainly absorbs, and is degraded by, UVB and UVC, radiation that does not penetrate the earth's atmosphere and the human skin well...
  49. doi request reprint Photodegradation of cobalamins in aqueous solutions and in human blood
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 122:7-14. 2013
    ..Further work is needed to determine vitamin B12 photostability in humans living at lower latitudes or using sunbeds...
  50. doi request reprint Superficial-spreading and nodular melanomas in Norway: a comparison by body site distribution and latitude gradients
    Emanuela Micu
    Department of Radiation Biology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Melanoma Res 22:460-5. 2012
    ..Differences in sun exposure at northern latitudes have a major impact on different types of melanoma. It seems that NM is less sun-induced than SSM, for which other etiological and pathogenetic factors may play important roles...
  51. ncbi request reprint Spectroscopic evidence of monomeric aluminium phthalocyanine tetrasulphonate in aqueous solutions
    Petras Juzenas
    Institute for Cancer Research, Department of Radiation Biology, The Norwegian Radium Hospital, Oslo, Norway
    J Photochem Photobiol B 75:107-10. 2004
    ..In conclusion, the present spectroscopic results show that AlPcS(4) does not form aggregates and is a very stable compound in aqueous solutions...
  52. ncbi request reprint Solar radiation, vitamin D and survival rate of colon cancer in Norway
    Johan Moan
    Avdeling for strålingsbiologi, Institutt for kreftforskning, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 78:189-93. 2005
    ..One possible interpretation of the present data is that, the level of calcidiol, or its derivative calcitriol (1alpha,25-dihydroxyvitamin D3, 1alpha,25-(OH)2D3), may act positively in concert with conventional therapies of colon cancer...
  53. doi request reprint Clearance mechanism of protoporphyrin IX from mouse skin after application of 5-aminolevulinic acid
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway Electronic address
    Photodiagnosis Photodyn Ther 10:538-45. 2013
    ..The aim of this study is to investigate the factors controlling the clearance of intracellular PpIX from healthy skin of mice...
  54. ncbi request reprint In vitro and in vivo photosensitization by protoporphyrins possessing different lipophilicities and vertical localization in the membrane
    Irena Bronshteint
    Department of Physics, Bar Ilan University, Ramat Gan, Israel
    Photochem Photobiol 82:1319-25. 2006
    ..Tumors in mice that were treated with PPIX-PDT grew more slowly than control tumors. However, tumors that were given PPIXC6 followed by light exposure showed a significant delay in their growth...
  55. doi request reprint Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: potential for enhanced topical photodynamic therapy
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Control Release 129:154-62. 2008
    ..As ALA is expensive and degrades rapidly via a second order reaction, reducing the required dose is also a notable advantage...
  56. ncbi request reprint Kinetics of protoporphyrin IX formation in rat oral mucosa and skin after application of 5-aminolevulinic acid and its methylester
    Stefan Kristiansson
    Department of Otolaryngology, Orebro University Hospital, Orebro, Sweden
    Photochem Photobiol 81:394-7. 2005
    ..Maximal PpIX fluorescence appeared later after application of high concentrations of the drugs (around 8 h for 5% and 20% wt/wt) than after application of low concentrations (around 3-5 h for 1% and 2% wt/wt)...
  57. doi request reprint Immunotherapy: a way to improve the therapeutic outcome of photodynamic therapy?
    Mateusz Kwitniewski
    Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, ul Do Studzienki 38, 80 227, Gdansk, Poland
    Photochem Photobiol Sci 7:1011-7. 2008
    ..This review summarizes the current knowledge about different immunotherapeutic approaches which can be used to improve effectiveness and extend the applications of PDT in clinics...
  58. ncbi request reprint Photodegradation and phototransformation of 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (m-THPBC) in solution
    Henri Pierre Lassalle
    Centre Alexis Vautrin, CRAN CNRS UMR 7039, Vandoeuvre les Nancy, France
    Photochem Photobiol Sci 3:999-1005. 2004
    ....
  59. ncbi request reprint Choice of optimal wavelength for PDT: the significance of oxygen depletion
    Kristian P Nielsen
    Department of Physics and Technology, University of Bergen, N 5007 Bergen, Norway
    Photochem Photobiol 81:1190-4. 2005
    ..At 390 nm, the light penetration into a tumor does not depend on the oxygenation of the blood...
  60. ncbi request reprint Spectroscopic measurements of photoinduced processes in human skin after topical application of the hexyl ester of 5-aminolevulinic acid
    Lu Zhao
    Department of Physics and Technology, University of Bergen, Allégt 55, N 5007 Bergen, Norway
    J Environ Pathol Toxicol Oncol 25:307-20. 2006
    ..Using these methods we were able to quantify melanogenesis, O2 level, erythema, vasoconstriction, and vasodilatation...
  61. ncbi request reprint On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation
    Sabine Collaud
    School of Pharmacy Geneva Lausanne, University of Geneva, 1211 Geneva, Switzerland
    Curr Med Chem Anticancer Agents 4:301-16. 2004
    ..Thereby, morphological, environmental, enzymatic, as well as cell-specific factors will be discussed...