Trygve Holmøy

Summary

Affiliation: Institute for Cancer Research
Country: Norway

Publications

  1. doi [Termination of mechanical ventilation in amyotrophic lateral sclerosis]
    Trygve Holmøy
    Nevrologisk avdeling Ullevål universitetssykehus 0407 Oslo
    Tidsskr Nor Laegeforen 129:628-31. 2009
  2. doi The idiotype connection: linking infection and multiple sclerosis
    Trygve Holmøy
    Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Trends Immunol 31:56-62. 2010
  3. doi Multiple sclerosis: immunopathogenesis and controversies in defining the cause
    Trygve Holmøy
    Institute of Immunology, Faculty of Medicine, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
    Curr Opin Infect Dis 21:271-8. 2008
  4. doi 25-hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis
    Trygve Holmøy
    Institute of Immunology, Faculty of Medicine, University of Oslo, Oslo, Norway
    Mult Scler 15:1280-5. 2009
  5. doi G127R: A novel SOD1 mutation associated with rapidly evolving ALS and severe pain syndrome
    Trygve Holmøy
    Department of Neurology, Oslo University Hospital Ulleval, Norway
    Amyotroph Lateral Scler 11:478-80. 2010
  6. doi The immunological basis for treatment of stiff person syndrome
    Trygve Holmøy
    Department of Neurology, Oslo University Hospital Ulleval, Oslo, Norway
    J Neuroimmunol 231:55-60. 2011
  7. ncbi Genetic and molecular approaches to the immunopathogenesis of multiple sclerosis: an update
    Trygve Holmøy
    Institute of Immunology, University of Oslo, Oslo, Norway
    Curr Mol Med 9:591-611. 2009
  8. ncbi Cost-effectiveness of natalizumab in multiple sclerosis
    Trygve Holmoy
    Department of Neurology, Ulleval University Hospital, 0407 Oslo, Norway Institute of Immunology, Faculty of Medicine, University of Oslo, Norway
    Expert Rev Pharmacoecon Outcomes Res 8:11-21. 2008
  9. doi [Development of new therapies for multiple sclerosis]
    Trygve Holmøy
    Nevrologisk avdeling, Oslo universitetssykehus, Ullevål ogImmunologisk institutt, Universitetet i Oslo, Norway
    Tidsskr Nor Laegeforen 131:832-6. 2011
  10. doi Stiff person syndrome associated with lower motor neuron disease and infiltration of cytotoxic T cells in the spinal cord
    Trygve Holmøy
    Department of Neurology, Oslo University Hospital Ulleval, Oslo, Norway
    Clin Neurol Neurosurg 111:708-12. 2009

Collaborators

Detail Information

Publications43

  1. doi [Termination of mechanical ventilation in amyotrophic lateral sclerosis]
    Trygve Holmøy
    Nevrologisk avdeling Ullevål universitetssykehus 0407 Oslo
    Tidsskr Nor Laegeforen 129:628-31. 2009
    ..Mechanical ventilation may relieve symptoms and prolong life for patients with amyotrophic lateral sclerosis, but may also prolong suffering. More knowledge is needed on ethical, legal and medical aspects upon termination...
  2. doi The idiotype connection: linking infection and multiple sclerosis
    Trygve Holmøy
    Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Trends Immunol 31:56-62. 2010
    ..This model may explain the intrathecal synthesis of low-avidity IgG against viruses, and the synthesis of oligoclonal IgG with unknown specificity in multiple sclerosis...
  3. doi Multiple sclerosis: immunopathogenesis and controversies in defining the cause
    Trygve Holmøy
    Institute of Immunology, Faculty of Medicine, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
    Curr Opin Infect Dis 21:271-8. 2008
    ..This paper discusses recent progress and controversies in the understanding of the pathogenesis and cause of multiple sclerosis...
  4. doi 25-hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis
    Trygve Holmøy
    Institute of Immunology, Faculty of Medicine, University of Oslo, Oslo, Norway
    Mult Scler 15:1280-5. 2009
    ..These results do not support that 25-hydroxyvitamin D is actively transported to the cerebrospinal fluid, or that the cerebrospinal fluid or serum levels or their ratio exert a major impact on MS activity...
  5. doi G127R: A novel SOD1 mutation associated with rapidly evolving ALS and severe pain syndrome
    Trygve Holmøy
    Department of Neurology, Oslo University Hospital Ulleval, Norway
    Amyotroph Lateral Scler 11:478-80. 2010
    ..In addition to a predominating lower motor neuron syndrome, the phenotype was characterized by a severe lower back and leg pain syndrome which was treated successfully with spinal anaesthesia...
  6. doi The immunological basis for treatment of stiff person syndrome
    Trygve Holmøy
    Department of Neurology, Oslo University Hospital Ulleval, Oslo, Norway
    J Neuroimmunol 231:55-60. 2011
    ..Their pathogenic role has therefore been questioned. We here discuss the role of autoantibodies and T cells in SPS...
  7. ncbi Genetic and molecular approaches to the immunopathogenesis of multiple sclerosis: an update
    Trygve Holmøy
    Institute of Immunology, University of Oslo, Oslo, Norway
    Curr Mol Med 9:591-611. 2009
    ..We here review how different genetic approaches can be combined to elucidate the immuno-pathogenesis of MS...
  8. ncbi Cost-effectiveness of natalizumab in multiple sclerosis
    Trygve Holmoy
    Department of Neurology, Ulleval University Hospital, 0407 Oslo, Norway Institute of Immunology, Faculty of Medicine, University of Oslo, Norway
    Expert Rev Pharmacoecon Outcomes Res 8:11-21. 2008
    ..Given the high socioeconomic burden of multiple sclerosis, natalizumab may be cost effective from a societal perspective, however, the models used to reach this conclusion rest on several uncertain assumptions...
  9. doi [Development of new therapies for multiple sclerosis]
    Trygve Holmøy
    Nevrologisk avdeling, Oslo universitetssykehus, Ullevål ogImmunologisk institutt, Universitetet i Oslo, Norway
    Tidsskr Nor Laegeforen 131:832-6. 2011
    ..Current first line treatment for multiple sclerosis is only moderately effective and is associated with frequent and disturbing side effects. We here describe opportunities and challenges related to drugs under development...
  10. doi Stiff person syndrome associated with lower motor neuron disease and infiltration of cytotoxic T cells in the spinal cord
    Trygve Holmøy
    Department of Neurology, Oslo University Hospital Ulleval, Oslo, Norway
    Clin Neurol Neurosurg 111:708-12. 2009
    ....
  11. ncbi The discovery of oligoclonal bands: a 50-year anniversary
    Trygve Holmøy
    Institute of Immunology, Faculty of Medicine, University of Oslo, Oslo University Hospital Rikshospitalet and Department of Neurology, Oslo University Hospital Ulleval, Oslo, Norway
    Eur Neurol 62:311-5. 2009
    ..The discovery of OCB led to the still prevailing concept that MS is mediated by clonally expanded lymphocytes, and provided the basis for modern diagnostic procedures in MS...
  12. ncbi The immunology of multiple sclerosis: disease mechanisms and therapeutic targets
    T Holmøy
    Institute of Immunology, Rikshospitalet University Hospital, Faculty of Medicine, University of Oslo, Oslo, Norway
    Minerva Med 99:119-40. 2008
    ..This paper reviews some important concepts and controversies in the understanding of the immunological basis for MS and its treatment...
  13. ncbi Cerebrospinal fluid T cell clones from patients with multiple sclerosis: recognition of idiotopes on monoclonal IgG secreted by autologous cerebrospinal fluid B cells
    Trygve Holmøy
    Institute of Immunology, Rikshospitalet University Hospital, and University of Oslo, Rikshospitalet, Oslo, Norway
    Eur J Immunol 35:1786-94. 2005
    ..The finding of Id-specific T cells and Id-bearing B cells in the CSF indicates that they coexist within the diseased organ, and provide a basis for the study of Id-driven T-B cell collaboration in a human autoimmune disease...
  14. pmc Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity
    Trygve Holmøy
    Department of Neurology, Akershus University Hospital, Lørenskog, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 8:e75021. 2013
    ..We aimed to explore the relationship between serum levels of inflammation markers and MRI activity in patients with relapsing remitting MS, as well as the effect of ω-3 fatty acids on these markers...
  15. doi Cerebrospinal fluid T cell responses against glutamic acid decarboxylase 65 in patients with stiff person syndrome
    Gjertrud Skorstad
    Department of Neurology, Ulleval University Hospital, Oslo, Norway
    J Autoimmun 32:24-32. 2009
    ..We conclude that GAD65-specific T cells and clonally expanded GAD65-specific B cells coexist intrathecally, where they may collaborate in the synthesis of GAD65 IgG...
  16. doi Retinol levels are associated with magnetic resonance imaging outcomes in multiple sclerosis
    Kristin I Løken-Amsrud
    Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway
    Mult Scler 19:451-7. 2013
    ..Vitamin A has immunomodulatory properties and may regulate the transcription of genes involved in remyelination...
  17. ncbi Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis
    Egil Røsjø
    Department of Neurology, Akershus University Hospital, Lørenskog, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway Electronic address
    J Neuroimmunol 271:60-5. 2014
    ..These findings suggest associations with diverse inflammatory pathways, which may be differentially influenced by interferon-β1a treatment. ..
  18. pmc Alpha-tocopherol and MRI outcomes in multiple sclerosis--association and prediction
    Kristin I Løken-Amsrud
    Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway
    PLoS ONE 8:e54417. 2013
    ..The aim of this study was to study alpha-tocopherol concentrations and their relationship to disease activity in Norwegian multiple sclerosis (MS) patients...
  19. doi Month of birth as a latitude-dependent risk factor for multiple sclerosis in Norway
    Nina Grytten
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Mult Scler 19:1028-34. 2013
    ..We aimed to determine if the risk of Multiple Sclerosis (MS) is associated with month of birth in Norway and to explore a possible latitudinal gradient...
  20. ncbi Infectious causes of multiple sclerosis
    Trygve Holmøy
    Institute of Immunology, Rikshospitalet University Hospital and University of Oslo, Norway
    Lancet Neurol 4:268; discussion 269. 2005
  21. pmc A one year follow-up study of natural killer and dendritic cells activities in multiple sclerosis patients receiving glatiramer acetate (GA)
    Rune A Høglund
    Department of Physiology, Institute of Medical Basal Sciences, University of Oslo, Oslo, Norway
    PLoS ONE 8:e62237. 2013
    ..More recently, cells of the innate immune system such as dendritic cells (DCs) and natural killer (NK) cells have been in focus. Glatiramer acetate (GA) is an approved drug for treating MS patients...
  22. ncbi Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein
    Trygve Holmøy
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    J Neurovirol 10:278-83. 2004
    ..These findings prove that Epstein-Barr-virus specific CD4+ T cells can gain access to the intrathecal compartment, and suggest that Epstein-Barr virus-specific CD4+ T cells could target myelin basic protein in the central nervous system...
  23. doi Vitamin D sensitive EBNA-1 specific T cells in the cerebrospinal fluid of patients with multiple sclerosis
    Andreas Lossius
    Institute of Immunology, Oslo University Hospital Rikshospitalet, 0027 Oslo, Norway
    J Neuroimmunol 240:87-96. 2011
    ..1,25-dihydroxyvitamin D inhibited proliferation and suppressed secretion of IFN-γ and IL-17, irrespective of T cell origin and HLA restriction...
  24. pmc Bone turnover and metabolism in patients with early multiple sclerosis and prevalent bone mass deficit: a population-based case-control study
    Stine Marit Moen
    Department of Neurology, Oslo University Hospital Ulleval, Oslo, Norway
    PLoS ONE 7:e45703. 2012
    ..The aim of this study was to explore the mechanism of the low bone mass in early-stage MS patients...
  25. doi Vitamin D in multiple sclerosis: implications for assessment and treatment
    Trygve Holmøy
    Department of Neurology, Akershus University Hospital, Lørenskog, Norway
    Expert Rev Neurother 12:1101-12. 2012
    ..This level is sufficient for maintenance of bone health, is not known to be associated with adverse events, and is in the range that has been associated with low risk of developing MS and low disease activity...
  26. ncbi ALS: cytokine profile in cerebrospinal fluid T-cell clones
    Trygve Holmøy
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Amyotroph Lateral Scler 7:183-6. 2006
    ..These data suggest that in vivo activated intrathecal T-cells can be induced to secrete cytokines which may play a role in ALS...
  27. doi Idiotope-specific CD4(+) T cells induce apoptosis of human oligodendrocytes
    Anne Lise Karlsgot Hestvik
    Institute of Immunology, Faculty of Medicine, University of Oslo, Oslo University Hospital Rikshospitalet, Oslo, Norway
    J Autoimmun 32:125-32. 2009
    ..Activated CD4(+) T cells specific for glutamic acid decarboxylase 65 also induced apoptosis, showing that killing does not depend on cognate interaction between T cells and target cells but rather on the activation status of the T cells...
  28. doi Expression and functional activity of chemokine receptors in glatiramer acetate-specific T cells isolated from multiple sclerosis patient receiving the drug glatiramer acetate
    Rune Alexander Høglund
    Department of Physiology, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
    Hum Immunol 72:124-34. 2011
    ..The results may also explain the beneficial synergistic effects of combining immunosuppressive drugs with GA in MS patients...
  29. doi [A young woman with a weakening leg]
    Trygve Holmøy
    Nevrologisk avdeling, Oslo universitetssykehus, Ulleval, 0407 Oslo, Norway
    Tidsskr Nor Laegeforen 131:583-6. 2011
    ..SOD1 mutations account for less than 25 % of cases with familial amyotrophic lateral sclerosis and may cause atypical phenotypes...
  30. doi Calprotectin levels in the cerebrospinal fluid reflect disease activity in multiple sclerosis
    Pål Berg-Hansen
    Department of Neurology, Oslo University Hospital Ulleval, Oslo, Norway
    J Neuroimmunol 216:98-102. 2009
    ..8% between 2 and 4 weeks and 17.0% thereafter (p<0.001). We conclude that CSF calprotectin reflects the disease activity in MS but does not discriminate between MS and other inflammatory or infectious conditions...
  31. ncbi Cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transformed B cells
    Trygve Holmøy
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    J Neurovirol 10:52-6. 2004
    ..These findings support that the immunological response to Epstein-Barr virus could contribute to the pathogenesis of multiple sclerosis...
  32. ncbi Medicine and the arts. Three Elling Solheim poems translated by Alison Arderne Philip. Commentary
    Trygve Holmøy
    Department of Neurology, Ulleval University Hospital, Oslo, Norway
    Acad Med 81:474-5. 2006
  33. pmc Epstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis—association and causation
    Andreas Lossius
    Institute of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Viruses 4:3701-30. 2012
    ..In this review, we discuss possible viral and immunological mechanisms that might explain associations between EBV and autoimmune diseases and whether these associations represent causes or effects of inflammation and autoimmunity...
  34. pmc Identification of human NK17/NK1 cells
    Abhilash D Pandya
    Department of Physiology, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    PLoS ONE 6:e26780. 2011
    ..We recently described that these cells release the inflammatory cytokines IL-17 and IFN-γ. However, the precise identity of the NK cell subset(s) that secrete these cytokines is not known...
  35. ncbi Vitamin D status modulates the immune response to Epstein Barr virus: Synergistic effect of risk factors in multiple sclerosis
    Trygve Holmøy
    Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center and Department of Neurology, Ulleval University Hospital, 0027 Oslo, Norway
    Med Hypotheses 70:66-9. 2008
    ..I propose that vitamin D modulates the immune response to EBV, and that detrimental activation of autoreactive T cells leading to MS is more likely if the vitamin D status is suboptimal...
  36. ncbi Season of infectious mononucleosis and risk of multiple sclerosis at different latitudes; the EnvIMS Study
    Andreas Lossius
    Institute of Clinical Medicine, University of Oslo, Norway
    Mult Scler 20:669-74. 2014
    ..Seasonal fluctuations in solar radiation and vitamin D levels could modulate the immune response against Epstein-Barr virus (EBV) infection and influence the subsequent risk of multiple sclerosis (MS)...
  37. ncbi [Quality of life of patients with amyotrophic lateral sclerosis]
    Atle Leirvik
    Det medisinske fakultet, Universitetet i Oslo, Oslo, Norway
    Tidsskr Nor Laegeforen 126:2520-2. 2006
    ..We have investigated QoL in ALS patients treated by a multidisciplinary ALS team, and to which degree this team met the patients' needs...
  38. doi Vitamin D and disease activity in multiple sclerosis before and during interferon-β treatment
    Kristin I Løken-Amsrud
    Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway
    Neurology 79:267-73. 2012
    ..Seasonal fluctuation of vitamin D varies between individuals, thus the relationship to disease activity should preferentially be studied by repeated and simultaneous vitamin D and MRI measurements from each patient...
  39. ncbi [Knowledge, association capacity and drowsiness]
    Trygve Holmøy
    Nevrologisk avdeling, Ullevål universitetssykehus og Immunologisk institutt, Det medisinske fakultet, Universitetet i Oslo, Rikshospitalet, 0027 Oslo
    Tidsskr Nor Laegeforen 127:3088. 2007
  40. ncbi [A stiff-legged man with a bizarre gait]
    Trygve Holmøy
    Nevrologisk avdeling, Ulleval universitetssykehus, 0407 Oslo
    Tidsskr Nor Laegeforen 127:1529-30. 2007
    ....
  41. ncbi [Stories about life with amyotrophic lateral sclerosis]
    Trygve Holmøy
    Nevrologisk avdeling, Ulleval universitetssykehus, 0407 Oslo
    Tidsskr Nor Laegeforen 126:3297-9. 2006
    ..Nevertheless, many patients claim to have a good quality of life. Pathographies, i.e. biographical books describing disease experiences, may contribute to our understanding of the impact of severe disease on quality of life...
  42. ncbi [Communication aids in amyotrophic lateral sclerosis]
    Trygve Holmøy
    Nevrologisk avdeling, Ulleval universitetssykehus, 0407 Oslo, Norway
    Tidsskr Nor Laegeforen 126:2523-5. 2006
    ..Social isolation is one of the greatest burdens of this disease. Implementation of alternative and augmentative communication can increase the quality of life even in advanced disease...
  43. ncbi A Norse contribution to the history of neurological diseases
    Trygve Holmøy
    Department of Neurology, Ulleval University Hospital, Oslo, Norway
    Eur Neurol 55:57-8. 2006
    ..The diagnosis is uncertain, but the story shows that symptoms associated with MS were known in Iceland at the end of the 11th century...