Kjersti Flatmark

Summary

Affiliation: Institute for Cancer Research
Country: Norway

Publications

  1. doi request reprint Immunotoxin targeting EpCAM effectively inhibits peritoneal tumor growth in experimental models of mucinous peritoneal surface malignancies
    Kjersti Flatmark
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Int J Cancer 133:1497-506. 2013
  2. pmc Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy
    Ase Bratland
    Department of Oncology, Akershus University Hospital, Lørenskog, Norway
    Radiat Oncol 6:33. 2011
  3. pmc Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning 1H magnetic resonance spectroscopy
    Therese Seierstad
    Department of Medical Physics, Rikshospitalet Radiumhospitalet Medical Center, 0310 Oslo, Norway
    Mol Cancer 7:33. 2008
  4. doi request reprint Exploring the peritoneal surface malignancy phenotype--a pilot immunohistochemical study of human pseudomyxoma peritonei and derived animal models
    Kjersti Flatmark
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Hum Pathol 41:1109-19. 2010
  5. pmc Disseminated tumour cells as a prognostic biomarker in colorectal cancer
    K Flatmark
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Oslo 0424, Norway
    Br J Cancer 104:1434-9. 2011
  6. pmc Pseudomyxoma peritonei--two novel orthotopic mouse models portray the PMCA-I histopathologic subtype
    Kjersti Flatmark
    Department of Surgical Oncology, Rikshospitalet Radiumhospitalet Medical Centre, Montebello, Oslo, Norway
    BMC Cancer 7:116. 2007
  7. pmc Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition
    Kjersti Flatmark
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, 0310 Oslo, Norway
    Radiat Oncol 1:25. 2006
  8. doi request reprint Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling
    Sigurd Folkvord
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Norway
    Int J Radiat Oncol Biol Phys 78:555-62. 2010
  9. pmc Tumor kinase activity in locally advanced rectal cancer: angiogenic signaling and early systemic dissemination
    Marie Grøn Saelen
    Department of Tumor Biology, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    Angiogenesis 14:481-9. 2011
  10. doi request reprint Radiosensitization by SAHA in experimental colorectal carcinoma models-in vivo effects and relevance of histone acetylation status
    Sigurd Folkvord
    Department of Tumor Biology, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Int J Radiat Oncol Biol Phys 74:546-52. 2009

Collaborators

Detail Information

Publications37

  1. doi request reprint Immunotoxin targeting EpCAM effectively inhibits peritoneal tumor growth in experimental models of mucinous peritoneal surface malignancies
    Kjersti Flatmark
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Int J Cancer 133:1497-506. 2013
    ..The present results suggest that adding MOC31PE to MMC-based i.p. chemotherapy should be further explored for EpCAM-expressing peritoneal surface malignancies, and a phase I trial is in preparation...
  2. pmc Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy
    Ase Bratland
    Department of Oncology, Akershus University Hospital, Lørenskog, Norway
    Radiat Oncol 6:33. 2011
    ....
  3. pmc Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning 1H magnetic resonance spectroscopy
    Therese Seierstad
    Department of Medical Physics, Rikshospitalet Radiumhospitalet Medical Center, 0310 Oslo, Norway
    Mol Cancer 7:33. 2008
    ..A further aim was to investigate metabolic changes following irradiation of HT29 xenografts...
  4. doi request reprint Exploring the peritoneal surface malignancy phenotype--a pilot immunohistochemical study of human pseudomyxoma peritonei and derived animal models
    Kjersti Flatmark
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Hum Pathol 41:1109-19. 2010
    ....
  5. pmc Disseminated tumour cells as a prognostic biomarker in colorectal cancer
    K Flatmark
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Oslo 0424, Norway
    Br J Cancer 104:1434-9. 2011
    ..The study was performed to determine detection rate and prognostic relevance of disseminated tumour cells (DTC) in patients receiving curatively intended surgery for colorectal cancer (CRC)...
  6. pmc Pseudomyxoma peritonei--two novel orthotopic mouse models portray the PMCA-I histopathologic subtype
    Kjersti Flatmark
    Department of Surgical Oncology, Rikshospitalet Radiumhospitalet Medical Centre, Montebello, Oslo, Norway
    BMC Cancer 7:116. 2007
    ..Since the disease is infrequent, the task of carrying out studies of treatment efficacy and disease biology in the clinical setting is challenging, warranting the development of relevant in vitro and in vivo PMP models...
  7. pmc Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition
    Kjersti Flatmark
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, 0310 Oslo, Norway
    Radiat Oncol 1:25. 2006
    ....
  8. doi request reprint Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling
    Sigurd Folkvord
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Norway
    Int J Radiat Oncol Biol Phys 78:555-62. 2010
    ..This study aimed to determine whether tumor kinase activity profiles might predict tumor response to preoperative CRT in locally advanced rectal cancer (LARC)...
  9. pmc Tumor kinase activity in locally advanced rectal cancer: angiogenic signaling and early systemic dissemination
    Marie Grøn Saelen
    Department of Tumor Biology, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    Angiogenesis 14:481-9. 2011
    ..In this cohort of rectal cancer patients, tumor phenotypes defined by a subset of tyrosine kinase activities correlating with weak ex vivo inhibition by sunitinib, was associated with early systemic dissemination...
  10. doi request reprint Radiosensitization by SAHA in experimental colorectal carcinoma models-in vivo effects and relevance of histone acetylation status
    Sigurd Folkvord
    Department of Tumor Biology, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Int J Radiat Oncol Biol Phys 74:546-52. 2009
    ..The aim of the present study was to evaluate the radiosensitizing properties of suberoylanilide hydroxamic acid (SAHA) and the possible requirement of histone hyperacetylation at radiation exposure...
  11. ncbi request reprint Inhibitory effects of oxaliplatin in experimental radiation treatment of colorectal carcinoma: does oxaliplatin improve 5-fluorouracil-dependent radiosensitivity?
    Sigurd Folkvord
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Radiother Oncol 86:428-34. 2008
    ..However, only limited preclinical data are available on oxaliplatin as radiosensitizer in colorectal carcinoma...
  12. pmc Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma
    Marie Grøn Saelen
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, P, O, Box 4953, Nydalen, 0424, Oslo, Norway
    Radiat Oncol 7:165. 2012
    ....
  13. doi request reprint Different expression and clinical role of S100A4 in serous ovarian carcinoma at different anatomic sites
    Gunhild M Maelandsmo
    Department of Tumor Biology and Surgery, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Tumour Biol 30:15-25. 2009
    ....
  14. doi request reprint Nuclear S100A4 is a novel prognostic marker in colorectal cancer
    Kjetil Boye
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Eur J Cancer 46:2919-25. 2010
    ....
  15. ncbi request reprint Detection of disseminated tumour cells in bone marrow of patients with isolated liver metastases from colorectal cancer
    Kristin Bjørnland
    Surgical Department, Rikshospitalet, University Hospital, Oslo, Norway
    J Surg Oncol 82:224-7. 2003
    ..The aim of the present study was to evaluate the frequency of micrometastatic cells in the bone marrow of patients with potentially resectable liver metastases...
  16. doi request reprint B7-H3 expression in colorectal cancer: nuclear localization strongly predicts poor outcome in colon cancer
    Vibeke Anett Ingebrigtsen
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Int J Cancer 131:2528-36. 2012
    ..The results indicate that nuclear B7-H3 might be involved in colon cancer progression and metastasis, and suggest that nuclear B7-H3 could become a useful prognostic marker in colon cancer...
  17. doi request reprint Investigation of nonspecific cross-reacting antigen 2 as a prognostic biomarker in bone marrow plasma from colorectal cancer patients
    Kristina Schee
    Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, 0424 Oslo, Norway
    Tumour Biol 33:73-83. 2012
    ..The results from this study indicate that NCA-2 is probably not a prognostic biomarker in CRC and, furthermore, underline the issue of antibody specificity when investigating CEA species molecules...
  18. ncbi request reprint Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude mice
    Kjersti Flatmark
    Department of Tumor Biology and Institute for Cancer Research, The Norwegian Radium Hospital, Oslo 0310, Norway
    Eur J Cancer 40:1593-8. 2004
    ..The study provides useful background information on the 12 colorectal cancer cell lines in a clinically relevant orthotopic tumour model...
  19. ncbi request reprint Immunofluorometric assay for the metastasis-related protein S100A4: release of S100A4 from normal blood cells prohibits the use of S100A4 as a tumor marker in plasma and serum
    Kjersti Flatmark
    Department of Tumor Biology and Institute for Cancer Research, Norwegian Radium Hospital, Oslo, Norway
    Tumour Biol 25:31-40. 2004
    ..The antibodies and the IFMA may still be useful for research purposes...
  20. doi request reprint Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study
    Anne Hansen Ree
    Department of Tumour Biology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Lancet Oncol 11:459-64. 2010
    ..Histone deacetylase (HDAC) inhibitors have shown radiosensitising activity in preclinical tumour models. This phase 1 study assessed the use of vorinostat combined with pelvic palliative radiotherapy for gastrointestinal carcinoma...
  21. pmc Early changes in apparent diffusion coefficient predict the quantitative antitumoral activity of capecitabine, oxaliplatin, and irradiation in HT29 xenografts in athymic nude mice
    Therese Seierstad
    Department of Medical Physics, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Neoplasia 9:392-400. 2007
    ....
  22. pmc Nuclear legumain activity in colorectal cancer
    Mads H Haugen
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital The Norwegian Radium Hospital, Oslo, Norway
    PLoS ONE 8:e52980. 2013
    ..1. The discovery of nuclear localized legumain launches an entirely novel arena of legumain biology and functions in cancer...
  23. doi request reprint Rab25 is overexpressed in Müllerian serous carcinoma compared to malignant mesothelioma
    Kjersti Brusegard
    Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, 0424 Oslo, Norway
    Virchows Arch 460:193-202. 2012
    ..Our data confirm that Rab25 effectively differentiates Müllerian carcinomas from malignant mesothelioma at the mRNA and protein level, suggesting a role in the diagnostic work-up of serosal cancers...
  24. doi request reprint Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma
    Gisle Berge
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, 0310, Oslo, Norway
    Amino Acids 41:875-84. 2011
    ..In conclusion, S100A4 and p53 were shown to be colocalized in individual nuclei of CRC cells, and it might be speculated whether the proteins interact in this subcellular compartment...
  25. doi request reprint Bone marrow micrometastases in advanced stage non-small cell lung carcinoma patients
    Paal Fr Brunsvig
    Cancer Clinic, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, N 0310 Oslo, Norway
    Lung Cancer 61:170-6. 2008
    ..The clinical relevance of bone marrow micrometastases in non-small cell lung cancer (NSCLC) is undetermined, and the value of such analyses in advanced stage patients has not been assessed previously...
  26. pmc The metastasis-associated protein S100A4 exists in several charged variants suggesting the presence of posttranslational modifications
    Mads H Haugen
    Dept, of Tumor Biology, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, 0310 Oslo, Norway
    BMC Cancer 8:172. 2008
    ....
  27. pmc Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer
    Kristina Schee
    Departments of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital, N 0310, Oslo, Norway
    BMC Cancer 12:505. 2012
    ..The miRNAs were chosen based on previous studies for their biomarker potential and suggested biological relevance in colorectal cancer...
  28. ncbi request reprint Nuclear localization of the metastasis-related protein S100A4 correlates with tumour stage in colorectal cancer
    Kjersti Flatmark
    Department of Tumor Biology and Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
    J Pathol 200:589-95. 2003
    ..The nuclear localization of S100A4 in colorectal cancer and its relationship to tumour stage suggest that this protein may be involved in gene regulatory pathways of relevance to the metastatic phenotype of cancer cells...
  29. pmc Validation and use of microdialysis for determination of pharmacokinetic properties of the chemotherapeutic agent mitomycin C - an experimental study
    Olaf Sørensen
    Department of Surgical Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    BMC Cancer 10:469. 2010
    ..Microdialysis is an established method for continuous monitoring of low-molecular substances in tissues, and in the present study microdialysis of mitomycin C was studied in vitro and in vivo...
  30. pmc Tumor phosphatidylinositol-3-kinase signaling and development of metastatic disease in locally advanced rectal cancer
    Anne Hansen Ree
    Department of Oncology, Akershus University Hospital, Lørenskog, Norway
    PLoS ONE 7:e50806. 2012
    ....
  31. doi request reprint TD-11 workshop report: characterization of monoclonal antibodies to S100 proteins
    Elisabeth Paus
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
    Tumour Biol 32:1-12. 2011
    ..1 and 22.3 recognized linear epitopes of S100A4, while MAb S195 reacted with a conformational dependent epitope. Surprisingly, MAb 14B3 did not demonstrate any reactivity to the panel of antigens used in this study...
  32. ncbi request reprint DNA damage responses in cell cycle G2 phase and mitosis--tracking and targeting
    Anne Hansen Ree
    Department of Tumor Biology, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Anticancer Res 26:1909-16. 2006
    ..Moreover, the targeting of cell cycle checkpoint responses may modify the cytotoxic effect of DNA damage...
  33. ncbi request reprint Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patients
    Kjersti Flatmark
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Clin Cancer Res 8:444-9. 2002
    ..Furthermore, that screening of 2 x 10(7) MNCs in a BM sample can be completed in <3 h makes the method an attractive alternative to other techniques...
  34. doi request reprint MR-guided simultaneous integrated boost in preoperative radiotherapy of locally advanced rectal cancer following neoadjuvant chemotherapy
    Therese Seierstad
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
    Radiother Oncol 93:279-84. 2009
    ..To evaluate a simultaneous integrated boost (SIB) strategy in preoperative radiotherapy of rectal cancer patients following neoadjuvant chemotherapy using pre- and post-chemotherapy tumor volumes assessed by MRI...
  35. pmc MicroRNAs as biomarkers in colorectal cancer
    Kristina Schee
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Am J Pathol 177:1592-9. 2010
    ..In this review, we explore the literature regarding the relevance of miRNAs in colorectal cancer, focusing in particular on miRNAs as potential diagnostic, prognostic, and predictive biomarkers...
  36. ncbi request reprint Matrix metalloproteinases participate in osteosarcoma invasion
    Kristin Bjørnland
    Institute for Surgical Research, Rikshospitalet, 0027 Oslo, Norway
    J Surg Res 127:151-6. 2005
    ..Thus, the aim of the present study was to evaluate the involvement of MMPs in a panel of human OS cell lines, xenografts and biopsies...
  37. doi request reprint HDAC2 deficiency and histone acetylation
    Anne Hansen Ree
    Nat Genet 40:812-3; author reply 813. 2008