Elisabeth Ersvaer

Summary

Affiliation: Institute of Medicine
Country: Norway

Publications

  1. pmc Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
    Therese Bredholt
    Department of Clinical Science, University of Bergen, Bergen, Norway
    BMC Pharmacol Toxicol 14:35. 2013
  2. ncbi request reprint Cyclin B1 is commonly expressed in the cytoplasm of primary human acute myelogenous leukemia cells and serves as a leukemia-associated antigen associated with autoantibody response in a subset of patients
    Elisabeth Ersvaer
    Institute of Medicine, University of Bergen, Bergen, Norway
    Eur J Haematol 79:210-25. 2007
  3. ncbi request reprint Effects of interferon gamma on native human acute myelogenous leukaemia cells
    Elisabeth Ersvaer
    Institute of Medicine, Section for Hematology, The University of Bergen and Haukeland University Hospital, Bergen, Norway
    Cancer Immunol Immunother 56:13-24. 2007
  4. ncbi request reprint T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005
    Elisabeth Ersvaer
    Section for Hematology, Institute of Medicine, The University of Bergen and Haukeland University Hospital, 5021 Bergen, Norway
    Cancer Immunol Immunother 56:913-25. 2007
  5. pmc Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells
    Elisabeth Ersvaer
    Institute of Medicine, University of Bergen, Bergen, Norway
    BMC Immunol 11:38. 2010
  6. ncbi request reprint Circulating T cells in patients with untreated acute myelogenous leukemia are heterogeneous and can be activated through the CD3/TCR complex
    Elisabeth Ersvaer
    University of Bergen and Haukeland University Hospital, Institute of Medicine, Bergen, Norway
    Hematology 12:199-207. 2007
  7. pmc The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity
    Elisabeth Ersvaer
    Section for Hematology, The University of Bergen, Bergen, Norway
    Toxins (Basel) 2:174-94. 2010
  8. doi request reprint Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release
    Hakon Reikvam
    University of Bergen, Institute of Internal Medicine, Division of Haematology, Bergen, Norway
    Expert Opin Investig Drugs 19:169-83. 2010
  9. ncbi request reprint The protein kinase C agonist PEP005 increases NF-kappaB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells
    Astrid Marta Olsnes
    Division for Haematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway
    Br J Haematol 145:761-74. 2009
  10. doi request reprint Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention
    Hakon Reikvam
    Division for Haematology, Institute of Medicine, University of Bergen, Norway
    Br J Haematol 156:468-80. 2012

Collaborators

Detail Information

Publications24

  1. pmc Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
    Therese Bredholt
    Department of Clinical Science, University of Bergen, Bergen, Norway
    BMC Pharmacol Toxicol 14:35. 2013
    ....
  2. ncbi request reprint Cyclin B1 is commonly expressed in the cytoplasm of primary human acute myelogenous leukemia cells and serves as a leukemia-associated antigen associated with autoantibody response in a subset of patients
    Elisabeth Ersvaer
    Institute of Medicine, University of Bergen, Bergen, Norway
    Eur J Haematol 79:210-25. 2007
    ..We therefore investigated (i) whether a similar expression pattern could be detected in native human acute myelogenous leukemia (AML) cells and (ii) whether cyclin B1 specific antibodies could be detected in AML...
  3. ncbi request reprint Effects of interferon gamma on native human acute myelogenous leukaemia cells
    Elisabeth Ersvaer
    Institute of Medicine, Section for Hematology, The University of Bergen and Haukeland University Hospital, Bergen, Norway
    Cancer Immunol Immunother 56:13-24. 2007
    ..We conclude that IFNgamma can be released in the presence of native human AML cells and affect AML cell proliferation, regulation of apoptosis and the balance between pro- and antiangiogenic chemokine release...
  4. ncbi request reprint T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005
    Elisabeth Ersvaer
    Section for Hematology, Institute of Medicine, The University of Bergen and Haukeland University Hospital, 5021 Bergen, Norway
    Cancer Immunol Immunother 56:913-25. 2007
    ....
  5. pmc Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells
    Elisabeth Ersvaer
    Institute of Medicine, University of Bergen, Bergen, Norway
    BMC Immunol 11:38. 2010
    ..We therefore investigated the frequencies of various T cell subsets (TC1, TH1, TH17) and CD25+ FoxP3+ TREG cells in AML patients with untreated disease and following intensive chemotherapy...
  6. ncbi request reprint Circulating T cells in patients with untreated acute myelogenous leukemia are heterogeneous and can be activated through the CD3/TCR complex
    Elisabeth Ersvaer
    University of Bergen and Haukeland University Hospital, Institute of Medicine, Bergen, Norway
    Hematology 12:199-207. 2007
    ..For a subset of patients T cell responsiveness can be further increased by targeting PKC and these data therefore suggest that T cell function is not inhibited in AML patients...
  7. pmc The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity
    Elisabeth Ersvaer
    Section for Hematology, The University of Bergen, Bergen, Norway
    Toxins (Basel) 2:174-94. 2010
    ....
  8. doi request reprint Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release
    Hakon Reikvam
    University of Bergen, Institute of Internal Medicine, Division of Haematology, Bergen, Norway
    Expert Opin Investig Drugs 19:169-83. 2010
    ..Tie-2 can be expressed both by primary human acute myeloid leukaemia (AML) cells and endothelial cells, and Tie-2-blocking antibodies are now being evaluated in clinical trials for cancer treatment...
  9. ncbi request reprint The protein kinase C agonist PEP005 increases NF-kappaB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells
    Astrid Marta Olsnes
    Division for Haematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway
    Br J Haematol 145:761-74. 2009
    ..Previous studies have described proapoptotic and T cell stimulatory effects and the present study describes additional T cell chemotactic and differentiation-inducing effects...
  10. doi request reprint Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention
    Hakon Reikvam
    Division for Haematology, Institute of Medicine, University of Bergen, Norway
    Br J Haematol 156:468-80. 2012
    ..Finally, HSP90 inhibition counteracted the leukaemia-stimulating effect of endothelial cells. Our studies demonstrate that HSP90 inhibition mediates anti-leukaemic effects through both direct and indirect activity...
  11. ncbi request reprint In vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22
    Astrid Marta Olsnes
    Department of Medicine, Division for Hematology, Haukeland University Hospital Institute of Medicine and The University of Bergen, Bergen, Norway
    J Interferon Cytokine Res 28:297-310. 2008
    ..Induction of a dendritic AML cell phenotype is associated with an altered chemokine release profile. Detailed characterization of chemokine release should be included in future studies of AML-DC vaccination...
  12. doi request reprint Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect
    Hakon Reikvam
    Department of Clinical Science, University of Bergen, Bergen, Norway Division of Haematology, Department of Medicine, Haukeland University, Bergen, Norway
    Br J Haematol 164:200-11. 2014
    ....
  13. pmc Combination of intensive chemotherapy and anticancer vaccines in the treatment of human malignancies: the hematological experience
    Knut Liseth
    Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway
    J Biomed Biotechnol 2010:692097. 2010
    ..Such combinatory regimens should be suitable for patients with aggressive hematological malignancies and probably also for other cancer patients...
  14. doi request reprint Use of different DMSO concentrations for cryopreservation of autologous peripheral blood stem cell grafts does not have any major impact on levels of leukocyte- and platelet-derived soluble mediators
    Ciğdem Akalin Akkök
    Division of Hematology, Department of Medicine, Haukeland University Hospital and Institute of Medicine, University of Bergen, Bergen, Norway
    Cytotherapy 11:749-60. 2009
    ....
  15. doi request reprint Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators
    Kimberley Hatfield
    Section for Haematology, Institute of Medicine, University of Bergen, Norway
    Br J Haematol 144:53-68. 2009
    ..Our study indicates a role for the leukaemic-endothelium crosstalk in leukaemogenesis with enhancement of endothelial cell growth and increased AML cell proliferation possibly mediated by angiopoietin-1 and the STAT signalling pathway...
  16. doi request reprint Early pre-engraftment, functional, in vitro responsiveness of T lymphocytes in allotransplanted, acute leukemia patients: proliferation and release of a broad profile of cytokines, possibly predictive of graft-versus-host disease
    Knut Liseth
    The Blood Bank, Haukeland University Hospital, Bergen, Norway
    Eur Cytokine Netw 21:40-9. 2010
    ..We conclude that allotransplanted patients have a functional T cell system even during the pre-engraftment period of severe pancytopenia...
  17. ncbi request reprint Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2:Bax ratio and low levels of heat shock protein 70 and 90
    Anita Ryningen
    Division for Hematology, Department of Medicine, Haukeland University Hospital and the University of Bergen, Bergen, Norway
    Leuk Res 30:1531-40. 2006
    ....
  18. ncbi request reprint The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells
    Camilla Stapnes
    Institute of Medicine, University of Bergen, Bergen, Norway
    Br J Haematol 136:814-28. 2007
    ..We conclude that nanomolar levels of the proteasome inhibitors tested had dose-dependent antiproliferative and proapoptotic effects on primary AML cells in vitro...
  19. ncbi request reprint Circulating T cells derived from acute leukemia patients with severe therapy-induced cytopenia express a wide range of chemokine receptors
    Astrid Marta Olsnes
    Division for Hematology, Department of Medicine, Haukeland University Hospital and the University of Bergen, Bergen, Norway
    Hematology 13:329-32. 2008
    ....
  20. ncbi request reprint In vitro effects of native human acute myelogenous leukemia blasts on fibroblasts and osteoblasts
    Nils Glenjen
    Section for Hematology, Department of Medicine, Haukeland University Hospital and University of Bergen, Bergen, Norway
    Int J Cancer 111:858-67. 2004
    ....
  21. ncbi request reprint Anticancer immunotherapy in combination with proapoptotic therapy
    Øystein Bruserud
    Section for Hematology, Institute for Internal Medicine, University of Bergen, Bergen, Norway
    Curr Cancer Drug Targets 8:666-75. 2008
    ..All these issues need to be considered in the design of future clinical studies combining chemotherapy and immunotherapy...
  22. doi request reprint Minor diurnal and activity-induced variations in daytime peripheral blood platelet counts do not have any major impact on platelet yield by platelet apheresis
    Ciğdem Akalin Akkök
    The Blood Bank, Haukeland University Hospital, Bergen, Norway
    Transfus Apher Sci 43:33-6. 2010
    ..In conclusion, minor intra-individual variations in platelet counts do not seem to have major influence on platelet yields by platelet apheresis...
  23. ncbi request reprint Targeted anti-leukemic therapy as disease-stabilizing treatment for acute myeloid leukemia relapse after allogeneic stem cell transplantation: Will it be possible to combine these strategies with retransplantation or donor lymphocyte infusions?
    Hakon Reikvam
    Section of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway
    Curr Cancer Drug Targets 13:30-47. 2013
    ..The designs of future clinical trials have to carefully consider the antileukemic and immunomodulatory effects together with the risk of especially hematological toxicity...
  24. pmc Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies
    Elisabeth Ersvaer
    Division of Hematology, Department of Medicine, Haukeland University Hospital and Institute of Medicine, University of Bergen, N 5021 Bergen, Norway
    Bone Marrow Res 2011:570796. 2011
    ....