Jostein Dahle

Summary

Affiliation: Institute for Cancer Research
Country: Norway

Publications

  1. doi request reprint Assessment of long-term radiotoxicity after treatment with the low-dose-rate alpha-particle-emitting radioimmunoconjugate (227)Th-rituximab
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
    Eur J Nucl Med Mol Imaging 37:93-102. 2010
  2. doi request reprint Relative biologic effects of low-dose-rate alpha-emitting 227Th-rituximab and beta-emitting 90Y-tiuexetan-ibritumomab versus external beam X-radiation
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Radiat Oncol Biol Phys 72:186-92. 2008
  3. doi request reprint Overexpression of human OGG1 in mammalian cells decreases ultraviolet A induced mutagenesis
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Cancer Lett 267:18-25. 2008
  4. ncbi request reprint A one-step method for determining the maximum number of bound antibodies, and the affinity and association rate constants for antibody binding
    Jostein Dahle
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Nucl Med Commun 28:742-7. 2007
  5. ncbi request reprint Targeted cancer therapy with a novel low-dose rate alpha-emitting radioimmunoconjugate
    Jostein Dahle
    Department of Radiation Biology, Norwegian Radium Hospital, Oslo, Norway
    Blood 110:2049-56. 2007
  6. doi request reprint In vitro cytotoxicity of low-dose-rate radioimmunotherapy by the alpha-emitting radioimmunoconjugate Thorium-227-DOTA-rituximab
    Jostein Dahle
    Department of Radiation Biology, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Radiat Oncol Biol Phys 75:886-95. 2009
  7. ncbi request reprint Dosimetry of a 238Pu-based alpha-particle irradiator and its biological application in a study of the bystander effect
    Jostein Dahle
    Department of Radiation Biology, Oslo University Hospital, Oslo, Norway
    Anticancer Res 31:2113-20. 2011
  8. ncbi request reprint Toxicity and relative biological effectiveness of alpha emitting radioimmunoconjugates
    Jostein Dahle
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Curr Radiopharm 4:321-8. 2011
  9. ncbi request reprint Initial evaluation of (227)Th-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy
    Jostein Dahle
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet HE, Montebello, 0310 Oslo, Norway
    Nucl Med Biol 33:271-9. 2006
  10. ncbi request reprint Comparing high LET 227Th- and low LET 177Lu-trastuzumab in mice with HER-2 positive SKBR-3 xenografts
    Nasir Abbas
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Curr Radiopharm 6:78-86. 2013

Collaborators

Detail Information

Publications30

  1. doi request reprint Assessment of long-term radiotoxicity after treatment with the low-dose-rate alpha-particle-emitting radioimmunoconjugate (227)Th-rituximab
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
    Eur J Nucl Med Mol Imaging 37:93-102. 2010
    ..To evaluate possible late side effects of (227)Th-rituximab, the long-term radiotoxicity of this potential radiopharmaceutical was investigated...
  2. doi request reprint Relative biologic effects of low-dose-rate alpha-emitting 227Th-rituximab and beta-emitting 90Y-tiuexetan-ibritumomab versus external beam X-radiation
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Radiat Oncol Biol Phys 72:186-92. 2008
    ..To determine the relative biologic effects (RBE) of alpha-particle radiation from 227Th-rituximab and of beta-radiation from 90Y-tiuexetan-ibritumomab (Zevalin) compared with external beam X-radiation in the Raji lymphoma xenograft model...
  3. doi request reprint Overexpression of human OGG1 in mammalian cells decreases ultraviolet A induced mutagenesis
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Cancer Lett 267:18-25. 2008
    ..The results suggest a link between the 8-oxoG lesion and UVA-induced mutagenesis. We propose that hOGG1 has a role in maintaining genomic stability in mammalian cells after oxidative stress...
  4. ncbi request reprint A one-step method for determining the maximum number of bound antibodies, and the affinity and association rate constants for antibody binding
    Jostein Dahle
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Nucl Med Commun 28:742-7. 2007
    ..The on and off rate constants are determined by kinetic binding experiments. However, it is necessary to perform two to three different types of experiment in order to determine these parameters...
  5. ncbi request reprint Targeted cancer therapy with a novel low-dose rate alpha-emitting radioimmunoconjugate
    Jostein Dahle
    Department of Radiation Biology, Norwegian Radium Hospital, Oslo, Norway
    Blood 110:2049-56. 2007
    ..Thorium-227 based constructs may provide a novel approach for targeted therapy against a wide variety of cancers...
  6. doi request reprint In vitro cytotoxicity of low-dose-rate radioimmunotherapy by the alpha-emitting radioimmunoconjugate Thorium-227-DOTA-rituximab
    Jostein Dahle
    Department of Radiation Biology, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Radiat Oncol Biol Phys 75:886-95. 2009
    ....
  7. ncbi request reprint Dosimetry of a 238Pu-based alpha-particle irradiator and its biological application in a study of the bystander effect
    Jostein Dahle
    Department of Radiation Biology, Oslo University Hospital, Oslo, Norway
    Anticancer Res 31:2113-20. 2011
    ..In conclusion, the broad-beam α-particle irradiator improved in this study represents a useful tool in the investigation of direct and non-targeted effects of α-particle radiation...
  8. ncbi request reprint Toxicity and relative biological effectiveness of alpha emitting radioimmunoconjugates
    Jostein Dahle
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Curr Radiopharm 4:321-8. 2011
    ..This review will provide a brief overview of the most promising radionuclides for targeted α-therapy and compare their relative biological effectiveness (RBE) and normal tissue toxicity...
  9. ncbi request reprint Initial evaluation of (227)Th-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy
    Jostein Dahle
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet HE, Montebello, 0310 Oslo, Norway
    Nucl Med Biol 33:271-9. 2006
    ..4 days. Incubation of lymphoma cells with (227)Th-DOTA-p-benzyl-rituximab resulted in a significant antigen-dependent inhibition of cell growth. The data presented here warrant further studies of (227)Th-DOTA-p-benzyl-rituximab...
  10. ncbi request reprint Comparing high LET 227Th- and low LET 177Lu-trastuzumab in mice with HER-2 positive SKBR-3 xenografts
    Nasir Abbas
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Curr Radiopharm 6:78-86. 2013
    ....
  11. ncbi request reprint Evaluation of the binding of radiolabeled rituximab to CD20-positive lymphoma cells: an in vitro feasibility study concerning low-dose-rate radioimmunotherapy with the alpha-emitter 227Th
    Katrine B Melhus
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Cancer Biother Radiopharm 22:469-79. 2007
    ..These results were confirmed using flow cytometry. Rituximab was found to be localized in patches on the cell membrane. The findings indicated that 227Th-labeled rituximab has relevant antigen-targeting properties for radioimmunotherapy...
  12. ncbi request reprint Targeted alpha therapy with 227Th-trastuzumab of intraperitoneal ovarian cancer in nude mice
    Helen Heyerdahl
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital The Norwegian Radium Hospital, Oslo, Norway
    Curr Radiopharm 6:106-16. 2013
    ..The aim of the current study was to investigate the therapeutic effect of 227Th-radioimmunotherapy on intraperitoneally growing human bioluminescent HER2 positive ovarian cancer cells...
  13. doi request reprint Treatment of HER2-expressing breast cancer and ovarian cancer cells with alpha particle-emitting 227Th-trastuzumab
    Helen Heyerdahl
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway
    Int J Radiat Oncol Biol Phys 79:563-70. 2011
    ....
  14. ncbi request reprint Preparation of TH227-labeled radioimmunoconjugates, assessment of serum stability and antigen binding ability
    Roy H Larsen
    Department of Radiation Biology, University of Oslo and The Norwegian Radium Hospital, Oslo, Norway
    Cancer Biother Radiopharm 22:431-7. 2007
    ..The overall labeling yield spanned from 6% to 17%. The radioimmunoconjugates demonstrated a relevant stability in serum and showed appropriate antigen-binding abilities...
  15. ncbi request reprint Bystander effects may modulate ultraviolet A and B radiation-induced delayed mutagenesis
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Radiat Res 163:289-95. 2005
    ..In conclusion, the results suggest that a bystander effect is involved in ultraviolet-radiation-induced genomic instability and that it may be mediated in part by gap junctional intercellular communication...
  16. pmc Fractionated therapy of HER2-expressing breast and ovarian cancer xenografts in mice with targeted alpha emitting 227Th-DOTA-p-benzyl-trastuzumab
    Helen Heyerdahl
    Department of Radiation Biology, Institute for Cancer Research, Oslo University, Hospital The Norwegian Radium Hospital, Oslo, Norway
    PLoS ONE 7:e42345. 2012
    ....
  17. ncbi request reprint Transcriptional responses in irradiated and bystander fibroblasts after low dose α-particle radiation
    Erta Kalanxhi
    Department of Radiation Biology, Oslo University Hospital, Institute for Cancer Research, Oslo, Norway
    Int J Radiat Biol 88:713-9. 2012
    ....
  18. doi request reprint Modifications in dynamic contrast-enhanced magnetic resonance imaging parameters after α-particle-emitting ²²⁷Th-trastuzumab therapy of HER2-expressing ovarian cancer xenografts
    Helen Heyerdahl
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital The Norwegian Radium Hospital, Oslo, Norway Electronic address
    Int J Radiat Oncol Biol Phys 87:153-9. 2013
    ..The purpose of this study was to investigate the effect of α-particle-emitting (227)Th-trastuzumab radioimmunotherapy on tumor vasculature to increase the knowledge about the mechanisms of action of (227)Th-trastuzumab...
  19. doi request reprint A (238)Pu irradiator for exposure of cultured cells with alpha-radiation: construction, calibration and dosimetry
    Nikolai Tisnek
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo, Norway
    Appl Radiat Isot 67:1998-2002. 2009
    ..2 Gy/s. The (238)Pu alpha-particle irradiator is feasible for irradiation of cells and it can be used for studies of both direct effects and bystander effects of alpha-radiation...
  20. ncbi request reprint The pheomelanin precursor 5-S-cysteinyldopa protects melanocytes from membrane damage induced by ultraviolet A radiation
    Egil Kvam
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Cancer Lett 221:131-4. 2005
    ..Thus, 5-S-cysteinyldopa, may at the same time sensitise DNA and protect membranes from damage induced by ultraviolet radiation...
  21. ncbi request reprint The role of serotonin and p53 status in the radiation-induced bystander effect
    Erta Kalanxhi
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
    Int J Radiat Biol 88:773-6. 2012
    ..The aim of this study was to investigate the role of serotonin and protein 53 (p53) status of the cells in the radiation-induced bystander effects (RIBE)...
  22. doi request reprint Preclinical evaluation of 227Th-labeled and 177Lu-labeled trastuzumab in mice with HER-2-positive ovarian cancer xenografts
    Nasir Abbas
    Department of Radiation Biology, Norwegian Radium Hospital, Oslo, Norway
    Nucl Med Commun 33:838-47. 2012
    ....
  23. ncbi request reprint Genome-wide microarray analysis of human fibroblasts in response to γ radiation and the radiation-induced bystander effect
    Erta Kalanxhi
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello 0310 Oslo, Norway
    Radiat Res 177:35-43. 2012
    ..A set of 14 genes, many of which were regulated by p53, were found to be induced early after irradiation (prior to medium transfer) and may be important in the generation or propagation of the bystander effect...
  24. pmc Experimental α-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTA-trastuzumab
    Nasir Abbas
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    EJNMMI Res 1:18. 2011
    ..abstract:..
  25. ncbi request reprint Multiplex polymerase chain reaction analysis of UV-A- and UV-B-induced delayed and early mutations in V79 Chinese hamster cells
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol 81:114-9. 2005
    ..Therefore, the present results support the hypothesis that persistent increase in oxidative stress is involved in the mechanism of UV-induced genomic instability...
  26. ncbi request reprint Induction of delayed mutations and chromosomal instability in fibroblasts after UVA-, UVB-, and X-radiation
    Jostein Dahle
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Cancer Res 63:1464-9. 2003
    ..Thus, the mechanism of UVA-induced chromosomal instability is apparently different from that of UVB and X-radiation...
  27. ncbi request reprint Automated counting of mammalian cell colonies by means of a flat bed scanner and image processing
    Jostein Dahle
    Department of Radiation Biology, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Cytometry A 60:182-8. 2004
    ..However, several commercial automatic colony counters are available. Based on CCD video imaging and image analysis they are relatively expensive and can analyze only one petri dish at a time...
  28. ncbi request reprint Increased level of oxidative stress in genomically unstable cell clones
    Jostein Dahle
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 74:23-8. 2004
    ..The unstable clones had elevated levels of oxidants, supporting the hypothesis that intermediate reactive oxygen species might have a role in the maintenance of genomic instability induced by ultraviolet radiation...
  29. ncbi request reprint Pigmented melanocytes are protected against ultraviolet-A-induced membrane damage
    Egil Kvam
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Invest Dermatol 121:564-9. 2003
    ..Thus, pigmented melanocytes apparently contain antioxidants more potent than glutathione, protecting them from ultraviolet-A-induced membrane damage...
  30. ncbi request reprint Melanin synthesis may sensitize melanocytes to oxidative DNA damage by ultraviolet A radiation and protect melanocytes from direct DNA damage by ultraviolet B radiation
    Egil Kvam
    Pigment Cell Res 17:549-50. 2004