L Gullestad

Summary

Country: Norway

Publications

  1. ncbi [Immunomodulating treatment in advanced heart failure--effect of intravenous immunoglobulin]
    L Gullestad
    Nukleaermedisinsk seksjon Klinisk kjemisk avdeling Rikshospitalet 0027 Oslo
    Tidsskr Nor Laegeforen 121:1902-7. 2001
  2. ncbi Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure
    L Gullestad
    Section of Clinical Immunology and Infectious Diseases and Research Institute for Internal Medicine, Medical Department A, Rikshospitalet University Hosptial, Oslo, Norway
    J Am Coll Cardiol 34:2061-7. 1999
  3. ncbi Postexercise ischemia is associated with increased neuropeptide Y in patients with coronary artery disease
    L Gullestad
    Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    Circulation 102:987-93. 2000
  4. ncbi Effect of metoprolol CR/XL on exercise tolerance in chronic heart failure - a substudy to the MERIT-HF trial
    L Gullestad
    Department of Cardiology, Division of Heart and Lung Diseases, Rikshospitalet, 0027 Oslo, Norway
    Eur J Heart Fail 3:463-8. 2001
  5. ncbi Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines
    T Holm
    Department of Cardiology, University of Oslo, Rikshospitalet, Norway
    Clin Transplant 14:218-25. 2000
  6. ncbi Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients
    T Holm
    Department of Cardiology, Research Institute for Internal Medicine, University of Oslo, Rikshospitalet, Norway
    Am J Cardiol 87:815-8, A9. 2001
  7. ncbi Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    P Aukrust
    Medical Department A, University of Oslo, Rikshospitalet, Norway
    Am J Cardiol 83:376-82. 1999
  8. ncbi Enhanced gene expression of chemokines and their corresponding receptors in mononuclear blood cells in chronic heart failure--modulatory effect of intravenous immunoglobulin
    J K Damas
    Department of Cardiology, University of Oslo, The National Hospital, Norway
    J Am Coll Cardiol 38:187-93. 2001
  9. ncbi Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
    J K Damas
    Department of Cardiology, Division of Heart and Lung Diseases, The National Hospital, Oslo, Norway
    Cardiovasc Res 47:778-87. 2000
  10. ncbi Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure
    L Gullestad
    Department of Cardiology, Medical Department, Rikshospitalet, Oslo, Norway
    Circulation 103:220-5. 2001

Collaborators

Detail Information

Publications33

  1. ncbi [Immunomodulating treatment in advanced heart failure--effect of intravenous immunoglobulin]
    L Gullestad
    Nukleaermedisinsk seksjon Klinisk kjemisk avdeling Rikshospitalet 0027 Oslo
    Tidsskr Nor Laegeforen 121:1902-7. 2001
    ..Congestive heart failure is characterised by enhanced immune activation. Immune-mediated mechanisms may play a pathogenic role, hence the growing interest in therapeutic regimens that could modulate the immune response in heart failure...
  2. ncbi Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure
    L Gullestad
    Section of Clinical Immunology and Infectious Diseases and Research Institute for Internal Medicine, Medical Department A, Rikshospitalet University Hosptial, Oslo, Norway
    J Am Coll Cardiol 34:2061-7. 1999
    ..We examined the effect of long-term treatment with two doses of the angiotensin converting enzyme (ACE) inhibitor enalapril on various immunological variables in patients with chronic congestive heart failure (CHF)...
  3. ncbi Postexercise ischemia is associated with increased neuropeptide Y in patients with coronary artery disease
    L Gullestad
    Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    Circulation 102:987-93. 2000
    ..We therefore examined its possible association with the ischemic response to exercise in patients with coronary artery disease...
  4. ncbi Effect of metoprolol CR/XL on exercise tolerance in chronic heart failure - a substudy to the MERIT-HF trial
    L Gullestad
    Department of Cardiology, Division of Heart and Lung Diseases, Rikshospitalet, 0027 Oslo, Norway
    Eur J Heart Fail 3:463-8. 2001
    ..The effect of metoprolol controlled release/extended release (CR/XL) on peak oxygen uptake (peak VO(2)) in this patient population has not previously been investigated...
  5. ncbi Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines
    T Holm
    Department of Cardiology, University of Oslo, Rikshospitalet, Norway
    Clin Transplant 14:218-25. 2000
    ..This endothelial dysfunction may be related to enhanced levels of proinflammatory cytokines in these patients...
  6. ncbi Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients
    T Holm
    Department of Cardiology, Research Institute for Internal Medicine, University of Oslo, Rikshospitalet, Norway
    Am J Cardiol 87:815-8, A9. 2001
    ....
  7. ncbi Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    P Aukrust
    Medical Department A, University of Oslo, Rikshospitalet, Norway
    Am J Cardiol 83:376-82. 1999
    ..The present study analyzing the complexity of the cytokine network in CHF, demonstrates profound disturbances in the levels of both inflammatory and anti-inflammatory mediators with a marked dysbalance favoring inflammatory effects...
  8. ncbi Enhanced gene expression of chemokines and their corresponding receptors in mononuclear blood cells in chronic heart failure--modulatory effect of intravenous immunoglobulin
    J K Damas
    Department of Cardiology, University of Oslo, The National Hospital, Norway
    J Am Coll Cardiol 38:187-93. 2001
    ....
  9. ncbi Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
    J K Damas
    Department of Cardiology, Division of Heart and Lung Diseases, The National Hospital, Oslo, Norway
    Cardiovasc Res 47:778-87. 2000
    ..The objective of this study was to examine mRNA levels and cellular localisation of chemokines and chemokine receptors in human CHF...
  10. ncbi Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure
    L Gullestad
    Department of Cardiology, Medical Department, Rikshospitalet, Oslo, Norway
    Circulation 103:220-5. 2001
    ..This effect was significantly correlated with an improvement in LVEF, suggesting a potential for immunomodulating therapy in addition to optimal conventional cardiovascular treatment regimens in CHF patients...
  11. ncbi Omega-3 fatty acids enhance tumor necrosis factor-alpha levels in heart transplant recipients
    T Holm
    Department of Cardiology, Research Institute for Internal Medicine, University of Oslo, Rikshospitalet, Norway
    Transplantation 72:706-11. 2001
    ..In this study, we examined plasma levels of tumor necrosis factor alpha (TNF-alpha), interleukin (IL) 10, and their relations to antioxidant vitamins in 45 HTx recipients before and after treatment with omega-3 fatty acids or placebo...
  12. ncbi Elevated circulating levels of C-C chemokines in patients with congestive heart failure
    P Aukrust
    Research Institute for Internal Medicine, Medical Department A, University of Oslo, Rikshospitalet, Norway
    Circulation 97:1136-43. 1998
    ....
  13. ncbi Clopidogrel increases expression of chemokines in peripheral blood mononuclear cells in patients with coronary artery disease: results of a double-blind placebo-controlled study
    T Waehre
    Research Institute of Internal Medicine, Rikshospitalet, University of Oslo, Oslo, Norway
    J Thromb Haemost 4:2140-7. 2006
    ..Platelet inhibitors are widely used in coronary artery disease (CAD), and we hypothesized that the platelet inhibitor clopidogrel could modify chemokines in CAD patients...
  14. ncbi Monocyte chemoattractant protein-1 enhances and interleukin-10 suppresses the production of inflammatory cytokines in adult rat cardiomyocytes
    J K Damas
    Department of Cardiology, Research Institute for Internal Medicine, Rikshospitalet, Oslo, Norway
    Basic Res Cardiol 96:345-52. 2001
    ....
  15. ncbi Osteoprotegerin levels predict mortality in patients with symptomatic aortic stenosis
    T Ueland
    Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
    J Intern Med 270:452-60. 2011
    ..To examine the prognostic value of osteoprotegerin (OPG) levels in relation to all-cause mortality in patients with symptomatic severe aortic stenosis (AS)...
  16. ncbi Complement activation in patients with congestive heart failure: effect of high-dose intravenous immunoglobulin treatment
    P Aukrust
    Section of Clinical Immunology and Infectious Diseases, Research Institute for Internal Medicine, Rikshospitalet, University of Oslo, Norway
    Circulation 104:1494-500. 2001
    ..Increasing evidence implicates innate immunity in the pathogenesis of congestive heart failure (CHF). In the present study, we examined the possible role of complement, an important part of innate immunity, in CHF...
  17. ncbi Effect of metoprolol on cytokine levels in chronic heart failure--a substudy in the Metoprolol Controlled-Release Randomised Intervention Trial in Heart Failure (MERIT-HF)
    L Gullestad
    Division of Heart and Lung Diseases, Department of Cardiology, Rikshospitalet, Sognsvannsveien 20, 0027 Oslo, Norway
    Am Heart J 141:418-21. 2001
    ..However, an enhanced immune activation also persisted in the metoprolol group, suggesting a potential for more specific immunomodulatory therapy in CHF...
  18. ncbi Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality
    E Øie
    Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    J Intern Med 270:263-72. 2011
    ..The aim of this study was to investigate whether total levels and composition of FAs and FFAs in plasma are altered in clinical heart failure (HF) and whether any alterations in these parameters are correlated with the severity of HF...
  19. ncbi Systemic markers of inflammation are associated with cardiac allograft vasculopathy and an increased intimal inflammatory component
    S Arora
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Am J Transplant 10:1428-36. 2010
    ..Forthcoming studies should clarify if routine measurements of these markers can accurately identify HTx recipients at risk of developing advanced CAV and vulnerable lesions...
  20. ncbi The effect of a neuropeptide Y Y1 receptor antagonist in patients with angina pectoris
    L Gullestad
    Department of Cardiology Rikshospitalet University Hospital, Oslo, Norway
    Eur Heart J 24:1120-7. 2003
    ..Despite this effect, the Y1 receptor antagonist did not influence exercise-induced ischaemic parameters in patients with coronary artery disease...
  21. ncbi Effect of folic acid treatment on endothelium-dependent vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects
    K B Holven
    Lipid Clinic, University Hospital, Rikshospitalet, Oslo, Norway
    Am J Med 110:536-42. 2001
    ..CONCLUSIONS: Homocysteine appears to induce its atherogenic effect, at least in part, by depressing endothelial function, possibly through nitric oxide-dependent mechanisms. This effect can be reversed by folic acid supplementation...
  22. ncbi Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipients
    T Holm
    Department of Cardiology, University of Oslo, Rikshospitalet, N-0027 Oslo, Norway
    Eur Heart J 22:428-36. 2001
    ....
  23. ncbi Heart failure biomarkers: focus on interleukin-1 receptor-like 1-based blood tests
    K Broch
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Drugs Today (Barc) 48:479-91. 2012
    ..Ultimately, the IL-33/IL1RL1 pathway may become a therapeutic target in heart failure...
  24. ncbi CXC-chemokines in coronary artery disease: possible pathogenic role of interactions between oxidized low-density lipoprotein, platelets and peripheral blood mononuclear cells
    T Holm
    Department of Cardiology, Rikshospitalet, Oslo, Norway
    J Thromb Haemost 1:257-62. 2003
    ..Our findings suggest enhanced inflammatory interactions between ox-LDL, platelets and PBMC in CAD patients involving CXC-chemokine related mechanisms, possible contributing to atherogenesis in these and other CAD patients...
  25. ncbi Plasma N-terminal proatrial natriuretic factor can predict normal pulmonary capillary wedge pressure in cardiac transplant recipients
    M G Dahle
    Department of Cardiology, Rikshospitalet, University Hospital, Oslo, Norway
    Scand Cardiovasc J 35:367-71. 2001
    ..Plasma N-terminal proatrial natriuretic factor (proANP) is closely related to atrial filling pressure, but this may be distorted in heart transplant recipients...
  26. ncbi Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis
    T Ueland
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Intern Med 268:483-92. 2010
    ..We hypothesized that patients with calcific valvular aortic stenosis (AS) would have dysregulated circulating MGP levels...
  27. ncbi Inflammatory imbalance between IL-10 and TNFalpha in unstable angina potential plaque stabilizing effects of IL-10
    T Waehre
    Research Institute for Internal Medicine, Rikshospitalet, Oslo, Norway
    Eur J Clin Invest 32:803-10. 2002
    ..We hypothesized that patients with unstable angina may have an imbalance between inflammatory and anti-inflammatory cytokines...
  28. ncbi Undiagnosed dysglycaemia and inflammation in cardiovascular disease
    O E Johansen
    Diabetic Out Patient Clinic, Medical Department, Asker and Baerum Hospital, Rud, Oslo, Norway
    Eur J Clin Invest 36:544-51. 2006
    ..e. coronary artery disease (CAD), cerebrovascular disease (CVD) and peripheral artery disease (PAD)...
  29. ncbi Increased inflammatory markers in children with familial hypercholesterolaemia
    T Ueland
    Research Institute for Internal Medicine, Section of Endocrinology, Rikshospitalet, University of Oslo, Norway
    Eur J Clin Invest 36:147-52. 2006
    ....
  30. ncbi The cytokine network in heart failure: pathogenetic importance and potential therapeutic targets
    L Gullestad
    Department of Medicine, Baerum Hospital, Sandvika, Oslo, Norway
    Heart Fail Monit 2:8-13. 2001
    ..More importantly, further research in this area will have to precisely identify the most important components in the immunopathogenesis of chronic heart failure, in order to develop more specific immunomodulating agents in this disorder...
  31. ncbi Virtual histology assessment of cardiac allograft vasculopathy following introduction of everolimus--results of a multicenter trial
    S Arora
    Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Am J Transplant 12:2700-9. 2012
    ..A significant increase in vWF and VCAM accompanied these qualitative changes and the prognostic implication of these findings requires further investigation...
  32. ncbi High-intensity interval training improves peak oxygen uptake and muscular exercise capacity in heart transplant recipients
    K Nytrøen
    Department of Cardiology, Oslo University Hospital HF Rikshospitalet, Norway
    Am J Transplant 12:3134-42. 2012
    ..The results indicate that HIIT should be more frequently used among stable HTx recipients in the future...
  33. ncbi Exercise capacity and hormonal response in adults with childhood onset growth hormone deficiency during long-term somatropin treatment
    L Gullestad
    Medical Department B, Rikshospitalet University Hospital, Oslo, Norway
    Growth Horm IGF Res 8:377-84. 1998
    ..We conclude that somatropin therapy to childhood onset GH deficient adults has a favourable effect on exercise capacity and may have a potentially beneficial effect on plasma catecholamines...