Elin Bergseng

Summary

Country: Norway

Publications

  1. ncbi Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule
    Elin Bergseng
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Biol Chem 280:21791-6. 2005
  2. doi Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation
    Lars Egil Fallang
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Nat Immunol 10:1096-101. 2009
  3. ncbi Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation
    Shuo Wang Qiao
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    J Immunol 175:254-61. 2005
  4. doi Analysis of the binding of gluten T-cell epitopes to various human leukocyte antigen class II molecules
    Elin Bergseng
    Centre for Immune Regulation and Institute of Immunology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Hum Immunol 69:94-100. 2008
  5. ncbi Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
    Shuo Wang Qiao
    Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Immunol 173:1757-62. 2004
  6. ncbi Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM
    Lars Egil Fallang
    Centre for Immune Regulation and Institute of Immunology, University of Oslo, Oslo, Norway
    J Immunol 181:5451-61. 2008
  7. doi Soluble HLA-DQ2 expressed in S2 cells copurifies with a high affinity insect cell derived protein
    Ulrike Jüse
    Centre for Immune Regulation, Institute of Immunology, University of Oslo, Oslo, Norway
    Immunogenetics 61:81-9. 2009
  8. pmc Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients
    Melinda Raki
    Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
    Proc Natl Acad Sci U S A 104:2831-6. 2007
  9. pmc Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease
    Jiang Xia
    Department of Chemistry, Stanford University, Stanford, CA 94305 5025, USA
    Bioorg Med Chem 15:6565-73. 2007
  10. pmc Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin
    Jiang Xia
    Departments of Chemistry, Chemical Engineering, and Biochemistry, Stanford University, Stanford, CA 94305 5025, USA
    J Am Chem Soc 128:1859-67. 2006

Collaborators

Detail Information

Publications11

  1. ncbi Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule
    Elin Bergseng
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Biol Chem 280:21791-6. 2005
    ..This is a unique feature of DQ2 and is likely a key parameter for preferential binding of proline-rich gluten peptides and development of celiac disease...
  2. doi Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation
    Lars Egil Fallang
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Nat Immunol 10:1096-101. 2009
    ..2 (phenylalanine) cannot. Our findings suggest that the kinetic stability of complexes of peptide and major histocompatibility complex (MHC) is of importance for the association of HLA with disease...
  3. ncbi Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation
    Shuo Wang Qiao
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    J Immunol 175:254-61. 2005
    ..Contrary to previous findings, our data do not show selective presentation of DQ2.5 over DQ2.2 for gluten epitopes that carry proline residues at the P3 position...
  4. doi Analysis of the binding of gluten T-cell epitopes to various human leukocyte antigen class II molecules
    Elin Bergseng
    Centre for Immune Regulation and Institute of Immunology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Hum Immunol 69:94-100. 2008
    ..The results demonstrate that the gluten T-cell epitopes mainly bind to the DQ2 molecule...
  5. ncbi Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
    Shuo Wang Qiao
    Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Immunol 173:1757-62. 2004
    ..The 33-mer is thus a potent T cell stimulator that does not require further processing within APC for T cell presentation and that binds to DQ2 with a pH profile that promotes extracellular binding...
  6. ncbi Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM
    Lars Egil Fallang
    Centre for Immune Regulation and Institute of Immunology, University of Oslo, Oslo, Norway
    J Immunol 181:5451-61. 2008
    ..We suggest that the unusual interaction of DQ2 with Ii and DM may provide a basis for the known disease associations of DQ2...
  7. doi Soluble HLA-DQ2 expressed in S2 cells copurifies with a high affinity insect cell derived protein
    Ulrike Jüse
    Centre for Immune Regulation, Institute of Immunology, University of Oslo, Oslo, Norway
    Immunogenetics 61:81-9. 2009
    ..Further mapping of this fragment of 54 residues identified a pentadecapeptide with high affinity for sDQ2 which may serve as a lead compound for the design of HLA-DQ2 blockers...
  8. pmc Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients
    Melinda Raki
    Institute of Immunology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
    Proc Natl Acad Sci U S A 104:2831-6. 2007
    ..Most of the cells had a memory phenotype, but many other phenotypic markers showed a heterogeneous pattern. Tetramer staining of gluten-specific T cells has the potential to be used for diagnosis of celiac disease...
  9. pmc Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease
    Jiang Xia
    Department of Chemistry, Stanford University, Stanford, CA 94305 5025, USA
    Bioorg Med Chem 15:6565-73. 2007
    ..One dimeric peptide analogue with an intermediate linker length was found to be especially effective at inhibiting DQ2 mediated antigen presentation. The implications of these findings for the treatment of celiac disease are discussed...
  10. pmc Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin
    Jiang Xia
    Departments of Chemistry, Chemical Engineering, and Biochemistry, Stanford University, Stanford, CA 94305 5025, USA
    J Am Chem Soc 128:1859-67. 2006
    ....
  11. pmc Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease
    Chu Young Kim
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:4175-9. 2004
    ..Finally, surface-exposed proline residues in the proteolytically resistant ligand were replaced with functionalized analogs, thereby providing a starting point for the design of orally active agents for blocking gluten-induced toxicity...