Will Norton

Summary

Affiliation: CNRS
Location: Gif sur Yvette, France
Summary:
I am interested in using zebrafish as a behavioral genetic model organism. My current projects look at different aspects of both larval and adult behaviour. I am particularly interested in larval locomotor hyperactivity, as well as aggression, addiction, anxiety and exploration in adult zebrafish

Publications

  1. pmc Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine
    Katharine J Webb
    Department Zebrafish Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse, Neuherberg, 85764 Germany
    Genome Biol 10:R81. 2009
  2. doi Comparative analysis of serotonin receptor (HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain
    William H J Norton
    Zebrafish Neurogenetics, Institute of Developmental Genetics, HelmholtzZentrum muenchen, 85764, Neuherberg, Germany
    J Comp Neurol 511:521-42. 2008
  3. doi NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain
    Maryline Blin
    Laboratory of Development, Evolution and Plasticity of the Nervous System, UPR2197, Institute of Neurobiology A Fessard, CNRS and University Paris Sud, 91198 Gif sur Yvette Cedex, France
    Mol Cell Neurosci 39:592-604. 2008
  4. doi Dynamic Fgf signaling couples morphogenesis and migration in the zebrafish lateral line primordium
    Virginie Lecaudey
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
    Development 135:2695-705. 2008
  5. ncbi Fgf10 regulates hepatopancreatic ductal system patterning and differentiation
    P Duc Si Dong
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
    Nat Genet 39:397-402. 2007
  6. ncbi HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development
    William H J Norton
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 132:4963-73. 2005
  7. ncbi Histone deacetylase 1 is required for cell cycle exit and differentiation in the zebrafish retina
    Jochen A Stadler
    European Molecular Biology Laboratory, Heidelberg, Germany
    Dev Dyn 233:883-9. 2005
  8. pmc Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones
    Will H Norton
    Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Development 132:645-58. 2005
  9. ncbi Embryonic expression of a P2X(3) receptor encoding gene in zebrafish
    W H Norton
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK
    Mech Dev 99:149-52. 2000
  10. pmc Adult zebrafish as a model organism for behavioural genetics
    William Norton
    CNRS, UPR, Institute of Neurobiology Albert Fessard, Gif sur Yvette, France
    BMC Neurosci 11:90. 2010

Detail Information

Publications11

  1. pmc Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine
    Katharine J Webb
    Department Zebrafish Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse, Neuherberg, 85764 Germany
    Genome Biol 10:R81. 2009
    ....
  2. doi Comparative analysis of serotonin receptor (HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain
    William H J Norton
    Zebrafish Neurogenetics, Institute of Developmental Genetics, HelmholtzZentrum muenchen, 85764, Neuherberg, Germany
    J Comp Neurol 511:521-42. 2008
    ....
  3. doi NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain
    Maryline Blin
    Laboratory of Development, Evolution and Plasticity of the Nervous System, UPR2197, Institute of Neurobiology A Fessard, CNRS and University Paris Sud, 91198 Gif sur Yvette Cedex, France
    Mol Cell Neurosci 39:592-604. 2008
    ..Our results shed new light on NR4A2 function in the DA differentiation pathway, and stress the effect of DA dysregulation on the control of locomotor activity...
  4. doi Dynamic Fgf signaling couples morphogenesis and migration in the zebrafish lateral line primordium
    Virginie Lecaudey
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
    Development 135:2695-705. 2008
    ..Furthermore, this work uncovers a surprising link between internal tissue organization and collective migration...
  5. ncbi Fgf10 regulates hepatopancreatic ductal system patterning and differentiation
    P Duc Si Dong
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
    Nat Genet 39:397-402. 2007
    ..These data shed light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopancreatic duct, are directed toward different organ fates...
  6. ncbi HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development
    William H J Norton
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 132:4963-73. 2005
    ..This reveals an unexpected specificity of HSPGs in regulating distinct vertebrate Fgfs...
  7. ncbi Histone deacetylase 1 is required for cell cycle exit and differentiation in the zebrafish retina
    Jochen A Stadler
    European Molecular Biology Laboratory, Heidelberg, Germany
    Dev Dyn 233:883-9. 2005
    ..These results demonstrate that the in vivo role of HDAC1 in regulating cell cycle progression is region-specific, as HDAC1 promotes cell cycle exit in the retina but stimulates proliferation in other cellular contexts...
  8. pmc Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones
    Will H Norton
    Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Development 132:645-58. 2005
    ....
  9. ncbi Embryonic expression of a P2X(3) receptor encoding gene in zebrafish
    W H Norton
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK
    Mech Dev 99:149-52. 2000
    ..p2x3 is also expressed in the spinal sensory Rohon-Beard cells and in the putative posterior lateral line ganglion...
  10. pmc Adult zebrafish as a model organism for behavioural genetics
    William Norton
    CNRS, UPR, Institute of Neurobiology Albert Fessard, Gif sur Yvette, France
    BMC Neurosci 11:90. 2010
    ..As a result of this, studies of adult zebrafish are now helping to uncover the genetic pathways and neural circuits that control vertebrate behaviour...