David R McCance

Summary

Affiliation: Northern Ireland

Publications

  1. doi request reprint Pregnancy and diabetes
    David R McCance
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Best Pract Res Clin Endocrinol Metab 25:945-58. 2011
  2. pmc Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial
    David R McCance
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Lancet 376:259-66. 2010
  3. ncbi request reprint Protective effects of ascorbic acid on arterial hemodynamics during acute hyperglycemia
    Brian A Mullan
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland
    Am J Physiol Heart Circ Physiol 287:H1262-8. 2004
  4. doi request reprint Effects of dehydroepiandrosterone sulphate (DHEAS) replacement on insulin action and quality of life in hypopituitary females: a double-blind, placebo-controlled study
    Claire M McHenry
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Clin Endocrinol (Oxf) 77:423-9. 2012
  5. pmc Low-fat versus low-carbohydrate weight reduction diets: effects on weight loss, insulin resistance, and cardiovascular risk: a randomized control trial
    Una Bradley
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, U K
    Diabetes 58:2741-8. 2009
  6. ncbi request reprint Pretreatment with intravenous ascorbic acid preserves endothelial function during acute hyperglycaemia (R1)
    Brian A Mullan
    Department of Anaesthesia and Intensive Care Medicine, Queen s University Belfast, Belfast, Northern Ireland, UK
    Clin Exp Pharmacol Physiol 32:340-5. 2005
  7. ncbi request reprint Low- and standard-dose corticotropin and insulin hypoglycemia testing in the assessment of hypothalamic-pituitary-adrenal function after pituitary surgery
    C Hamish Courtney
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast BT12 6BA, United Kingdom
    J Clin Endocrinol Metab 89:1712-7. 2004
  8. pmc Optimal glycemic control, pre-eclampsia, and gestational hypertension in women with type 1 diabetes in the diabetes and pre-eclampsia intervention trial
    Valerie A Holmes
    School of Nursing and Midwifery, Queen s University Belfast, Belfast, UK
    Diabetes Care 34:1683-8. 2011
  9. doi request reprint The assessment of vascular function during dietary intervention trials in human subjects
    Damian O McCall
    Centre for Public Health, Queen s University Belfast, Belfast, UK
    Br J Nutr 106:981-94. 2011
  10. ncbi request reprint Effect of eucaloric high- and low-sucrose diets with identical macronutrient profile on insulin resistance and vascular risk: a randomized controlled trial
    R Neil A Black
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Grosvenor Road, Belfast, U K
    Diabetes 55:3566-72. 2006

Collaborators

Detail Information

Publications20

  1. doi request reprint Pregnancy and diabetes
    David R McCance
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Best Pract Res Clin Endocrinol Metab 25:945-58. 2011
    ..An expanding therapeutic armamentarium and increasing awareness of the long-term implications of diabetic pregnancy for both mother and child present new challenges for clinical care, research and public health...
  2. pmc Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial
    David R McCance
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Lancet 376:259-66. 2010
    ..We aimed to assess whether supplementation with vitamins C and E reduced incidence of pre-eclampsia in women with type 1 diabetes...
  3. ncbi request reprint Protective effects of ascorbic acid on arterial hemodynamics during acute hyperglycemia
    Brian A Mullan
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland
    Am J Physiol Heart Circ Physiol 287:H1262-8. 2004
    ..Pretreatment with AA prevented the hyperglycemia-induced hemodynamic changes. By protecting hemodynamics during acute hyperglycemia, AA may have therapeutic use...
  4. doi request reprint Effects of dehydroepiandrosterone sulphate (DHEAS) replacement on insulin action and quality of life in hypopituitary females: a double-blind, placebo-controlled study
    Claire M McHenry
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Clin Endocrinol (Oxf) 77:423-9. 2012
    ..We examined the effects of DHEAS on insulin action and the quality of life in female patients with hypopituitary hypoadrenalism...
  5. pmc Low-fat versus low-carbohydrate weight reduction diets: effects on weight loss, insulin resistance, and cardiovascular risk: a randomized control trial
    Una Bradley
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, U K
    Diabetes 58:2741-8. 2009
    ..Low-carbohydrate, high-fat diets are advocated as an alternative, but reciprocal increases in dietary fat may have detrimental effects on insulin resistance and offset the benefits of weight reduction...
  6. ncbi request reprint Pretreatment with intravenous ascorbic acid preserves endothelial function during acute hyperglycaemia (R1)
    Brian A Mullan
    Department of Anaesthesia and Intensive Care Medicine, Queen s University Belfast, Belfast, Northern Ireland, UK
    Clin Exp Pharmacol Physiol 32:340-5. 2005
    ..Therefore, ascorbic acid may have potential therapeutic use in clinical situations where acute hyperglycaemia may be a complication...
  7. ncbi request reprint Low- and standard-dose corticotropin and insulin hypoglycemia testing in the assessment of hypothalamic-pituitary-adrenal function after pituitary surgery
    C Hamish Courtney
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast BT12 6BA, United Kingdom
    J Clin Endocrinol Metab 89:1712-7. 2004
    ..7 micro g/dl) indicates ACTH deficiency. No further testing is then required. An intermediate level of 350-650 nmol/liter (12.7-23.6 micro g/dl) warrants further assessment using the insulin hypoglycemia test...
  8. pmc Optimal glycemic control, pre-eclampsia, and gestational hypertension in women with type 1 diabetes in the diabetes and pre-eclampsia intervention trial
    Valerie A Holmes
    School of Nursing and Midwifery, Queen s University Belfast, Belfast, UK
    Diabetes Care 34:1683-8. 2011
    ..To assess the relationship between glycemic control, pre-eclampsia, and gestational hypertension in women with type 1 diabetes...
  9. doi request reprint The assessment of vascular function during dietary intervention trials in human subjects
    Damian O McCall
    Centre for Public Health, Queen s University Belfast, Belfast, UK
    Br J Nutr 106:981-94. 2011
    ..The present review identifies commonly employed techniques, discusses the relative merits of each and highlights emerging approaches...
  10. ncbi request reprint Effect of eucaloric high- and low-sucrose diets with identical macronutrient profile on insulin resistance and vascular risk: a randomized controlled trial
    R Neil A Black
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Grosvenor Road, Belfast, U K
    Diabetes 55:3566-72. 2006
    ..In this study, a high-sucrose intake as part of an eucaloric, weight-maintaining diet had no detrimental effect on insulin sensitivity, glycemic profiles, or measures of vascular compliance in healthy nondiabetic subjects...
  11. doi request reprint Randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis
    William J Cash
    Department of Hepatology Liver Unit, Royal Victoria Hospital, Belfast, UK
    Liver Int 33:1166-74. 2013
    ..This study evaluated the effect of statins in Primary biliary cirrhosis (PBC) on endothelial function, anti-oxidant status and vascular compliance...
  12. ncbi request reprint Reduced prevalence of limited joint mobility in type 1 diabetes in a U.K. clinic population over a 20-year period
    John R Lindsay
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Grosvenor Rd, Belfast, BT12 6BA U K
    Diabetes Care 28:658-61. 2005
    ..We hypothesize that the prevalence of LJM may have decreased during the past two decades due to improved standards of glycemic control...
  13. ncbi request reprint Susceptibility of low-density lipoprotein to oxidation and circulating cell adhesion molecules in young healthy adult offspring of parents with type 2 diabetes
    Paul T McSorley
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Metabolism 53:755-9. 2004
    ..Reduced resistance of LDL to oxidation and increased circulating sICAM-1 in young healthy adult offspring of parents with type 2 diabetes may be intrinsic to increased risk of atherosclerosis in these subjects...
  14. doi request reprint Restoration of adipose function in obese glucose-tolerant men following pioglitazone treatment is associated with CCAAT enhancer-binding protein β up-regulation
    Lesley A Powell
    Nutrition and Metabolism Group, Centre for Public Health, Queen s University Belfast, and Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Clin Sci (Lond) 123:135-46. 2012
    ....
  15. ncbi request reprint Effect of the alpha-adrenergic blocker, doxazosin, on endothelial function and insulin action
    C Hamish Courtney
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Metabolism 52:1147-52. 2003
    ..These results indicate that doxazosin can be used safely in patients with insulin resistance, while its positive effect on endothelial function may lessen the subsequent incidence of atherosclerosis...
  16. ncbi request reprint The PPAR-gamma activator rosiglitazone fails to lower plasma ACTH levels in patients with Nelson's syndrome
    Karen R Mullan
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Clin Endocrinol (Oxf) 64:519-22. 2006
    ..The PPAR-gamma activator rosiglitazone has been shown to suppress ACTH secretion in human adrenocorticotroph tumour cells in vitro, and prevent and reduce adrenocorticotroph tumour development in mouse models in vivo...
  17. ncbi request reprint Leptin concentrations in maternal serum and cord blood in diabetic and nondiabetic pregnancy
    John G Manderson
    Royal Jubilee Maternity Hospital, Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Am J Obstet Gynecol 188:1326-32. 2003
    ..The purpose of this study was to examine the relationships between maternal and cord leptin concentrations, maternal and neonatal outcomes, and measures of glycemic control in diabetic and nondiabetic pregnancy...
  18. ncbi request reprint Long-term remission rates after pituitary surgery for Cushing's disease: the need for long-term surveillance
    A Brew Atkinson
    Regional Centre for Endocrinology and Diabetes, Belfast, Northern Ireland, UK
    Clin Endocrinol (Oxf) 63:549-59. 2005
    ..Endocrinological factors associated with late relapse were also studied...
  19. doi request reprint Primary biliary cirrhosis is associated with oxidative stress and endothelial dysfunction but not increased cardiovascular risk
    William J Cash
    Liver Unit Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital Department of Medicine, Queen s University, Belfast, UK
    Hepatol Res 40:1098-106. 2010
    ..78 m/s, P = 0.022). Conclusion:  PBC patients appear to have reduced vascular risk as assessed by pulse wave velocity but concurrently have evidence of endothelial dysfunction, inflammation and anti-oxidant deficiency...
  20. ncbi request reprint Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes
    Brian A Mullan
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland
    Hypertension 40:804-9. 2002
    ..As strict control of blood pressure reduces cardiovascular risk in diabetes, ascorbic acid supplementation may potentially be a useful and inexpensive adjunctive therapy. Larger and longer studies now need to be performed...