P M Bell

Summary

Affiliation: Northern Ireland

Publications

  1. doi Effects on insulin action of adding low-dose thiazide to angiotensin-converting enzyme inhibitor in essential hypertension
    Claire M McHenry
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland
    Hypertension 61:800-5. 2013
  2. doi Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes
    P M Bell
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Diabetes Res Clin Pract 91:e68-70. 2011
  3. ncbi Prevalence of diabetes and impaired glucose tolerance in adult hypopituitarism on low dose oral hydrocortisone replacement therapy
    E M McConnell
    Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, UK
    Clin Endocrinol (Oxf) 54:593-9. 2001
  4. ncbi Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes
    J R Lindsay
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Coleraine, Northern Ireland, UK
    Diabet Med 22:654-7. 2005
  5. doi Comparison of effects of combined ACE inhibitor and low-dose thiazide diuretic with ACE inhibitor alone on insulin action in patients with hypertension and Type 2 diabetes: a double-blind crossover study
    D M McLaughlin
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Diabet Med 25:631-4. 2008
  6. ncbi Insulin action and skeletal muscle blood flow in patients with Type 1 diabetes and microalbuminuria
    M I Wiggam
    Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, BT12 6BA, Northern Ireland, Belfast, UK
    Diabetes Res Clin Pract 53:73-83. 2001
  7. doi Is there value in routine screening for Cushing's syndrome in patients with diabetes?
    K Mullan
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast BT12 6BA, United Kingdom
    J Clin Endocrinol Metab 95:2262-5. 2010
  8. doi Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes
    J Cuthbertson
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK
    Diabet Med 26:649-54. 2009
  9. ncbi The effects on insulin action in adult hypopituitarism of recombinant human GH therapy individually titrated for six months
    E M McConnell
    Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, BT12 6BA, Northern Ireland, United Kingdom
    J Clin Endocrinol Metab 86:5342-7. 2001
  10. ncbi The effect of manipulation of basal pulsatile insulin on insulin action in Type 2 diabetes
    S Au
    Regional Centre of Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Diabet Med 22:1064-71. 2005

Collaborators

  • A B Atkinson
  • F P M O'Harte
  • D R Hadden
  • Peter R Flatt
  • Aine M McKillop
  • M H Mooney
  • D M McLaughlin
  • B Sheridan
  • D R McCance
  • J R Lindsay
  • C H Courtney
  • E M McConnell
  • H Leslie
  • S J Hunter
  • M I Wiggam
  • C N Ennis
  • Claire M McHenry
  • J Shaw
  • K Mullan
  • I R Wallace
  • J Cuthbertson
  • S Au
  • P T McSorley
  • Steven J Hunter
  • Brian Sheridan
  • Cieran N Ennis
  • John S Henry
  • Jonathan N Browne
  • C Ennis
  • V L Armstrong
  • K M Lagan
  • M R Stevenson
  • C R Irwin
  • C M Hughes
  • C Burgess
  • N Black
  • A Thiraviaraj
  • N Satti
  • S Patterson
  • J P H Fee
  • N A Duffy
  • I S Young
  • J Ardill
  • A I Traub
  • P K Ellis
  • A Walmsley

Detail Information

Publications21

  1. doi Effects on insulin action of adding low-dose thiazide to angiotensin-converting enzyme inhibitor in essential hypertension
    Claire M McHenry
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland
    Hypertension 61:800-5. 2013
    ..30). In contrast to the situation in type 2 diabetes mellitus, ACE inhibitor combined with low-dose thiazide diuretic does not adversely affect insulin action when compared with ACE inhibitor alone in nondiabetic hypertensive patients...
  2. doi Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes
    P M Bell
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Diabetes Res Clin Pract 91:e68-70. 2011
    ..Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia...
  3. ncbi Prevalence of diabetes and impaired glucose tolerance in adult hypopituitarism on low dose oral hydrocortisone replacement therapy
    E M McConnell
    Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, UK
    Clin Endocrinol (Oxf) 54:593-9. 2001
    ..This lower prevalence may eventually result in reduced vascular complication rates...
  4. ncbi Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes
    J R Lindsay
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Coleraine, Northern Ireland, UK
    Diabet Med 22:654-7. 2005
    ..We investigated the acute effects of metformin on DPP IV activity in Type 2 diabetes to elucidate inhibition of DPP IV as a possible mechanism of action...
  5. doi Comparison of effects of combined ACE inhibitor and low-dose thiazide diuretic with ACE inhibitor alone on insulin action in patients with hypertension and Type 2 diabetes: a double-blind crossover study
    D M McLaughlin
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Diabet Med 25:631-4. 2008
    ..To establish the safety in terms of insulin sensitivity of a low dose thiazide/ACE inhibitor combination...
  6. ncbi Insulin action and skeletal muscle blood flow in patients with Type 1 diabetes and microalbuminuria
    M I Wiggam
    Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, BT12 6BA, Northern Ireland, Belfast, UK
    Diabetes Res Clin Pract 53:73-83. 2001
    ..4+/-0.3 vs 2.3+/-0.4 ml x 100-ml(-1) x min(-1)). In conclusion, microalbuminuria in Type 1 diabetes was found to be associated with impairment of insulin-mediated skeletal muscle blood flow, but not with insulin resistance...
  7. doi Is there value in routine screening for Cushing's syndrome in patients with diabetes?
    K Mullan
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast BT12 6BA, United Kingdom
    J Clin Endocrinol Metab 95:2262-5. 2010
    ..Subclinical Cushing's syndrome has been described among diabetic populations in recent years, but no consensus has emerged about the value of screening...
  8. doi Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes
    J Cuthbertson
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK
    Diabet Med 26:649-54. 2009
    ..We investigated the acute effects of metformin with and without food on DPP-4 activity in Type 2 diabetes...
  9. ncbi The effects on insulin action in adult hypopituitarism of recombinant human GH therapy individually titrated for six months
    E M McConnell
    Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, BT12 6BA, Northern Ireland, United Kingdom
    J Clin Endocrinol Metab 86:5342-7. 2001
    ..There was no effect on peripheral or hepatic insulin sensitivity. Patients receiving GH therapy require long-term monitoring of glucose tolerance...
  10. ncbi The effect of manipulation of basal pulsatile insulin on insulin action in Type 2 diabetes
    S Au
    Regional Centre of Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Diabet Med 22:1064-71. 2005
    ..We investigated this relationship further by studying the effect of overnight (10 h) pulsatile insulin infusion on subsequent insulin sensitivity...
  11. ncbi Low dose bendrofluazide (1.25 mg) effectively lowers blood pressure over 24 h: results of a randomized, double-blind, placebo-controlled crossover study
    M I Wiggam
    Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, Northern Ireland
    Am J Hypertens 12:528-31. 1999
    ..01). Trough:peak ratios were 0.67 +/- 0.07 for systolic and 0.72 +/- 0.15 for diastolic blood pressure reduction. In conclusion, 1.25 mg bendrofluazide daily produced a useful antihypertensive effect across the full 24-h period...
  12. ncbi Effects of nateglinide on the secretion of glycated insulin and glucose tolerance in type 2 diabetes
    J R Lindsay
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, BT12 6BA Belfast, UK
    Diabetes Res Clin Pract 61:167-73. 2003
    ..We used a novel radioimmunoassay to evaluate the effect of nateglinide on plasma concentrations of glycated insulin and glucose tolerance in type 2 diabetes...
  13. ncbi Insulin action and insulin secretion in polycystic ovary syndrome treated with ethinyl oestradiol/cyproterone acetate
    V L Armstrong
    Metabolic Unit, Royal Victoria Hospital, Royal Maternity Hospital and Regional Endocrinology Laboratory, Royal Hospital Trust, Belfast, UK
    QJM 94:31-7. 2001
    ..Despite considerable improvement in androgen profile, treatment with ethinyl oestradiol/cyproterone acetate did not alter insulin action in PCOS, and this insulin resistance does not appear to be determined by insulin pulse frequency...
  14. doi Ten-year clinical follow-up of a cohort of 51 patients with macroprolactinemia establishes it as a benign variant
    I R Wallace
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UK
    J Clin Endocrinol Metab 95:3268-71. 2010
    ..Macroprolactinemia is a common finding in patients with hyperprolactinemia. There are no published long-term follow-up studies...
  15. ncbi Laboratory and clinical experience in 55 patients with macroprolactinemia identified by a simple polyethylene glycol precipitation method
    H Leslie
    Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, United Kingdom BT12 6BA
    J Clin Endocrinol Metab 86:2743-6. 2001
    ..However, follow-up of a large cohort is required to ensure that the long-term outlook is likewise benign. This would have important implications for both patients and healthcare systems...
  16. ncbi Endothelial function, insulin action and cardiovascular risk factors in young healthy adult offspring of parents with Type 2 diabetes: effect of vitamin E in a randomized double-blind, controlled clinical trial
    P T McSorley
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, N Ireland, UK
    Diabet Med 22:703-10. 2005
    ..We aimed to determine the effect of the antioxidant vitamin E on endothelial function, insulin action and cardiovascular risk markers in young healthy adult offspring of parents with Type 2 diabetes...
  17. doi The effect of topical phenytoin on healing in diabetic foot ulcers: a randomized controlled trial
    J Shaw
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK
    Diabet Med 28:1154-7. 2011
    ..The aim of the study was to evaluate the effect of topical phenytoin on healing in diabetic foot ulcers. A randomized, controlled, double-blind, clinical trial was conducted...
  18. ncbi Effects of low-dose oral hydrocortisone replacement versus short-term reproduction of physiological serum cortisol concentrations on insulin action in adult-onset hypopituitarism
    E M McConnell
    Sir George E Clark Metabolic Unit and Regional Endocrine Laboratory, Royal Victoria Hospital, Belfast, UK
    Clin Endocrinol (Oxf) 56:195-201. 2002
    ..The use of lower doses of hydrocortisone replacement therapy might prevent some of the adverse metabolic effects seen with conventional doses...
  19. ncbi Comparison of the priming effects of pulsatile and continuous insulin delivery on insulin action in man
    C H Courtney
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Metabolism 52:1050-5. 2003
    ..A priming effect cannot therefore explain the previously demonstrated association between endogenous insulin pulse frequency and peripheral insulin action...
  20. ncbi Demonstration of increased concentrations of circulating glycated insulin in human Type 2 diabetes using a novel and specific radioimmunoassay
    J R Lindsay
    Regional Centre for Endocrinology, Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Diabetologia 46:475-8. 2003
    ..Glycation of insulin, resulting in impaired bioactivity, has been shown within pancreatic beta cells. We have used a novel and specific radioimmunoassay to detect glycated insulin in plasma of Type 2 diabetic subjects...