H Nohl

Summary

Publications

  1. ncbi request reprint Evaluation of the antioxidant capacity of ubiquinol and dihydrolipoic acid
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Z Naturforsch C 53:250-3. 1998
  2. ncbi request reprint Effects of tocopheryl quinone on the heart: model experiments with xanthine oxidase, heart mitochondria, and isolated perfused rat hearts
    L Gille
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Vienna, Austria
    Free Radic Biol Med 30:865-76. 2001
  3. ncbi request reprint Antioxidant-derived prooxidant formation from ubiquinol
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Free Radic Biol Med 25:666-75. 1998
  4. ncbi request reprint Critical aspects of the antioxidant function of coenzyme Q in biomembranes
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Biofactors 9:155-61. 1999
  5. ncbi request reprint The biochemical, pathophysiological, and medical aspects of ubiquinone function
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Ann N Y Acad Sci 854:394-409. 1998
  6. ncbi request reprint The ubiquinol/bc1 redox couple regulates mitochondrial oxygen radical formation
    L Gille
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Arch Biochem Biophys 388:34-8. 2001
  7. ncbi request reprint Mitochondria recycle nitrite back to the bioregulator nitric monoxide
    H Nohl
    Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria
    Acta Biochim Pol 47:913-21. 2000
  8. ncbi request reprint The existence and significance of redox-cycling ubiquinone in lysosomes
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, , A-1210 Vienna, Austria
    Protoplasma 217:9-14. 2001
  9. ncbi request reprint Lipid radicals: properties and detection by spin trapping
    K Stolze
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Acta Biochim Pol 47:923-30. 2000
  10. ncbi request reprint The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Z Naturforsch C 53:279-85. 1998

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Evaluation of the antioxidant capacity of ubiquinol and dihydrolipoic acid
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Z Naturforsch C 53:250-3. 1998
    ..The efficiency of the antioxidative capacity of the latter was found to be diminished through prooxidant activities of the antioxidant-derived metabolites...
  2. ncbi request reprint Effects of tocopheryl quinone on the heart: model experiments with xanthine oxidase, heart mitochondria, and isolated perfused rat hearts
    L Gille
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Vienna, Austria
    Free Radic Biol Med 30:865-76. 2001
    ..Our results demonstrate that TQ derivatives may induce pro-oxidative and antioxidative effects depending on the distribution of TQ derivatives in the heart tissue and the interacting redox system...
  3. ncbi request reprint Antioxidant-derived prooxidant formation from ubiquinol
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Free Radic Biol Med 25:666-75. 1998
    ..This discrepancy reveals that the antioxidative activity of coenzyme Q is compulsorily linked to the formation of split products counteracting the membrane protective effect of this natural antioxidant...
  4. ncbi request reprint Critical aspects of the antioxidant function of coenzyme Q in biomembranes
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Biofactors 9:155-61. 1999
    ..The present study not only provides data which document this discrepancy but also contributes experimental data on the existence of ubiquinol derived pro-oxidants, which give an explanation of this phenomenon...
  5. ncbi request reprint The biochemical, pathophysiological, and medical aspects of ubiquinone function
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Ann N Y Acad Sci 854:394-409. 1998
    ..In addition, reaction products emerging from the antioxidant activity of ubiquinol were found to stimulate the formation of inorganic as well as organic oxygen radicals...
  6. ncbi request reprint The ubiquinol/bc1 redox couple regulates mitochondrial oxygen radical formation
    L Gille
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Arch Biochem Biophys 388:34-8. 2001
    ..The regulator which controls leakage of electrons to oxygen appears to be the electron branching activity of the bc1 complex...
  7. ncbi request reprint Mitochondria recycle nitrite back to the bioregulator nitric monoxide
    H Nohl
    Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria
    Acta Biochim Pol 47:913-21. 2000
    ..The high affinity of NO to the heme-iron of cytochrome oxidase will result in an impairment of mitochondrial energy-production. "Nitrite tolerance" of angina pectoris patients using NO-donors may be explained in that way...
  8. ncbi request reprint The existence and significance of redox-cycling ubiquinone in lysosomes
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, , A-1210 Vienna, Austria
    Protoplasma 217:9-14. 2001
    ..Oxygen was found to be the terminal electron acceptor thereby also regulating acidification of the lysosomal matrix. The role of the proton-pumping redox chain has to be elucidated...
  9. ncbi request reprint Lipid radicals: properties and detection by spin trapping
    K Stolze
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Acta Biochim Pol 47:923-30. 2000
    ..The observed ESR parameters were similar to those of alkoxyl radical adducts, which were independently synthesized in model experiments using Fe3+-catalyzed nucleophilic addition of methanol or t-butanol to the respective spin trap...
  10. ncbi request reprint The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Z Naturforsch C 53:279-85. 1998
    ..This organ-specific enzyme initiates a sequence of one electron transfer reactions ending up in the establishment of oxidative stress...
  11. ncbi request reprint Kynurenic acid influences the respiratory parameters of rat heart mitochondria
    H Baran
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Pharmacology 62:119-23. 2001
    ....
  12. ncbi request reprint The multiple functions of coenzyme Q
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, , Vienna, A-1210, Austria
    Bioorg Chem 29:1-13. 2001
    ..Another novel finding documents the bioenergetic role of UQ in lysosomal proton intransport. A lysosomal chain of redox couples will be presented, which includes UQ and which requires oxygen as the terminal electron acceptor...