C L Noble

Summary

Publications

  1. doi request reprint Low body mass not vitamin D receptor polymorphisms predict osteoporosis in patients with inflammatory bowel disease
    C L Noble
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Aliment Pharmacol Ther 27:588-96. 2008
  2. doi request reprint Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis
    C L Noble
    Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, Edinburgh, EH4 2XU, UK
    Gut 57:1398-405. 2008
  3. pmc Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease
    R K Russell
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, UK
    Gut 55:1114-23. 2006
  4. doi request reprint A trial of mercaptopurine is a safe strategy in patients with inflammatory bowel disease intolerant to azathioprine: an observational study, systematic review and meta-analysis
    N A Kennedy
    Gastrointestinal Unit, Western General Hospital, Edinburgh, UK Gastrointestinal research, Centre for Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Aliment Pharmacol Ther 38:1255-66. 2013
  5. pmc DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population
    C L Noble
    Gastrointestinal Unit, Western General Hospital, Edinburgh, UK
    Gut 54:1416-20. 2005
  6. ncbi request reprint A retrospective analysis of the efficacy and safety of infliximab as rescue therapy in acute severe ulcerative colitis
    C W Lees
    Gastrointestinal Unit, Western General Hospital, Edinburgh, UK
    Aliment Pharmacol Ther 26:411-9. 2007
  7. ncbi request reprint Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts
    B L Browning
    J Med Genet 45:36-42. 2008
  8. ncbi request reprint Combination therapy of infliximab and azathioprine reduces disease progression in Crohn's disease
    S Din
    Inflamm Bowel Dis 14:143-5. 2008

Collaborators

Detail Information

Publications8

  1. doi request reprint Low body mass not vitamin D receptor polymorphisms predict osteoporosis in patients with inflammatory bowel disease
    C L Noble
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Aliment Pharmacol Ther 27:588-96. 2008
    ..Osteoporosis is a recognized complication of inflammatory bowel disease (IBD). Aim To investigate the role of environmental factors and vitamin D receptor (VDR) variants on the prevalence of osteoporosis...
  2. doi request reprint Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis
    C L Noble
    Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, Edinburgh, EH4 2XU, UK
    Gut 57:1398-405. 2008
    ..To investigate differential intestinal gene expression in patients with ulcerative colitis and in controls...
  3. pmc Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease
    R K Russell
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, UK
    Gut 55:1114-23. 2006
    ..The OCTN1 (SLC22A4 1672C-->T) and OCTN2 (SLC22A5 -207G-->C) variants within the IBD5 locus have been associated with susceptibility to adult onset Crohn's disease (CD), but their contribution in children has not been examined...
  4. doi request reprint A trial of mercaptopurine is a safe strategy in patients with inflammatory bowel disease intolerant to azathioprine: an observational study, systematic review and meta-analysis
    N A Kennedy
    Gastrointestinal Unit, Western General Hospital, Edinburgh, UK Gastrointestinal research, Centre for Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Aliment Pharmacol Ther 38:1255-66. 2013
    ..Use is limited by intolerance and subsequent drug withdrawal in approximately 17% of patients treated with azathioprine. Previous case series have addressed the success rates of re-treatment with mercaptopurine in these individuals...
  5. pmc DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population
    C L Noble
    Gastrointestinal Unit, Western General Hospital, Edinburgh, UK
    Gut 54:1416-20. 2005
    ..Haplotype D, notably characterised by the presence of a G-->A substitution at nucleotide 113, was associated with susceptibility to Crohn's disease (CD) whereas an extended haplotype A conferred protection...
  6. ncbi request reprint A retrospective analysis of the efficacy and safety of infliximab as rescue therapy in acute severe ulcerative colitis
    C W Lees
    Gastrointestinal Unit, Western General Hospital, Edinburgh, UK
    Aliment Pharmacol Ther 26:411-9. 2007
    ..A recent controlled trial has suggested that infliximab may be effective as rescue therapy...
  7. ncbi request reprint Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts
    B L Browning
    J Med Genet 45:36-42. 2008
    ..Male-female differences in population allele frequencies and male-specific risk could explain the difficulty in replicating the association with CD...
  8. ncbi request reprint Combination therapy of infliximab and azathioprine reduces disease progression in Crohn's disease
    S Din
    Inflamm Bowel Dis 14:143-5. 2008