Roberta Noberini

Summary

Publications

  1. pmc Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening
    Natalie L Prigozhina
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Biol Cell 103:467-81. 2011
  2. pmc Targeted delivery of paclitaxel to EphA2-expressing cancer cells
    Si Wang
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 90237, USA
    Clin Cancer Res 19:128-37. 2013
  3. doi request reprint HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery
    Bainan Wu
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 20:19-33. 2013
  4. pmc Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols
    Roberta Noberini
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Res 66:363-73. 2012
  5. pmc A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors
    Roberta Noberini
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Chem Biol Drug Des 78:667-78. 2011
  6. pmc PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinity
    Roberta Noberini
    Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e28611. 2011
  7. pmc Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor
    Ilaria Lamberto
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Biochem J 445:47-56. 2012
  8. pmc Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach
    Roberta Noberini
    Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Cell Adh Migr 6:102-12. 2012
  9. pmc Targeting Eph receptors with peptides and small molecules: progress and challenges
    Roberta Noberini
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Semin Cell Dev Biol 23:51-7. 2012
  10. pmc Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells
    Si Wang
    Cancer Research Center, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 55:2427-36. 2012

Collaborators

  • Maurizio Pellecchia
  • Paul B Fisher
  • Clemencia Pinilla
  • Ziwei Huang
  • Jianxing Song
  • Ombretta Salvucci
  • Elena B Pasquale
  • Si Wang
  • Bainan Wu
  • Ziming Zhang
  • Sayantan Mitra
  • John L Stebbins
  • Ilaria Lamberto
  • Natalie L Prigozhina
  • Marc Giulianotti
  • Sandrine Billet
  • Ana Fernandez
  • Elisa Barile
  • Shinichi Kitada
  • Swadesh Das
  • Richard A Houghten
  • Neil A Bhowmick
  • Russell Dahl
  • William J Placzek
  • Haina Qin
  • Lakshmanane Premkumar
  • Stefan J Riedl
  • Caroline Bourgin
  • Mitchell Koolpe
  • Mark Mercola
  • Jordan R Seldeen
  • Ke Wei
  • Andrew Heisel
  • Pilar Ruiz-Lozano
  • Jeffrey H Price
  • Edward A Hunter
  • Diego Calzolari

Detail Information

Publications10

  1. pmc Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening
    Natalie L Prigozhina
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Biol Cell 103:467-81. 2011
    ..We then evaluated HMEC cultures, both alone and co-cultured with an EMC (epicardial mesothelial cell) line that contributes vascular smooth muscle cells, to determine the suitability for HTS or HCS...
  2. pmc Targeted delivery of paclitaxel to EphA2-expressing cancer cells
    Si Wang
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 90237, USA
    Clin Cancer Res 19:128-37. 2013
    ..YSA is an EphA2-targeting peptide that effectively delivers anticancer agents to prostate cancer tumors. Here, we report on how we increased the drug-like properties of this delivery system...
  3. doi request reprint HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery
    Bainan Wu
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 20:19-33. 2013
    ..We used the method to identify compounds that target protein-protein interactions...
  4. pmc Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols
    Roberta Noberini
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Res 66:363-73. 2012
    ..Thus, the Eph receptor tyrosine kinase family represents an important class of targets for tea-derived phytochemicals...
  5. pmc A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors
    Roberta Noberini
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Chem Biol Drug Des 78:667-78. 2011
    ..These findings suggest that salicylic acid derivatives could be used as starting points to design new small molecule antagonists of Eph receptors...
  6. pmc PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinity
    Roberta Noberini
    Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e28611. 2011
    ..Furthermore, the PEGylated peptide is suitable for other cell culture and in vivo applications requiring prolonged EphB4 receptor targeting...
  7. pmc Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor
    Ilaria Lamberto
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Biochem J 445:47-56. 2012
    ..The peptides exhibit a long half-life in cell culture medium which, with their substantial binding affinity and selectivity for EphA4, makes them excellent research tools to modulate EphA4 function...
  8. pmc Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach
    Roberta Noberini
    Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Cell Adh Migr 6:102-12. 2012
    ..The new mass spectrometry approach we have developed represents a useful tool for the identification of the spectrum of Eph receptors present in a biological sample and could also be extended to profiling ephrin expression...
  9. pmc Targeting Eph receptors with peptides and small molecules: progress and challenges
    Roberta Noberini
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Semin Cell Dev Biol 23:51-7. 2012
    ..Strategies that could also be explored include targeting additional Eph receptor interfaces and the ephrin ligands...
  10. pmc Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells
    Si Wang
    Cancer Research Center, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 55:2427-36. 2012
    ..We believe these studies open the way to the development of a new class of therapeutic compounds that exploit the EphA2 receptor for drug delivery to cancer cells...