Andrew Jonathan Nok

Summary

Affiliation: University of Ibadan
Country: Nigeria

Publications

  1. ncbi request reprint Inhibition of Naja nigricolis venom acidic phospholipase A2 catalysed hydrolysis of ghost red blood cells by columbin
    A J Nok
    J Enzyme Inhib Med Chem 17:55-9. 2002
  2. ncbi request reprint Azaanthraquinone inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma congolense
    Andrew Jonathan Nok
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    Cell Biochem Funct 20:205-12. 2002
  3. ncbi request reprint A 45-kDa midgut glycoprotein from Anopheles albimanus mosquito mediates the killing of trypanosomes
    Andrew J Nok
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    Cell Biochem Funct 20:257-62. 2002
  4. ncbi request reprint Transferrin coupled azanthraquinone enhances the killing effect on trypanosomes. The role of lysosomal mannosidase
    A J Nok
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    Parasite 9:375-9. 2002
  5. ncbi request reprint Characterization of sialidase from Entamoaeba hystolitica and possible pathogenic role in amebiasis
    Andrew J Nok
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    Parasitol Res 89:302-7. 2003
  6. ncbi request reprint Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis
    Andrew Jonathan Nok
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    Parasitol Res 90:71-9. 2003
  7. ncbi request reprint A bloodstream Trypanosoma congolense sialidase could be involved in anemia during experimental trypanosomiasis
    Andrew J Nok
    Department of Biochemistry, Ahmadu Bello University Zaria, Nigeria
    J Biochem 133:725-30. 2003
  8. ncbi request reprint Trypanosoma evansi sialidase: surface localization, properties and hydrolysis of ghost red blood cells and brain cells-implications in trypanosomiasis
    Andrew J Nok
    Department of Biochemistry, Ahmadu Bello University Zaria, Nigeria
    Z Naturforsch C 58:594-601. 2003
  9. ncbi request reprint Effective measures for controlling trypanosomiasis
    Andrew J Nok
    Department of Biochemistry, Ahmadou Bello University, Zaria, Nigeria
    Expert Opin Pharmacother 6:2645-53. 2005

Detail Information

Publications9

  1. ncbi request reprint Inhibition of Naja nigricolis venom acidic phospholipase A2 catalysed hydrolysis of ghost red blood cells by columbin
    A J Nok
    J Enzyme Inhib Med Chem 17:55-9. 2002
    ..Columbin also inhibited PLA2 hydrolysis of ghost RBC in a dose-dependent fashion. At least 70% suppression of PLA2-catalysed haemolysis of RBC was observed in the presence of 2 microM columbin...
  2. ncbi request reprint Azaanthraquinone inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma congolense
    Andrew Jonathan Nok
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    Cell Biochem Funct 20:205-12. 2002
    ..The susceptible site could be due to ubiquinone redox system which links the two enzyme activities...
  3. ncbi request reprint A 45-kDa midgut glycoprotein from Anopheles albimanus mosquito mediates the killing of trypanosomes
    Andrew J Nok
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    Cell Biochem Funct 20:257-62. 2002
    ..congolense cells. The potential use of anopheline 45 kDa protein in the production of transgenic tsetse flies (Glossina spp.) in the control of trypanosomiasis is discussed...
  4. ncbi request reprint Transferrin coupled azanthraquinone enhances the killing effect on trypanosomes. The role of lysosomal mannosidase
    A J Nok
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    Parasite 9:375-9. 2002
    ..congolense and T. b. brucei respectively. The results are discussed as regards the potency of using transferrin as suitable drug carrier in the chemotherapy of Human sleeping sickness...
  5. ncbi request reprint Characterization of sialidase from Entamoaeba hystolitica and possible pathogenic role in amebiasis
    Andrew J Nok
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    Parasitol Res 89:302-7. 2003
    ..However, the motility of the parasite was highly diminished when incubated with Neu5Acalpha2en and sialic acid-containing compounds. Lysed E. histolytica trophozoites were found to lack neuraminic acid...
  6. ncbi request reprint Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis
    Andrew Jonathan Nok
    Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
    Parasitol Res 90:71-9. 2003
    ..This is largely due to the inability to find compounds that can cross the blood brain barrier and kill the CSF-residing trypanosomes. This review summarises our current understanding on the treatment of HAT...
  7. ncbi request reprint A bloodstream Trypanosoma congolense sialidase could be involved in anemia during experimental trypanosomiasis
    Andrew J Nok
    Department of Biochemistry, Ahmadu Bello University Zaria, Nigeria
    J Biochem 133:725-30. 2003
    ..The possible role of a secreted bloodstream Trypanosoma congolense SD and the development of anemia in the pathogensesis of trypanosomiasis are discussed...
  8. ncbi request reprint Trypanosoma evansi sialidase: surface localization, properties and hydrolysis of ghost red blood cells and brain cells-implications in trypanosomiasis
    Andrew J Nok
    Department of Biochemistry, Ahmadu Bello University Zaria, Nigeria
    Z Naturforsch C 58:594-601. 2003
    ..It was activated by Mg2+ ion and inhibited by Cu2+ and Zn2+...
  9. ncbi request reprint Effective measures for controlling trypanosomiasis
    Andrew J Nok
    Department of Biochemistry, Ahmadou Bello University, Zaria, Nigeria
    Expert Opin Pharmacother 6:2645-53. 2005
    ..This review discusses the current treatment of trypanosomiasis and the progress made towards the effective control of trypanosomiasis...