Research Topics
| Ebenezer O FarombiSummaryAffiliation: University of Ibadan Country: Nigeria Publications
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Detail Information
Publications
Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoidEbenezer O Farombi
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
Int J Environ Res Public Health 8:2533-55. 2011....
Nigerian Bonny light crude oil disrupts antioxidant systems in testes and sperm of ratsEbenezer O Farombi
Department of Biochemistry, University of Ibadan, Nigeria
Arch Environ Contam Toxicol 59:166-74. 2010..These results suggest that exposure to BLCO, such as its use in ailment management, may promote infertility by altering the function of the testes and sperm, particularly by way of induction of oxidative stress...- Role of oxidative stress in reproductive toxicity induced by co-administration of chloramphenicol and multivitamin-haematinics complex in ratsAdemola A Oyagbemi
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Basic Clin Pharmacol Toxicol 107:703-8. 2010..In summary, while MHC-induced testicular toxicity via oxidative stress, CAP did not and their combination is implicated in reproductive dysfunction within the time course of our investigation... - Selenium provides protection to the liver but not the reproductive organs in an atrazine-model of experimental toxicityAdebukola C Adesiyan
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
Exp Toxicol Pathol 63:201-7. 2011..Selenium might therefore be useful in ameliorating oxidative stress in the liver... - Hepatic, testicular and spermatozoa antioxidant status in rats chronically treated with Garcinia kolaseedEbenezer O Farombi
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
J Ethnopharmacol 146:536-42. 2013..The present study evaluated the hepatic, testicular and spermatozoa antioxidant status in rats chronically treated with Garcinia kolaseed... - Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in ratsEbenezer O Farombi
Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
J Basic Clin Physiol Pharmacol 23:39-44. 2012..Quinine, a rapidly acting blood schizonticide with a long history of use for the treatment of malaria, is gradually been implicated in reproductive toxicity... 
Tissues distribution of heavy metals and erythrocytes antioxidant status in rats exposed to Nigerian bonny light crude oilIsaac A Adedara
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Toxicol Ind Health 29:162-8. 2013..Collectively, the results showed that BLCO induces oxidative damage to erythrocytes of rats...- Induction of oxidative stress in liver and kidney of rats exposed to Nigerian bonny light crude oilIsaac A Adedara
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Environ Toxicol 27:372-9. 2012..The hepatorenal toxicity of BLCO could be due to induction of oxidative stress in liver and kidney... - Modulatory effect of methanolic extract of Vernonia amygdalina (MEVA) on tert-butyl hydroperoxide-induced erythrocyte haemolysisOmolola A Adesanoye
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Cell Biochem Funct 31:545-50. 2013..These findings therefore suggest that MEVA may have protective antioxidant properties, making it suitable for incorporation into food and drug products... - Neurotoxicity of Nigerian bonny light crude oil in ratsAzubike P Ebokaiwe
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Drug Chem Toxicol 36:187-95. 2013..The neurotoxicity of BLCO may be the result of oxidative stress resulting from loss of biometal homeostasis as well as toxicant injury from other constituents of BLCO... - Lack of recovery from hepatic oxidative damage in rats treated with Nigerian bonny light crude oilIsaac A Adedara
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Cell Biochem Funct 30:480-6. 2012..Taken together, BLCO-induced hepatotoxicity could be due to increased oxidative stress which was not reversible upon withdrawal of treatment within the time course of investigation in male rats... - Kolaviron, a natural antioxidant and anti-inflammatory phytochemical prevents dextran sulphate sodium-induced colitis in ratsEbenezer O Farombi
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Basic Clin Pharmacol Toxicol 113:49-55. 2013..In conclusion, the anti-colitis effect of kolaviron is related to its intrinsic anti-inflammatory and anti-oxidative properties... - Ramipril-like activity of Spondias mombin linn against no-flow ischemia and isoproterenol-induced cardiotoxicity in rat heartAfolabi C Akinmoladun
Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Cardiovasc Toxicol 10:295-305. 2010..Disruption in the structure of cardiac myofibrils by ISP intoxication was reduced by treatment with SM. Comparable results were obtained for ramipril. These results are indicative of the potent cardioprotective property of SM... - Sperm functional parameters and erythrocytes oxidant-antioxidant imbalance during municipal landfill leachate treatment withdrawal in ratsIsaac A Adedara
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, 20005, Nigeria Electronic address
Environ Toxicol Pharmacol 37:460-7. 2014..These findings highlight potential adverse effects of OMLL on individuals unduly exposed to leachates contaminated substances. .. - Induction of oxidative damage in the testes and spermatozoa and hematotoxicity in rats exposed to multiple doses of ethylene glycol monoethyl etherIsaac A Adedara
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Hum Exp Toxicol 29:801-12. 2010..In summary, short term administration of EGEE is hematotoxic and gonadotoxic and its effects on male reproduction could be due to the induction of oxidative stress in testes and spermatozoa... - Morphological and biochemical investigation into the possible neuroprotective effects of kolaviron (Garcinia kola bioflavonoid) on the brains of rats exposed to vanadiumOlumayowa O Igado
Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria
Drug Chem Toxicol 35:371-80. 2012..24%) in all brain regions assessed, when compared with the group administered vanadium alone. Results obtained from this study led to the conclusion that kolaviron reduces vanadium-induced oxidative stress in the brain... - Evaluation of antioxidant and free radical scavenging capacities of some Nigerian indigenous medicinal plantsAfolabi C Akinmoladun
Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Ibadan, Oyo State, Nigeria
J Med Food 13:444-51. 2010..In addition, multiple assay methods should be used in comparing antioxidant capacities of samples to have a reliable result... - Nigerian bonny light crude oil induces endocrine disruption in male ratsIsaac A Adedara
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria and
Drug Chem Toxicol 37:198-203. 2014..These observations highlight the potential risk to public health for a population where, unfortunately, oil spillages occur frequently... - Changes in sperm characteristics and induction of oxidative stress in the testis and epididymis of experimental rats by a herbicide, atrazineSunny O Abarikwu
Drug Metabolism Laboratory, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Arch Environ Contam Toxicol 58:874-82. 2010..The results suggest that atrazine impairs reproductive function and elicits a depletion of the antioxidant defense system in the testis and epididymis, indicating the induction of oxidative stress... - Aflatoxin B1 disrupts the androgen biosynthetic pathway in rat Leydig cellsIsaac A Adedara
Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Food Chem Toxicol 65:252-9. 2014.... - Influence of kolaviron and vitamin E on ethylene glycol monoethyl ether-induced haematotoxicity and renal apoptosis in ratsIsaac A Adedara
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Cell Biochem Funct 32:31-8. 2014..Co-administration with kolaviron or vitamin E exhibited chemoprotective effects against EGEE-mediated haematotoxicity, augmented renal antioxidant status and prevented the induction of renal apoptosis... - Involvement of oxidative stress in municipal landfill leachate-induced toxicity in boar spermIsaac A Adedara
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria Electronic address
Environ Toxicol Pharmacol 36:972-8. 2013..In conclusion, OMLL elicited spermatotoxicity via induction of oxidative stress possibly generated through an enhanced intracellular reactive oxygen species... - Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachlorideOmolola A Adesanoye
Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
Exp Toxicol Pathol 62:197-206. 2010..05) and catalase activity at 500-1000 mg/kg doses. These results suggest that methanolic extract of V. amygdalina leaves posseses protective effect against CCl(4)-induced hepatotoxicity by the antioxidant mechanism of action...