Ebenezer O Farombi

Summary

Affiliation: University of Ibadan
Country: Nigeria

Publications

  1. pmc Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid
    Ebenezer O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    Int J Environ Res Public Health 8:2533-55. 2011
  2. doi request reprint Nigerian Bonny light crude oil disrupts antioxidant systems in testes and sperm of rats
    Ebenezer O Farombi
    Department of Biochemistry, University of Ibadan, Nigeria
    Arch Environ Contam Toxicol 59:166-74. 2010
  3. doi request reprint Role of oxidative stress in reproductive toxicity induced by co-administration of chloramphenicol and multivitamin-haematinics complex in rats
    Ademola A Oyagbemi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Basic Clin Pharmacol Toxicol 107:703-8. 2010
  4. doi request reprint Selenium provides protection to the liver but not the reproductive organs in an atrazine-model of experimental toxicity
    Adebukola C Adesiyan
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Exp Toxicol Pathol 63:201-7. 2011
  5. doi request reprint Hepatic, testicular and spermatozoa antioxidant status in rats chronically treated with Garcinia kolaseed
    Ebenezer O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    J Ethnopharmacol 146:536-42. 2013
  6. doi request reprint Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats
    Ebenezer O Farombi
    Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    J Basic Clin Physiol Pharmacol 23:39-44. 2012
  7. ncbi request reprint Tissues distribution of heavy metals and erythrocytes antioxidant status in rats exposed to Nigerian bonny light crude oil
    Isaac A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Toxicol Ind Health 29:162-8. 2013
  8. doi request reprint Induction of oxidative stress in liver and kidney of rats exposed to Nigerian bonny light crude oil
    Isaac A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Environ Toxicol 27:372-9. 2012
  9. ncbi request reprint Modulatory effect of methanolic extract of Vernonia amygdalina (MEVA) on tert-butyl hydroperoxide-induced erythrocyte haemolysis
    Omolola A Adesanoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Cell Biochem Funct 31:545-50. 2013
  10. doi request reprint Neurotoxicity of Nigerian bonny light crude oil in rats
    Azubike P Ebokaiwe
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Drug Chem Toxicol 36:187-95. 2013

Collaborators

  • Sunny O Abarikwu
  • Afolabi C Akinmoladun
  • Benson T Akingbemi
  • Martins Ekor
  • James O Olopade
  • Madhu Dikshit
  • Isaac A Adedara
  • Azubike P Ebokaiwe
  • Omolola A Adesanoye
  • Adebayo A Adesina
  • Tajudeen A Lawal
  • Oluwatosin O Oyebiyi
  • Olumayowa O Igado
  • Adebukola C Adesiyan
  • Ademola A Oyagbemi
  • Manjunatha K Nanjappa
  • Premendu P Mathur
  • Adetutu A Delima
  • Olatunde Owoeye
  • Adeniyi S Adefegha
  • Olorunfemi R Molehin
  • Adebukola Adesida
  • Theresa Ehwerhemuepha
  • Oluwasanmi O Aina
  • Roy Teberen
  • Titilola O Oyejola
  • Matthew O Oyeyemi
  • Adebowale B Saba

Detail Information

Publications23

  1. pmc Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid
    Ebenezer O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    Int J Environ Res Public Health 8:2533-55. 2011
    ....
  2. doi request reprint Nigerian Bonny light crude oil disrupts antioxidant systems in testes and sperm of rats
    Ebenezer O Farombi
    Department of Biochemistry, University of Ibadan, Nigeria
    Arch Environ Contam Toxicol 59:166-74. 2010
    ..These results suggest that exposure to BLCO, such as its use in ailment management, may promote infertility by altering the function of the testes and sperm, particularly by way of induction of oxidative stress...
  3. doi request reprint Role of oxidative stress in reproductive toxicity induced by co-administration of chloramphenicol and multivitamin-haematinics complex in rats
    Ademola A Oyagbemi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Basic Clin Pharmacol Toxicol 107:703-8. 2010
    ..In summary, while MHC-induced testicular toxicity via oxidative stress, CAP did not and their combination is implicated in reproductive dysfunction within the time course of our investigation...
  4. doi request reprint Selenium provides protection to the liver but not the reproductive organs in an atrazine-model of experimental toxicity
    Adebukola C Adesiyan
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Exp Toxicol Pathol 63:201-7. 2011
    ..Selenium might therefore be useful in ameliorating oxidative stress in the liver...
  5. doi request reprint Hepatic, testicular and spermatozoa antioxidant status in rats chronically treated with Garcinia kolaseed
    Ebenezer O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    J Ethnopharmacol 146:536-42. 2013
    ..The present study evaluated the hepatic, testicular and spermatozoa antioxidant status in rats chronically treated with Garcinia kolaseed...
  6. doi request reprint Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats
    Ebenezer O Farombi
    Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    J Basic Clin Physiol Pharmacol 23:39-44. 2012
    ..Quinine, a rapidly acting blood schizonticide with a long history of use for the treatment of malaria, is gradually been implicated in reproductive toxicity...
  7. ncbi request reprint Tissues distribution of heavy metals and erythrocytes antioxidant status in rats exposed to Nigerian bonny light crude oil
    Isaac A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Toxicol Ind Health 29:162-8. 2013
    ..Collectively, the results showed that BLCO induces oxidative damage to erythrocytes of rats...
  8. doi request reprint Induction of oxidative stress in liver and kidney of rats exposed to Nigerian bonny light crude oil
    Isaac A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Environ Toxicol 27:372-9. 2012
    ..The hepatorenal toxicity of BLCO could be due to induction of oxidative stress in liver and kidney...
  9. ncbi request reprint Modulatory effect of methanolic extract of Vernonia amygdalina (MEVA) on tert-butyl hydroperoxide-induced erythrocyte haemolysis
    Omolola A Adesanoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Cell Biochem Funct 31:545-50. 2013
    ..These findings therefore suggest that MEVA may have protective antioxidant properties, making it suitable for incorporation into food and drug products...
  10. doi request reprint Neurotoxicity of Nigerian bonny light crude oil in rats
    Azubike P Ebokaiwe
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Drug Chem Toxicol 36:187-95. 2013
    ..The neurotoxicity of BLCO may be the result of oxidative stress resulting from loss of biometal homeostasis as well as toxicant injury from other constituents of BLCO...
  11. ncbi request reprint Lack of recovery from hepatic oxidative damage in rats treated with Nigerian bonny light crude oil
    Isaac A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Cell Biochem Funct 30:480-6. 2012
    ..Taken together, BLCO-induced hepatotoxicity could be due to increased oxidative stress which was not reversible upon withdrawal of treatment within the time course of investigation in male rats...
  12. doi request reprint Kolaviron, a natural antioxidant and anti-inflammatory phytochemical prevents dextran sulphate sodium-induced colitis in rats
    Ebenezer O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Basic Clin Pharmacol Toxicol 113:49-55. 2013
    ..In conclusion, the anti-colitis effect of kolaviron is related to its intrinsic anti-inflammatory and anti-oxidative properties...
  13. doi request reprint Ramipril-like activity of Spondias mombin linn against no-flow ischemia and isoproterenol-induced cardiotoxicity in rat heart
    Afolabi C Akinmoladun
    Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Cardiovasc Toxicol 10:295-305. 2010
    ..Disruption in the structure of cardiac myofibrils by ISP intoxication was reduced by treatment with SM. Comparable results were obtained for ramipril. These results are indicative of the potent cardioprotective property of SM...
  14. doi request reprint Sperm functional parameters and erythrocytes oxidant-antioxidant imbalance during municipal landfill leachate treatment withdrawal in rats
    Isaac A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, 20005, Nigeria Electronic address
    Environ Toxicol Pharmacol 37:460-7. 2014
    ..These findings highlight potential adverse effects of OMLL on individuals unduly exposed to leachates contaminated substances. ..
  15. doi request reprint Induction of oxidative damage in the testes and spermatozoa and hematotoxicity in rats exposed to multiple doses of ethylene glycol monoethyl ether
    Isaac A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Hum Exp Toxicol 29:801-12. 2010
    ..In summary, short term administration of EGEE is hematotoxic and gonadotoxic and its effects on male reproduction could be due to the induction of oxidative stress in testes and spermatozoa...
  16. doi request reprint Morphological and biochemical investigation into the possible neuroprotective effects of kolaviron (Garcinia kola bioflavonoid) on the brains of rats exposed to vanadium
    Olumayowa O Igado
    Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria
    Drug Chem Toxicol 35:371-80. 2012
    ..24%) in all brain regions assessed, when compared with the group administered vanadium alone. Results obtained from this study led to the conclusion that kolaviron reduces vanadium-induced oxidative stress in the brain...
  17. doi request reprint Evaluation of antioxidant and free radical scavenging capacities of some Nigerian indigenous medicinal plants
    Afolabi C Akinmoladun
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Ibadan, Oyo State, Nigeria
    J Med Food 13:444-51. 2010
    ..In addition, multiple assay methods should be used in comparing antioxidant capacities of samples to have a reliable result...
  18. doi request reprint Nigerian bonny light crude oil induces endocrine disruption in male rats
    Isaac A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria and
    Drug Chem Toxicol 37:198-203. 2014
    ..These observations highlight the potential risk to public health for a population where, unfortunately, oil spillages occur frequently...
  19. doi request reprint Changes in sperm characteristics and induction of oxidative stress in the testis and epididymis of experimental rats by a herbicide, atrazine
    Sunny O Abarikwu
    Drug Metabolism Laboratory, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Arch Environ Contam Toxicol 58:874-82. 2010
    ..The results suggest that atrazine impairs reproductive function and elicits a depletion of the antioxidant defense system in the testis and epididymis, indicating the induction of oxidative stress...
  20. doi request reprint Aflatoxin B1 disrupts the androgen biosynthetic pathway in rat Leydig cells
    Isaac A Adedara
    Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Food Chem Toxicol 65:252-9. 2014
    ....
  21. doi request reprint Influence of kolaviron and vitamin E on ethylene glycol monoethyl ether-induced haematotoxicity and renal apoptosis in rats
    Isaac A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Cell Biochem Funct 32:31-8. 2014
    ..Co-administration with kolaviron or vitamin E exhibited chemoprotective effects against EGEE-mediated haematotoxicity, augmented renal antioxidant status and prevented the induction of renal apoptosis...
  22. doi request reprint Involvement of oxidative stress in municipal landfill leachate-induced toxicity in boar sperm
    Isaac A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria Electronic address
    Environ Toxicol Pharmacol 36:972-8. 2013
    ..In conclusion, OMLL elicited spermatotoxicity via induction of oxidative stress possibly generated through an enhanced intracellular reactive oxygen species...
  23. doi request reprint Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride
    Omolola A Adesanoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Exp Toxicol Pathol 62:197-206. 2010
    ..05) and catalase activity at 500-1000 mg/kg doses. These results suggest that methanolic extract of V. amygdalina leaves posseses protective effect against CCl(4)-induced hepatotoxicity by the antioxidant mechanism of action...