Christof Niehrs

Summary

Publications

  1. doi request reprint The complex world of WNT receptor signalling
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Rev Mol Cell Biol 13:767-79. 2012
  2. doi request reprint Active DNA demethylation by Gadd45 and DNA repair
    Christof Niehrs
    Institute of Molecular Biology, 55128 Mainz, Germany
    Trends Cell Biol 22:220-7. 2012
  3. doi request reprint Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling
    Cristina Maria Cruciat
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Science 327:459-63. 2010
  4. doi request reprint Cell cycle control of wnt receptor activation
    Gary Davidson
    Division of Molecular Embryology, Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, 76344 Eggenstein Leopoldshafen, Germany
    Dev Cell 17:788-99. 2009
  5. ncbi request reprint An atlas of differential gene expression during early Xenopus embryogenesis
    Nicolas Pollet
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mech Dev 122:365-439. 2005
  6. ncbi request reprint Global gene expression profiling and cluster analysis in Xenopus laevis
    Danila Baldessari
    Division of Molecular Embryology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mech Dev 122:441-75. 2005
  7. pmc LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling
    Andrei Glinka
    Division of Molecular Embryology, DKFZ ZMBH Alliance, DKFZ, Im Neuenheimer Feld 580, Heidelberg D 69120, Germany
    EMBO Rep 12:1055-61. 2011
  8. pmc Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3
    Andrea Schäfer
    Institute of Molecular Biology, 55128 Mainz, Germany
    Genes Dev 27:261-73. 2013
  9. pmc Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos
    Emil Karaulanov
    Division of Molecular Embryology, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 4:e5742. 2009
  10. ncbi request reprint Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
    Gary Davidson
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 438:867-72. 2005

Collaborators

Detail Information

Publications55

  1. doi request reprint The complex world of WNT receptor signalling
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Rev Mol Cell Biol 13:767-79. 2012
    ..These are regulated both extracellularly by agonists such as R-spondin and intracellularly by post-translational modifications such as phosphorylation, proteolytic processing and endocytosis...
  2. doi request reprint Active DNA demethylation by Gadd45 and DNA repair
    Christof Niehrs
    Institute of Molecular Biology, 55128 Mainz, Germany
    Trends Cell Biol 22:220-7. 2012
    ..Gadd45 recruits nucleotide and/or base excision repair factors to gene-specific loci and acts as an adapter between repair factors and chromatin, thereby creating a nexus between epigenetics and DNA repair...
  3. doi request reprint Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling
    Cristina Maria Cruciat
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Science 327:459-63. 2010
    ..The results reveal an unsuspected role for the prorenin receptor, V-ATPase activity, and acidification during Wnt/beta-catenin signaling...
  4. doi request reprint Cell cycle control of wnt receptor activation
    Gary Davidson
    Division of Molecular Embryology, Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, 76344 Eggenstein Leopoldshafen, Germany
    Dev Cell 17:788-99. 2009
    ..G2/M priming of LRP6 by a Cyclin/CDK complex introduces an unexpected new layer of regulation of Wnt signaling...
  5. ncbi request reprint An atlas of differential gene expression during early Xenopus embryogenesis
    Nicolas Pollet
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mech Dev 122:365-439. 2005
    ..In conclusion, this study represents an atlas of gene expression patterns, which reveals embryonic regionalization, provides novel marker genes, and makes predictions about the functional role of unknown genes...
  6. ncbi request reprint Global gene expression profiling and cluster analysis in Xenopus laevis
    Danila Baldessari
    Division of Molecular Embryology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mech Dev 122:441-75. 2005
    ..The study provides insights into the higher order of vertebrate gene expression, identifies synexpression groups and marker genes, and makes predictions for the biological role of numerous uncharacterized genes...
  7. pmc LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling
    Andrei Glinka
    Division of Molecular Embryology, DKFZ ZMBH Alliance, DKFZ, Im Neuenheimer Feld 580, Heidelberg D 69120, Germany
    EMBO Rep 12:1055-61. 2011
    ..R-spondin-triggered β-catenin signalling requires Clathrin, while Wnt3a-mediated β-catenin signalling requires Caveolin-mediated endocytosis, suggesting that internalization has a mechanistic role in R-spondin signalling...
  8. pmc Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3
    Andrea Schäfer
    Institute of Molecular Biology, 55128 Mainz, Germany
    Genes Dev 27:261-73. 2013
    ..We show that reduced H3K4 methylation impairs recruitment of Gadd45a/Ing1 and gene-specific DNA demethylation. Our results indicate that histone methylation directs DNA demethylation...
  9. pmc Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos
    Emil Karaulanov
    Division of Molecular Embryology, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 4:e5742. 2009
    ..The results suggest that FLRT3, Unc5B and Rnd1 proteins interact to modulate cell adhesion in early Xenopus development...
  10. ncbi request reprint Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
    Gary Davidson
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 438:867-72. 2005
    ..Our results reveal an evolutionarily conserved mechanism that couples Wnt receptor activation to the cytoplasmic signal transduction apparatus...
  11. ncbi request reprint Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling
    Christine Hassler
    Department of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Development 134:4255-63. 2007
    ..Furthermore, Krm2 knockdown specifically reduces LRP6 protein levels in NC explants. The results indicate that in the absence of Dkks, Kremens activate Wnt/beta-catenin signaling through LRP6...
  12. pmc Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density
    Kristina Ellwanger
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mol Cell Biol 28:4875-82. 2008
    ..Our study provides the first genetic evidence for a functional interaction of Kremen proteins with Dkk1 as negative regulators of Wnt/beta-catenin signaling and reveals that Kremen proteins are not universally required for Dkk1 function...
  13. ncbi request reprint R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis
    Olga Kazanskaya
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Dev Cell 7:525-34. 2004
    ..In Xenopus embryos depleted of Rspo2, the muscle markers myoD and myf5 fail to be activated and later muscle development is impaired. Thus, Rspo2 functions in a positive feedback loop to stimulate the Wnt/beta-catenin cascade...
  14. ncbi request reprint Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
    Guillermo Barreto
    Division of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 445:671-5. 2007
    ..Active demethylation occurs by DNA repair and Gadd45a interacts with and requires the DNA repair endonuclease XPG. We conclude that Gadd45a relieves epigenetic gene silencing by promoting DNA repair, which erases methylation marks...
  15. pmc Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation
    Andrea Schäfer
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    PLoS ONE 5:e14060. 2010
    ..The results indicate that gemcitabine induces epigenetic gene silencing by inhibiting repair mediated DNA demethylation. Thus, gemcitabine can function epigenetically and provides a tool to manipulate DNA methylation...
  16. ncbi request reprint Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
    Josipa Bilic
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Science 316:1619-22. 2007
    ..We propose that Wnts induce coclustering of receptors and Dvl in LRP6-signalosomes, which in turn triggers LRP6 phosphorylation to promote Axin recruitment and beta-catenin stabilization...
  17. ncbi request reprint Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning
    Gary Davidson
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Development 129:5587-96. 2002
    ..The results indicate that Krm proteins function in a Wnt inhibition pathway regulating early AP patterning of the CNS...
  18. ncbi request reprint Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling
    Bingyu Mao
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Gene 302:179-83. 2003
    ..Finally, we show that interaction with Krm2 is mediated by the second cysteine-rich domain of Dkks. These results suggest that Krm2 can function as a switch that turns Dkk2 from an activator into an inhibitor of Wnt/lRP6 signaling...
  19. doi request reprint The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development
    Olga Kazanskaya
    Division of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Development 135:3655-64. 2008
    ..We show that vascular endothelial growth factor is an immediate early response gene and a mediator of R-spondin signaling. The results identify Rspo3 as a novel, evolutionarily conserved angiogenic factor in embryogenesis...
  20. doi request reprint Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis
    Bisei Ohkawara
    Division of Molecular Embryology, DKFZ ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, Germany
    Dev Cell 20:303-14. 2011
    ..We show that this internalization is essential for PCP signal transduction, suggesting that endocytosis of Wnt-receptor complexes is a key mechanism by which R-spondins promote Wnt signaling...
  21. doi request reprint RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling
    Cristina Maria Cruciat
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Science 339:1436-41. 2013
    ..The results also suggest that the kinase-stimulatory function extends to other DDX and CK1 members, opening fresh perspectives for one of the longest-studied protein kinase families...
  22. ncbi request reprint The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling
    Ralph T Böttcher
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nat Cell Biol 6:38-44. 2004
    ..The results indicate that XFLRT3 is a transmembrane modulator of FGF-MAP kinase signalling in vertebrates...
  23. ncbi request reprint Mitotic wnt signaling promotes protein stabilization and regulates cell size
    Sergio P Acebron
    DKFZ ZMBH Alliance, Division of Molecular Embryology, DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany Electronic address
    Mol Cell 54:663-74. 2014
    ..We propose that Wnt/STOP signaling slows down protein degradation as cells prepare to divide. ..
  24. ncbi request reprint RAB8B is required for activity and caveolar endocytosis of LRP6
    Kubilay Demir
    German Cancer Research Center DKFZ, Division of Signaling and Functional Genomics, Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim, 69120 Heidelberg, Germany
    Cell Rep 4:1224-34. 2013
    ..Our results implicate RAB8B as an essential evolutionary conserved component of Wnt/β-catenin signaling through regulation of LRP6 activity and endocytosis...
  25. ncbi request reprint The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition
    Cristina Maria Cruciat
    Department of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 281:12986-93. 2006
    ..The results indicate that Erlectin functions in N-glycan recognition in the endoplasmic reticulum, suggesting that it may regulate glycoprotein traffic...
  26. pmc Transcriptional regulation of BMP4 synexpression in transgenic Xenopus
    Emil Karaulanov
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, Germany
    EMBO J 23:844-56. 2004
    ..The results highlight that in vivo analysis is required to reveal the physiological, spatio-temporal regulation of BMP-responsive genes...
  27. ncbi request reprint Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1
    Christoph Hansis
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Curr Biol 14:1475-80. 2004
    ..Dissection of the molecular machinery using a simplified assay system may aid in achieving complete nuclear reprogramming of somatic cells for regenerative medicine...
  28. pmc Gadd45a is an RNA binding protein and is localized in nuclear speckles
    Yuliya A Sytnikova
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Krebsforschungszentrum, Heidelberg, Germany
    PLoS ONE 6:e14500. 2011
    ..Gadd45 proteins have sequence homology with the L7Ae/L30e/S12e RNA binding superfamily of ribosomal proteins, which raises the question if they may interact directly with nucleic acids...
  29. doi request reprint GADD45G functions in male sex determination by promoting p38 signaling and Sry expression
    Mathias S Gierl
    Institute of Molecular Biology, 55128 Mainz, Germany
    Dev Cell 23:1032-42. 2012
    ..The results suggest that a signaling cascade, involving GADD45G → p38 MAPK → GATA4 → SRY, regulates male sex determination...
  30. pmc Dkk1 and noggin cooperate in mammalian head induction
    Ivan del Barco Barrantes
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Genes Dev 17:2239-44. 2003
    ..The results provide genetic evidence for the dual inhibition model and indicate that dkk1 and noggin functionally cooperate in the head organizer...
  31. doi request reprint Gadd45a and Gadd45g regulate neural development and exit from pluripotency in Xenopus
    Lilian T Kaufmann
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, Heidelberg, Germany
    Mech Dev 128:401-11. 2011
    ..The results indicate that Gadd45ag are required for early embryonic cells to exit pluripotency and enter differentiation...
  32. ncbi request reprint Polarized Wnt signaling regulates ectodermal cell fate in Xenopus
    Ya Lin Huang
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
    Dev Cell 29:250-7. 2014
    ..We conclude that coordinated Wnt/PCP and Wnt/β-catenin signaling convert apicobasal polarity information to specify ectodermal cell fate. ..
  33. ncbi request reprint Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction
    Sonia Pinho
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Differentiation 75:957-67. 2007
    ..Furthermore, depletion of Dkk3 up-regulates FGF signaling, while Dkk3 overexpression reduces it. These results indicate that Dkk3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development...
  34. doi request reprint On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Development 137:845-57. 2010
    ....
  35. pmc Reliability of gene expression ratios for cDNA microarrays in multiconditional experiments with a reference design
    Rainer König
    Division of Theoretical Bioinformatics, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Nucleic Acids Res 32:e29. 2004
    ..Finally, we compared microarray-based gene expression profiles with the corresponding expression patterns obtained by whole-mount in situ hybridizations, resulting in a 90% correspondence...
  36. ncbi request reprint An ancient Wnt-Dickkopf antagonism in Hydra
    Corina Guder
    Molecular Evolution and Genomics, Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Development 133:901-11. 2006
    ..Based on the corresponding expression patterns of hydkk1/2/4 and neuronal genes, we suggest that the body column of Hydra is a neurogenic environment suppressing Wnt signalling and facilitating neurogenesis...
  37. ncbi request reprint Regionally specific induction by the Spemann-Mangold organizer
    Christof Niehrs
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Rev Genet 5:425-34. 2004
  38. ncbi request reprint Fibroblast growth factor signaling during early vertebrate development
    Ralph T Böttcher
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Endocr Rev 26:63-77. 2005
    ..We focus on FGF signaling during early embryonic processes in vertebrates, such as induction and patterning of the three germ layers as well as its function in the control of morphogenetic movements...
  39. doi request reprint Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline
    Désirée R M Seib
    Division of Molecular Neurobiology, DKFZ ZMBH Alliance, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cell Stem Cell 12:204-14. 2013
    ..Taken together, our findings show that upregulating Wnt signaling by reducing Dkk1 expression can counteract age-related decrease in neurogenesis and its associated cognitive decline...
  40. pmc Secreted and transmembrane wnt inhibitors and activators
    Cristina Maria Cruciat
    Division of Molecular Embryology, DKFZ ZMBH Alliance, DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cold Spring Harb Perspect Biol 5:a015081. 2013
    ..Here we discuss their interactions with Wnt ligands and Wnt receptors, their role in developmental processes, as well as their implication in disease...
  41. doi request reprint Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development
    Lilian T Kaufmann
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Gene Expr Patterns 11:465-70. 2011
    ..In summary, Gadd45 genes are expressed in evolutionary conserved, but also divergent domains, which predominantly encompass areas of cell differentiation, consistent with their established function in growth arrest and DNA demethylation...
  42. doi request reprint Regulation of Lrp6 phosphorylation
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, Heidelberg, Germany
    Cell Mol Life Sci 67:2551-62. 2010
    ....
  43. ncbi request reprint Norrin and frizzled; a new vein for the eye
    Christof Niehrs
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Dev Cell 6:453-4. 2004
    ..Though we become accustomed to novel components, the discovery of an unexpected Wnt receptor ligand, Norrin, is surprising even to the connoisseur...
  44. pmc A role for fibronectin-leucine-rich transmembrane cell-surface proteins in homotypic cell adhesion
    Emil E Karaulanov
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    EMBO Rep 7:283-90. 2006
    ..Therefore, FLRT-mediated FGF signal transduction and homotypic cell sorting can be molecularly uncoupled. The results indicate that FLRT proteins have a dual role, promoting FGF signalling and modulating homotypic cell adhesion...
  45. doi request reprint Trafficking, acidification, and growth factor signaling
    Christof Niehrs
    1German Cancer Research Center DKFZ, DKFZ Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH Alliance, Division of Molecular Embryology, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Sci Signal 3:pe26. 2010
    ..These findings raise new questions concerning the mechanism by which low pH promotes signal transduction and may open new possibilities for therapeutic intervention through the targeting of acidifying enzymes...
  46. doi request reprint An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos
    Bisei Ohkawara
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Dev Dyn 240:188-94. 2011
    ..We also mapped Wnt/PCP signaling in the early Xenopus embryo and find that it peaks in the dorso-vegetal region, paralleling Wnt/β-catenin signaling...
  47. ncbi request reprint Axis formation: redundancy rules
    Christof Niehrs
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Curr Biol 15:R391-3. 2005
    ..The role of BMP antagonists in the Spemann-Mangold organizer of vertebrate embryos is a controversial issue. A study using combined knock down of multiple antagonists finally reveals dramatic effects...
  48. ncbi request reprint Cyclic expression of esr9 gene in Xenopus presomitic mesoderm
    Yan Li
    Division of Molecular Embryology, Deutches Krebsforschungszentrum, Heidelberg, Germany
    Differentiation 71:83-9. 2003
    ..Thus, expression of esr9 and esr10 is an indicator of the segmentation clock in the amphibian embryo. This confirms the evolutionary conservation of a molecular pathway involved in vertebrate segmentation clock...
  49. doi request reprint Active DNA demethylation and DNA repair
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Differentiation 77:1-11. 2009
    ..Far from merely protecting genomic integrity from environmental insult, DNA repair is therefore at the heart of an epigenetic activation process...
  50. pmc Mitotic and mitogenic Wnt signalling
    Christof Niehrs
    Division of Molecular Embryology, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
    EMBO J 31:2705-13. 2012
    ..Here, we review the complex interplay between Wnt signalling and the cell cycle...
  51. doi request reprint Dialectics, systems biology and embryonic induction
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Differentiation 81:209-16. 2011
    ..The example highlights that despite its shortcomings, dialectics can be of heuristic value as a theory of systems biology...
  52. ncbi request reprint Wnt-Fzd Signaling Sensitizes Peripheral Sensory Neurons via Distinct Noncanonical Pathways
    Manuela Simonetti
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany Molecular Medicine Partnership Unit, Otto Meyerhof Center, Im Neuenheimer Feld, 69120 Heidelberg, Germany Electronic address
    Neuron 83:104-21. 2014
    ..Finally, this study provides proof-of-concept for a translational potential for Wnt3a-Frizzled3 signaling in alleviating disease-related pain hypersensitivity in cancer-associated pain in vivo. ..
  53. ncbi request reprint Secreted and transmembrane Wnt inhibitors and activators
    Cristina Maria Cruciat
    Division of Molecular Embryology, DKFZ ZMBH Alliance, DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cold Spring Harb Perspect Med 3:a015081. 2013
    ..Here we discuss their interactions with Wnt ligands and Wnt receptors, their role in developmental processes, as well as their implication in disease...
  54. ncbi request reprint Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
    Bingyu Mao
    Molecular Embryology Division, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 417:664-7. 2002
    ..The results indicate that Kremen1 and Kremen2 are components of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates...
  55. ncbi request reprint Wnt Signaling: Multivesicular Bodies Hold GSK3 Captive
    Christof Niehrs
    German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Division of Molecular Embryology, Im Neuenheimer Feld 581, Heidelberg, Germany Institute of Molecular Biology IMB, 55128 Mainz, Germany
    Cell 143:1044-6. 2010
    ..Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling...