C Nieder

Summary

Publications

  1. doi request reprint Use of the Graded Prognostic Assessment (GPA) score in patients with brain metastases from primary tumours not represented in the diagnosis-specific GPA studies
    C Nieder
    Department of Oncology and Palliative Medicine, Nordland Hospital, 8092, Bodø, Norway
    Strahlenther Onkol 188:692-5. 2012
  2. pmc Diagnosis-specific graded prognostic assessment score is valid in patients with brain metastases treated in routine clinical practice in two European countries
    Carsten Nieder
    Department of Oncology and Palliative Medicine, Nordland Hospital, Bodo, Norway
    Med Sci Monit 18:CR450-5. 2012
  3. pmc Leptomeningeal carcinomatosis from renal cell cancer: treatment attempt with radiation and sunitinib (case report)
    Astrid Dalhaug
    Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway
    World J Surg Oncol 8:36. 2010
  4. ncbi request reprint Combined modality treatment of glioblastoma multiforme: the role of temozolomide
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str 22, 81675 Munich, Germany
    Rev Recent Clin Trials 1:43-51. 2006
  5. pmc Integration of chemotherapy into current treatment strategies for brain metastases from solid tumors
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str, 22, 81675 Munich, Germany
    Radiat Oncol 1:19. 2006
  6. ncbi request reprint Evaluation of insulin-like growth factor-1 for prevention of radiation-induced spinal cord damage
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Growth Factors 23:15-8. 2005
  7. ncbi request reprint Radiotherapy and chemotherapy for myoepithelioma of the sellar region
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Germany
    Strahlenther Onkol 181:260-3. 2005
  8. ncbi request reprint Proposal of human spinal cord reirradiation dose based on collection of data from 40 patients
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    Int J Radiat Oncol Biol Phys 61:851-5. 2005
  9. ncbi request reprint Brain metastases in renal cell cancer: diagnostic and therapeutic aspects
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str 22, 81675 Munich, Germany
    Am J Clin Oncol 27:632-4. 2004
  10. pmc Prognostic indices for brain metastases--usefulness and challenges
    Carsten Nieder
    Medical Department, Division of Oncology, Nordland Hospital, 8092 Bodø, Norway
    Radiat Oncol 4:10. 2009

Detail Information

Publications97

  1. doi request reprint Use of the Graded Prognostic Assessment (GPA) score in patients with brain metastases from primary tumours not represented in the diagnosis-specific GPA studies
    C Nieder
    Department of Oncology and Palliative Medicine, Nordland Hospital, 8092, Bodø, Norway
    Strahlenther Onkol 188:692-5. 2012
    ..However, patients with unknown or rare primary tumours are not represented in this model. A pragmatic approach might be use of the first GPA version which is not limited to specific primary tumours...
  2. pmc Diagnosis-specific graded prognostic assessment score is valid in patients with brain metastases treated in routine clinical practice in two European countries
    Carsten Nieder
    Department of Oncology and Palliative Medicine, Nordland Hospital, Bodo, Norway
    Med Sci Monit 18:CR450-5. 2012
    ..The present multi-institutional analysis examined for the first time whether DS-GPA is a valid score in European patients managed in routine clinical practice...
  3. pmc Leptomeningeal carcinomatosis from renal cell cancer: treatment attempt with radiation and sunitinib (case report)
    Astrid Dalhaug
    Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway
    World J Surg Oncol 8:36. 2010
    ..The untreated lung metastases progressed very slowly during almost 3 years of observation. This case illustrates important issues around both biological behaviour and treatment approaches in metastatic renal cell cancer...
  4. ncbi request reprint Combined modality treatment of glioblastoma multiforme: the role of temozolomide
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str 22, 81675 Munich, Germany
    Rev Recent Clin Trials 1:43-51. 2006
    ..The optimum schedule of temozolomide administration and the influence of combinations with additional antineoplastic agents remains to be studied. Early results of clinical trials addressing these issues are presented...
  5. pmc Integration of chemotherapy into current treatment strategies for brain metastases from solid tumors
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str, 22, 81675 Munich, Germany
    Radiat Oncol 1:19. 2006
    ..A potential chemotherapy indication might exist as palliative option for patients who have progressive disease after radiotherapy...
  6. ncbi request reprint Evaluation of insulin-like growth factor-1 for prevention of radiation-induced spinal cord damage
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Growth Factors 23:15-8. 2005
    ....
  7. ncbi request reprint Radiotherapy and chemotherapy for myoepithelioma of the sellar region
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Germany
    Strahlenther Onkol 181:260-3. 2005
    ..Myoepithelioma might arise in the head and neck area, especially within the salivary glands. It is very uncommon as a primary intracranial tumor...
  8. ncbi request reprint Proposal of human spinal cord reirradiation dose based on collection of data from 40 patients
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    Int J Radiat Oncol Biol Phys 61:851-5. 2005
    ..However, prospective clinical studies are lacking. Therefore, a combined analysis of all published clinical data might provide a valuable basis for future trials...
  9. ncbi request reprint Brain metastases in renal cell cancer: diagnostic and therapeutic aspects
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str 22, 81675 Munich, Germany
    Am J Clin Oncol 27:632-4. 2004
    ..However, further work-up revealed abscesses from bronchopneumonia. Diagnostic and therapeutic aspects as well as potential pitfalls in the management of patients with brain metastases are discussed...
  10. pmc Prognostic indices for brain metastases--usefulness and challenges
    Carsten Nieder
    Medical Department, Division of Oncology, Nordland Hospital, 8092 Bodø, Norway
    Radiat Oncol 4:10. 2009
    ..e. between 1997 and 2008. In addition, other analyses of prognostic factors in groups of patients, which typically are underrepresented in large trials or databases, published in the same time period are reviewed...
  11. ncbi request reprint Radiotherapy for high-grade gliomas. Does altered fractionation improve the outcome?
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Germany
    Strahlenther Onkol 180:401-7. 2004
    ..e., application of more than one fraction per day, in high-grade gliomas. This review summarizes the results of trials published between January 1997 and June 2002...
  12. ncbi request reprint Response monitoring by positron emission tomography during radiotherapy of a squamous cell skin carcinoma
    Carsten Nieder
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universitat Munchen, Germany
    Onkologie 28:505-7. 2005
    ..Methods of biological response monitoring might be helpful in achieving a favorable therapeutic ratio...
  13. ncbi request reprint Acceleration of normal-tissue damage expression by early stimulation of cell proliferation in rat spinal cord
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    Strahlenther Onkol 182:680-4. 2006
    ..To examine experimental strategies for prevention of radiation-induced late spinal cord damage...
  14. ncbi request reprint Therapeutic options for recurrent high-grade glioma in adult patients: recent advances
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str 22, 81675 Munich, Germany
    Crit Rev Oncol Hematol 60:181-93. 2006
    ..Individual tailoring of such strategies based on molecular profiling is hoped to improve the outcome...
  15. ncbi request reprint Update of human spinal cord reirradiation tolerance based on additional data from 38 patients
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Int J Radiat Oncol Biol Phys 66:1446-9. 2006
    ..To update a combined analysis of all published clinical data...
  16. ncbi request reprint Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Anticancer Res 27:183-7. 2007
    ....
  17. ncbi request reprint Current status of angiogenesis inhibitors combined with radiation therapy
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Cancer Treat Rev 32:348-64. 2006
    ..Early results suggest that acute toxicity is acceptable, planned surgery after such treatment is feasible, and that further evaluation of such combined modality treatment is warranted...
  18. pmc Can prophylactic breast irradiation contribute to cardiac toxicity in patients with prostate cancer receiving androgen suppressing drugs?
    Carsten Nieder
    Radiation Oncology Unit, Nordlandssykehuset HF, 8092 Bodø, Norway
    Radiat Oncol 3:2. 2008
    ..Possible explanations were provided, however, they disregard the potential contribution of prophylactic radiotherapy to the mamillary regions (PMRT, prescribed to avoid gynecomastia)...
  19. ncbi request reprint Dose to the intracranial arteries in stereotactic and intensity-modulated radiotherapy for skull base tumors
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 64:1055-9. 2006
    ..To examine retrospectively the maximum dose to the large skull base/intracranial arteries in fractionated stereotactic radiotherapy (FSRT) and intensity-modulated radiotherapy (IMRT), because of the potential risk of perfusion disturbances...
  20. ncbi request reprint Treatment of unresectable glioblastoma multiforme
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany
    Anticancer Res 25:4605-10. 2005
    ..Recent data suggest that class prediction models, based on defined molecular profiles, and assessment of MGMT promoter methylation might contribute to improved patient stratification and decision making...
  21. ncbi request reprint Effects of insulin-like growth factor-1 (IGF-1) and amifostine in spinal cord reirradiation
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Germany
    Strahlenther Onkol 181:691-5. 2005
    ..Because of different modes of action, a follow-up study was undertaken to test the combined treatment...
  22. ncbi request reprint The role of pentoxifylline as a modifier of radiation therapy
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str 22, 81675 Munich, Germany
    Cancer Treat Rev 31:448-55. 2005
    ..It is therefore necessary to evaluate Ptx in larger clinical trials with less baseline variation and to improve the recording of long-term results...
  23. ncbi request reprint Radiotherapy-induced lung toxicity: risk factors and prevention strategies
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str 22, 81675 Munich, Germany
    Anticancer Res 23:4991-8. 2003
    ..This review summarizes translational research data as well as clinical strategies for response modification and prediction...
  24. ncbi request reprint Comparison of serum growth factors and tumor markers as prognostic factors for survival in non-small cell lung cancer
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str 22, 81675 Munich, Germany
    Anticancer Res 23:5117-23. 2003
    ..In virtually all large studies with multivariate analysis, their influence was higher than that of emerging factors...
  25. ncbi request reprint Cervical lymph node metastases from occult squamous cell carcinoma
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, TU Munich, Ismaninger Str 22, 81675 Munich, Germany
    Curr Treat Options Oncol 3:33-40. 2002
    ..A randomized trial to compare the therapeutic value of comprehensive versus volume-limited radiotherapy is being planned. No data were found to support the benefit of chemotherapy for the treatment of this disease...
  26. ncbi request reprint The challenge of p53 as prognostic and predictive factor in Hodgkin's or non-Hodgkin's lymphoma
    C Nieder
    Department of Radiation Oncology, Technical University Munich, Klinikum rechts der Isar, Germany
    Ann Hematol 80:2-8. 2001
    ..These studies should also be stratified according to histologic subtypes...
  27. ncbi request reprint Prognostic factors in brain metastases: should patients be selected for aggressive treatment according to recursive partitioning analysis (RPA) classes?
    C Nieder
    The Department of Radiotherapy, The Saarland University Hospital, Homburg Saar, Germany
    Int J Radiat Oncol Biol Phys 46:297-302. 2000
    ..Inclusion of time to non-CNS death as additional endpoint besides death from any cause might result in further valuable information, as survival limitation due to uncontrolled extracranial disease can be explored...
  28. ncbi request reprint [Biological prevention and/or therapy possibility of radiation myelopathy. A discussion of recent perspectives]
    C Nieder
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, USA
    Strahlenther Onkol 175:437-43. 1999
    ..This review discusses recent advances in basic research that alter the view on the pathogenesis of radiation myelopathy, possibly offering strategies for prevention and/or therapy...
  29. pmc Anaemia and thrombocytopenia in patients with prostate cancer and bone metastases
    Carsten Nieder
    Department of Internal Medicine Division of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway
    BMC Cancer 10:284. 2010
    ..The purpose of this study was to determine the incidence, risk factors and prognostic impact of anaemia and thrombocytopenia in patients with bone metastases (BM) from prostate cancer...
  30. ncbi request reprint Radiation myelopathy: new perspective on an old problem
    C Nieder
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Radiat Oncol Investig 7:193-203. 1999
    ..Rationally designed animal experiments pursuing such strategies could further elucidate the pathogenesis of radiation-induced CNS damage...
  31. ncbi request reprint Recursive partitioning analysis (RPA) class does not predict survival in patients with four or more brain metastases
    Carsten Nieder
    Department of Radiotherapy and Radiologic Oncology, Klinikum rechts der Isar, Technical University of Munich, Germany
    Strahlenther Onkol 179:16-20. 2003
    ..If up to three brain metastases are present, surgical resection or radiosurgery are currently being considered in case of favorable prognostic factors...
  32. ncbi request reprint Influence of differing radiotherapy strategies on treatment results in diffuse large-cell lymphoma: a review
    C Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str 22, Munich, Germany
    Cancer Treat Rev 29:11-9. 2003
    ..it appears prudent to resolve the open questions in prospective trials with careful documentation of side effects...
  33. pmc Presentation and outcome in cancer patients with extensive spread to the brain
    Carsten Nieder
    Department of Internal Medicine Division of Oncology and Palliative Medicine, Nordland Hospital, 8092 Bodø, Norway
    BMC Res Notes 2:247. 2009
    ..Controversy exists around the preferred management of patients with brain metastases and limited survival expectation, e.g. because of extensive brain involvement. Few studies have focused on this particular group of patients...
  34. ncbi request reprint Report of a male patient with brain metastases from breast cancer
    C Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    Breast 12:345-7. 2003
    ..When performance status is poor the survival of patients with brain metastases is very limited. Treatment recommendations are the same as those for female patients with brain metastases from breast cancer...
  35. ncbi request reprint Hyperfractionated and accelerated-hyperfractionated radiotherapy for glioblastoma multiforme
    C Nieder
    Department of Radiotherapy, University Hospital of Saarland, Homburg Saar, Germany
    Radiat Oncol Investig 7:36-41. 1999
    ..A short radiotherapy course might be appropriate for many patients with gbm who are not suitable for rather aggressive investigational therapies...
  36. ncbi request reprint Cervical lymph node metastases from occult squamous cell carcinoma: cut down a tree to get an apple?
    C Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, TU Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 50:727-33. 2001
    ....
  37. ncbi request reprint A palliative accelerated irradiation regimen for advanced non-small-cell lung cancer vs. conventionally fractionated 60 GY: results of a randomized equivalence study
    U Nestle
    Department of Radiotherapy, Saarland University Medical Center, Homburg Saar, Germany
    Int J Radiat Oncol Biol Phys 48:95-103. 2000
    ..Some physicians treat these patients palliatively, whereas others advocate more intensive treatment. To find out if there is a substantial difference in outcome between these approaches, we performed a randomized prospective study...
  38. ncbi request reprint 18F-deoxyglucose positron emission tomography (FDG-PET) for the planning of radiotherapy in lung cancer: high impact in patients with atelectasis
    U Nestle
    Department of Radiotherapy, Saarland University Medical Center Homburg Saar, Germany
    Int J Radiat Oncol Biol Phys 44:593-7. 1999
    ..This study analyzes the potential contribution of PET in radiotherapy planning for LC with special respect to tumor-associated atelectasis...
  39. doi request reprint Does overall treatment time impact on survival after whole-brain radiotherapy for brain metastases?
    C Nieder
    Department of Oncology and Palliative Medicine, Nordland Hospital, Bodo, Norway
    Clin Transl Oncol 13:885-8. 2011
    ..While survival might be largely independent from OTT, it should also be evaluated whether this parameter has any impact on quality of life and duration of palliation...
  40. doi request reprint Prediction of short survival in patients with brain metastases based on three different scores: a role for 'triple-negative' status?
    C Nieder
    Radiation Oncology Unit, Nordland Hospital, Bodø, Norway Institute of Clinical Medicine, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    Clin Oncol (R Coll Radiol) 22:65-9. 2010
    ..To evaluate models predicting short survival in patients with brain metastases treated with whole-brain radiotherapy (WBRT)...
  41. ncbi request reprint Stereotactic hypofractionated radiotherapy in stage I (T1-2 N0 M0) non-small-cell lung cancer (NSCLC)
    Frank B Zimmermann
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University, Munich, FRG
    Acta Oncol 45:796-801. 2006
    ..Hypofractionated SRT is safe even in elderly patients with stage I NSCLC and significantly reduced lung capacity. It leads to high local control rates and should be offered to patients not amenable for curative resection...
  42. ncbi request reprint Modulation of rodent spinal cord radiation tolerance by administration of platelet-derived growth factor
    Nicolaus H Andratschke
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 60:1257-63. 2004
    ..To examine the role of platelet-derived growth factor (PDGF) for ameliorating radiation myelopathy of the cervical spinal cord in a rodent model...
  43. ncbi request reprint Comparison of three different mediastinal radiotherapy techniques in female patients: Impact on heart sparing and dose to the breasts
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Radiother Oncol 82:301-7. 2007
    ..Especially in highly curable diseases such as lymphoma, long-term survivors might develop late cardiac damage and radiation-induced second cancer...
  44. ncbi request reprint Potential role of growth factors in diminishing radiation therapy neural tissue injury
    Nicolaus H Andratschke
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Semin Oncol 32:S67-70. 2005
    ..Additional investigation is required to define potentially clinically useful growth factor regimens in the clinic...
  45. doi request reprint Colorectal cancer metastatic to the brain: time trends in presentation and outcome
    Carsten Nieder
    Department of Internal Medicine, Division of Oncology and Palliative Medicine, Nordlandssykehuset HF, Bodø, Norway
    Oncology 76:369-74. 2009
    ..It was the aim of this study to compare differences in disease pattern, patient characteristics and survival in patient cohorts treated during different decades...
  46. doi request reprint Fractionated stereotactic radiotherapy in the treatment of pituitary adenomas
    C Kopp
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstr 22, 81675, Munich, Germany
    Strahlenther Onkol 189:932-7. 2013
    ..The purpose of this work was to evaluate tumor control and side effects associated with fractionated stereotactic radiotherapy (FSRT) in the management of residual or recurrent pituitary adenomas...
  47. ncbi request reprint Preclinical evaluation of erythropoietin administration in a model of radiation-induced kidney dysfunction
    Nicolaus Andratschke
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 64:1513-8. 2006
    ..To test whether the clinically available growth factor erythropoietin (EPO) influences radiation-induced normal-tissue damage in a model of kidney dysfunction...
  48. ncbi request reprint Disease presentation and outcome in very young patients with brain metastases from breast cancer
    Carsten Nieder
    Radiation Oncology Unit, Department of Internal Medicine, Nordlandssykehuset HF, Bodø, Norway
    Tumori 94:691-3. 2008
    ..Little information is available on disease presentation and treatment outcome in very young patients with brain metastases from breast cancer. Therefore, we evaluated our results in this group...
  49. ncbi request reprint Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy
    Anca L Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    Int J Radiat Oncol Biol Phys 63:511-9. 2005
    ..To develop a valid treatment strategy for recurrent high-grade gliomas using stereotactic hypofractionated reirradiation based on biologic imaging and temozolomide...
  50. doi request reprint Dose-escalated simultaneous integrated-boost treatment of prostate cancer patients via helical tomotherapy
    M Geier
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat Munchen, Ismaninger Str 22, 81675, Munchen, Germany
    Strahlenther Onkol 188:410-6. 2012
    ....
  51. ncbi request reprint The results of colorectal cancer treatment by p53 status: treatment-specific overview
    S Petersen
    Department of Experimental Radiation Oncology The University of Texas, M.D. Anderson Cancer Center, Houston, USA
    Dis Colon Rectum 44:322-33; discussion 333-4. 2001
    ..p53 wild-type, it is unlikely that p53 can be applied in a routine clinical setting alongside factors such as T stage, nodal status, and residual tumor, whose prognostic value is much stronger...
  52. doi request reprint Improvement, clinical course, and quality of life after palliative radiotherapy for recurrent glioblastoma
    Carsten Nieder
    Department of Internal Medicine Oncology and Radiation Oncology Units, Nordlandssykehuset HF, Bodø, Norway
    Am J Clin Oncol 31:300-5. 2008
    ..Salvage chemotherapy or targeted agents should be prospectively tested against re-irradiation alone...
  53. ncbi request reprint Disease presentation and treatment outcome in very young patients with brain metastases from lung cancer
    Carsten Nieder
    Radiation Oncology Unit, Nordlandssykehuset HF, Bodø, Norway
    Onkologie 31:305-8. 2008
    ..While elderly patients with brain metastases from lung cancer appear to have an unfavorable prognosis, little information is available on disease presentation and treatment outcome in very young patients...
  54. ncbi request reprint High-precision radiation therapy with integrated biological imaging and tumor monitoring: evolution of the Munich concept and future research options
    Anca L Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Germany
    Strahlenther Onkol 182:361-8. 2006
    ..To describe an emerging concept of high-precision radiotherapy, a modality characterized by adaptation to patient and organ movements, which might occur between fractions or even during radiation delivery...
  55. ncbi request reprint Evaluation of late neurologic adverse events in patients with brain metastases from non-small cell lung cancer
    Carsten Nieder
    Department of Internal Medicine Oncology, Radiation Oncology Unit, Nordlandssykehuset HF, Bodø, Norway
    Anticancer Res 27:1701-4. 2007
    ....
  56. ncbi request reprint Perspectives in the treatment of malignant gliomas in adults
    N Andratschke
    Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77025, USA
    Anticancer Res 21:3541-50. 2001
    ..This review discusses the available laboratory and clinical data as well as recent advances in our knowledge about prognostic and predictive factors and their implications for the design of future clinical trials...
  57. pmc Prognostic scores in brain metastases from breast cancer
    Carsten Nieder
    Radiation Oncology Unit, Nordlandssykehuset HF, Bodø, Norway
    BMC Cancer 9:105. 2009
    ..The available scores for patients with brain metastases have never been tested specifically in patients with primary breast cancer. It is therefore unknown which score is most appropriate for these patients...
  58. ncbi request reprint The role of postoperative radiotherapy after resection of a single brain metastasis. Combined analysis of 643 patients
    Carsten Nieder
    Radiation Oncology Unit, Department of Internal Medicine, Nordlandssykehuset HF, Bodø, Norway
    Strahlenther Onkol 183:576-80. 2007
    ....
  59. doi request reprint Resource utilization in patients with brain metastases managed with best supportive care, radiotherapy and/or surgical resection: a Markov analysis
    Carsten Nieder
    Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway
    Oncology 78:348-55. 2010
    ..In spite of the large number of patients and increasing financial pressure on health care budgets worldwide, limited data on resource utilization after diagnosis of brain metastases are available...
  60. ncbi request reprint [Experimental data for administration of insulin-like growth factor 1 (IGF-1) and basic fibroblast growth factor (bFGF) for prevention of radiation myelopathy]
    Carsten Nieder
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat, Klinikum rechts der Isar, Munchen
    Strahlenther Onkol 178:147-52. 2002
    ..Thus, we tested whether insulin-like growth factor-1 (IGF-1) and basic fibroblast growth factor (bFGF) alone or in combination modulate radiation tolerance of the rat cervical spinal cord...
  61. ncbi request reprint Radiation therapy plus angiogenesis inhibition with bevacizumab: rationale and initial experience
    Carsten Nieder
    Radiation Oncology Unit, Department of Internal Medicine and Skin Diseases, Nordlandssykehuset HF, 8092 Bodø, Norway
    Rev Recent Clin Trials 2:163-8. 2007
    ..Early results suggest that acute toxicity is acceptable, planned surgery after such treatment is feasible, and that further evaluation of such combined modality treatment is warranted...
  62. ncbi request reprint Validation of the graded prognostic assessment index for surgically treated patients with brain metastases
    Carsten Nieder
    Medical Department, Radiation Oncology Unit, Nordlandssykehuset HF, Bodø, Norway
    Anticancer Res 28:3015-7. 2008
    ..9, 9.8, 5.5, and 3.7 months, respectively (p<0.05). In conclusion, these results confirm the validity of the GPA index in a patient population that previously has not been assessed with this new tool...
  63. ncbi request reprint 11C-methionine PET improves the target volume delineation of meningiomas treated with stereotactic fractionated radiotherapy
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 66:339-44. 2006
    ..To evaluate the role of 11C-methionine positron emission tomography (MET-PET) in target volume delineation for meningiomas and to determine the interobserver variability...
  64. ncbi request reprint Prevention of radiation-induced central nervous system toxicity: a role for amifostine?
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str 22, 81765 Munich, Germany
    Anticancer Res 24:3803-9. 2004
    ..To review the role of amifostine (WR-2721) in ameliorating radiation-induced central nervous system (CNS) toxicity...
  65. doi request reprint Prognostic scores in patients with brain metastases from non-small cell lung cancer
    Carsten Nieder
    Radiation Oncology Unit, Department of Internal Medicine Oncology, Nordland Hospital, Bodø, Norway
    J Thorac Oncol 4:1337-41. 2009
    ..No comparison to the two NSCLC-specific scores has been made either. Hence, it remains unclear which score is most appropriate for these patients...
  66. ncbi request reprint The role of growth factors in central nervous system tumours
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str 22, 81675 Munich, Germany
    Anticancer Res 23:1681-6. 2003
    ..Some inhibitory agents have now entered clinical trials, mainly for recurrent gliomas. Early results are presented...
  67. ncbi request reprint Retreatment of the spinal cord with palliative radiotherapy
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 52:1288-92. 2002
    ..We conducted this retrospective review of patients whose spinal cord was irradiated twice to evaluate the outcome in terms of palliation and long-term side effects...
  68. doi request reprint Validation of the graded prognostic assessment index for patients with brain metastases
    Carsten Nieder
    Medical Department, Radiation Oncology Unit, Nordlandssykehuset HF, Bodø, Norway
    Acta Oncol 48:457-9. 2009
    ....
  69. ncbi request reprint Immunohistochemically detected p53 mutations in epithelial tumors and results of treatment with chemotherapy and radiotherapy. A treatment-specific overview of the clinical data
    Howard D Thames
    Department of Biomathematics, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Strahlenther Onkol 178:411-21. 2002
    ..The aim was to ascertain whether many hundreds of clinical reports over the last decade are consistent with the prediction of a poorer outcome in cancer patients with p53 abnormalities treated with cytotoxic drugs and radiation...
  70. doi request reprint Estimating need for palliative external beam radiotherapy in adult cancer patients
    Carsten Nieder
    Division of Hematology and Oncology, Department of Internal Medicine, Nordlandssykehuset HF Hospital, Bodø, Norway
    Int J Radiat Oncol Biol Phys 76:207-11. 2010
    ..The corresponding number for Norway was 95 (95% CI 93-98) in 2004. New data are lacking, although new systemic treatment options might alter this number...
  71. ncbi request reprint Analysis of long-term survivors of glioblastoma multiforme in a single institution with aggressive local retreatment protocol
    Carsten Nieder
    Radiation Oncology Unit, Nordlandssykehuset HF, 8092 Bodo, Norway
    Anticancer Res 27:2993-6. 2007
    ..Our institution has used an aggressive policy of local retreatment, including surgery and radiotherapy, at first relapse. Long-term survival (>2 years) after such an approach was evaluated...
  72. pmc Influence of different treatment techniques on radiation dose to the LAD coronary artery
    Carsten Nieder
    Radiation Oncology Unit, Nordlandssykehuset HF, 8092 Bodø, Norway
    Radiat Oncol 2:20. 2007
    ..Radiation-induced heart disease might be a serious complication in long-term cancer survivors...
  73. pmc Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation
    Carsten Nieder
    Radiation Oncology Unit, Nordlandssykehuset HF, 8092 Bodø, Norway
    Radiat Oncol 2:23. 2007
    ....
  74. ncbi request reprint Detrimental effects of an antibody directed against tumor necrosis factor alpha in experimental kidney irradiation
    Carsten Nieder
    Department of Internal Medicine Oncology, Radiation Oncology Unit, Nordlandssykehuset HF, Bodø, Norway
    Anticancer Res 27:2353-7. 2007
    ..These data suggest that administration of infliximab concomitant to radiotherapy causes profound alterations in the development of kidney dysfunction. Importantly, other radiation-related toxicities were similar across all groups...
  75. ncbi request reprint Prognostic models predicting survival of patients with brain metastases: integration of lactate dehydrogenase, albumin and extracranial organ involvement
    C Nieder
    Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway Institute of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway Electronic address
    Clin Oncol (R Coll Radiol) 26:447-52. 2014
    ..e. surrogates of disease extent, in survival prediction models for patients with brain metastases...
  76. doi request reprint Prediction of very short survival in patients with brain metastases from breast cancer
    C Nieder
    Radiation Oncology Unit, Nordlandssykehuset HF, 8092 Bodø, Norway
    Clin Oncol (R Coll Radiol) 20:337-9. 2008
    ..e. <2 months, who are unlikely to derive major benefit from whole brain radiotherapy. Our aim was to develop a more reliable model...
  77. doi request reprint Combined radio- and chemotherapy of brain tumours in adult patients
    C Nieder
    Radiation Oncology Unit, Nordland Hospital, Bodø, Norway
    Clin Oncol (R Coll Radiol) 21:515-24. 2009
    ..The challenges associated with brain tumour treatment remain formidable, but rationally designed clinical trials are gradually leading to improved outcomes...
  78. doi request reprint Is whole-brain radiotherapy effective and safe in elderly patients with brain metastases?
    Carsten Nieder
    Radiation Oncology Unit, Nordlandssykehuset HF, Bodø, Norway
    Oncology 72:326-9. 2007
    ..The outcome of whole-brain radiotherapy in elderly patients with brain metastases is not well documented. As the number of such patients is expected to increase, we evaluated our results...
  79. ncbi request reprint Extensive local and systemic therapy in extraneural metastasized glioblastoma multiforme
    Sabrina T Astner
    Department of Radiation Oncology, Technical University of Munich, Germany
    Anticancer Res 26:4917-20. 2006
    ..In conclusion, liver metastases of GBM can be effectively treated by chemotherapy. This case report suggests suitable substances which can be chosen according to clinical circumstances...
  80. ncbi request reprint Treatment of malignant gliomas: radiotherapy, chemotherapy and integration of new targeted agents
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str 22, 81675 Munich, Germany
    Expert Rev Neurother 4:691-703. 2004
    ..e., drugs, antibodies and antisense oligonucleotides) have now entered clinical trials, mainly for recurrent gliomas and a small number are being tested in combination with radiotherapy. Early results of such approaches are presented...
  81. ncbi request reprint Implications of IMT-SPECT for postoperative radiotherapy planning in patients with gliomas
    Anca Ligia Grosu
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Int J Radiat Oncol Biol Phys 54:842-54. 2002
    ..The goal of this study was to analyze the value of 123I-alpha-methyl-tyrosine-single photon emission CT (IMT-SPECT) in radiotherapy planning of patients with brain gliomas after surgical resection...
  82. ncbi request reprint A new prognostic score derived from phase I study participants with advanced solid tumours is also valid in patients with brain metastasis
    Carsten Nieder
    Radiation Oncology Unit, Department of Oncology and Palliative Medicine, Nordland Hospital, 8092 Bodø, Norway
    Anticancer Res 30:977-9. 2010
    ..Its performance should be evaluated in larger groups of patients and head to head comparisons of the established brain metastases scores with this new model should be made...
  83. ncbi request reprint L-(methyl-11C) methionine positron emission tomography for target delineation in resected high-grade gliomas before radiotherapy
    Anca Ligia Grosu
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 63:64-74. 2005
    ..The goal of this trial was to quantify the affect of MET-PET vs. with MRI in gross tumor volume definition for radiotherapy planning of high-grade gliomas...
  84. ncbi request reprint Simultaneous precise chemoradiation under inhalation anesthesia in an experimental mouse tumor model
    Markus Adam
    Radiotherapy Practice Weilheim, Röntgenstr 4, 82362 Weilheim, Germany
    Anticancer Res 25:2815-20. 2005
    ..p.) anesthesia. This is especially true for experiments where highly fractionated treatment schedules are used...
  85. ncbi request reprint Influence of whole-brain radiotherapy on remission of brain metastases
    Carsten Nieder
    J Clin Oncol 24:4037; author reply 4037-8. 2006
  86. ncbi request reprint Salvage radiotherapy in patients with PET-Positive residual non-Hodgkin's lymphoma after chemotherapy: in regard to Kahn et al. (Int J Radiat Oncol Biol Phys 2006;66:961-965)
    Carsten Nieder
    Int J Radiat Oncol Biol Phys 67:1278; author reply 1278. 2007
  87. ncbi request reprint Effects of radiotherapy and chemotherapy on sensory deficits from spinal cord damage
    Carsten Nieder
    Acta Oncol 44:412-4. 2005
  88. ncbi request reprint Treatment of newly diagnosed glioblastoma multiforme
    Carsten Nieder
    J Clin Oncol 20:3179-80; author reply 3181-2. 2002
  89. ncbi request reprint Necessity of identifying the patterns of failure after concurrent radiochemotherapy part of a combined modality approach in patients with stage III non-small cell lung cancer [Sakai et al., Lung Cancer 2004;43:195-201]
    Branislav Jeremic
    Lung Cancer 46:263-4. 2004
  90. ncbi request reprint [Evaluation of the toxicity of tirapazamine plus cisplatin in a mouse tumor model]
    Markus Adam
    Praxis für Strahlentherapie und Radioonkologie, Röntgenstrasse 4, 82362 Weilheim
    Strahlenther Onkol 182:231-9. 2006
    ..The authors evaluated the toxicity of TPZ in combination with cisplatin in a mouse tumor model. For this purpose, general toxicity was monitored and all inner organs were examined histologically...
  91. ncbi request reprint Glioma treatment, radionecrosis, and growth factors. In regard to Levin et al., IJROBP 2002;53:58-66
    Carsten Nieder
    Int J Radiat Oncol Biol Phys 55:849; author reply 849. 2003
  92. ncbi request reprint Tirapazamine plus cisplatin and irradiation in a mouse model: improved tumor control at the cost of increased toxicity
    Markus Adam
    Radiotherapy Practice Weilheim, Weilheim, Germany
    J Cancer Res Clin Oncol 134:137-46. 2008
    ..Tirapazamine (TPZ) reportedly enhances the tumor cell killing effect of cisplatin up to fivefold and it is an attractive drug for combination with radiotherapy. We evaluated the toxicity of a fractionated combined treatment...
  93. ncbi request reprint Does prophylactic breast irradiation in patients with prostate cancer influence cardiac toxicity?
    Carsten Nieder
    J Natl Cancer Inst 99:1646-7. 2007
  94. ncbi request reprint Radiation therapy alone as an alternative to surgery in patients with early stage non-small-cell lung cancer having cardiovascular (and other) comorbidity
    Branislav Jeremic
    Eur J Cardiothorac Surg 25:297. 2004
  95. ncbi request reprint Re-irradiation for recurrent head and neck cancer: in regard to Lee et Al. (Int j radiat oncol biol phys 2007;68:731-740)
    Carsten Nieder
    Int J Radiat Oncol Biol Phys 69:1652-3; author reply 1653. 2007
  96. ncbi request reprint What approach will lead to cure of glioblastoma multiforme? In regard to Barani et al. (Int J Radiat Oncol Biol Phys 2007;68:324-333) and Jones and Sanghera (Int J Radiat Oncol Biol Phys 2007;68:441-448)
    Carsten Nieder
    Int J Radiat Oncol Biol Phys 69:640-1; author reply 641. 2007
  97. ncbi request reprint Innovative prevention strategies for radiation necrosis of the central nervous system
    Carsten Nieder
    Department of Radiation Oncology, Technical University, Klinikum rechts der Isar, Munich, Germany
    Anticancer Res 22:1017-23. 2002
    ..The present pathogenetic model forms the basis of rational innovative prevention strategies, which are now being studied in vivo. They include treatment with growth factors as well as neural stem cell transplantation and neoangiogenesis...