Barbara J Nicklas

Summary

Publications

  1. doi request reprint Intervening on spontaneous physical activity to prevent weight regain in older adults: design of a randomized, clinical trial
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, United States
    Contemp Clin Trials 33:450-5. 2012
  2. pmc Chronic inflammation is associated with low physical function in older adults across multiple comorbidities
    Tina E Brinkley
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 64:455-61. 2009
  3. pmc Cardiometabolic risk after weight loss and subsequent weight regain in overweight and obese postmenopausal women
    Daniel P Beavers
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 68:691-8. 2013
  4. pmc Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Clin Nutr 89:1043-52. 2009
  5. pmc Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults
    John R Stehle
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1212-8. 2012
  6. pmc The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss
    M Kyla Shea
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 19:1636-46. 2011
  7. pmc The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study
    M Kyla Shea
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 65:519-25. 2010
  8. pmc Fat mass loss predicts gain in physical function with intentional weight loss in older adults
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 68:80-6. 2013
  9. pmc Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach
    Tina E Brinkley
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1099-106. 2012
  10. pmc Pericardial fat loss in postmenopausal women under conditions of equal energy deficit
    Tina E Brinkley
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Med Sci Sports Exerc 43:808-14. 2011

Detail Information

Publications40

  1. doi request reprint Intervening on spontaneous physical activity to prevent weight regain in older adults: design of a randomized, clinical trial
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, United States
    Contemp Clin Trials 33:450-5. 2012
    ....
  2. pmc Chronic inflammation is associated with low physical function in older adults across multiple comorbidities
    Tina E Brinkley
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 64:455-61. 2009
    ....
  3. pmc Cardiometabolic risk after weight loss and subsequent weight regain in overweight and obese postmenopausal women
    Daniel P Beavers
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 68:691-8. 2013
    ..The objective of this study was to determine how cardiometabolic risk factors change in the year following significant intentional weight loss in postmenopausal women, and if observed changes were affected by weight and fat regain...
  4. pmc Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Clin Nutr 89:1043-52. 2009
    ..Exercise intensity may affect the selective loss of abdominal adipose tissue...
  5. pmc Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults
    John R Stehle
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1212-8. 2012
    ..We hypothesized that markers of MT, soluble CD14 (sCD14) and lipopolysaccharide (LPS) binding protein (LBP), may be a source of chronic inflammation in older persons and be associated with poorer physical function...
  6. pmc The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss
    M Kyla Shea
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 19:1636-46. 2011
    ..Additional studies are needed to clarify the observed gender differences and evaluate how these changes in body composition influence functional status...
  7. pmc The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study
    M Kyla Shea
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 65:519-25. 2010
    ..Data from the Arthritis, Diet, and Activity Promotion Trial (ADAPT) were used to determine whether randomization to a weight reduction program was associated with total mortality in overweight/obese older adults...
  8. pmc Fat mass loss predicts gain in physical function with intentional weight loss in older adults
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 68:80-6. 2013
    ..The purpose of this study is to determine the independent associations between changes in fat and lean mass and changes in physical function in older, overweight, and obese adults undergoing intentional WL...
  9. pmc Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach
    Tina E Brinkley
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1099-106. 2012
    ..We used factor analysis to identify inflammatory factor(s) and examine their associations with adiposity in older adults at risk for disability...
  10. pmc Pericardial fat loss in postmenopausal women under conditions of equal energy deficit
    Tina E Brinkley
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Med Sci Sports Exerc 43:808-14. 2011
    ..Weight loss induced by caloric restriction (CR) or aerobic exercise can reduce pericardial fat, and these reductions may help improve cardiovascular health...
  11. pmc Weight regain is related to decreases in physical activity during weight loss
    Xuewen Wang
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Med Sci Sports Exerc 40:1781-8. 2008
    ..To examine whether adaptations in physical activity energy expenditure (PAEE) and resting metabolic rate (RMR) during weight loss were associated with future weight regain in overweight/obese, older women...
  12. pmc Resting energy expenditure changes with weight loss: racial differences
    Xuewen Wang
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 18:86-91. 2010
    ..254 for total, limb, and trunk, respectively; P < 0.05) independent of baseline REE in white women. Therefore, with weight loss, REE decreased in proportion to the amount of fat and lean mass lost in white, but not black, women...
  13. ncbi request reprint Physical function and its response to exercise: associations with cytokine gene variation in older adults with knee osteoarthritis
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 60:1292-8. 2005
    ....
  14. pmc Is lost lean mass from intentional weight loss recovered during weight regain in postmenopausal women?
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Clin Nutr 94:767-74. 2011
    ..Despite the well-known recidivism of obesity, surprisingly little is known about the composition of body weight during weight regain...
  15. pmc The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 68:617-23. 2013
    ..Metabolic syndrome (MetS) and functional limitation have been linked, but whether and how specific components of MetS and associated factors, such as inflammation, drive this relationship is unknown...
  16. pmc Exercise training and plasma C-reactive protein and interleukin-6 in elderly people
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 56:2045-52. 2008
    ..To determine the effects of a long-term exercise intervention on two prominent biomarkers of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)) in elderly men and women...
  17. pmc Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adults
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, J Paul Sticht Center on Aging, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 61:1089-94. 2013
    ..To determine the independent effect of long-term physical activity (PA) and the combined effects of long-term PA and weight loss (WL) on inflammation in overweight and obese older adults...
  18. ncbi request reprint Abdominal obesity is an independent risk factor for chronic heart failure in older people
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 54:413-20. 2006
    ..To examine whether total and abdominal adiposity are risk factors for the development of chronic heart failure (CHF) in older men and women...
  19. pmc Lean mass loss is associated with low protein intake during dietary-induced weight loss in postmenopausal women
    Melanie J Bopp
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, General Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Diet Assoc 108:1216-20. 2008
    ..Therefore, inadequate protein intake during caloric restriction may be associated with adverse body-composition changes in postmenopausal women...
  20. ncbi request reprint Knee strength maintained despite loss of lean body mass during weight loss in older obese adults with knee osteoarthritis
    Xuewen Wang
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 62:866-71. 2007
    ..The effects of weight loss on muscle function in older adults have not been well studied. This study determined the effects of a 6-month weight-loss intervention on muscle strength and quality in older obese adults with knee osteoarthritis...
  21. pmc Long-term physical activity and inflammatory biomarkers in older adults
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Med Sci Sports Exerc 42:2189-96. 2010
    ..The purpose of this study was to determine the effects of a 12-month physical activity (PA) intervention on inflammatory biomarkers in elderly men and women...
  22. pmc The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial
    M Kyla Shea
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 94:839-46. 2011
    ....
  23. ncbi request reprint Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke
    Jingzhong Ding
    Department of Internal Medicine Geriatrics, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Am Heart J 152:1109-15. 2006
    ..We investigated the association of polymorphisms and common haplotypes of the PAI-1 gene with plasma PAI-1 levels, as well as the risk of myocardial infarction and stroke...
  24. doi request reprint Weighty concerns: the growing prevalence of obesity among older adults
    Denise K Houston
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Am Diet Assoc 109:1886-95. 2009
    ....
  25. pmc Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    CMAJ 172:1199-209. 2005
    ....
  26. ncbi request reprint Chronic inflammation: role of adipose tissue and modulation by weight loss
    Tongjian You
    J Paul Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Diabetes Rev 2:29-37. 2006
    ..e. interleukin 10, interleukin 1 receptor antagonist). More studies are needed to investigate the role of regional adipose tissue cytokine production in regulation of inflammation and the modulating effects of weight loss...
  27. pmc Effects of lifestyle interventions on inflammatory markers in the metabolic syndrome
    Kristen M Beavers
    J Paul Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest, University School of Medicine, Winston Salem, North Carolina 27157, USA
    Front Biosci (Schol Ed) 3:168-77. 2011
    ..Data currently suggest that alterations in dietary composition may be the most effective lifestyle change, although there is a need for more research in this area...
  28. ncbi request reprint Heritability of body composition measured by DXA in the diabetes heart study
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Obes Res 13:312-9. 2005
    ..The purpose of this study was to investigate the heritability of body composition measured by DXA in the Diabetes Heart Study (DHS)...
  29. pmc Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study
    Tina E Brinkley
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Hypertension 53:846-52. 2009
    ..These data suggest that ox-LDL may be related to the pathogenesis of arterial stiffness...
  30. doi request reprint The effects of a long-term physical activity intervention on serum uric Acid in older adults at risk for physical disability
    Kristen M Beavers
    Dept of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC
    J Aging Phys Act 22:25-33. 2014
    ..028). Compared with a health education intervention, a 1-yr PA intervention results in a modest increase in systemic concentration of UA in older adults at risk for mobility disability. ..
  31. ncbi request reprint Effects of birth cohort and age on body composition in a sample of community-based elderly
    Jingzhong Ding
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Clin Nutr 85:405-10. 2007
    ..The effect of the recent obesity epidemic on body composition remains unknown. Furthermore, age-related changes in body composition are still unclear...
  32. pmc Exercise training as a treatment for chronic inflammation in the elderly
    Barbara J Nicklas
    J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Exerc Sport Sci Rev 37:165-70. 2009
    ..This article highlights emerging data suggesting that increasing physical activity could be effective for reducing chronic inflammation in the elderly...
  33. pmc Change in 25-hydroxyvitamin D and physical performance in older adults
    Denise K Houston
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1207, USA
    J Gerontol A Biol Sci Med Sci 66:430-6. 2011
    ....
  34. pmc Effect of exercise training on chronic inflammation
    Kristen M Beavers
    J Paul Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Clin Chim Acta 411:785-93. 2010
    ....
  35. pmc Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Aging Clin Exp Res 20:302-9. 2008
    ..The purpose of this study was to determine whether physical function is independently associated with histologic and metabolic properties of skeletal muscle in elderly adults...
  36. pmc Self-monitoring of spontaneous physical activity and sedentary behavior to prevent weight regain in older adults
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine J Paul Sticht Center on Aging Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA
    Obesity (Silver Spring) 22:1406-12. 2014
    ....
  37. doi request reprint The effects of a long-term physical activity intervention on serum uric acid in older adults at risk for physical disability
    Kristen M Beavers
    Dept of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC
    J Aging Phys Act 22:25-33. 2014
    ..028). Compared with a health education intervention, a 1-yr PA intervention results in a modest increase in systemic concentration of UA in older adults at risk for mobility disability. ..
  38. ncbi request reprint Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors
    Tongjian You
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Endocrinol Metab 288:E741-7. 2005
    ..26 +/- 0.46 vs. 3.31 +/- 0.33, P < 0.05). We conclude that abdominal subcutaneous adipose tissue expression of inflammatory cytokines is a potential mechanism linking obesity with its metabolic comorbidities...
  39. ncbi request reprint Inflammatory markers and physical function among older adults with knee osteoarthritis
    Brenda W J H Penninx
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Rheumatol 31:2027-31. 2004
    ..To investigate whether serum concentrations of various inflammatory markers are associated with physical function and disease severity among older obese adults with knee osteoarthritis (OA)...
  40. ncbi request reprint Angiotensin-converting enzyme insertion/deletion genotype, exercise, and physical decline
    Stephen B Kritchevsky
    The Sticht Center on Aging and Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    JAMA 294:691-8. 2005
    ....