Ferdinando Nicoletti



  1. Notartomaso S, Nakao H, Mascio G, Scarselli P, Cannella M, Zappulla C, et al. mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors. Sci Rep. 2018;8:13361 pubmed publisher
    ..These findings add complexity to the the finely tuned mechanisms that regulate PC biology during development and in the adult life and lay the groundwork for an in-depth analysis of the role played by mGlu5 receptors in PC maturation. ..
  2. Orlando R, Borro M, Motolese M, Molinaro G, Scaccianoce S, Caruso A, et al. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740. Neuropharmacology. 2014;86:133-44 pubmed publisher
  3. Truini A, Piroso S, Pasquale E, Notartomaso S, Di Stefano G, Lattanzi R, et al. N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans. Mol Pain. 2015;11:14 pubmed publisher
    ..These data lay the groundwork for investigating the therapeutic potential of NAC in patients with chronic pain. ..
  4. Busceti C, Di Pietro P, Riozzi B, Traficante A, Biagioni F, Nisticò R, et al. 5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacol Res. 2015;99:258-68 pubmed publisher
    ..Drugs that block 5-HT2C receptors might protect the hippocampus against the detrimental effect of environmental stressors. ..
  5. Motolese M, Mastroiacovo F, Cannella M, Bucci D, Gaglione A, Riozzi B, et al. Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage. Mol Brain. 2015;8:66 pubmed publisher
  6. Moyanova S, De Fusco A, Santolini I, Celli R, Bucci D, Mastroiacovo F, et al. Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats?. Int J Mol Sci. 2018;19: pubmed publisher
  7. Romano M, Di Menna L, Scarselli P, Mascio G, Madonna M, Notartomaso S, et al. Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina. Neurochem Res. 2016;41:924-32 pubmed publisher
    ..In addition, the mGlu1 receptor caters the potential as a drug target in the experimental treatment of degenerative disorders of the retina. ..
  8. Notartomaso S, Mascio G, Scarselli P, Martinello K, Fucile S, Gradini R, et al. Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors. Neuropharmacology. 2017;115:51-59 pubmed publisher
    ..This article is part of the Special Issue entitled 'Metabotropic Glutamate Receptors, 5 years on'. ..
  9. Iacovelli L, Di Menna L, Peterlik D, Stangl C, Orlando R, Molinaro G, et al. Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling. Neuropharmacology. 2017;113:343-353 pubmed publisher
    ..Our data demonstrate that α1-adrenergic and mGlu7 receptors functionally interact and suggest that this interaction might be targeted in the treatment of stress-related disorders. ..

More Information


  1. Gatta E, Lefebvre T, Gaetani S, Dos Santos M, Marrocco J, Mir A, et al. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacol Res. 2016;105:186-97 pubmed publisher
    ..These data demonstrate that an imbalance between tau phosphorylation and O-GlcNAcylation exists in AD mice, and strengthens the hypothesis that O-GlcNAcylation might be targeted by disease modifying drugs in AD. ..
  2. Nicoletti F. Shedding Light on Metabotropic Glutamate Receptors. Cell Chem Biol. 2016;23:887-8 pubmed publisher
    ..This compound is rapidly and reversibly inactivated by light and represents a powerful pharmacological tool for the study of mGlu4 receptors in their native environment. ..
  3. Mastroiacovo F, Moyanova S, Cannella M, Gaglione A, Verhaeghe R, Bozza G, et al. Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia. Mol Brain. 2017;10:39 pubmed publisher
    ..These findings support the hypothesis that activation of mGlu2 receptors is detrimental in the post-ischemic phase, and support the use of mGlu2 receptor antagonists in the experimental treatment of brain ischemia. ..
  4. Liberatore F, Bucci D, Mascio G, Madonna M, Di Pietro P, Beneventano M, et al. Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017;363:142-149 pubmed publisher
    ..These findings demonstrate that mGlu1 receptors play a key role in excitotoxic degeneration of RGCs, and encourage the study of mGlu1 receptor NAMs in models of retinal neurodegeneration. ..
  5. Di Menna L, Joffe M, Iacovelli L, Orlando R, Lindsley C, Mairesse J, et al. Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system. Neuropharmacology. 2018;128:301-313 pubmed publisher
    ..These findings shed new light into the complex role played by mGlu receptors in physiology and pathology, and suggest reconsideration of some of the current dogmas in the mGlu receptor field. ..
  6. Battaglia G, Riozzi B, Bucci D, Di Menna L, Molinaro G, Pallottino S, et al. Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis. Neurobiol Dis. 2015;74:126-36 pubmed publisher
    ..LY379268 had no significant effect on the mortality rate of SODG93A. These findings encourage the development of selective mGlu3 receptor agonists/enhancers as neuroprotective agents in ALS. ..
  7. Nicoletti F, Bruno V, Ngomba R, Gradini R, Battaglia G. Metabotropic glutamate receptors as drug targets: what's new?. Curr Opin Pharmacol. 2015;20:89-94 pubmed publisher
    ..In addition, the increasing availability of pharmacological tools may push mGlu7 and mGlu8 receptors into the clinical scenario. After almost 30 years from their discovery, mGlu receptors are still alive. ..