Notartomaso S, Nakao H, Mascio G, Scarselli P, Cannella M, Zappulla C, et al
. mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors. Sci Rep. 2018;8:13361 pubmed publisher
..These findings add complexity to the the finely tuned mechanisms that regulate PC biology during development and in the adult life and lay the groundwork for an in-depth analysis of the role played by mGlu5 receptors in PC maturation. ..
Orlando R, Borro M, Motolese M, Molinaro G, Scaccianoce S, Caruso A, et al
. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740. Neuropharmacology. 2014;86:133-44 pubmed publisher
Truini A, Piroso S, Pasquale E, Notartomaso S, Di Stefano G, Lattanzi R, et al
. N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans. Mol Pain. 2015;11:14 pubmed publisher
..These data lay the groundwork for investigating the therapeutic potential of NAC in patients with chronic pain. ..
Busceti C, Di Pietro P, Riozzi B, Traficante A, Biagioni F, NisticÃ² R, et al
. 5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacol Res. 2015;99:258-68 pubmed publisher
..Drugs that block 5-HT2C receptors might protect the hippocampus against the detrimental effect of environmental stressors. ..
Motolese M, Mastroiacovo F, Cannella M, Bucci D, Gaglione A, Riozzi B, et al
. Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage. Mol Brain. 2015;8:66 pubmed publisher
Moyanova S, De Fusco A, Santolini I, Celli R, Bucci D, Mastroiacovo F, et al
. Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats?. Int J Mol Sci. 2018;19: pubmed publisher
Romano M, Di Menna L, Scarselli P, Mascio G, Madonna M, Notartomaso S, et al
. Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina. Neurochem Res. 2016;41:924-32 pubmed publisher
..In addition, the mGlu1 receptor caters the potential as a drug target in the experimental treatment of degenerative disorders of the retina. ..
Notartomaso S, Mascio G, Scarselli P, Martinello K, Fucile S, Gradini R, et al
. Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors. Neuropharmacology. 2017;115:51-59 pubmed publisher
..This article is part of the Special Issue entitled 'Metabotropic Glutamate Receptors, 5 years on'. ..
Iacovelli L, Di Menna L, Peterlik D, Stangl C, Orlando R, Molinaro G, et al
. Type-7 metabotropic glutamate receptors negatively regulate Î±1-adrenergic receptor signalling. Neuropharmacology. 2017;113:343-353 pubmed publisher
..Our data demonstrate that Î±1-adrenergic and mGlu7 receptors functionally interact and suggest that this interaction might be targeted in the treatment of stress-related disorders. ..