Efficacy of combined radiation, paclitaxel and carboplatin for locally advanced non-small cell lung carcinomaNam P Nguyen
Department of Radiation Oncology, Southwestern University, VA North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA
Anticancer Res 22:3429-35. 2002
..The decrease of tumor volume following induction chemotherapy allows sparing of the lungs from the toxicity of radiation. However, grades 3-4 esophagitis remain significant. The addition of amifostine may be beneficial in this setting...
Analysis of the factors influencing dysphagia severity upon diagnosis of head and neck cancerN P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
Br J Radiol 81:706-10. 2008
..Patients with oral cavity tumours appear to be less at risk of dysphagia than those with tumours in different anatomic locations. The role of age and co-morbidity factors should be investigated in future prospective studies...
- Single versus customized treatment planning for image-guided high-dose-rate brachytherapy for cervical cancer: dosimetric comparison and predicting factor for organs at risk overdose with single plan approach
Alexander Chi
Department of Radiation Oncology, Loyola University Medical Center, Maywood, IL 60153, USA
Int J Radiat Oncol Biol Phys 75:309-14. 2009
..To compare the dose distribution between customized planning (CP) and adopting a single plan (SP) in multifractionated high-dose-rate brachytherapy and to establish predictors for the necessity of CP in a given patient...
Feasibility of Tomotherapy-based image-guided radiotherapy to reduce aspiration risk in patients with non-laryngeal and non-pharyngeal head and neck cancerNam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, Arizona, United States of America
PLoS ONE 8:e56290. 2013
..Mean middle and inferior pharyngeal dose was recorded and correlated with the MBS results to determine aspiration risk...
- Feasibility of tomotherapy to reduce cochlea radiation dose in patients with locally advanced nasopharyngeal cancer
Nam P Nguyen
Radiation Oncology, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724 5081, USA
Tumori 98:709-14. 2012
..To evaluate the effectiveness of tomotherapy-based image-guided radiotherapy (IGRT) on the radiation dose to the cochlea in patients with nasopharyngeal cancer...
- Effectiveness of prophylactic retropharyngeal lymph node irradiation in patients with locally advanced head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, USA
BMC Cancer 12:253. 2012
..The aim of the study is to assess the effectiveness of intensity-modulated radiotherapy (IMRT) or image-guided radiotherapy (IGRT) for the prevention of retropharyngeal nodal recurrences in locally advanced head and neck cancer...
- Feasibility of intensity-modulated and image-guided radiotherapy for functional organ preservation in locally advanced laryngeal cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, Arizona, USA
PLoS ONE 7:e42729. 2012
..Loco-regional control, speech quality and feeding-tube dependency were assessed during follow-up visits...
- Impact of intensity-modulated and image-guided radiotherapy on elderly patients undergoing chemoradiation for locally advanced head and neck cancer
N P Nguyen
Department of Radiation Oncology, University of Arizona, 1501 N Campbell Ave, 85724 5081, Tucson, AZ, USA
Strahlenther Onkol 188:677-83. 2012
..In this work, the treatment tolerance of elderly patients (≥70 years) undergoing intensity-modulated radiotherapy (IMRT) and image-guided radiotherapy (IGRT) and chemotherapy for locally advanced head and neck cancer was assessed...
- Effectiveness of intensity-modulated and image-guided radiotherapy to spare the mandible from excessive radiation
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ, United States
Oral Oncol 48:653-7. 2012
..Sharp dose falloff associated with IMRT and IGRT decreased excessive radiation of the mandible and may reduce the risks of osteoradionecrosis...
- Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724, USA
BMC Cancer 12:175. 2012
..To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases...
- Analysis of factors influencing aspiration risk following chemoradiation for oropharyngeal cancer
N P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
Br J Radiol 82:675-80. 2009
..Patients with large tumours had a significant risk of developing aspiration following treatment...
- Safety and effectiveness of vascular endoprosthesis for malignant superior vena cava syndrome
N P Nguyen
Department of Radiation Oncology, University of Arizona, N Campbell Ave, PO Box 245081, Tucson, AZ 85724 5081, USA
Thorax 64:174-8. 2009
..This review examines findings from the published series which used endovascular prosthesis for this syndrome with regards to efficacy and safety...
- Risk of aspiration following radiation for non-nasopharyngeal head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
J Otolaryngol Head Neck Surg 37:225-9. 2008
..We assessed the rate of aspiration following radiation for non-nasopharyngeal head and neck cancer...
- Pattern of failure following chemoradiation for locally advanced non-small cell lung cancer: potential role for stereotactic body radiotherapy
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724 5081, USA
Anticancer Res 30:953-61. 2010
..The current radiation dose appears insufficient to reliably establish local control. Stereotactic body radiotherapy may allow radiation dose escalation and should be tested in future clinical trials...
- Prevalence of pharyngeal and esophageal stenosis following radiation for head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
J Otolaryngol Head Neck Surg 37:219-24. 2008
..To evaluate the risk and outcome of pharyngoesophageal stenosis in patients who complained of dysphagia following radiation for head and neck cancer...
- Impact of tumor board recommendations on treatment outcome for locally advanced head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, Arizona 85724 5081, USA
Oncology 75:186-91. 2008
..To identify physician selection factors in the treatment of locally advanced head and neck cancer and how treatment outcome is affected by Tumor Board recommendations...
- Can stereotactic fractionated radiation therapy become the standard of care for early stage non-small cell lung carcinoma
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ, USA
Cancer Treat Rev 34:719-27. 2008
..Stereotactic body radiation therapy may become standard of care for operable early stages non-small cell lung cancer...
- Long-term aspiration following treatment for head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, Arizona 85724 5081, USA
Oncology 74:25-30. 2008
..We would like to assess the prevalence of aspiration in patients with long-term persistence of dysphagia (1 year or more) following treatment for head and neck cancer and to identify potential risk factors of aspiration...
- Analysis of factors influencing Dysphagia severity following treatment of head and neck cancer
Nam P Nguyen
Radiation Oncology Department, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724 5081, USA
Anticancer Res 29:3299-304. 2009
..MBS is a useful tool to monitor dysphagia severity and to identify aspiration risk. Stages of disease and treatment modality do not seem to impact on the course of dysphagia...
- Human papillomavirus-associated oropharyngeal cancer: a new clinical entity
N P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
QJM 103:229-36. 2010
..A history of oral sex should be elicited in young patients with enlarged neck nodes and/or tonsillar masses...
- Impact of image-guided radiotherapy to reduce laryngeal edema following treatment for non-laryngeal and non-hypopharyngeal head and neck cancers
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, United States
Oral Oncol 47:900-4. 2011
..IGRT results in low rates and low severity of laryngeal edema following treatment for non-laryngeal and non-hypopharyngeal head and neck cancers and may preserve voice quality...
- Feasibility of tomotherapy for Graves' ophthalmopathy: Dosimetry comparison with conventional radiotherapy
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA
Strahlenther Onkol 187:568-74. 2011
..To compare the dosimetry of tomotherapy and the conventional half-beam technique (HBT) or non-split beam technique (NSBT) for target coverage and radiation dose to the lacrimal glands and lens...
- Feasibility of Tomotherapy to spare the cochlea from excessive radiation in head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
Oral Oncol 47:414-9. 2011
..Helical Tomotherapy for head and neck cancer may significantly decrease radiation dose to the cochlea without sacrificing target volume coverage...
- Effectiveness of image-guided radiotherapy for locally advanced rectal cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA
Ann Surg Oncol 18:380-5. 2011
..We have assessed the effectiveness of IGRT for locally advanced rectal cancer...
- Importance of age as a prognostic factor for tonsillar carcinoma
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA
Ann Surg Oncol 17:2570-7. 2010
..We would like to evaluate the prognostic significance of young age (defined as 50 years old or less) for tonsillar carcinoma because of its association with HPV 16 virus infection...
- Molecular biology of breast cancer stem cells: potential clinical applications
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, N Campbell Ave, Tucson, AZ 85724 5081, USA
Cancer Treat Rev 36:485-91. 2010
..Future clinical trials for breast cancer should include anti-cancer stem cells targeting agents in addition to conventional chemotherapy. Hypofractionation radiotherapy may be indicated for residual disease post chemotherapy...
- Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
Oral Oncol 46:283-6. 2010
..0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes...
- Altered glucose metabolism during chemoradiation for head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
Anticancer Res 29:4683-7. 2009
..The aim of the present study was to determine whether the administration of chemoradiation for head and neck carcinoma alters glucose metabolism during and after treatment...
- Dysphagia severity and aspiration following postoperative radiation for locally advanced oropharyngeal cancer
Nam P Nguyen
Department Radiation Oncology, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724 5081, USA
Anticancer Res 28:431-4. 2008
..The aim of the present study was to assess dysphagia severity following postoperative radiation for locally advanced oropharyngeal cancer...
- Effectiveness of the cough reflex in patients with aspiration following radiation for head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, 1501 N Campbell Avenue, P O Box 245081, Tucson, Arizona 85724, USA
Lung 185:243-8. 2007
..The cough reflex was frequently ineffective or absent in patients who aspirated following radiation for head and neck cancer. Cough may also be intermittently ineffective to protect the airways following radiation...
- Aspiration occurence during chemoradiation for head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
Anticancer Res 27:1669-72. 2007
..To assess the risk of developing aspiration during chemoradiation for head and neck cancer...
- Aspiration rate following chemoradiation for head and neck cancer: an underreported occurrence
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75216, USA
Radiother Oncol 80:302-6. 2006
..We would like to assess the prevalence of aspiration before and following chemoradiation for head and neck cancer...
- Evaluation and management of swallowing dysfunction following chemoradiation for head and neck cancer
Nam P Nguyen
Radiation Oncology Department, University of Arizona, Tucson, Arizona 85724, USA
Curr Opin Otolaryngol Head Neck Surg 15:130-3. 2007
..We review the prevalence of post-treatment swallowing dysfunction, describe current thinking about its pathogenesis and management, and signal possible directions for future research...
- Safety and effectiveness of prophylactic gastrostomy tubes for head and neck cancer patients undergoing chemoradiation
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, 101 N Campbell Avenue, P O Box 45081 Tucson, AZ 85724 508, USA
Surg Oncol 15:199-203. 2006
..We would like to assess the safety and effectiveness of prophylactic percutaneous endoscopic gastrostomy (PEG) tube feedings during concurrent chemoradiation for head and neck cancer...
- Impact of swallowing therapy on aspiration rate following treatment for locally advanced head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, VA North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA
Oral Oncol 43:352-7. 2007
..However, a significant number of patients still suffered from chronic severe aspiration. New strategies must be devised to improve their outcome...
- Aspiration rate following nonsurgical therapy for laryngeal cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85124 5081, USA
ORL J Otorhinolaryngol Relat Spec 69:116-20. 2007
..Diagnostic studies such as modified barium swallow should be part of future laryngeal cancer prospective studies to assess the prevalence of aspiration as it may be silent...
- Feasibility of image-guided radiotherapy based on tomotherapy for the treatment of locally advanced anal carcinoma
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724 5081, USA
Anticancer Res 31:4393-6. 2011
..The feasibility of new radiotherapy techniques such as image-guided radiotherapy (IGRT) in combination with chemotherapy for the treatment of this malignancy was assessed...
- Feasibility of tomotherapy to reduce normal lung and cardiac toxicity for distal esophageal cancer compared to three-dimensional radiotherapy
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, USA
Radiother Oncol 101:438-42. 2011
..To compare the effectiveness of tomotherapy and three-dimensional (3D) conformal radiotherapy to spare normal critical structures (spinal cord, lungs, and ventricles) from excessive radiation in patients with distal esophageal cancers...
- Dysphagia following chemoradiation for locally advanced head and neck cancer
N P Nguyen
Radiation Oncology, VA North Texas Health Care System, Dallas 75216, USA
Ann Oncol 15:383-8. 2004
..To assess the prevalence, severity and morbidity of dysphagia following concurrent chemoradiation for head and neck cancer...
- Interferon-alpha combined with radiotherapy in the treatment of unresectable melanoma
N P Nguyen
Department of Radiation Oncology, Southwestern University, Dallas, Texas, USA
Cancer Invest 19:261-5. 2001
..Possible mechanisms of potentiation between interferon and radiation are discussed. The unexpected result in this case report raises interesting questions about this treatment combination...
- Aspiration risk and postoperative radiation for head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Arizona, Tucson, Arizona 85724 5081, USA
Cancer Invest 27:47-51. 2009
..Nineteen percent (7/37) of the patients developed aspiration (grade 5-7). Aspiration is life-threatening and may develop for all tumor sites and stages...
- Concurrent interferon-alpha and radiation for head and neck melanoma
N P Nguyen
Department of Radiation Oncology and Division of Hematology Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
Melanoma Res 13:67-71. 2003
..The combination of IFNalpha with radiation is considered feasible in terms of outcome and should be investigated with a larger cohort of patients. Toxicity is significant, and the addition of radioprotectors could be desirable...
- Prognosis for papillary serous carcinoma of the endometrium after surgical staging
N P Nguyen
Department of Radiation Oncology, Southwestern University, Dallas, Texas 75216, USA
Int J Gynecol Cancer 11:305-11. 2001
..To investigate the pattern of failure and the prognosis following pathological staging for uterine papillary serous carcinoma (UPSC)...
- Neuroblastoma producing spinal cord compression: rapid relief with low dose of radiation
N P Nguyen
Department of Radiation Oncology, Southwestern University School of Medicine, VA North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA
Anticancer Res 20:4687-90. 2000
..We describe a successful decompression by low dose radiation to a progressing neuroblastoma in a child. Magnetic resonance imaging post radiation should be performed to assess the response of the tumor to radiation...
- Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: clinical implications
Alexander Chi
Department of Radiation Oncology, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA
Radiother Oncol 94:1-11. 2010
..To analyze the patterns of failure, the toxicity profile, and the factors influencing efficacy of stereotactic body radiation (SBRT) for early-stage non-small-cell lung cancer (NSCLC)...
- Preoperative chemotherapy and radiation for advanced esophageal carcinoma: comparison between once a day radiation and hyperfractionation, a single-institution experience
Nam P Nguyen
Department of Radiation Oncology, Southwestern University, Dallas, Texas, U.S.A
Am J Clin Oncol 25:358-64. 2002
..Both radiation therapy fractionation schedules are comparable in efficacy and toxicity. Further investigations should be done to assess whether ethnicity may play a role in the prognosis of esophageal carcinoma...
- Concurrent chemoradiation for locally advanced oropharyngeal cancer
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Am J Otolaryngol 28:3-8. 2007
..The aim of this study was to assess the survival, pattern of failure, morbidity, and prognostic factors of concurrent chemoradiation for locally advanced oropharyngeal cancer...
- Dysphagia severity following chemoradiation and postoperative radiation for head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, VA North Texas Health Care System, Radiation Oncology Service 140, 4500 S, Lancaster Road, Dallas, TX 72516, United States
Eur J Radiol 59:453-9. 2006
..The purpose of the study is to evaluate dysphagia severity following chemoradiation and postoperative radiation for head and neck cancer, and particularly the aspiration risk because of its potential life-threatening consequence...
- Evolution of chronic dysphagia following treatment for head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Radiation Oncology Service, VA North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA
Oral Oncol 42:374-80. 2006
..Patients with chronic dysphagia are at risk of malnutrition, and aspiration. Management of chronic dysphagia requires a team approach with nutritional support, psychological counseling, dilation, and tube feedings when indicated...
- Severity and duration of chronic dysphagia following treatment for head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75216, USA
Anticancer Res 25:2929-34. 2005
..Excessive scarring following treatment may be responsible for the persistence and severity of dysphagia. Physicians should be aware of the long-term effects of dysphagia on patient nutrition and psychological well-being...
- The risk of venous thromboembolic disease in patients with monoclonal gammopathy of undetermined significance
S Sallah
Thrombosis and Hemostasis Program and Feist Weiller Cancer, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA
Ann Oncol 15:1490-4. 2004
..However, information on the occurrence of VTD in a related disorder, benign monoclonal gammopathy of undetermined significance (MGUS), is limited...
- Amifostine and curative intent chemoradiation for compromised cancer patients
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, VA North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA
Anticancer Res 23:1649-56. 2003
..All patients achieved improved quality of life. Successful chemoradiation appears to be feasible in patients with advanced stage, age and/or underlying medical conditions when amifostine is integrated in the treatment...
- Recombinant activated factor VII in patients with cancer and hemorrhagic disseminated intravascular coagulation
Sabah Sallah
Thrombosis and Hemostasis Program and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103, USA
Blood Coagul Fibrinolysis 15:577-82. 2004
..Our data provide evidence that rFVIIa can be used successfully to control the hemorrhagic episodes associated with DIC. Although this type of treatment appears to be safe, close monitoring of the patients is warranted...
- Quality of life following chemoradiation and postoperative radiation for locally advanced head and neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
ORL J Otorhinolaryngol Relat Spec 69:271-6. 2007
..To evaluate the impact of chemoradiation and postoperative radiation on patients' quality of life (QOL) in a single institution...
- Impact of dysphagia on quality of life after treatment of head-and-neck cancer
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, and VA North Texas Health Care System, S Lancaster Road, Dallas, TX 75216, USA
Int J Radiat Oncol Biol Phys 61:772-8. 2005
..To evaluate the quality of life (QOL) associated with dysphagia after head-and-neck cancer treatment...
- Technical aspects of the integration of three-dimensional treatment planning dose parameters (GEC-ESTRO Working Group) into pre-implant planning for LDR gynecological interstitial brachytherapy
A Chi
Department of Radiation Oncology, Loyola University Medical Center, Maywood, IL 60153, USA
Technol Cancer Res Treat 8:181-6. 2009
..In the process, this pre-implant technique also demonstrates a good approximation of the target volume dose coverage, and doses to the OARs...
- Combined chemotherapy and radiation therapy for head and neck malignancies: quality of life issues
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
Cancer 94:1131-41. 2002
....
- Current concepts in radiation enteritis and implications for future clinical trials
Nam P Nguyen
Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 75216, USA
Cancer 95:1151-63. 2002
..New treatment modalities may be devised to improve the outcome of patients who are affected with this complication...
- Venous thrombosis in patients with solid tumors: determination of frequency and characteristics
Sabah Sallah
Division of Hematology Oncology, University of Tennessee Health Science Center, Memphis 38103, USA
Thromb Haemost 87:575-9. 2002
..Also, we evaluated the impact of VTD on the survival of these patients...
- Plasma coagulation markers in patients with solid tumors and venous thromboembolic disease receiving oral anticoagulation therapy
Sabah Sallah
Thrombosis and Hemostasis Program and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103, USA
Clin Cancer Res 10:7238-43. 2004
..To correlate the concentration of plasma coagulation markers at baseline and during follow-up in patients with solid tumors and venous thromboembolic disease with the risk of recurrence and death...
