Adrian Newman-Tancredi

Summary

Publications

  1. ncbi request reprint The importance of 5-HT1A receptor agonism in antipsychotic drug action: rationale and perspectives
    Adrian Newman-Tancredi
    NeuroAct Communication, 25 rue des Généraux Ricard, Castres, France
    Curr Opin Investig Drugs 11:802-12. 2010
  2. doi request reprint Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties
    Adrian Newman-Tancredi
    NeuroAct Communication, Castres, France
    Psychopharmacology (Berl) 216:451-73. 2011
  3. ncbi request reprint Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade
    Agnès L Auclair
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Neuropsychopharmacology 31:1900-9. 2006
  4. doi request reprint F15599, a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity
    Marie Bernadette Assié
    Neurobiology II Division, Centre de Recherche Pierre Fabre, Castres, France
    Int J Neuropsychopharmacol 13:1285-98. 2010
  5. ncbi request reprint Antipsychotic-like vs cataleptogenic actions in mice of novel antipsychotics having D2 antagonist and 5-HT1A agonist properties
    Laurent Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Neuropsychopharmacology 31:1869-79. 2006
  6. ncbi request reprint Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia
    Adrian Newman-Tancredi
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Int J Neuropsychopharmacol 8:341-56. 2005
  7. doi request reprint The central serotonin 2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity
    Agnès L Auclair
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    J Neurochem 114:1323-32. 2010
  8. ncbi request reprint Putative antipsychotics with pronounced agonism at serotonin 5-HT1A and partial agonist activity at dopamine D2 receptors disrupt basal PPI of the startle reflex in rats
    Agnès L Auclair
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106, Castres, France
    Psychopharmacology (Berl) 193:45-54. 2007
  9. ncbi request reprint Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics
    Laurent Bardin
    Division of Neurobiology, Pierre Fabre Research Centre, Castres, France
    Behav Pharmacol 18:103-18. 2007
  10. ncbi request reprint Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells
    Adrian Newman-Tancredi
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Int J Neuropsychopharmacol 11:293-307. 2008

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The importance of 5-HT1A receptor agonism in antipsychotic drug action: rationale and perspectives
    Adrian Newman-Tancredi
    NeuroAct Communication, 25 rue des Généraux Ricard, Castres, France
    Curr Opin Investig Drugs 11:802-12. 2010
    ..The balance of 5-HT1A/D2 receptor properties should therefore be considered when selecting compounds as antipsychotic development candidates...
  2. doi request reprint Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties
    Adrian Newman-Tancredi
    NeuroAct Communication, Castres, France
    Psychopharmacology (Berl) 216:451-73. 2011
    ..Such a strategy reduces side-effects such as the extrapyramidal syndrome (EPS), weight gain, and autonomic disturbance liability...
  3. ncbi request reprint Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade
    Agnès L Auclair
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Neuropsychopharmacology 31:1900-9. 2006
    ....
  4. doi request reprint F15599, a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity
    Marie Bernadette Assié
    Neurobiology II Division, Centre de Recherche Pierre Fabre, Castres, France
    Int J Neuropsychopharmacol 13:1285-98. 2010
    ..The distinctive pharmacological profile of F15599 suggests that preferential targeting of post-synaptic 5-HT(1A)Rs constitutes a promising strategy for improved antidepressant therapy...
  5. ncbi request reprint Antipsychotic-like vs cataleptogenic actions in mice of novel antipsychotics having D2 antagonist and 5-HT1A agonist properties
    Laurent Bardin
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Neuropsychopharmacology 31:1869-79. 2006
    ..Further, they indicate that the balance of affinity and/or efficacy between D2 and 5-HT1A receptors profoundly influences their pharmacological activities, and will likely impact their therapeutic profiles...
  6. ncbi request reprint Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia
    Adrian Newman-Tancredi
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Int J Neuropsychopharmacol 8:341-56. 2005
    ..Thus, the contribution of 5-HT1A receptor activation to the pharmacological profile of action of the antipsychotics will depend on the relative 5-HT1A/D2 affinities and on 5-HT1A agonist efficacy of the drugs...
  7. doi request reprint The central serotonin 2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity
    Agnès L Auclair
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    J Neurochem 114:1323-32. 2010
    ..63 mg/kg). These findings demonstrate that 5-HT(2B)Rs exert a facilitatory control on mesoaccumbens DA pathway activity, and suggest that they may constitute a new target for improved treatment of DA-related neuropsychiatric disorders...
  8. ncbi request reprint Putative antipsychotics with pronounced agonism at serotonin 5-HT1A and partial agonist activity at dopamine D2 receptors disrupt basal PPI of the startle reflex in rats
    Agnès L Auclair
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106, Castres, France
    Psychopharmacology (Berl) 193:45-54. 2007
    ..A novel class of potential antipsychotics (SSR181507, bifeprunox, and SLV313) possess partial agonist/antagonist properties at D(2) receptors and various levels of 5-HT(1A) activation...
  9. ncbi request reprint Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics
    Laurent Bardin
    Division of Neurobiology, Pierre Fabre Research Centre, Castres, France
    Behav Pharmacol 18:103-18. 2007
    ....
  10. ncbi request reprint Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells
    Adrian Newman-Tancredi
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Int J Neuropsychopharmacol 11:293-307. 2008
    ..These data indicate that, unlike conventional or 'atypical' antipsychotics, several 'third generation' agents display D4 receptor partial agonism that may be sufficient to influence physiological D4 receptor activity in vivo...
  11. doi request reprint Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors
    Ronan Depoortere
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Behav Pharmacol 20:303-11. 2009
    ..5 mg/kg). The present data do not support a major implication of either DA D3 or D4 receptors in the control of PE and YA in rats, but indicate a preponderant role of DA D2 receptors...