A Newman-Tancredi

Summary

Publications

  1. ncbi request reprint Inverse agonism and constitutive activity as functional correlates of serotonin h5-HT(1B) receptor/G-protein stoichiometry
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy sur Seine Paris, France
    Mol Pharmacol 58:1042-9. 2000
  2. ncbi request reprint The 5HT(1A) receptor ligand, S15535, antagonises G-protein activation: a [35S]GTPgammaS and [3H]S15535 autoradiography study
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, F 78290 Croissy sur Seine, Paris, France
    Eur J Pharmacol 384:111-21. 1999
  3. pmc Differential modulation by GTPgammaS of agonist and inverse agonist binding to h5-HT(1A) receptors revealed by [3H]-WAY100,635
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, 125, Chemin de Ronde, 78290, Croissy sur Seine, France
    Br J Pharmacol 132:518-24. 2001
  4. ncbi request reprint Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors
    A Newman-Tancredi
    Psychopharmacology Department, Institut de Recherches Servier, Croissy sur Seine Paris, France
    Naunyn Schmiedebergs Arch Pharmacol 359:447-53. 1999
  5. ncbi request reprint G protein activation by human dopamine D3 receptors in high-expressing Chinese hamster ovary cells: A guanosine-5'-O-(3-[35S]thio)- triphosphate binding and antibody study
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy sur Seine Paris, France
    Mol Pharmacol 55:564-74. 1999
  6. ncbi request reprint Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Paris, France
    Eur J Pharmacol 355:245-56. 1998
  7. ncbi request reprint Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Eur J Pharmacol 428:177-84. 2001
  8. ncbi request reprint Dopamine D2 receptor-mediated G-protein activation in rat striatum: functional autoradiography and influence of unilateral 6-hydroxydopamine lesions of the substantia nigra
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Brain Res 920:41-54. 2001
  9. ncbi request reprint [(35)S]-GTPgammaS autoradiography reveals alpha(2) adrenoceptor-mediated G-protein activation in amygdala and lateral septum
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Neuropharmacology 39:1111-3. 2000
  10. ncbi request reprint Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy sur Seine, France
    Naunyn Schmiedebergs Arch Pharmacol 355:682-8. 1997

Collaborators

  • D Cussac
  • A Dekeyne
  • J A Boutin
  • G Milligan
  • M Spedding
  • E Jacoby
  • M J Millan
  • V Audinot
  • J M Rivet
  • A Gobert
  • F Lejeune
  • A A Cordi
  • D Duqueyroix
  • J L Peglion
  • J P Nicolas
  • M Brocco
  • V Pasteau
  • S Lochon
  • M Touzard
  • S Aubry
  • A Auclair
  • I Berque-Bestel
  • C Carr
  • T Persigand
  • Y Quentric
  • J M Lacoste
  • N Despaux
  • S Queriaux
  • J P Galizzi
  • F Coge
  • L Maiofiss
  • L Cistarelli

Detail Information

Publications28

  1. ncbi request reprint Inverse agonism and constitutive activity as functional correlates of serotonin h5-HT(1B) receptor/G-protein stoichiometry
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy sur Seine Paris, France
    Mol Pharmacol 58:1042-9. 2000
    ....
  2. ncbi request reprint The 5HT(1A) receptor ligand, S15535, antagonises G-protein activation: a [35S]GTPgammaS and [3H]S15535 autoradiography study
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, F 78290 Croissy sur Seine, Paris, France
    Eur J Pharmacol 384:111-21. 1999
    ....
  3. pmc Differential modulation by GTPgammaS of agonist and inverse agonist binding to h5-HT(1A) receptors revealed by [3H]-WAY100,635
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, 125, Chemin de Ronde, 78290, Croissy sur Seine, France
    Br J Pharmacol 132:518-24. 2001
    ....
  4. ncbi request reprint Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors
    A Newman-Tancredi
    Psychopharmacology Department, Institut de Recherches Servier, Croissy sur Seine Paris, France
    Naunyn Schmiedebergs Arch Pharmacol 359:447-53. 1999
    ..7%). The present data suggest that roxindole activates mainly D3 vs. D2 or D4 receptors and 5-HT1A vs. 5-HT1B or 5-HT1D receptors. Activation of D3 and/or 5-HT1A receptors may thus contribute to its potential antidepressant properties...
  5. ncbi request reprint G protein activation by human dopamine D3 receptors in high-expressing Chinese hamster ovary cells: A guanosine-5'-O-(3-[35S]thio)- triphosphate binding and antibody study
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy sur Seine Paris, France
    Mol Pharmacol 55:564-74. 1999
    ....
  6. ncbi request reprint Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Paris, France
    Eur J Pharmacol 355:245-56. 1998
    ..It is suggested that agonist activity at 5-HT1A receptors may be of utility for certain antipsychotic agents...
  7. ncbi request reprint Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Eur J Pharmacol 428:177-84. 2001
    ..In conclusion, modulation of [3H]-WAY100,635 binding by GTPgammaS differentiated agonist vs. inverse agonist properties of antipsychotics at 5-HT(1A) receptors. These may contribute to differing profiles of antipsychotic activity...
  8. ncbi request reprint Dopamine D2 receptor-mediated G-protein activation in rat striatum: functional autoradiography and influence of unilateral 6-hydroxydopamine lesions of the substantia nigra
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Brain Res 920:41-54. 2001
    ....
  9. ncbi request reprint [(35)S]-GTPgammaS autoradiography reveals alpha(2) adrenoceptor-mediated G-protein activation in amygdala and lateral septum
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Neuropharmacology 39:1111-3. 2000
    ..Conversely, in caudate nucleus, which expresses few alpha(2) receptors, noradrenaline-induced stimulation was not inhibited by atipamezole, suggesting that it is not mediated by alpha(2)-adrenoceptors...
  10. ncbi request reprint Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy sur Seine, France
    Naunyn Schmiedebergs Arch Pharmacol 355:682-8. 1997
    ....
  11. ncbi request reprint Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release
    A Gobert
    Institut de Recherches Servier, Psychopharmacology Department, Croissy sur Seine, France
    Neuroscience 84:413-29. 1998
    ..Control of serotonin release is expressed phasically and that of noradrenaline and dopamine release tonically...
  12. ncbi request reprint Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization
    M J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, Centre de Recherches de Croissy, Paris, France
    J Pharmacol Exp Ther 297:876-87. 2001
    ..6). In conclusion, piribedil displays essentially antagonist properties at cloned, human and cerebral, rat alpha(2)-ARs. Blockade of alpha(2)-ARs may, thus, contribute to its clinical antiparkinsonian profile...
  13. ncbi request reprint Comparison of hippocampal G protein activation by 5-HT(1A) receptor agonists and the atypical antipsychotics clozapine and S16924
    A Newman-Tancredi
    Dept of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy sur Seine, France
    Naunyn Schmiedebergs Arch Pharmacol 368:188-99. 2003
    ..These data support a role of postsynaptic 5-HT(1A) receptors in the functional profiles of certain antipsychotic agents...
  14. ncbi request reprint Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic tr
    M J Millan
    Psychopharmacology Department, Institut de Recherches Servier, Centre de Recherches de Croissy, 125, Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Synapse 35:79-95. 2000
    ..However, in contrast to the selective alpha(2)-AR antagonist, fluparoxan, the 5-HT(1A) agonist actions of yohimbine suppress 5-HT levels alone and underlie its inability to augment the influence of fluoxetine upon 5-HT levels...
  15. ncbi request reprint S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: II. Functional profile and a multipara
    M J Millan
    Psychopharmacology Department, Institut de Recherches Servier, Centre de Recherches de Croissy, Paris, Croissy sur Seine, France
    J Pharmacol Exp Ther 292:54-66. 2000
    ..In this respect, S18327 closely resembles clozapine, but it is chemically distinct and displays weak affinity for histaminic and muscarinic receptors...
  16. ncbi request reprint [35S]Guanosine-5'-O-(3-thio)triphosphate binding as a measure of efficacy at human recombinant dopamine D4.4 receptors: actions of antiparkinsonian and antipsychotic agents
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy sur Seine, France
    J Pharmacol Exp Ther 282:181-91. 1997
    ..4 receptors might be associated with a lesser incidence of side effects. Furthermore, antagonist activity at D4.4 receptors is a common property of many typical and atypical antipsychotic agents...
  17. ncbi request reprint Noradrenaline and adrenaline are high affinity agonists at dopamine D4 receptors
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy sur Seine, Paris, France
    Eur J Pharmacol 319:379-83. 1997
    ..These results indicate that dopamine D4 receptors are activated by noradrenaline and adrenaline, although at 50-100-fold higher concentrations than dopamine...
  18. ncbi request reprint Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization
    M J Millan
    Psychopharmacology Department, Centre de Recherches de Croissy, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Pharmacol Biochem Behav 71:589-98. 2002
    ..In conclusion, [3H]GR125,743 is an appropriate tool for the radiolabelling of native, rat 5-HT(1B) receptors and permitted determination of the affinities of an extensive series of ligands at these sites...
  19. ncbi request reprint The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways
    M J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy Seine, France
    J Pharmacol Exp Ther 306:954-64. 2003
    ..In conclusion, in contrast to melatonin, agomelatine behaves as an antagonist at 5-HT2B and 5-HT2C receptors: blockade of the latter reinforces frontocortical adrenergic and dopaminergic transmission...
  20. ncbi request reprint S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine
    M J Millan
    Psychopharmacology Department, Institut de Recherches Servier, Centre de Recherches de Croissy, Paris, France
    J Pharmacol Exp Ther 298:565-80. 2001
    ..It enhances extracellular levels of 5-HT and NE throughout corticolimbic structures and selectively elevates dialysis levels of DA in frontal cortex versus subcortical regions...
  21. ncbi request reprint Agonist and inverse agonist efficacy at human recombinant serotonin 5-HT1A receptors as a function of receptor:G-protein stoichiometry
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Croissysur Seine, Paris, France
    Neuropharmacology 36:451-9. 1997
    ..Furthermore, these data suggest that spiperone induces, or stabilises, a G-protein-coupled, but inactive conformation of the receptor...
  22. ncbi request reprint Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties
    A A Cordi
    Institut de Recherches Servier, 11, rue des Moulineaux, F 92150 Suresnes, France
    J Med Chem 44:787-805. 2001
    ..Structure-activity relationships permitted the selection of 14c (4(5)-[(5-fluoroindan-2-yl)methyl]-4,5-dihydroimidazole) as a development candidate...
  23. ncbi request reprint Inverse agonist properties of antipsychotic agents at cloned, human (h) serotonin (5-HT)(1B) and h5-HT(1D) receptors
    V Audinot
    Dept. of Molecular and Cellular Pharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, Paris, France
    Neuropsychopharmacology 25:410-22. 2001
    ..In conclusion, with the exception of ziprasidone, all antipsychotics were inverse agonists at h5-HT(1B) and h5-HT(1D) receptors, although they differed markedly in their potency at these sites as compared to hD(2) receptors...
  24. ncbi request reprint Agonist properties of pindolol at h5-HT1A receptors coupled to mitogen-activated protein kinase
    M J Millan
    Psychopharmacology Department, Centre de Recherches de Croissy, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Eur J Pharmacol 424:13-7. 2001
    ..Thus, stimulation of MAPK provides an intracellular marker and signal for expression of the agonist actions of (-)-pindolol at h5-HT1A receptors...
  25. ncbi request reprint [3H]S33084: a novel, selective and potent radioligand at cloned, human dopamine D3 receptors
    D Cussac
    Psychopharmacology Department, Institut de Recherches Servier, Croissy sur Seine Paris, France
    Naunyn Schmiedebergs Arch Pharmacol 361:569-72. 2000
    ..99) with that of [3H]spiperone. In conclusion, [3H]S33084 is a highly potent and selective radioligand at dopamine D3 receptors, which should be of considerable use for their characterisation...
  26. ncbi request reprint Pindolol antagonises G-protein activation at both pre- and postsynaptic serotonin 5-HT1A receptors: a
    A Newman-Tancredi
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy-sur-Seine Paris, France
    Naunyn Schmiedebergs Arch Pharmacol 363:391-8. 2001
    ..In conclusion, these data suggest that, as characterised by [35S]GTPgammaS autoradiography, and compared with 5-HT and 8-OH-DPAT, pindolol possesses low efficacy at both pre- and postsynaptic 5-HT1A receptors...
  27. ncbi request reprint The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors
    M J Millan
    Institut de Recherches Servier, Psychopharmacology Department, Paris, France
    Psychopharmacology (Berl) 156:58-62. 2001
    ..57 nM. CONCLUSIONS: SCH23390 is a potent and high efficacy agonist at h5-HT2C receptors. Activation of 5-HT2C receptors by SCH23390 may contribute to its functional properties both in animals and in humans...
  28. ncbi request reprint Interaction of the anxiogenic agent, RS-30199, with 5-HT1A receptors: modulation of sexual activity in the male rat
    M Spedding
    Institut de Internationales, Servier, Croissy Research Centre, Paris, France
    Neuropharmacology 37:769-80. 1998
    ..RS-30199 can be considered an atypical agonist at 5-HT1A receptors...