Robert P Young

Summary

Country: New Zealand

Publications

  1. pmc Genetic evidence linking lung cancer and COPD: a new perspective
    Robert P Young
    Department of Medicine and School of Biological Sciences, University of Auckland, Auckland, New Zealand Synergenz Biosciences Ltd, Auckland, New Zealand
    Appl Clin Genet 4:99-111. 2011
  2. pmc GSTM1 null genotype in COPD and lung cancer: evidence of a modifier or confounding effect?
    Robert P Young
    Schools of Biological Science and Health Sciences, University of Auckland Department of Medicine, Auckland City Hospital, Auckland, New Zealand
    Appl Clin Genet 4:137-44. 2011
  3. pmc FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer
    Robert P Young
    Department of Medicine, Auckland Hospital, Auckland, New Zealand
    Appl Clin Genet 4:1-10. 2011
  4. pmc Clinical applications of gene-based risk prediction for lung cancer and the central role of chronic obstructive pulmonary disease
    R P Young
    Faculty of Medical and Health Sciences, and Biological Sciences, University of Auckland Auckland, New Zealand
    Front Genet 3:210. 2012
  5. doi request reprint Pharmacological actions of statins: potential utility in COPD
    R P Young
    Dept of Medicine Auckland Hospital Private Bag 92019, Auckland, New Zealand
    Eur Respir Rev 18:222-32. 2009
  6. doi request reprint A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers
    R P Young
    Department of Medicine, Auckland Hospital, Private Bag 92019, Auckland, New Zealand
    Postgrad Med J 85:515-24. 2009
  7. doi request reprint COPD prevalence is increased in lung cancer, independent of age, sex and smoking history
    R P Young
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Eur Respir J 34:380-6. 2009
  8. doi request reprint How the genetics of lung cancer may overlap with COPD
    Robert P Young
    Schools of Biological Sciences and Health Sciences, University of Auckland, Auckland, New Zealand
    Respirology 16:1047-55. 2011
  9. pmc Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD
    Robert P Young
    Department of Medicine, Auckland Hospital, Auckland, New Zealand
    PLoS ONE 6:e16476. 2011
  10. doi request reprint Chromosome 4q31 locus in COPD is also associated with lung cancer
    R P Young
    Dept of Medicine, Auckland Hospital, Auckland, New Zealand
    Eur Respir J 36:1375-82. 2010

Detail Information

Publications19

  1. pmc Genetic evidence linking lung cancer and COPD: a new perspective
    Robert P Young
    Department of Medicine and School of Biological Sciences, University of Auckland, Auckland, New Zealand Synergenz Biosciences Ltd, Auckland, New Zealand
    Appl Clin Genet 4:99-111. 2011
    ..Early studies suggest that single nucleotide polymorphism-based risk stratification of smokers might help better target novel prevention and early diagnostic strategies in lung cancer...
  2. pmc GSTM1 null genotype in COPD and lung cancer: evidence of a modifier or confounding effect?
    Robert P Young
    Schools of Biological Science and Health Sciences, University of Auckland Department of Medicine, Auckland City Hospital, Auckland, New Zealand
    Appl Clin Genet 4:137-44. 2011
    ..However, a modifier or confounding effect from COPD mediating the GSTM1 association with lung cancer has not been previously explored...
  3. pmc FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer
    Robert P Young
    Department of Medicine, Auckland Hospital, Auckland, New Zealand
    Appl Clin Genet 4:1-10. 2011
    ..72, P = 0.0009, and CC genotype OR = 0.61, P = 0.003). This study suggests that genetic predisposition to COPD is shared with lung cancer through shared pathogenetic factors such as the 4q22.1 locus implicating the Rho-kinase pathway...
  4. pmc Clinical applications of gene-based risk prediction for lung cancer and the central role of chronic obstructive pulmonary disease
    R P Young
    Faculty of Medical and Health Sciences, and Biological Sciences, University of Auckland Auckland, New Zealand
    Front Genet 3:210. 2012
    ..We suggest that such an approach could facilitate the targeted selection of smokers for cost-effective life-saving interventions...
  5. doi request reprint Pharmacological actions of statins: potential utility in COPD
    R P Young
    Dept of Medicine Auckland Hospital Private Bag 92019, Auckland, New Zealand
    Eur Respir Rev 18:222-32. 2009
    ..This review examines the pleiotropic pharmacological action of statins which inhibit key inflammatory and remodelling pathways in COPD and concludes that statins have considerable potential as adjunct therapy in COPD...
  6. doi request reprint A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers
    R P Young
    Department of Medicine, Auckland Hospital, Private Bag 92019, Auckland, New Zealand
    Postgrad Med J 85:515-24. 2009
    ..Chronic obstructive pulmonary disease (COPD) is also an independent risk factor for lung cancer and coexists in 40-60% of lung cancer cases...
  7. doi request reprint COPD prevalence is increased in lung cancer, independent of age, sex and smoking history
    R P Young
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Eur Respir J 34:380-6. 2009
    ..We conclude that COPD is both a common and important independent risk factor for lung cancer...
  8. doi request reprint How the genetics of lung cancer may overlap with COPD
    Robert P Young
    Schools of Biological Sciences and Health Sciences, University of Auckland, Auckland, New Zealand
    Respirology 16:1047-55. 2011
    ..Finally, if low-dose computerized tomography can identify treatable lung cancer, gene-based tests of susceptibility might help identify those smokers who should undergo radiological screening...
  9. pmc Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD
    Robert P Young
    Department of Medicine, Auckland Hospital, Auckland, New Zealand
    PLoS ONE 6:e16476. 2011
    ..70). We suggest that genetic susceptibility to lung cancer includes genes conferring susceptibility to COPD and that sub-phenotyping with spirometry is critical to identifying genes underlying the development of lung cancer...
  10. doi request reprint Chromosome 4q31 locus in COPD is also associated with lung cancer
    R P Young
    Dept of Medicine, Auckland Hospital, Auckland, New Zealand
    Eur Respir J 36:1375-82. 2010
    ..We conclude that genetic susceptibility to lung cancer includes COPD-related gene variants...
  11. ncbi request reprint Forced expiratory volume in one second: not just a lung function test but a marker of premature death from all causes
    R P Young
    Department of Medicine, Auckland Hospital, Private Bag 92019, Auckland, New Zealand
    Eur Respir J 30:616-22. 2007
    ....
  12. doi request reprint Smoking cessation: the potential role of risk assessment tools as motivational triggers
    Robert P Young
    Department of Medicine, Auckland Hospital, Auckland, New Zealand
    Postgrad Med J 86:26-33; quiz 31-2. 2010
    ....
  13. doi request reprint Potential benefits of statins on morbidity and mortality in chronic obstructive pulmonary disease: a review of the evidence
    R P Young
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Postgrad Med J 85:414-21. 2009
    ..Given the undisputed benefit of statins in high risk populations and the growing body of data suggesting statins may benefit patients with COPD, the question arises "Should statins be considered more often in patients with COPD?"...
  14. pmc Lung cancer susceptibility model based on age, family history and genetic variants
    Robert P Young
    Department of Medicine, Auckland Hospital, Auckland, New Zealand
    PLoS ONE 4:e5302. 2009
    ..In a case control association study of healthy smokers and lung cancer cases, we identified genetic markers associated with either susceptibility or protection to lung cancer...
  15. doi request reprint Lung cancer gene associated with COPD: triple whammy or possible confounding effect?
    R P Young
    Dept of Medicine, University of Auckland, Auckland, New Zealand
    Eur Respir J 32:1158-64. 2008
    ..These findings suggest that the association between the alpha5 subunit nicotinic acetylcholine receptor single nucleotide polymorphism and lung cancer may, in part, be confounded by chronic obstructive pulmonary disease...
  16. pmc Within a smoking-cessation program, what impact does genetic information on lung cancer need to have to demonstrate cost-effectiveness?
    Louisa G Gordon
    Queensland Institute of Medical Research, Genetics and Population Health Division, PO Royal Brisbane Hospital, Herston Q4029, Australia
    Cost Eff Resour Alloc 8:18. 2010
    ..The purpose of this study was to explore what the impact of a genetic test needs to have within a typical smoking-cessation program aimed at heavy smokers in order to be cost-effective...
  17. doi request reprint The cyclooxygenase-2-765C promoter polymorphism protects against the development of chronic obstructive pulmonary disease
    Lian Wu
    Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Respir Med 105:506-10. 2011
    ..Susceptibility to Chronic Obstructive Pulmonary Disease (COPD) has a genetic component. We undertook a study to determine if a genetic variant of the gene encoding the cyclooxygenase-2 gene influences the likelihood of developing COPD...
  18. doi request reprint Update on the potential role of statins in chronic obstructive pulmonary disease and its co-morbidities
    Robert P Young
    School of Biological Sciences and Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Expert Rev Respir Med 7:533-44. 2013
    ....