R Beasley

Summary

Affiliation: Wellington School of Medicine
Country: New Zealand

Publications

  1. ncbi Is enhanced fetal growth a risk factor for the development of atopy or asthma?
    R Beasley
    Wellington Asthma Research Group, Department of Medicine, Wellington School of Medicine, Wellington, New Zealand
    Int Arch Allergy Immunol 118:408-10. 1999
  2. ncbi Prevalence and etiology of asthma
    R Beasley
    Wellington Asthma Research Group, Department of Medicine, Wellington School of Medicine, Wellington, New Zealand
    J Allergy Clin Immunol 105:S466-72. 2000
  3. ncbi The effect of delipidated deglycolipidated (DDMV) and heat-killed Mycobacterium vaccae in asthma
    P M Shirtcliffe
    Wellington Asthma Research Group, Department of Medicine, Wellington School of Medicine, Wellington South, New Zealand
    Am J Respir Crit Care Med 163:1410-4. 2001
  4. doi Childhood asthma and GOLD-defined chronic obstructive pulmonary disease
    P Shirtcliffe
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Intern Med J 42:83-8. 2012
  5. pmc Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma
    M Masoli
    Medical Research Institute of New Zealand, P O Box 10055, Wellington, New Zealand
    Thorax 60:730-4. 2005
  6. doi Dose-response relationship for risk of non-vertebral fracture with inhaled corticosteroids
    M Weatherall
    University of Otago Wellington, Wellington, New Zealand
    Clin Exp Allergy 38:1451-8. 2008
  7. pmc Systematic review of the dose-response relation of inhaled fluticasone propionate
    M Masoli
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Arch Dis Child 89:902-7. 2004
  8. doi The risk of asthma mortality with inhaled long acting beta-agonists
    M Wijesinghe
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Postgrad Med J 84:467-72. 2008
  9. doi Meta-analysis of the risk of mortality with salmeterol and the effect of concomitant inhaled corticosteroid therapy
    M Weatherall
    University of Otago Wellington, Wellington, New Zealand
    Thorax 65:39-43. 2010
  10. pmc Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis
    S Holt
    Wellington Asthma Research Group, Wellington School of Medicine, PO Box 7343, Wellington, New Zealand
    BMJ 323:253-6. 2001

Detail Information

Publications49

  1. ncbi Is enhanced fetal growth a risk factor for the development of atopy or asthma?
    R Beasley
    Wellington Asthma Research Group, Department of Medicine, Wellington School of Medicine, Wellington, New Zealand
    Int Arch Allergy Immunol 118:408-10. 1999
    ..This has led to consideration of factors such as fetomaternal health which may programme the initial susceptibility to allergic sensitisation, or contribute to the development of asthma independently of sensitisation...
  2. ncbi Prevalence and etiology of asthma
    R Beasley
    Wellington Asthma Research Group, Department of Medicine, Wellington School of Medicine, Wellington, New Zealand
    J Allergy Clin Immunol 105:S466-72. 2000
    ..These issues are now the focus of an intensive research effort worldwide, and the next few years are likely to see exciting advances in our understanding of the causes of asthma...
  3. ncbi The effect of delipidated deglycolipidated (DDMV) and heat-killed Mycobacterium vaccae in asthma
    P M Shirtcliffe
    Wellington Asthma Research Group, Department of Medicine, Wellington School of Medicine, Wellington South, New Zealand
    Am J Respir Crit Care Med 163:1410-4. 2001
    ..The results indicate no effect of low dose intradermal DDMV or M. vaccae on asthma severity in patients with established asthma...
  4. doi Childhood asthma and GOLD-defined chronic obstructive pulmonary disease
    P Shirtcliffe
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Intern Med J 42:83-8. 2012
    ..This study aimed to investigate the strength of association of various known risk factors for COPD...
  5. pmc Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma
    M Masoli
    Medical Research Institute of New Zealand, P O Box 10055, Wellington, New Zealand
    Thorax 60:730-4. 2005
    ..There is uncertainty as to the dose of inhaled corticosteroids (ICS) at which to start concomitant long acting beta agonist (LABA) treatment in patients with asthma not adequately controlled by ICS alone...
  6. doi Dose-response relationship for risk of non-vertebral fracture with inhaled corticosteroids
    M Weatherall
    University of Otago Wellington, Wellington, New Zealand
    Clin Exp Allergy 38:1451-8. 2008
    ..To determine the strength of association between the dose of inhaled corticosteroids (ICS) and risk of non-vertebral fracture in adults...
  7. pmc Systematic review of the dose-response relation of inhaled fluticasone propionate
    M Masoli
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Arch Dis Child 89:902-7. 2004
    ..To examine the dose-response relation of inhaled fluticasone for both efficacy and adrenal function in children with asthma...
  8. doi The risk of asthma mortality with inhaled long acting beta-agonists
    M Wijesinghe
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Postgrad Med J 84:467-72. 2008
    ..We propose that in the management of asthma, a case can now be made to limit the availability of LABAs to combination LABA/ICS therapy...
  9. doi Meta-analysis of the risk of mortality with salmeterol and the effect of concomitant inhaled corticosteroid therapy
    M Weatherall
    University of Otago Wellington, Wellington, New Zealand
    Thorax 65:39-43. 2010
    ..There is concern that long-acting beta agonist (LABA) drugs may increase the risk of asthma mortality...
  10. pmc Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis
    S Holt
    Wellington Asthma Research Group, Wellington School of Medicine, PO Box 7343, Wellington, New Zealand
    BMJ 323:253-6. 2001
    ..However, these findings were limited by the lack of data on individual patients and by the paucity of dose-response studies that included doses of >500 microg/day...
  11. ncbi Lack of evidence for beta-2 receptor selectivity: a study of metaproterenol, fenoterol, isoproterenol, and epinephrine in patients with asthma
    C D Burgess
    Department of Medicine, Wellington School of Medicine, New Zealand
    Am Rev Respir Dis 143:444-6. 1991
    ..The concept of increasing beta-2 selectivity for metaproterenol and fenoterol compared with isoproterenol are not supported in the clinical setting...
  12. doi Quality of life measured by the St George's Respiratory Questionnaire and spirometry
    M Weatherall
    University of Otago Wellington, Wellington, New Zealand
    Eur Respir J 33:1025-30. 2009
    ....
  13. ncbi Dose-response relationship of inhaled budesonide in adult asthma: a meta-analysis
    M Masoli
    Medical Research Institute of New Zealand, PO Box 10055, Wellington, New Zealand
    Eur Respir J 23:552-8. 2004
    ..This conclusion is qualified by the recognition that there is considerable individual variability in the response to inhaled corticosteroids and that the subjects included in this meta-analysis had predominantly mild to moderate asthma...
  14. ncbi Cumulative and single-dose design to assess the bronchodilator effects of beta2-agonists in individuals with asthma
    D Fishwick
    Department of Medicine, Wellington School of Medicine, Wellington, New Zealand
    Am J Respir Crit Care Med 163:474-7. 2001
    ....
  15. pmc Comparison of potency of inhaled beclomethasone and budesonide in New Zealand: retrospective study of computerised general practice records
    B D Pethica
    Wellington Asthma Research Group, Wellington School of Medicine, University of Otago, Wellington, PO Box 7343, Wellington South, New Zealand
    BMJ 317:986-90. 1998
    ..To determine whether inhaled budesonide and beclomethasone are equipotent in the treatment of asthma in primary care...
  16. ncbi Inhaled fluticasone propionate and adrenal effects in adult asthma: systematic review and meta-analysis
    M Masoli
    Medical Research Institute of New Zealand, PO Box 10055, Wellington, New Zealand
    Eur Respir J 28:960-7. 2006
    ..This conclusion is limited by the paucity of long-term studies of daily doses of fluticasone propionate >1,000 mug and by the considerable individual variability in the response...
  17. doi Distinct clinical phenotypes of airways disease defined by cluster analysis
    M Weatherall
    University of Otago Wellington, Wellington, New Zealand
    Eur Respir J 34:812-8. 2009
    ..Five distinct clinical phenotypes of airflow obstruction were identified. If confirmed in other populations, these findings may form the basis of a modified taxonomy for the disorders of airways obstruction...
  18. doi Risk of mortality associated with formoterol: a systematic review and meta-analysis
    M Wijesinghe
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Eur Respir J 34:803-11. 2009
    ..However, the point estimates of a 2.0- to 3.2-fold increased risk of asthma death are not reassuring and add weight to evidence that LABA use in certain circumstances may increase the risk of asthma mortality...
  19. pmc Cannabis use and risk of lung cancer: a case-control study
    S Aldington
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Eur Respir J 31:280-6. 2008
    ..7 (95% CI 1.5-21.6)), after adjustment for confounding variables including cigarette smoking. In conclusion, the results of the present study indicate that long-term cannabis use increases the risk of lung cancer in young adults...
  20. ncbi Seasonal variation in asthma hospitalizations and death rates in New Zealand
    M Kimbell-Dunn
    Wellington Asthma Research Group, Wellington School of Medicine, New Zealand
    Respirology 5:241-6. 2000
    ..The aim of this study was to determine if there is a seasonal pattern to asthma hospitalizations and mortality in New Zealand...
  21. doi The role of paracetamol in the pathogenesis of asthma
    H Farquhar
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Clin Exp Allergy 40:32-41. 2010
    ..Importantly, RCTs will also enable evidence-based guidelines for the recommended use of paracetamol to be developed...
  22. doi The effects of early and late paracetamol exposure on asthma and atopy: a birth cohort
    K Wickens
    Wellington Asthma Research Group, Department of Medicine, School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand
    Clin Exp Allergy 41:399-406. 2011
    ..Despite reports of positive associations between paracetamol and asthma, the nature of these associations is unclear...
  23. pmc COPD prevalence in a random population survey: a matter of definition
    P Shirtcliffe
    Medical Research Institute of New Zealand, P O Box 10055, Wellington, New Zealand
    Eur Respir J 30:232-9. 2007
    ..Further research using longitudinal rather than cross-sectional data will help decide the preferred approach in chronic obstructive pulmonary disease prevalence surveys...
  24. ncbi Measuring morbidity in adult asthmatics
    N Pearce
    Department of Medicine, Wellington School of Medicine, New Zealand
    Int J Tuberc Lung Dis 3:185-91. 1999
    ..Whereas prevalence studies usually involve a general population sample, morbidity studies often involve the evaluation of factors that affect asthma severity within an asthmatic population...
  25. doi Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis
    S Eyers
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Clin Exp Allergy 41:482-9. 2011
    ..There is evidence to suggest that the risk of asthma might be increased with exposure to paracetamol in the intrauterine environment, infancy, later childhood and adult life...
  26. ncbi The airways effects of inhaled chlorbutol in asthmatic subjects
    H Windom
    Dept of Medicine, Wellington School of Medicine, New Zealand
    Eur Respir J 3:725-7. 1990
    ..In the remaining eight subjects, inhalation of chlorbutol did not affect airway calibre. We conclude that chlorbutol, in the concentration present in Bricanyl nebulizer solution, has no clinically significant effect on airway calibre...
  27. ncbi Metrics of salbutamol use as predictors of future adverse outcomes in asthma
    M Patel
    Medical Research Institute of New Zealand, Wellington, New Zealand Capital and Coast District Health Board, Wellington, New Zealand Division of Respiratory Medicine, School of Clinical Sciences, University of Nottingham, Nottingham, UK
    Clin Exp Allergy 43:1144-51. 2013
    ..Beta-agonist overuse is associated with adverse outcomes in asthma, however, the relationships between different metrics of salbutamol use and future risk are uncertain...
  28. doi Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III
    Sunia Foliaki
    Center for Public Health Research, Massey University, Wellington, New Zealand
    J Allergy Clin Immunol 124:982-9. 2009
    ..Phase III of the International Study of Asthma and Allergies in Childhood measured the global prevalence of symptoms of asthma, rhinoconjunctivitis, and eczema in children...
  29. ncbi Agreement between written and video questions for comparing asthma symptoms in ISAAC
    J Crane
    Wellington Asthma Research Group, Dept of Medicine, School of Medicine, Wellington, New Zealand
    Eur Respir J 21:455-61. 2003
    ..This relationship and the interpretation of both written and audiovisual presentation of symptoms requires further study in order to better predict asthma...
  30. pmc Efficacy of bupropion in the indigenous Maori population in New Zealand
    S Holt
    P3 Research, Bowen Hospital, Crofton Downs, Wellington, New Zealand
    Thorax 60:120-3. 2005
    ..A study was undertaken to determine whether bupropion is effective in the treatment of smoking cessation in the indigenous Maori population in New Zealand...
  31. doi Routine use of oxygen in the treatment of myocardial infarction: systematic review
    M Wijesinghe
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Heart 95:198-202. 2009
    ..International guidelines recommend the routine use of oxygen therapy in the treatment of myocardial infarction (MI)...
  32. doi Randomised double-blind, placebo-controlled trial of the effects of the 'party pills' BZP/TFMPP alone and in combination with alcohol
    I Thompson
    Medical Research Institute of New Zealand, Wellington, New Zealand
    J Psychopharmacol 24:1299-308. 2010
    ..BZP/TFMPP alone or with alcohol carries a significant risk of severe adverse events when taken in similar doses to those recommended by manufacturers...
  33. pmc Cannabis use and cancer of the head and neck: case-control study
    Sarah Aldington
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Otolaryngol Head Neck Surg 138:374-80. 2008
    ..To investigate whether cannabis smoking increases the risk of head and neck cancer...
  34. ncbi Analysis of two IL-4 promoter polymorphisms in a cohort of atopic and asthmatic subjects
    S Hook
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington, New
    Exp Clin Immunogenet 16:33-5. 1999
    ..Neither polymorphism was identified in any of the samples tested. The data suggest that either the polymorphisms are present at very low frequencies or are artefacts of the B cell lines from which they were identified...
  35. ncbi The extrapulmonary effects of inhaled hexoprenaline and salbutamol in healthy individuals
    P Bremner
    Department of Medicine, Wellington School of Medicine, New Zealand
    Eur J Clin Pharmacol 45:37-9. 1993
    ..Salbutamol significantly increased heart rate compared with hexoprenaline. Hexoprenaline caused a significantly greater fall in plasma potassium compared with salbutamol...
  36. ncbi Asthma and allergy: a worldwide problem of meanings and management?
    J Crane
    The Department of Medicine, School of Medicine, PO Box 7343, Wellington, New Zealand
    Allergy 57:663-72. 2002
  37. doi Prolonged seated immobility at work is a common risk factor for venous thromboembolism leading to hospital admission
    S Aldington
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Intern Med J 38:133-5. 2008
    ..We conclude that prolonged seated immobility at work may represent a common and important risk factor for VTE...
  38. ncbi Effect of repeated intradermal injections of heat-inactivated Mycobacterium bovis bacillus Calmette-Guérin in adult asthma
    P M Shirtcliffe
    Wellington School of Medicine and Health Sciences, Wellington, New Zealand
    Clin Exp Allergy 34:207-12. 2004
    ..There is also epidemiological and experimental evidence that exposure to mycobacteria has the potential to suppress the development of asthma/atopy...
  39. pmc Clinical dose-response relationship of fluticasone propionate in adults with asthma
    M Masoli
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Thorax 59:16-20. 2004
    ..A study was undertaken to examine the dose-response relation of inhaled fluticasone in adolescents and adults with asthma...
  40. ncbi Sleep disorders: a potential role in New Zealand motor vehicle accidents
    B Yee
    WellSleep, Department of Medicine, Wellington School of Medicine, Wellington South, New Zealand
    Intern Med J 32:297-304. 2002
    ..Aims: To trial a recruitment method and document the frequency of sleep disorders in drivers attending an emergency department with injury following MVA...
  41. ncbi A serological survey of antibodies to rabbit haemorrhagic disease virus (rabbit calicivirus disease) in two rural Central Otago communities
    E Greenslade
    Department of Public Health, Wellington School of Medicine
    N Z Med J 114:55-7. 2001
    ..CONCLUSIONS. No serological evidence of infection with RHDV was found in a cohort including many heavily exposed individuals...
  42. ncbi Frequency of venous thromboembolism in low to moderate risk long distance air travellers: the New Zealand Air Traveller's Thrombosis (NZATT) study
    R J Hughes
    Green Lane Hospital, Auckland, New Zealand
    Lancet 362:2039-44. 2003
    ..We aimed to establish the frequency of this disorder in a group of long distance air travellers and to investigate the role of potential risk factors...
  43. ncbi The international study of asthma and allergies in childhood (ISAAC): phase three rationale and methods
    P Ellwood
    Department of Paediatrics, The University of Auckland, Auckland, New Zealand
    Int J Tuberc Lung Dis 9:10-6. 2005
    ....
  44. ncbi Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
    M Humbert
    Hopital Antoine Beclere, Clamart, France
    Allergy 60:309-16. 2005
    ..We determined the effect of omalizumab on clinically significant asthma exacerbations (requiring systemic corticosteroids) in the first omalizumab study to exclusively enrol patients from this difficult-to-treat patient population...
  45. pmc Optimal starting dose of inhaled corticosteroids in adult asthma: why has it taken so long?
    M Masoli
    Thorax 60:93-4. 2005
  46. doi International correlations between indicators of prevalence, hospital admissions and mortality for asthma in children
    H R Anderson
    Division of Community Health Sciences, St George s, University of London, UK
    Int J Epidemiol 37:573-82. 2008
    ..There are extensive data on the prevalence of childhood asthma world-wide but the relationships between asthma symptom prevalence, mortality and hospital admissions have not been investigated...
  47. ncbi Determinants of plasma D-dimer levels in a traveling population
    R Hughes
    Green Lane Hospital, Auckland, New Zealand
    J Thromb Haemost 3:2445-8. 2005
    ..Whilst a negative test is helpful in ruling out thrombosis, the significance and determinants of an elevated plasma D-dimer level in otherwise healthy subjects are poorly understood...
  48. ncbi Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood
    Bengt Bjorksten
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Pediatr Allergy Immunol 19:110-24. 2008
    ..The increases were more pronounced in the older age group, suggesting that environmental influences on the development of allergy may not be limited to early childhood...
  49. ncbi Epidemiology and costs of chronic obstructive pulmonary disease
    K R Chapman
    Asthma and Airway Centre, Toronto University Health Network, Toronto Western Hospital, Room 7 451 New East Wing, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Eur Respir J 27:188-207. 2006