John H Miller

Summary

Affiliation: Victoria University of Wellington
Country: New Zealand

Publications

  1. ncbi request reprint Resistance to peloruside A and laulimalide: functional significance of acquired βI-tubulin mutations at sites important for drug-tubulin binding
    Arun Kanakkanthara
    Centre for Biodiscovery and School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand
    Curr Cancer Drug Targets 14:79-90. 2014
  2. ncbi request reprint Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae
    Reem Hanna
    Centre for Biodiscovery, School of Biological Sciences, Victoria University of Wellington, Kelburn Parade, Kelburn, Wellington, 6012, New Zealand
    Mol Biosyst 10:110-6. 2014
  3. ncbi request reprint Laulimalide and peloruside A inhibit mitosis of Saccharomyces cerevisiae by preventing microtubule depolymerisation-dependent steps in chromosome separation and nuclear positioning
    Heather A Best
    Centre for Biodiscovery, School of Biological Sciences, Victoria University of Wellington, Kelburn Parade, Kelburn, Wellington, 6011, New Zealand
    Mol Biosyst 9:2842-52. 2013
  4. ncbi request reprint Peloruside A enhances apoptosis in H-ras-transformed cells and is cytotoxic to proliferating T cells
    J H Miller
    School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Apoptosis 9:785-96. 2004
  5. ncbi request reprint Growth inhibitory effects of a mu opioid on cultured cholinergic neurons from fetal rat ventral forebrain, brainstem, and spinal cord
    J H Miller
    School of Biological Sciences, Victoria University, P O Box 600, Wellington, New Zealand
    Brain Res Dev Brain Res 114:69-77. 1999
  6. pmc Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide
    John H Miller
    School of Biological Sciences and Centre for Biodiscovery, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Mar Drugs 8:1059-79. 2010
  7. doi request reprint Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae
    Anja Wilmes
    Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand
    Gene 497:140-6. 2012
  8. doi request reprint Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis
    Jessica J Field
    Centre for Biodiscovery, Victoria University of Wellington, P O Box 600, Wellington, New Zealand
    J Med Chem 52:7328-32. 2009
  9. doi request reprint βII-tubulin and βIII-tubulin mediate sensitivity to peloruside A and laulimalide, but not paclitaxel or vinblastine, in human ovarian carcinoma cells
    Arun Kanakkanthara
    Centre for Biodiscovery, Victoria University of Wellington, Wellington 6140, New Zealand
    Mol Cancer Ther 11:393-404. 2012
  10. doi request reprint Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues
    A Jonathan Singh
    Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand
    Org Biomol Chem 9:4456-66. 2011

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Resistance to peloruside A and laulimalide: functional significance of acquired βI-tubulin mutations at sites important for drug-tubulin binding
    Arun Kanakkanthara
    Centre for Biodiscovery and School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand
    Curr Cancer Drug Targets 14:79-90. 2014
    ..This study provides the first direct evidence that A296 and R306 of βI-tubulin are important determinants of the PLA and LAU response in cancer cells. ..
  2. ncbi request reprint Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae
    Reem Hanna
    Centre for Biodiscovery, School of Biological Sciences, Victoria University of Wellington, Kelburn Parade, Kelburn, Wellington, 6012, New Zealand
    Mol Biosyst 10:110-6. 2014
    ..Thus, we conclude that yeast is an appropriate model to screen for small molecule drugs that may be efficacious in cancer therapy in humans through the newly characterised laulimalide-peloruside binding site. ..
  3. ncbi request reprint Laulimalide and peloruside A inhibit mitosis of Saccharomyces cerevisiae by preventing microtubule depolymerisation-dependent steps in chromosome separation and nuclear positioning
    Heather A Best
    Centre for Biodiscovery, School of Biological Sciences, Victoria University of Wellington, Kelburn Parade, Kelburn, Wellington, 6011, New Zealand
    Mol Biosyst 9:2842-52. 2013
    ....
  4. ncbi request reprint Peloruside A enhances apoptosis in H-ras-transformed cells and is cytotoxic to proliferating T cells
    J H Miller
    School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Apoptosis 9:785-96. 2004
    ..It is concluded that peloruside preferentially targets oncogene-transformed cells over non-transformed cells by inducing transformed cells to undergo apoptosis...
  5. ncbi request reprint Growth inhibitory effects of a mu opioid on cultured cholinergic neurons from fetal rat ventral forebrain, brainstem, and spinal cord
    J H Miller
    School of Biological Sciences, Victoria University, P O Box 600, Wellington, New Zealand
    Brain Res Dev Brain Res 114:69-77. 1999
    ..There was no evidence for endogenous opioid activity in either VFB or spinal cord cultures...
  6. pmc Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide
    John H Miller
    School of Biological Sciences and Centre for Biodiscovery, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Mar Drugs 8:1059-79. 2010
    ....
  7. doi request reprint Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae
    Anja Wilmes
    Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand
    Gene 497:140-6. 2012
    ..In addition to its known target tubulin, based on these microarray 'hits', peloruside A was seen to interact genetically with other cell proteins involved in the cell cycle, mitosis, RNA splicing, and membrane trafficking...
  8. doi request reprint Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis
    Jessica J Field
    Centre for Biodiscovery, Victoria University of Wellington, P O Box 600, Wellington, New Zealand
    J Med Chem 52:7328-32. 2009
    ..Zampanolide, with only four stereogenic centers, may be amenable to large-scale synthetic preparation...
  9. doi request reprint βII-tubulin and βIII-tubulin mediate sensitivity to peloruside A and laulimalide, but not paclitaxel or vinblastine, in human ovarian carcinoma cells
    Arun Kanakkanthara
    Centre for Biodiscovery, Victoria University of Wellington, Wellington 6140, New Zealand
    Mol Cancer Ther 11:393-404. 2012
    ..It was concluded that the increased βII- and βIII-tubulin contributed significantly to the resistance phenotype, along with the tubulin structural mutation, and that the altered isotype effect was binding site specific...
  10. doi request reprint Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues
    A Jonathan Singh
    Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand
    Org Biomol Chem 9:4456-66. 2011
    ..Small-scale reactions on peloruside A (1) have been performed, which along with the isolation of 3 and 4, give further insight into the bioactive pharmacophore of 1...
  11. doi request reprint Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells
    Anja Wilmes
    Centre for Biodiscovery, Victoria University of Wellington, P O Box 600, Wellington, New Zealand
    Cancer Chemother Pharmacol 68:117-26. 2011
    ..The purpose of this study was to examine the synergistic interactions of these drugs when given in combination in relation to the differences in their binding sites on the microtubule...
  12. ncbi request reprint Structurally diverse hamigerans from the New Zealand marine sponge Hamigera tarangaensis: NMR-directed isolation, structure elucidation and antifungal activity
    A Jonathan Singh
    Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand
    Org Biomol Chem 11:8041-51. 2013
    ..Homozygous deletion profiling (HOP) analysis suggests Golgi apparatus function as a potential target of this unusual class of sponge-derived terpenoids...
  13. pmc Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules
    Jessica J Field
    School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand
    Chem Biol 19:686-98. 2012
    ..Our results strongly support the existence of the luminal taxane site of microtubules in tubulin dimers and suggest that microtubule nucleation induction by MSAs may proceed through an allosteric mechanism...
  14. ncbi request reprint Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines
    Anja Wilmes
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Mol Pharm 4:269-80. 2007
    ....
  15. pmc Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity
    A Jonathan Singh
    Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand
    J Org Chem 75:2-10. 2010
    ..The synthesis features Sharpless dihydroxylation, Brown's asymmetric allylboration reaction, reductive aldol coupling, Yamaguchi macrolactonization, and selective methylation...
  16. ncbi request reprint Mu and delta opioid receptor immunoreactivity and mu receptor regulation in brainstem cells cultured from late fetal and early postnatal rats
    Bronwyn M Kivell
    School of Biological Sciences, Victoria University, P O Box 600, Wellington, New Zealand
    Brain Res Dev Brain Res 149:9-19. 2004
    ..It was concluded that many brainstem neurons express functional MOR or DOR or coexpress both receptors, although intracellular distributions of the receptors are unique for each receptor type...
  17. pmc Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes
    Arun Kanakkanthara
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Mol Cancer Ther 10:1419-29. 2011
    ..These results provide insight into how alterations in tubulin lead to unique resistance profiles for two drugs, peloruside A and laulimalide, that have a similar mode of action...
  18. doi request reprint Methods for studying microtubule binding site interactions: zampanolide as a covalent binding agent
    Jessica J Field
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Methods Cell Biol 115:303-25. 2013
    ..The purpose of this chapter is to provide a step-by-step protocol for determining the binding site of a novel MSA...
  19. pmc Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole
    Kirsten J Meyer
    Centre for Biodiscovery and Schools of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Mar Drugs 10:900-17. 2012
    ....
  20. doi request reprint Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A
    Kevin P Crume
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand 6140
    J Leukoc Biol 86:949-58. 2009
    ..These results indicate that microtubule-stabilizing drugs are effective at reducing disease but require a prolonged exposure to paclitaxel in vivo to alter proliferation in the myeloid and lymphoid cell compartments...
  21. ncbi request reprint Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines
    Thomas N Gaitanos
    School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Cancer Res 64:5063-7. 2004
    ..It was concluded that peloruside and laulimalide have binding properties that are distinct from other microtubule-stabilizing compounds currently under investigation...
  22. doi request reprint Acquired resistance to peloruside A and laulimalide is associated with downregulation of vimentin in human ovarian carcinoma cells
    Arun Kanakkanthara
    Centre for Biodiscovery, Victoria University of Wellington, PO Box 600, Wellington, 6140, New Zealand
    Pharm Res 29:3022-32. 2012
    ..We examined the proteome of resistant cells to see what other protein changes occurred as a result of the acquired drug resistance...
  23. doi request reprint Non-taxoid site microtubule-stabilizing drugs work independently of tau overexpression in mouse N2a neuroblastoma cells
    Viswanath Das
    School of Biological Sciences and Centre for Biodiscovery, Victoria University of Wellington, Wellington 6140, New Zealand
    Brain Res 1489:121-32. 2012
    ..In the present study, we show that peloruside A and laulimalide stabilize microtubules independently of tau overexpression; whereas, the effects of paclitaxel and ixabepilone are masked by the presence of extra tau in the cell...
  24. doi request reprint Acute in utero morphine exposure slows G2/M phase transition in radial glial and basal progenitor cells in the dorsal telencephalon of the E15.5 embryonic mouse
    Tim J Sargeant
    School of Biological Sciences, Wellington 6140, New Zealand
    Eur J Neurosci 28:1060-7. 2008
    ..These findings indicate that opioid signalling plays a role in cell cycle progression of both radial glia and basal progenitor cells in vivo in the developing cerebral cortex...
  25. ncbi request reprint Mu opioid receptors are expressed on radial glia but not migrating neuroblasts in the late embryonic mouse brain
    Tim J Sargeant
    School of Biological Science, Victoria University of Wellington, New Zealand
    Brain Res 1175:28-38. 2007
    ..05) was found. The localization of MOR immunoreactivity within the embryonic ventricular neuroepithelia is consistent with a role for opioids in modulating neurogenesis...
  26. ncbi request reprint Lack of involvement of mu(1) opioid receptors in dermorphin-induced inhibition of hypoxic and hypercapnic ventilation in rat pups
    Atalie S Colman
    School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Respir Physiol Neurobiol 131:199-212. 2002
    ..Thus, mu opioid-induced inhibition of the hypoxic and hypercapnic responses in young rats does not occur via activation of mu(1) opioid receptors...
  27. doi request reprint Opioidergic regulation of astroglial/neuronal proliferation: where are we now?
    Tim J Sargeant
    School of Biological Sciences, Victoria University of Wellington, New Zealand
    J Neurochem 107:883-97. 2008
    ....
  28. ncbi request reprint The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C
    K A Hood
    School of Biological Sciences, Victoria University of Wellington, New Zealand
    Anticancer Drug Des 16:155-66. 2001
    ..In summary, although structurally similar to bryostatin, peloruside is a potent inhibitor of cell proliferation, has apoptosis-inducing properties and has a unique mode of action independent of PKC...
  29. doi request reprint Lehualides E-K, cytotoxic metabolites from the Tongan marine sponge Plakortis sp
    Jacqueline M Barber
    Centre for Biodiscovery and School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    J Nat Prod 74:809-15. 2011
    ..The biological activities of compounds 6-9 were investigated against human promyeloid leukemic HL-60 cells and two yeast strains, wild-type and a drug-sensitive mutant...
  30. ncbi request reprint Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity
    Kylie A Hood
    School of Biological Sciences, Victoria University of Wellington, New Zealand
    Cancer Res 62:3356-60. 2002
    ..The relatively simple structure of peloruside makes it suitable for the design and synthesis of analogues with improved tumor targeting and reduced tumor cross-resistance...
  31. doi request reprint Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells
    Anja Wilmes
    Centre for Biodiscovery and School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Invest New Drugs 29:544-53. 2011
    ..Our results also indicate a potential role of c-Myc in the cellular actions of peloruside consistent with an induction of aneuploidy seen at low concentrations of peloruside...
  32. ncbi request reprint Abundant expression of mu and delta opioid receptor mRNA and protein in the cerebellum of the fetal, neonatal, and adult rat
    Eli M Mrkusich
    School of Biological Sciences, Victoria University of Wellington, Kelburn Parade, P O Box 600, Wellington, New Zealand
    Brain Res Dev Brain Res 148:213-22. 2004
    ..In addition, using exon-specific cRNA probes, exons 1 and 4, which are both found in the MOR-1 splice variant mRNA, were detected in PK cells in the cerebellum and also within deep cerebellar nuclei in the adult...
  33. ncbi request reprint Cytoskeletal alterations that confer resistance to anti-tubulin chemotherapeutics
    Arun Kanakkanthara
    Centre for Biodiscovery and School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand
    Anticancer Agents Med Chem 13:147-58. 2013
    ..This review focuses on the mechanisms by which alterations in cytoskeletal proteins lead to drug resistance. This information will be helpful for improving the targeting of microtubule toxins...
  34. doi request reprint Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7
    Ariane Chan
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Invest New Drugs 29:615-26. 2011
    ..The results provide further insight into PelA's unique mode of stabilization and contribute to our understanding of how microtubule-targeting agents exert their anti-mitotic effects...
  35. doi request reprint The binding sites of microtubule-stabilizing agents
    Jessica J Field
    Centre for Biodiscovery, School of Biological Sciences, Victoria University of Wellington, P O Box 600, Wellington 6140, New Zealand
    Chem Biol 20:301-15. 2013
    ..This information can aid in the design of novel MSAs with improved properties...
  36. ncbi request reprint Daily patterns of metabolic rate among New Zealand lizards (Reptilia: Lacertilia: Diplodactylidae and Scincidae)
    Kelly M Hare
    School of Biological Sciences, Victoria University of Wellington, New Zealand
    Physiol Biochem Zool 79:745-53. 2006
    ..In conclusion, the metabolic rate of many species does not always correlate with the recorded activity period. The dichotomy of ecology and physiology may be clarified by more in-depth studies of species behaviors and activity periods...
  37. ncbi request reprint Conditioning reduces metabolic rate and time to steady-state in the lizard Naultinus manukanus (Reptilia: Gekkonidae)
    K M Hare
    School of Biological Sciences, Victoria University of Wellington, P O Box 600, New Zealand
    Comp Biochem Physiol A Mol Integr Physiol 139:245-50. 2004
    ..74%, respectively). We conclude that there may be hidden inaccuracies in studies that do not condition animals and that at least one conditioning trial should be used to obtain a metabolic rate at rest for small lizards...
  38. ncbi request reprint Low cost of locomotion in lizards that are active at low temperatures
    K M Hare
    School of Biological Sciences, Victoria University of Wellington, P O Box 600, Wellington, New Zealand
    Physiol Biochem Zool 80:46-58. 2007
    ..The low C(min) in lizards living at high latitudes may enable extension of their latitudinal range into otherwise thermally suboptimal habitats...
  39. ncbi request reprint Total lactate dehydrogenase activity of tail muscle is not cold-adapted in nocturnal lizards from cool-temperate habitats
    K M Hare
    School of Biological Sciences, Victoria University of Wellington, P O Box 600, New Zealand
    Comp Biochem Physiol B Biochem Mol Biol 142:438-44. 2005
    ..The total activity of LDH in tropical and temperate lizards is not cold-adapted. More data are required on biochemical adaptations and whole animal thermal preferences before trends can be established...
  40. doi request reprint Paclitaxel inhibits killing by murine cytotoxic T lymphocytes in vivo but not in vitro
    Marcus James Robinson
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Immunol Cell Biol 88:291-6. 2010
    ..The results also suggest that patients undergoing taxane anti-cancer therapy may be impaired in their ability to fight infection before the anti-mitotic effects of paclitaxel are apparent...
  41. doi request reprint Delta-9-tetrahydrocannabinol disrupts hippocampal neuroplasticity and neurogenesis in trained, but not untrained adolescent Sprague-Dawley rats
    Ryan W J Steel
    School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand
    Brain Res 1548:12-9. 2014
    ..Importantly no effects of THC were seen in the absence of training, indicating that these effects represent specific impairments by THC on training-induced responses...
  42. doi request reprint Microtubule-stabilizing agents delay the onset of EAE through inhibition of migration
    David O'Sullivan
    Centre for Biodiscovery, Schools of Biological Sciences and Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand
    Immunol Cell Biol 91:583-92. 2013
    ..Finally, we have shown that a combination treatment with synergizing MSA may provide enhanced protection at lower therapeutic doses...
  43. doi request reprint Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation
    Viswanath Das
    School of Biological Sciences and Centre for Biodiscovery, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Eur J Neurosci 35:1705-17. 2012
    ..Thus, microtubule-stabilizing drugs show promise as new therapeutic agents for treating damaged microtubule networks characteristic of neurodegenerative disease...
  44. doi request reprint MicroRNAs: novel mediators of resistance to microtubule-targeting agents
    Arun Kanakkanthara
    Centre for Biodiscovery and School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand
    Cancer Treat Rev 39:161-70. 2013
    ..Understanding the molecular role of miRNAs in drug resistance would help improve therapeutic efficacy of these agents by helping circumvent the problem of drug resistance...
  45. ncbi request reprint Comparative quantitation of mRNA expression in the central nervous system using fluorescence in situ hybridization
    Darren J Day
    School of Biological Sciences, Victoria University, Wellington, New Zealand
    Methods Mol Biol 353:125-42. 2007
    ..In this chapter, we describe protocols suitable for measuring relative changes in gene expression within individual cells of brain sections mounted on glass slides...
  46. ncbi request reprint Peloruside A, an antimitotic agent, specifically decreases tumor necrosis factor-alpha production by lipopolysaccharide-stimulated murine macrophages
    Kevin P Crume
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Exp Biol Med (Maywood) 232:607-13. 2007
    ....
  47. ncbi request reprint Developmental expression of mu and delta opioid receptors in the rat brainstem: evidence for a postnatal switch in mu isoform expression
    Bronwyn M Kivell
    School of Biological Sciences, Victoria University of Wellington, P O Box 600, Wellington, New Zealand
    Brain Res Dev Brain Res 148:185-96. 2004
    ....
  48. ncbi request reprint Regulation of T-cadherin by hormones, glucocorticoid and EGF
    Collette Bromhead
    Medical Laboratory Wellington, Wellington, New Zealand
    Gene 374:58-67. 2006
    ..The data suggest that T-cadherin is regulated in a complex manner indicative of a role in hormone and drug-induced changes in bone morphology and pathology...
  49. ncbi request reprint Method for serum-free culture of late fetal and early postnatal rat brainstem neurons
    B M Kivell
    School of Biological Sciences, Victoria University, P.O. Box 600, Wellington, New Zealand
    Brain Res Brain Res Protoc 6:91-9. 2001
    ..This paper describes the first reliable method for culturing brainstem neurons from late fetal and early postnatal stages of the rat for up to 6 days postpartum...
  50. ncbi request reprint mu-1 opioid receptor stimulation decreases body temperature in conscious, unrestrained neonatal rats
    Atalie S Colman
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Exp Biol Med (Maywood) 227:377-81. 2002
    ....
  51. doi request reprint Learning impairment by Δ(9)-tetrahydrocannabinol in adolescence is attributable to deficits in chunking
    Ryan W J Steel
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Behav Pharmacol 22:837-46. 2011
    ..We show that THC exposure impairs adolescent learning when tested in the postacute period, and that THC impairs the ability of animals to use a chunking strategy...
  52. ncbi request reprint Modulation of breathing by mu1 and mu2 opioid receptor stimulation in neonatal and adult rats
    A S Colman
    School of Biological Sciences, Victoria University of Wellington, P.O. Box 600, Wellington, New Zealand
    Respir Physiol 127:157-72. 2001
    ..The response of adults to fentanyl, but not dermorphin, was prevented by NALZ. These results suggest that both mu1 and mu2 receptors contribute to opioid-induced respiratory depression during neonatal and adult life...
  53. ncbi request reprint Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine
    K A Hood
    School of Biological Sciences, Victoria University of Wellington, New Zealand
    Apoptosis 6:207-19. 2001
    ....
  54. ncbi request reprint Quantal breathing frequency variation in halothane anaesthetised neonatal rats
    K M O'Keeffe
    Section of Anaesthesia, Wellington School of Medicine and Health Sciences PO Box 7343, Wellington, New Zealand
    Respir Physiol Neurobiol 146:147-53. 2005
    ..Dropped breaths were seen commonly in rats up to 11 days of age, but rarely in 11-14-day old rats, and were not associated with the presence or absence of cardioventilatory synchronisation...
  55. ncbi request reprint Cytochrome c unfolding on an anionic surface
    C W Herbold
    Department of Chemical Sciences, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    J Chromatogr A 863:137-46. 1999
    ..These results suggest that perturbations in the structure as well as unfolding of cytochrome c can be detected at a lower temperature on an anionic surface than in solution thereby acting like a catalyst for protein unfolding...
  56. pmc Characterization of a thermostable DNA glycosylase specific for U/G and T/G mismatches from the hyperthermophilic archaeon Pyrobaculum aerophilum
    H Yang
    Department of Microbiology and Molecular Genetics and the Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    J Bacteriol 182:1272-9. 2000
    ..The unique conserved amino acid motifs of MIG proteins are proposed to distinguish MIG proteins from the closely related Nth/MutY DNA glycosylases...
  57. ncbi request reprint Case series: neuropsychiatric symptoms with pediatric systemic lupus erythematosus
    S B Turkel
    Childrens Hospital Los Angeles, 4650 Sunset Blvd. #82, Los Angeles, CA 90027, USA
    J Am Acad Child Adolesc Psychiatry 40:482-5. 2001
    ..Initial SPECT was abnormal in all 10 patients and remained abnormal. CONCLUSION: SPECT and anti-neuronal antibodies help confirm CNS involvement in patients with SLE and neuropsychiatric symptoms...
  58. ncbi request reprint Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum
    A A Sartori
    Institute of Medical Radiobiology, , August Forel-Strasse 7, , Switzerland
    J Biol Chem 276:29979-86. 2001
    ..aerophilum was inhibited by this peptide. This implies that the hyperthermophilic archaeon possesses at least a three-pronged defense against the mutagenic threat of hydrolytic deamination of cytosines in its genomic DNA...
  59. pmc Isolation and characterization of Escherichia coli mutants with altered rates of deletion formation
    S K Whoriskey
    Department of Biology, University of California, Los Angeles 90024
    Genetics 127:21-30. 1991
    ..It is suggested that, whereas precise excision occurs predominantly via a pathway involving replication enzymes (for instance template strand slippage), deletions on an F'factor are stimulated by recombination enzymes...
  60. ncbi request reprint A model of cytokine shedding induced by low doses of gamma radiation
    J H Miller
    Washington State University Tri Cities, Richland, WA 99354, USA
    Radiat Res 163:337-42. 2005
    ....