Michael J A Williams

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. ncbi request reprint Impaired endothelial function following a meal rich in used cooking fat
    M J Williams
    Department of Medicine, University of Otago, Dunedin, New Zealand
    J Am Coll Cardiol 33:1050-5. 1999
  2. ncbi request reprint Association between C-reactive protein, metabolic cardiovascular risk factors, obesity and oral contraceptive use in young adults
    M J A Williams
    Department of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand
    Int J Obes Relat Metab Disord 28:998-1003. 2004
  3. ncbi request reprint Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women
    Michael J A Williams
    Department of Medical and Surgical Sciences, University of Otago, 201 Great King Street, Dunedin, New Zealand
    Atherosclerosis 165:179-84. 2002
  4. ncbi request reprint C-reactive protein and cardiorespiratory fitness in young adults
    Michael J A Williams
    Departments of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand
    Eur J Cardiovasc Prev Rehabil 12:216-20. 2005
  5. pmc Randomised comparison of the effects of nicardipine and esmolol on coronary artery wall stress: implications for the risk of plaque rupture
    M J Williams
    Department of Medicine, University of Otago, 201 Great King Street, Dunedin, New Zealand
    Heart 84:377-82. 2000
  6. ncbi request reprint Improved coronary artery flow after coronary angioplasty in patients with unstable angina
    M J Williams
    Department of Medicine, University of Otago, Dunedin, New Zealand
    Aust N Z J Med 30:226-30. 2000
  7. ncbi request reprint Coronary artery flow ten weeks after myocardial infarction or unstable angina: effects of combined warfarin and aspirin therapy
    M J Williams
    Department of Medicine, University of Otago, Dunedin, New Zealand
    Int J Cardiol 69:19-25. 1999
  8. doi request reprint Cardiorespiratory and cerebrovascular responses to head-up tilt II: influence of age, training status and acute exercise
    Carissa J Murrell
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Exp Gerontol 46:1-8. 2011
  9. doi request reprint Ingestion of native and thermally oxidized polyunsaturated fats acutely increases circulating numbers of endothelial microparticles
    Wayne H F Sutherland
    Medicine Section, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand
    Metabolism 59:446-53. 2010
  10. doi request reprint Syncope is unrelated to supine and postural hypotension following prolonged exercise
    Carissa J Murrell
    Department of Physiology, University of Otago, 270 Great King St, Dunedin, 9054, New Zealand
    Eur J Appl Physiol 111:469-76. 2011

Detail Information

Publications40

  1. ncbi request reprint Impaired endothelial function following a meal rich in used cooking fat
    M J Williams
    Department of Medicine, University of Otago, Dunedin, New Zealand
    J Am Coll Cardiol 33:1050-5. 1999
    ..The purpose of this study was to test the hypothesis that intake of used cooking fat is associated with impaired endothelial function...
  2. ncbi request reprint Association between C-reactive protein, metabolic cardiovascular risk factors, obesity and oral contraceptive use in young adults
    M J A Williams
    Department of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand
    Int J Obes Relat Metab Disord 28:998-1003. 2004
    ..This study sought to determine the relationship between levels of the inflammatory marker, C-reactive protein (CRP), cardiovascular risk factors and oral contraceptive use in young adults...
  3. ncbi request reprint Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women
    Michael J A Williams
    Department of Medical and Surgical Sciences, University of Otago, 201 Great King Street, Dunedin, New Zealand
    Atherosclerosis 165:179-84. 2002
    ..Confounding may contribute to reports of associations between ferritin and cardiovascular disease...
  4. ncbi request reprint C-reactive protein and cardiorespiratory fitness in young adults
    Michael J A Williams
    Departments of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand
    Eur J Cardiovasc Prev Rehabil 12:216-20. 2005
    ..The aim of this study was to examine the relationship between cardiorespiratory fitness and CRP, controlling for obesity in an unselected cohort of young adults...
  5. pmc Randomised comparison of the effects of nicardipine and esmolol on coronary artery wall stress: implications for the risk of plaque rupture
    M J Williams
    Department of Medicine, University of Otago, 201 Great King Street, Dunedin, New Zealand
    Heart 84:377-82. 2000
    ..To determine whether the beta blocker esmolol reduces coronary artery wall stress more than the short acting dihydropyridine calcium antagonist nicardipine...
  6. ncbi request reprint Improved coronary artery flow after coronary angioplasty in patients with unstable angina
    M J Williams
    Department of Medicine, University of Otago, Dunedin, New Zealand
    Aust N Z J Med 30:226-30. 2000
    ..Coronary artery flow is impaired after myocardial infarction but there is limited information regarding coronary flow in unstable angina...
  7. ncbi request reprint Coronary artery flow ten weeks after myocardial infarction or unstable angina: effects of combined warfarin and aspirin therapy
    M J Williams
    Department of Medicine, University of Otago, Dunedin, New Zealand
    Int J Cardiol 69:19-25. 1999
    ..Combination warfarin and aspirin therapy did not improve flow in vessels that remained patent but did reduce the risk of progression to occlusion...
  8. doi request reprint Cardiorespiratory and cerebrovascular responses to head-up tilt II: influence of age, training status and acute exercise
    Carissa J Murrell
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Exp Gerontol 46:1-8. 2011
    ..pre-exercise). Orthostatic tolerance was not reduced following 30 min of exercise, and did not differ with age or fitness, despite more pronounced post-exercise reductions in MCAv, MAP and SV with postural change...
  9. doi request reprint Ingestion of native and thermally oxidized polyunsaturated fats acutely increases circulating numbers of endothelial microparticles
    Wayne H F Sutherland
    Medicine Section, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand
    Metabolism 59:446-53. 2010
    ..The physiologic implications of these findings remain to be determined...
  10. doi request reprint Syncope is unrelated to supine and postural hypotension following prolonged exercise
    Carissa J Murrell
    Department of Physiology, University of Otago, 270 Great King St, Dunedin, 9054, New Zealand
    Eur J Appl Physiol 111:469-76. 2011
    ..Practically, endurance athletes who present with greater hypotension are not necessarily at a greater risk of syncope than those who present with lesser reductions in BP...
  11. pmc Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: effect of age and 12-week exercise training
    Carissa J Murrell
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Age (Dordr) 35:905-20. 2013
    ..01) and during exercise, irrespective of age. The finding of a training-induced elevation in cerebrovascular reactivity provides further support for exercise as a preventative tool in cerebrovascular and neurological disease with ageing...
  12. doi request reprint Cardiorespiratory and cerebrovascular responses to head-up tilt I: influence of age and training status
    Carissa J Murrell
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Exp Gerontol 46:9-17. 2011
    ..Thus, at least in this healthy population, neither age nor fitness impacts on the ability to adapt to postural change...
  13. doi request reprint Postprandial cytokine concentrations and meal composition in obese and lean women
    Patrick J Manning
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Obesity (Silver Spring) 16:2046-52. 2008
    ..These findings suggest that the postprandial response of plasma IL-6 concentrations may be influenced by the type of carbohydrate in the meal, central adiposity, and circulating cortisol concentrations in women...
  14. ncbi request reprint Aged garlic extract improves endothelial function in men with coronary artery disease
    Michael J A Williams
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Phytother Res 19:314-9. 2005
    ..Whether improvement in endothelial function decreases the risk of future cardiovascular events remains to be determined...
  15. ncbi request reprint Estimating exercise capacity from walking tests in elderly individuals with stable coronary artery disease
    Sandra Mandic
    Cardiac Rehabilitation Research Laboratory, School of Physical Education, University of Otago, Dunedin, New Zealand
    Disabil Rehabil 35:1853-8. 2013
    ..We developed multivariate models for predicting peak oxygen consumption (VO2peak) from 6-minute walk test (6MWT) distance and peak shuttle walk speed for elderly stable CAD patients...
  16. ncbi request reprint Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects
    Kate N Thomas
    Department of Physiology, School of Physical Education, University of Otago, Dunedin, New Zealand
    J Appl Physiol (1985) 107:506-17. 2009
    ....
  17. pmc Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate
    Brie Sorrenson
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    J Lipid Res 54:55-62. 2013
    ..These results suggest 4-PBA may warrant further investigation as a potential therapy for increasing cholesterol efflux and HDL-C levels...
  18. doi request reprint Homology modeling and functional testing of an ABCA1 mutation causing Tangier disease
    Rachel J Suetani
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Atherosclerosis 218:404-10. 2011
    ..To investigate the impact of the p.R1068H mutation on the structure and function of the ATP-binding cassette A1 (ABCA1) protein...
  19. ncbi request reprint Acute effect of drinking red and white wines on circulating levels of inflammation-sensitive molecules in men with coronary artery disease
    Michael J A Williams
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Ontago, Dunedin, New Zealand
    Metabolism 53:318-23. 2004
    ..These data suggest that moderate wine intake may acutely increase plasma levels of IL-6 in men with CAD. It is possible that this increase in plasma IL-6 is a response to alcohol-induced oxidative stress in the liver...
  20. doi request reprint Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function
    John W Chu
    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Int J Cardiol 167:1242-6. 2013
    ....
  21. pmc Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing
    Philip N Ainslie
    Department of Physiology, University of Otago, Dunedin, New Zealand
    J Physiol 586:4005-10. 2008
    ..The persistence of this finding in older endurance-trained men may therefore help explain why there is a lower risk of cerebrovascular disease in this population...
  22. pmc Systemic inflammation and lung function in young adults
    Robert J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Thorax 62:1064-8. 2007
    ..We explored the association between the forced expiratory volume in one second (FEV(1)) and the systemic inflammatory marker C-reactive protein (CRP) in young adults...
  23. ncbi request reprint Normal endothelial function after meals rich in olive or safflower oil previously used for deep frying
    M J Williams
    Department of Medicine, Dunedin School of Medicine, University of Otago, 201 Great King Street, Dunedin, New Zealand
    Nutr Metab Cardiovasc Dis 11:147-52. 2001
    ..These findings suggest that relatively short-term use of these vegetable oils for frying may not adversely affect postprandial endothelial function when foods containing the heat-modified oils are consumed...
  24. ncbi request reprint Vitamin C improves endothelial dysfunction in renal allograft recipients
    M J Williams
    Department of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Nephrol Dial Transplant 16:1251-5. 2001
    ..001). CONCLUSIONS: Vitamin C acutely improves flow-mediated, endothelium-dependent dilation and increases the resistance of lipoproteins in dilute serum to oxidation in renal transplant recipients...
  25. ncbi request reprint 'Exercise snacks' before meals: a novel strategy to improve glycaemic control in individuals with insulin resistance
    Monique E Francois
    School of Physical Education, Sport and Exercise Sciences, University of Otago, 46 Union St West, PO Box 56, Dunedin, 9076, New Zealand
    Diabetologia 57:1437-45. 2014
    ....
  26. doi request reprint Nonbacterial thrombotic endocarditis with ST-elevation myocardial infarction treated with percutaneous coronary aspiration thrombectomy
    Ing S Tiong
    Southern Blood and Cancer Service, Dunedin Hospital, Dunedin, New Zealand
    Heart Lung Circ 22:386-9. 2013
    ..The clinical manifestations and management of coronary embolisation from nonbacterial thrombotic endocarditis are reviewed...
  27. doi request reprint An ABCA1 truncation shows no dominant negative effect in a familial hypoalphalipoproteinemia pedigree with three ABCA1 mutations
    Brie Sorrenson
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Biochem Biophys Res Commun 409:400-5. 2011
    ..There was no evidence of a dominant negative effect on wildtype or p.N1800H protein levels. We conclude that in the case of the p.C978fsX988 truncated mutant a lack of expression precludes it from having a dominant negative effect...
  28. ncbi request reprint Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men
    Wayne H F Sutherland
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago Medical School, PO Box 913, Dunedin, New Zealand
    Atherosclerosis 160:195-203. 2002
    ..These findings may be relevant to the choice of fat to replace saturated fats in lipid-lowering diets and to low risk of coronary heart disease in communities which have a high consumption of olive oil...
  29. ncbi request reprint Plasma lipoprotein(a) indicates risk for 4 distinct forms of vascular disease
    Gregory T Jones
    Department of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand
    Clin Chem 53:679-85. 2007
    ..This study aimed to investigate Lp(a) risk association for 4 different types of vascular disease (including CAD) within a predominantly white population...
  30. ncbi request reprint The prevalence, incidence, progression, and risks of aortic valve sclerosis: a systematic review and meta-analysis
    Sean Coffey
    Department of Cardiology, Oxford University Hospitals, Oxford, United Kingdom Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand Electronic address
    J Am Coll Cardiol 63:2852-61. 2014
    ..The aim of this study was to comprehensively review the epidemiology of aortic sclerosis (ASc) and its association with cardiovascular events...
  31. ncbi request reprint Early morning impairment in cerebral autoregulation and cerebrovascular CO2 reactivity in healthy humans: relation to endothelial function
    Philip N Ainslie
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Exp Physiol 92:769-77. 2007
    ..05 versus evening). The early morning reduction in cerebral autoregulation may facilitate the onset of cerebrovascular accidents; this may be of particular relevance to at-risk groups, especially upon resuming the upright position...
  32. ncbi request reprint Fat embolism and acute hypotension during vertebroplasty: an experimental study in sheep
    Nikolaus Aebli
    Departments of Orthopaedic Surgery and Physiology, University of Otago, and the Department of Cardiology, Dunedin Hospital, Dunedin, New Zealand
    Spine (Phila Pa 1976) 27:460-6. 2002
    ..An experimental study of cardiovascular complications that arise during vertebroplasty was conducted...
  33. ncbi request reprint Lack of progress in valvular heart disease in the pre-transcatheter aortic valve replacement era: increasing deaths and minimal change in mortality rate over the past three decades
    Sean Coffey
    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand OxVALVE Study, Oxford University Hospitals, Oxford, United Kingdom Electronic address
    Am Heart J 167:562-567.e2. 2014
    ..With the development of new but expensive therapeutic options, health care systems require timely epidemiological information on VHD. We sought to determine the mortality burden of VHD and how it has changed over time...
  34. pmc A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm
    Gregory T Jones
    Department of Surgery, University of Otago, Dunedin 9054, New Zealand
    Hum Mol Genet 22:2941-7. 2013
    ....
  35. pmc Effects of community-based cardiac rehabilitation on body composition and physical function in individuals with stable coronary artery disease: 1.6-year followup
    Sandra Mandic
    Cardiac Rehabilitation Research Laboratory, School of Physical Education, Sport and Exercise Sciences, University of Otago, P O Box 56, Dunedin 9054, New Zealand
    Biomed Res Int 2013:903604. 2013
    ..To examine long-term changes in physical function and body composition in coronary artery disease (CAD) patients participating in ongoing community-based cardiac rehabilitation (CR)...
  36. doi request reprint Single high oral dose amiodarone for cardioversion of recent onset atrial fibrillation
    Kugathasan Nadarasa
    Department of Cardiology, Dunedin Hospital, Dunedin, New Zealand
    Heart Lung Circ 21:444-8. 2012
    ..Selection of a pharmacological agent and mode of administration for cardioversion is a challenging task in recent onset atrial fibrillation...
  37. doi request reprint Rapid cycle change to predominantly radial access coronary angiography and percutaneous coronary intervention: effect on vascular access site complications
    Kugathasan Nadarasa
    Department of Cardiology, Dunedin Hospital, Dunedin, New Zealand
    Catheter Cardiovasc Interv 79:589-94. 2012
    ..This study sought to evaluate the safety and feasibility of all operators at a single center changing from predominantly femoral to radial access for coronary percutaneous procedures...
  38. ncbi request reprint Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia
    Tania L Slatter
    Department of Biochemistry, University of Otago, P O Box 56, 710 Cumberland St, Dunedin 9001, Otago, New Zealand
    Atherosclerosis 187:393-400. 2006
    ..In contrast, the maternal 1068H allele has less effect and is associated with a relatively normal HDL level. We conclude that haplotypes of mutant ABCA1 alleles may contribute to the phenotypic variance shown between FHA individuals...
  39. doi request reprint The effects of age on the spontaneous low-frequency oscillations in cerebral and systemic cardiovascular dynamics
    Tingying Peng
    Department of Engineering Science, Oxford University, Oxford, UK
    Physiol Meas 29:1055-69. 2008
    ..001 for HR-O2Hb and ABP-O2Hb), but not in old subjects under orthostatic stress. The coupling between the cerebrovascular and wider cardiovascular systems in response to orthostatic stress thus appears to be impaired with ageing...
  40. ncbi request reprint Ferritin and cardiovascular risk
    Michael J A Williams
    Atherosclerosis 167:171. 2003