Srdjan M Vlajkovic

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi request reprint Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea
    Srdjan M Vlajkovic
    Division of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Hear Res 170:127-38. 2002
  2. ncbi request reprint Differential distribution of adenosine receptors in rat cochlea
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Cell Tissue Res 328:461-71. 2007
  3. doi request reprint Noise-induced changes in expression levels of NADPH oxidases in the cochlea
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand Electronic address
    Hear Res 304:145-52. 2013
  4. pmc Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Exp Gerontol 46:905-14. 2011
  5. pmc Role of adenosine kinase in cochlear development and response to noise
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Aukland, New Zealand
    J Neurosci Res 88:2598-609. 2010
  6. doi request reprint Preservation of cochlear function in Cd39 deficient mice
    Srdjan M Vlajkovic
    Department of Physiology, The University of Auckland, 85 Park Road, Grafton, Private Bag 92019, Auckland 1142, New Zealand
    Hear Res 253:77-82. 2009
  7. ncbi request reprint Activation-dependent trafficking of NTPDase2 in Chinese hamster ovary cells
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Int J Biochem Cell Biol 39:810-7. 2007
  8. ncbi request reprint NTPDase1 and NTPDase2 immunolocalization in mouse cochlea: implications for regulation of p2 receptor signaling
    Srdjan M Vlajkovic
    Discipline of Audiology and Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Histochem Cytochem 50:1435-42. 2002
  9. ncbi request reprint Noise-induced up-regulation of NTPDase3 expression in the rat cochlea: Implications for auditory transmission and cochlear protection
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 1104:55-63. 2006
  10. doi request reprint Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss
    Ann Chi Yan Wong
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Hear Res 260:81-8. 2010

Detail Information

Publications16

  1. ncbi request reprint Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea
    Srdjan M Vlajkovic
    Division of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Hear Res 170:127-38. 2002
    ....
  2. ncbi request reprint Differential distribution of adenosine receptors in rat cochlea
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Cell Tissue Res 328:461-71. 2007
    ..Our study provides a framework for further investigation of adenosine signalling in the inner ear, including putative roles in oxidative stress responses...
  3. doi request reprint Noise-induced changes in expression levels of NADPH oxidases in the cochlea
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand Electronic address
    Hear Res 304:145-52. 2013
    ..Inhibition of NADPH oxidases is potentially a novel pathway for therapeutic management of noise-induced hearing loss. ..
  4. pmc Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Exp Gerontol 46:905-14. 2011
    ..This study provides the first evidence that ARHL can be mitigated by enhancing adenosine signalling in the cochlea...
  5. pmc Role of adenosine kinase in cochlear development and response to noise
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Aukland, New Zealand
    J Neurosci Res 88:2598-609. 2010
    ....
  6. doi request reprint Preservation of cochlear function in Cd39 deficient mice
    Srdjan M Vlajkovic
    Department of Physiology, The University of Auckland, 85 Park Road, Grafton, Private Bag 92019, Auckland 1142, New Zealand
    Hear Res 253:77-82. 2009
    ..These findings suggest that Cd39 deletion alone does not adversely affect cochlear function, possibly as compensatory up-regulation of other surface located NTPDases may offset predicted alterations in cochlear homeostasis...
  7. ncbi request reprint Activation-dependent trafficking of NTPDase2 in Chinese hamster ovary cells
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Int J Biochem Cell Biol 39:810-7. 2007
    ..The increase in surface-located NTPDase2 may reflect a regulatory mechanism counteracting excessive stimulation and desensitisation of P2 receptors...
  8. ncbi request reprint NTPDase1 and NTPDase2 immunolocalization in mouse cochlea: implications for regulation of p2 receptor signaling
    Srdjan M Vlajkovic
    Discipline of Audiology and Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Histochem Cytochem 50:1435-42. 2002
    ..This differential expression of NTPDase1 and 2 in the cochlea suggests spatial regulation of P2 receptor signaling, potentially involving different nucleotide species and hydrolysis kinetics...
  9. ncbi request reprint Noise-induced up-regulation of NTPDase3 expression in the rat cochlea: Implications for auditory transmission and cochlear protection
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 1104:55-63. 2006
    ..The results suggest a role for NTPDase3 in regulating ATP signaling associated primarily with auditory neurotransmission, and the potential neuroprotective nature of noise-induced up-regulation of this ectonucleotidase in the cochlea...
  10. doi request reprint Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss
    Ann Chi Yan Wong
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Hear Res 260:81-8. 2010
    ..This study pinpoints A(1) adenosine receptors as attractive targets for pharmacological interventions to reduce noise-induced cochlear injury after exposure...
  11. pmc C-terminal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation
    Carol J H Wang
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Park Road, Grafton, Private Bag 92019, Auckland, New Zealand
    Biochem J 385:729-36. 2005
    ..These findings advance the molecular physiology of this enzyme system by characterizing the contribution of the C-terminal domain to many of the enzyme's signature properties...
  12. doi request reprint Developmentally regulated expression of ectonucleotidases NTPDase5 and NTPDase6 and UDP-responsive P2Y receptors in the rat cochlea
    Mary G O'Keeffe
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Histochem Cell Biol 133:425-36. 2010
    ..Spatiotemporal topographic expression of NTPDase5 and NTPDase6 and P2Y receptors in adult and developing cochlear tissues provide strong support for the role of pyrimidinergic signalling in cochlear development...
  13. ncbi request reprint Nucleoside transporter expression and adenosine uptake in the rat cochlea
    Abdul F Khan
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Neuroreport 18:235-9. 2007
    ..The study suggests that the bi-directional nucleoside transport supports the uptake and recycling of purines and regulates the activation of adenosine receptors by altering adenosine concentrations in cochlear fluid spaces...
  14. doi request reprint Hair cell specific NTPDase6 immunolocalisation in vestibular end organs: potential role of purinergic signaling in vestibular sensory transduction
    Mary G O'Keeffe
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    J Vestib Res 22:213-9. 2012
    ..NTPDase6 immunolocalisation in the vestibular end organ could be linked to the regulation of P2 receptor signalling and sensory transduction, including maintenance of vestibular hair bundles...
  15. pmc Adenosine and the auditory system
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Curr Neuropharmacol 7:246-56. 2009
    ..Manipulations of the adenosine signalling system thus hold significant promise in the therapeutic management of oxidative stress in the cochlea...
  16. doi request reprint Differential membrane redistribution of P2X receptor isoforms in response to osmotic and hyperglycemic stress in the rat lens
    Haruna Suzuki-Kerr
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Histochem Cell Biol 131:667-80. 2009
    ..Furthermore they suggest the involvement of specific P2X isoforms in the regulation of fiber cell volume and the initiation of diabetic cataract...