Arvind Varsani

Summary

Affiliation: University of Canterbury
Location: Christchurch, New Zealand

Publications

  1. doi request reprint Avihepadnavirus diversity in parrots is comparable to that found amongst all other avian species
    Tomasz Piasecki
    Department of Epizootiology with Clinic of Birds and Exotic Animals, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50 360 Wrocław, Poland
    Virology 438:98-105. 2013
  2. doi request reprint Discovery of a novel mastrevirus and alphasatellite-like circular DNA in dragonflies (Epiprocta) from Puerto Rico
    Karyna Rosario
    College of Marine Science, University of South Florida, St Petersburg, FL 33701, USA
    Virus Res 171:231-7. 2013
  3. doi request reprint A protocol for the rapid isolation of full geminivirus genomes from dried plant tissue
    Dionne N Shepherd
    Department of Molecular and Cell Biology, University of Cape Town, Private Bag, Rondebosch 7701, South Africa
    J Virol Methods 149:97-102. 2008
  4. doi request reprint Six novel begomoviruses infecting tomato and associated weeds in Southeastern Brazil
    Gloria P Castillo-Urquiza
    Dep de Fitopatologia BIOAGRO, Universidade Federal de Vicosa, Vicosa, MG, Brazil
    Arch Virol 153:1985-9. 2008
  5. pmc Experimental observations of rapid Maize streak virus evolution reveal a strand-specific nucleotide substitution bias
    Eric van der Walt
    Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa
    Virol J 5:104. 2008
  6. doi request reprint Complete sequences of tomato leaf curl Palampur virus isolates infecting cucurbits in Iran
    Jahangir Heydarnejad
    Department of Plant Protection, College of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran
    Arch Virol 154:1015-8. 2009
  7. pmc Dating the origins of the maize-adapted strain of maize streak virus, MSV-A
    Gordon W Harkins
    South African National Bioinformatics Institute, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
    J Gen Virol 90:3066-74. 2009
  8. doi request reprint Further characterization of tomato-infecting begomoviruses in Brazil
    Leonardo C Albuquerque
    Department Fitopatologia, Universidade de Brasilia, Brasilia, DF, 70910 900, Brazil
    Arch Virol 157:747-52. 2012
  9. doi request reprint Extensive recombination detected among beak and feather disease virus isolates from breeding facilities in Poland
    Laurel Julian
    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, 8140, New Zealand
    J Gen Virol 94:1086-95. 2013
  10. pmc Plant-produced cottontail rabbit papillomavirus L1 protein protects against tumor challenge: a proof-of-concept study
    T Kohl
    Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa
    Clin Vaccine Immunol 13:845-53. 2006

Collaborators

Detail Information

Publications80

  1. doi request reprint Avihepadnavirus diversity in parrots is comparable to that found amongst all other avian species
    Tomasz Piasecki
    Department of Epizootiology with Clinic of Birds and Exotic Animals, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50 360 Wrocław, Poland
    Virology 438:98-105. 2013
    ..All PHBV isolates display classical avihepadnavirus genome architecture...
  2. doi request reprint Discovery of a novel mastrevirus and alphasatellite-like circular DNA in dragonflies (Epiprocta) from Puerto Rico
    Karyna Rosario
    College of Marine Science, University of South Florida, St Petersburg, FL 33701, USA
    Virus Res 171:231-7. 2013
    ....
  3. doi request reprint A protocol for the rapid isolation of full geminivirus genomes from dried plant tissue
    Dionne N Shepherd
    Department of Molecular and Cell Biology, University of Cape Town, Private Bag, Rondebosch 7701, South Africa
    J Virol Methods 149:97-102. 2008
    ..This method should be extremely useful for the study of any circular DNA plant viruses with genome component lengths smaller than the maximum size amplifiable by RCA...
  4. doi request reprint Six novel begomoviruses infecting tomato and associated weeds in Southeastern Brazil
    Gloria P Castillo-Urquiza
    Dep de Fitopatologia BIOAGRO, Universidade Federal de Vicosa, Vicosa, MG, Brazil
    Arch Virol 153:1985-9. 2008
    ..These species could represent a distinct lineage of New World begomoviruses, found in Brazil for the first time...
  5. pmc Experimental observations of rapid Maize streak virus evolution reveal a strand-specific nucleotide substitution bias
    Eric van der Walt
    Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa
    Virol J 5:104. 2008
    ..Also, questions regarding both the mechanistic basis and adaptive value of high geminivirus mutation rates remain unanswered...
  6. doi request reprint Complete sequences of tomato leaf curl Palampur virus isolates infecting cucurbits in Iran
    Jahangir Heydarnejad
    Department of Plant Protection, College of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran
    Arch Virol 154:1015-8. 2009
    ..The increasing incidence of ToLCPMV in different cultivated species throughout Iran may signal the emergence of a serious new threat to agricultural production throughout the Middle East...
  7. pmc Dating the origins of the maize-adapted strain of maize streak virus, MSV-A
    Gordon W Harkins
    South African National Bioinformatics Institute, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
    J Gen Virol 90:3066-74. 2009
    ..This suggests a causal link between MSV recombination and the emergence of MSV-A as a serious pathogen of maize...
  8. doi request reprint Further characterization of tomato-infecting begomoviruses in Brazil
    Leonardo C Albuquerque
    Department Fitopatologia, Universidade de Brasilia, Brasilia, DF, 70910 900, Brazil
    Arch Virol 157:747-52. 2012
    ..Collectively, all of the analyzed sequences were phylogenetically clustered within the two major groups of Brazilian tomato-infecting begomoviruses...
  9. doi request reprint Extensive recombination detected among beak and feather disease virus isolates from breeding facilities in Poland
    Laurel Julian
    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, 8140, New Zealand
    J Gen Virol 94:1086-95. 2013
    ....
  10. pmc Plant-produced cottontail rabbit papillomavirus L1 protein protects against tumor challenge: a proof-of-concept study
    T Kohl
    Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa
    Clin Vaccine Immunol 13:845-53. 2006
    ..This is the first evidence that a plant-derived papillomavirus vaccine is protective in an animal model and is a proof of concept for human papillomavirus vaccines produced in plants...
  11. ncbi request reprint A new isolate of beak and feather disease virus from endemic wild red-fronted parakeets (Cyanoramphus novaezelandiae) in New Zealand
    Luis Ortiz-Catedral
    Ecology and Conservation Lab, Institute of Natural Sciences, Massey University, Auckland Campus, Private Bag 102904, North Shore Mail Centre, Auckland, New Zealand
    Arch Virol 155:613-20. 2010
    ....
  12. doi request reprint A novel species of mastrevirus (family Geminiviridae) isolated from Digitaria didactyla grass from Australia
    Rob W Briddon
    National Institute for Biotechnology and Genetic Engineering, Jhang Road, Faisalabad, Pakistan
    Arch Virol 155:1529-34. 2010
    ..We propose that the name first used during the 1980s be used for this species, Digitaria didactyla striate mosaic virus (DDSMV)...
  13. doi request reprint Fulfilling Koch's postulates for beet curly top Iran virus and proposal for consideration of new genus in the family Geminiviridae
    Jahangir Heydarnejad
    Department of Plant Protection, College of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran
    Arch Virol 158:435-43. 2013
    ....
  14. pmc Adaptive evolution by recombination is not associated with increased mutation rates in Maize streak virus
    Aderito L Monjane
    Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa
    BMC Evol Biol 12:252. 2012
    ....
  15. pmc East African cassava mosaic-like viruses from Africa to Indian ocean islands: molecular diversity, evolutionary history and geographical dissemination of a bipartite begomovirus
    Alexandre De Bruyn
    CIRAD, UMR PVBMT, Pole de protection des plantes, 7 chemin de l IRAT, Saint Pierre, Ile de La Réunion 97410, France
    BMC Evol Biol 12:228. 2012
    ....
  16. ncbi request reprint Turnip curly top virus, a highly divergent geminivirus infecting turnip in Iran
    Rob W Briddon
    National Institute for Biotechnology and Genetic Engineering, Jhang Road, Faisalabad, Pakistan
    Virus Res 152:169-75. 2010
    ..These findings show TCTV to be a highly divergent geminivirus with similarities to viruses of the genus curtovirus. The significance of these findings, particularly the taxonomic implications are discussed...
  17. pmc Reconstructing the history of maize streak virus strain a dispersal to reveal diversification hot spots and its origin in southern Africa
    Aderito L Monjane
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag X3, Rondebosch 7701, Cape Town, South Africa
    J Virol 85:9623-36. 2011
    ..Collectively, our results suggest that regular analysis of MSV-A genomes within these diversification hot spots could be used to monitor the emergence of future MSV-A lineages that could affect maize cultivation in Africa...
  18. doi request reprint Bromus catharticus striate mosaic virus: a new mastrevirus infecting Bromus catharticus from Australia
    James Hadfield
    School of Biological Sciences, University of Canterbury, Christchurch, New Zealand
    Arch Virol 156:335-41. 2011
    ..Specifically, it appears that DDSMV possesses a short intergenic region sequence that has been recombinationally derived from either BCSMV or a close relative that has not yet been identified...
  19. ncbi request reprint Expression of Human papillomavirus type 16 major capsid protein in transgenic Nicotiana tabacum cv. Xanthi
    A Varsani
    Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa
    Arch Virol 148:1771-86. 2003
    ..Rabbits immunised with small doses of plant-produced particles elicited a weak anti-HPV-16 L1 immune response. Our results support the feasibility of using transgenic plants for the production of HPV vaccines...
  20. pmc Recombination in eukaryotic single stranded DNA viruses
    Darren P Martin
    Computational Biology Group, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 4579, South Africa
    Viruses 3:1699-738. 2011
    ....
  21. pmc Comparative analysis of Panicum streak virus and Maize streak virus diversity, recombination patterns and phylogeography
    Arvind Varsani
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa
    Virol J 6:194. 2009
    ..Unlike MSV, however, PanSV has no known economic relevance...
  22. ncbi request reprint Molecular characterisation of beak and feather disease virus (BFDV) in New Zealand and its implications for managing an infectious disease
    Melanie Massaro
    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand
    Arch Virol 157:1651-63. 2012
    ..Pro-active screening and monitoring of BFDV infection rates in aviaries as well as in wild populations are necessary to limit the risk of transmission among threatened and endangered parrot populations in New Zealand...
  23. pmc Recombination hotspots and host susceptibility modulate the adaptive value of recombination during maize streak virus evolution
    Aderito L Monjane
    Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, 7701, Cape Town, South Africa
    BMC Evol Biol 11:350. 2011
    ..We then co-infected a selection of differentially MSV-resistant maize genotypes with pairs of reciprocal chimaeras to determine the efficiency with which recombination would give rise to high-fitness progeny genomes resembling MSV-MatA...
  24. pmc Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus
    Rachel A North
    Biomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8041, New Zealand
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:306-12. 2013
    ..Understanding the structural biology of N-acetylneuraminate lyase in pathogenic bacteria, such as methicillin-resistant S. aureus, will provide insights for the development of future antimicrobials...
  25. doi request reprint Paspalum striate mosaic virus: an Australian mastrevirus from Paspalum dilatatum
    Andrew D W Geering
    Centre for Plant Science, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Ecosciences Precinct, Brisbane, Qld 4001, Australia
    Arch Virol 157:193-7. 2012
    ..PSMV, BCSMV and Digitaria didactyla striate mosaic virus all contain a similar, small recombinant sequence in the small intergenic region...
  26. doi request reprint Replicative intermediates of maize streak virus found during leaf development
    Julia B Erdmann
    Department of Molecular Biology and Plant Virology, Institute of Biology, University of Stuttgart, Pfaffenwaldring 57, D 70550 Stuttgart, Germany
    J Gen Virol 91:1077-81. 2010
    ..Interestingly, in addition to RCR-associated DNA forms seen in other geminiviruses, MSV also apparently uses dimeric open circular DNA as a template for RCR...
  27. doi request reprint Diverse circular ssDNA viruses discovered in dragonflies (Odonata: Epiprocta)
    Karyna Rosario
    College of Marine Science, University of South Florida, St Petersburg, FL 33701, USA
    J Gen Virol 93:2668-81. 2012
    ..The novelty of CRESS-DNA viruses identified in dragonflies using simple molecular techniques indicates that there is an unprecedented diversity of ssDNA viruses among insect populations...
  28. doi request reprint Complete genome sequence of a dahlia common mosaic virus isolate from New Zealand
    James Hadfield
    School of Biological Sciences, University of Canterbury, Christchurch, New Zealand
    Arch Virol 156:2297-301. 2011
    ..The availability of the complete DCMV sequence provides a reference genome against which all others can be compared...
  29. pmc Complex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networks
    Darren P Martin
    Computational Biology Group, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, South Africa
    PLoS Pathog 7:e1002203. 2011
    ....
  30. pmc Development of phoH as a novel signature gene for assessing marine phage diversity
    Dawn B Goldsmith
    College of Marine Science, University of South Florida, St Petersburg, FL 33701, USA
    Appl Environ Microbiol 77:7730-9. 2011
    ..Each depth and geographic location had a distinct phoH composition, although most phoH clusters were recovered from multiple sites. Overall, phoH is an effective signature gene for examining phage diversity in the marine environment...
  31. doi request reprint Genetic diversity and host range studies of turnip curly top virus
    Sara Razavinejad
    Department of Plant Protection, College of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran
    Virus Genes 46:345-53. 2013
    ..We observed ~13 % diversity amongst all the TCTV isolates and found evidence of recombination in the CP- and Rep-coding regions of the genomes...
  32. pmc Brazilian begomovirus populations are highly recombinant, rapidly evolving, and segregated based on geographical location
    Carolina S Rocha
    Dep de Fitopatologia BIOAGRO and National Research Institute for Plant Pest Interactions, INCT IPP, Universidade Federal de Vicosa, Vicosa, MG, Brazil
    J Virol 87:5784-99. 2013
    ..While the population structures of five well-sampled viral species all displayed geographical subdivision, a noncultivated host-infecting virus was more genetically variable than the four predominantly tomato-infecting viruses...
  33. ncbi request reprint Novel ssDNA viruses discovered in yellow-crowned parakeet (Cyanoramphus auriceps) nesting material
    Alyssa Sikorski
    School of Biological Sciences, University of Canterbury, Ilam, Christchurch 8140, New Zealand
    Arch Virol 158:1603-7. 2013
    ..Maximum-likelihood phylogenetic analysis of the Reps reveals that these are two novel ssDNA viruses. At this point, we are unable to attribute the death of the parakeet to these two new novel ssDNA viruses. ..
  34. doi request reprint Molecular characterisation of an avihepadnavirus isolated from Psittacula krameri (ring-necked parrot)
    Tomasz Piasecki
    Department of Epizootiology with Clinic of Birds and Exotic Animals, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50 360 Wrocław, Poland
    Arch Virol 157:585-90. 2012
    ..Additionally, we identified an X-like ORF in the genome of PHBV. The full-genome data will be useful in developing screening tools for avihepadnaviruses in parrots...
  35. doi request reprint A novel maize-infecting mastrevirus from La Réunion Island
    Daniel Pande
    Department of Botany and Horticulture, Maseno University, Maseno, Kenya
    Arch Virol 157:1617-21. 2012
    ..The two isolates shared <57 % genome-wide identity with all other known mastreviruses. We propose calling the new species Maize streak Réunion virus...
  36. doi request reprint Diversity of beet curly top Iran virus isolated from different hosts in Iran
    Sara Gharouni Kardani
    Department of Plant Protection, College of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
    Virus Genes 46:571-5. 2013
    ..Our analysis reveals ~11 % diversity amongst BCTIV isolates and we detect evidence of recombination within these genomes...
  37. doi request reprint Molecular characterisation of a novel cassava associated circular ssDNA virus
    Anisha Dayaram
    School of Biological Sciences, University of Canterbury, Ilam, Christchurch 8140, New Zealand
    Virus Res 166:130-5. 2012
    ..However, host range studies using infectious clones will be required to demonstrate the novel virus' likely origin and actual host species...
  38. doi request reprint Molecular characterisation of dicot-infecting mastreviruses from Australia
    James Hadfield
    School of Biological Sciences, University of Canterbury, Ilam, Christchurch 8140, New Zealand
    Virus Res 166:13-22. 2012
    ....
  39. doi request reprint A genome-wide pairwise-identity-based proposal for the classification of viruses in the genus Mastrevirus (family Geminiviridae)
    Brejnev Muhire
    Institute of Infectious Diseases and Molecular Medicine, Computational Biology Group, University of Cape Town, Cape Town, 7925, South Africa
    Arch Virol 158:1411-24. 2013
    ....
  40. ncbi request reprint Evidence of inter-component recombination, intra-component recombination and reassortment in banana bunchy top virus
    Daisy Stainton
    School of Biological Sciences, University of Canterbury, Christchurch 8140, New Zealand
    J Gen Virol 93:1103-19. 2012
    ....
  41. doi request reprint Australian monocot-infecting mastrevirus diversity rivals that in Africa
    Simona Kraberger
    School of Biological Sciences, University of Canterbury, Christchurch 8140, New Zealand
    Virus Res 169:127-36. 2012
    ..We found that the patterns of inter- and intra-species recombination and the recombination hotspots mirror those found in both their African monocot-infecting counterparts and dicot-infecting mastrevirus...
  42. doi request reprint Evidence of multiple introductions of beak and feather disease virus into the Pacific islands of Nouvelle-Caledonie (New Caledonia)
    Laurel Julian
    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand
    J Gen Virol 93:2466-72. 2012
    ..Of more concern was the discovery of an infected bird from the vulnerable and endemic New Caledonian Parakeet (Cyanoramphus saisseti). Our results reveal that there have been at least two introductions of BFDV into Nouvelle-Calédonie...
  43. doi request reprint Novel ssDNA virus recovered from estuarine Mollusc (Amphibola crenata) whose replication associated protein (Rep) shares similarities with Rep-like sequences of bacterial origin
    Anisha Dayaram
    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, 8140, New Zealand
    J Gen Virol 94:1104-10. 2013
    ..The occurrence of previously unknown viruses in organisms associated with human pollution is a relatively unexplored field...
  44. doi request reprint Discovery of a novel circular single-stranded DNA virus from porcine faeces
    Alyssa Sikorski
    School of Biological Sciences, University of Canterbury, Ilam, Private Bag 4800, Christchurch 8140, New Zealand
    Arch Virol 158:283-9. 2013
    ....
  45. ncbi request reprint Analysis of Iranian Potato virus S isolates
    Khadijeh Salari
    Department of Plant Protection, College of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran
    Virus Genes 43:281-8. 2011
    ..Based on maximum likelihood phylogenetic analysis coupled with pairwise identity analysis, we propose 15 genotypes for the PVS(O) strain and 3 genotypes for the PVS(A) strain...
  46. ncbi request reprint Novel sugarcane streak and Sugarcane streak Réunion mastreviruses from southern Africa and La Réunion
    Dionne N Shepherd
    Department of Molecular and Cell Biology, University of Cape Town, Private Bag, Rondebosch, 7701, South Africa
    Arch Virol 153:605-9. 2008
    ..Phylogenetic and recombination analyses indicate continent-wide SSRV strain diversity and that our isolate potentially representing a new SISV species is a recombinant...
  47. ncbi request reprint An investigation into the use of human papillomavirus type 16 virus-like particles as a delivery vector system for foreign proteins: N- and C-terminal fusion of GFP to the L1 and L2 capsid proteins
    Oliver P Windram
    Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town, 7701, South Africa
    Arch Virol 153:585-9. 2008
    ..Conformation-specific monoclonal antibodies (Mabs) bound to the VLPs, thereby indicating that they possibly retain their antigenicity. In addition, all of the VLPs encapsidated DNA in the range of 6-8 kb...
  48. doi request reprint Panicum streak virus diversity is similar to that observed for maize streak virus
    A Varsani
    Electron Microscope Unit, University of Cape Town, Private Bag, Rondebosch, Cape Town 7701, South Africa
    Arch Virol 153:601-4. 2008
  49. ncbi request reprint Begomovirus 'melting pot' in the south-west Indian Ocean islands: molecular diversity and evolution through recombination
    P LeFeuvre
    CIRAD, UMR 53 PVBMT CIRAD Université de La Réunion, Pole de protection des plantes, 7 chemin de l IRAT, 97410 Saint Pierre, La Reunion, France
    J Gen Virol 88:3458-68. 2007
    ..We provide the first statistical support for three recombination hot-spots (V1/C3 interface, C1 centre and the entire IR) and two recombination cold-spots (the V2 and the third quarter of V1) in the genomes of begomoviruses...
  50. ncbi request reprint Genetic analysis of maize streak virus isolates from Uganda reveals widespread distribution of a recombinant variant
    Betty E Owor
    Department of Molecular and Cell Biology, University of Cape Town, Private Bag, Rondebosch 7701, South Africa
    J Gen Virol 88:3154-65. 2007
    ....
  51. ncbi request reprint HIV type 1 subtype C gag and nef diversity in Southern Africa
    Helba Bredell
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    AIDS Res Hum Retroviruses 23:477-81. 2007
    ..We do not, however, find much evidence of intersubtype recombination in the Southern African genes, implying that the likelihood of vaccine failure due to the emergence of intersubtype recombinants is probably low...
  52. ncbi request reprint Post-translational cleavage of recombinantly expressed nitrilase from Rhodococcus rhodochrous J1 yields a stable, active helical form
    R Ndoria Thuku
    Department of Biotechnology, University of the Western Cape, Bellville, South Africa
    FEBS J 274:2099-108. 2007
    ..The helical form can be generated by expressing only residues 1-327...
  53. ncbi request reprint Successful application of FTA Classic Card technology and use of bacteriophage phi29 DNA polymerase for large-scale field sampling and cloning of complete maize streak virus genomes
    Betty E Owor
    Department of Molecular and Cell Biology, University of Cape Town, Private Bag, Rondebosch 7701, South Africa
    J Virol Methods 140:100-5. 2007
    ....
  54. pmc Recombination patterns in aphthoviruses mirror those found in other picornaviruses
    Livio Heath
    Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Rondebosch 7701, South Africa
    J Virol 80:11827-32. 2006
    ....
  55. ncbi request reprint A deletion and point mutation study of the human papillomavirus type 16 major capsid gene
    Arvind Varsani
    Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa
    Virus Res 122:154-63. 2006
    ..The results have implications both for considering use of single-genotype HPV vaccines, and for design of novel second-generation vaccines...
  56. ncbi request reprint Evidence of ancient papillomavirus recombination
    Arvind Varsani
    Electron Microscope Unit, University of Cape Town, Observatory, Cape Town 7925, South Africa
    J Gen Virol 87:2527-31. 2006
    ..Here, a range of rigorous analyses is applied to full-genome sequences of papillomaviruses to provide convincing statistical and phylogenetic evidence that evolutionarily relevant papillomavirus recombination can occur...
  57. ncbi request reprint Transient expression of Human papillomavirus type 16 L1 protein in Nicotiana benthamiana using an infectious tobamovirus vector
    Arvind Varsani
    Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa
    Virus Res 120:91-6. 2006
    ..Immunisation of rabbits with the concentrated plant extract induced a weak immune response. This is the first report of the successful expression of an HPV L1 gene in plants using a plant virus vector...
  58. ncbi request reprint Restoration of native folding of single-stranded DNA sequences through reverse mutations: an indication of a new epigenetic mechanism
    Dionne N Shepherd
    Department of Molecular and Cell Biology, University of Cape Town, Cape Town 7700, South Africa
    Arch Biochem Biophys 453:108-22. 2006
    ..We propose that the selection of native nucleic acid folding is an epigenetic effect, which might have broad implications in the evolution of plants and their viruses...
  59. pmc Chimeric human papillomavirus type 16 (HPV-16) L1 particles presenting the common neutralizing epitope for the L2 minor capsid protein of HPV-6 and HPV-16
    Arvind Varsani
    Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa and Department of Pathology, The Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    J Virol 77:8386-93. 2003
    ..Moreover, it contributes to knowledge of the structure of HPV-16 L1 VLPs and their derivatives...
  60. pmc Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen
    Arvind Varsani
    Electron Microscope Unit, Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa
    J Gen Virol 89:2063-74. 2008
    ....
  61. ncbi request reprint Genetic diversity and distribution of tomato-infecting begomoviruses in Iran
    Roya Fazeli
    Department of Plant Protection, College of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran
    Virus Genes 38:311-9. 2009
    ..hierosolymitana. Our results indicate that the tomato producing areas in central, southern, and southeastern Iran are threatened by begomoviruses originating from both the Mediterranean basin and the Indian subcontinent...
  62. pmc Widely conserved recombination patterns among single-stranded DNA viruses
    P LeFeuvre
    CIRAD, UMR 53 PVBMT CIRAD Université de La Réunion, Pole de protection des plantes, Ligne Paradis, 97410 Saint Pierre, La Reunion, France
    J Virol 83:2697-707. 2009
    ..Collectively, these results imply that natural selection acting against viruses expressing recombinant proteins is a major determinant of nonrandom recombination breakpoint distributions observable in most ssDNA virus families...
  63. doi request reprint Recombination patterns in dicot-infecting mastreviruses mirror those found in monocot-infecting mastreviruses
    Darren P Martin
    Computational Biology Group, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, Cape Town, 7925, South Africa
    Arch Virol 156:1463-9. 2011
    ..This suggests that, despite host range differences, very similar biochemical, ecological and evolutionary factors must underlie recombination patterns in the dicot- and monocot-infecting mastreviruses...
  64. doi request reprint Dragonfly cyclovirus, a novel single-stranded DNA virus discovered in dragonflies (Odonata: Anisoptera)
    Karyna Rosario
    College of Marine Science, University of South Florida, St Petersburg, FL 33701, USA
    J Gen Virol 92:1302-8. 2011
    ..To our knowledge, this is the first report of a circular ssDNA virus identified in insects, and the data may help elucidate evolutionary links among novel Circoviridae recently identified in animals and environmental samples...
  65. doi request reprint Global genetic diversity and geographical and host-species distribution of beak and feather disease virus isolates
    Arvind Varsani
    School of Biological Sciences, University of Canterbury, Christchurch 8140, New Zealand
    J Gen Virol 92:752-67. 2011
    ..The implications of our results for the taxonomy and classification of circoviruses are discussed...
  66. doi request reprint Characterisation of potato virus Y isolates from Iran
    Atefe Hosseini
    Department of Plant Protection, College of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran
    Virus Genes 42:128-40. 2011
    ..The PVY(NTN) isolates from Iran more closely related to the European than North American PVY(NTN) isolates...
  67. ncbi request reprint Structural and biochemical characterization of a nitrilase from the thermophilic bacterium, Geobacillus pallidus RAPc8
    Dael S Williamson
    Electron Microscope Unit, University of Cape Town, Rondebosch, Cape Town, 7701, South Africa
    Appl Microbiol Biotechnol 88:143-53. 2010
    ..Electron microscopy and image classification showed complexes having crescent-like, "c-shaped", circular and "figure-8" shapes. Protein models suggested that the various complexes were composed of 6, 8, 10 and 20 subunits, respectively...
  68. doi request reprint A unique isolate of beak and feather disease virus isolated from budgerigars (Melopsittacus undulatus) in South Africa
    Arvind Varsani
    Electron Microscope Unit, University of Cape Town, Rondebosch, Cape Town, South Africa
    Arch Virol 155:435-9. 2010
    ..Maximum-likelihood analysis and recombination analysis suggest that the South African budgerigar BFDV isolates are unique to budgerigars, are non-recombinant in origin, and represent a new genotype of BFDV...
  69. ncbi request reprint Maize streak virus: an old and complex 'emerging' pathogen
    Dionne N Shepherd
    Department of Molecular and Cell Biology, University of Cape Town, PB Rondebosch, 7701, South Africa
    Mol Plant Pathol 11:1-12. 2010
    ..Even in epidemic years, disease incidences can vary from a few infected plants per field, with little associated yield loss, to 100% infection rates and complete yield loss...
  70. doi request reprint A novel sugarcane-infecting mastrevirus from South Africa
    Robert Lawry
    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Arch Virol 154:1699-703. 2009
    ..As with USV, the SacSV isolate we have characterized bears no obvious evidence of inter-species recombination...
  71. pmc Experimental evidence indicating that mastreviruses probably did not co-diverge with their hosts
    Gordon W Harkins
    South African National Bioinformatics Institute, University of the Western Cape, Cape Town, South Africa
    Virol J 6:104. 2009
    ..The credibility of this hypothesis, therefore, hinges on the testable claim that negative selection during mastrevirus evolution is so potent that it effectively purges 99.999% of all mutations that occur...
  72. doi request reprint A unicellular algal virus, Emiliania huxleyi virus 86, exploits an animal-like infection strategy
    Luke C M Mackinder
    Marine Biological Association of the UK, Citadel Hill, Plymouth PL1 2DP, UK
    J Gen Virol 90:2306-16. 2009
    ..EhV-86 therefore appears to have an infection mechanism different from that employed by other algal NCLDVs, with entry and exit strategies showing a greater analogy to animal-like NCLDVs...
  73. pmc A highly divergent South African geminivirus species illuminates the ancient evolutionary history of this family
    Arvind Varsani
    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Virol J 6:36. 2009
    ..ECSV represents a new genus-level geminivirus lineage, and has a mixture of features normally associated with other specific geminivirus genera...
  74. pmc Rapid host adaptation by extensive recombination
    Eric van der Walt
    Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa
    J Gen Virol 90:734-46. 2009
    ....
  75. doi request reprint Three-dimensional reconstruction of Heterocapsa circularisquama RNA virus by electron cryo-microscopy
    Jennifer L Miller
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Gen Virol 92:1960-70. 2011
    ..The handedness of the structure has been determined by a novel method involving high resolution scanning electron microscopy of the negatively stained viruses and secondary electron detection...
  76. pmc The spread of tomato yellow leaf curl virus from the Middle East to the world
    Pierre Lefeuvre
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    PLoS Pathog 6:e1001164. 2010
    ..We instead identify the Mediterranean basin as the main launch-pad of global TYLCV movements...