D Robin Taylor

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. doi request reprint Long term performance characteristics of an electrochemical nitric oxide analyser
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respir Med 105:211-7. 2011
  2. pmc Factors affecting exhaled nitric oxide measurements: the effect of sex
    D Robin Taylor
    Department of Respiratory Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respir Res 8:82. 2007
  3. doi request reprint The beta-agonist saga and its clinical relevance: on and on it goes
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Am J Respir Crit Care Med 179:976-8. 2009
  4. doi request reprint A new perspective on concepts of asthma severity and control
    D R Taylor
    Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Eur Respir J 32:545-54. 2008
  5. ncbi request reprint Respiratory health effects of cannabis: position statement of the Thoracic Society of Australia and New Zealand
    D R Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Intern Med J 33:310-3. 2003
  6. ncbi request reprint "As-required" combination therapy with inhaled corticosteroids and long-acting beta-2 agonists for asthma: current evidence and recommendations
    D Robin Taylor
    Thoracic Society of Australia and New Zealand New Zealand Branch
    N Z Med J 121:106-18. 2008
  7. ncbi request reprint Pharmacogenetics of beta2-agonist drugs in asthma
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Clin Rev Allergy Immunol 31:247-58. 2006
  8. pmc Exhaled nitric oxide measurements: clinical application and interpretation
    D R Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    Thorax 61:817-27. 2006
  9. ncbi request reprint Nitric oxide as a clinical guide for asthma management
    D Robin Taylor
    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    J Allergy Clin Immunol 117:259-62. 2006
  10. doi request reprint Biomarkers in the assessment and management of airways diseases
    D R Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Postgrad Med J 84:628-34; quiz 633. 2008

Detail Information

Publications79

  1. doi request reprint Long term performance characteristics of an electrochemical nitric oxide analyser
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respir Med 105:211-7. 2011
    ..Also, there are reports that reproducibility of FE(NO) may be reduced in patients with high FE(NO): our secondary aim was to address this issue...
  2. pmc Factors affecting exhaled nitric oxide measurements: the effect of sex
    D Robin Taylor
    Department of Respiratory Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respir Res 8:82. 2007
    ..However, many constitutional and environmental factors affect F(E)NO, making it difficult to devise reference values. Our aim was to evaluate the relative importance of factors affecting F(E)NO in a well characterised adult population...
  3. doi request reprint The beta-agonist saga and its clinical relevance: on and on it goes
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Am J Respir Crit Care Med 179:976-8. 2009
    ..Clinicians need to be aware of how to identify and manage patients for whom beta-agonist treatment is a problem rather than a solution. They constitute a small but important subgroup of patients with difficult asthma...
  4. doi request reprint A new perspective on concepts of asthma severity and control
    D R Taylor
    Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Eur Respir J 32:545-54. 2008
    ..These markers can also act as surrogate measures for future risk...
  5. ncbi request reprint Respiratory health effects of cannabis: position statement of the Thoracic Society of Australia and New Zealand
    D R Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Intern Med J 33:310-3. 2003
    ....
  6. ncbi request reprint "As-required" combination therapy with inhaled corticosteroids and long-acting beta-2 agonists for asthma: current evidence and recommendations
    D Robin Taylor
    Thoracic Society of Australia and New Zealand New Zealand Branch
    N Z Med J 121:106-18. 2008
    ..It is recognised that with further data these recommendations may require revision after three years...
  7. ncbi request reprint Pharmacogenetics of beta2-agonist drugs in asthma
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Clin Rev Allergy Immunol 31:247-58. 2006
    ..They are also relevant in the design of clinical trials involving beta2-agonist therapy...
  8. pmc Exhaled nitric oxide measurements: clinical application and interpretation
    D R Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    Thorax 61:817-27. 2006
    ..However, a number of issues still need to be resolved, including the diagnostic role of F(E)NO in preschool children and the use of reference values versus individual F(E)NO profiles in managing patients with difficult or severe asthma...
  9. ncbi request reprint Nitric oxide as a clinical guide for asthma management
    D Robin Taylor
    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    J Allergy Clin Immunol 117:259-62. 2006
    ..Either outcome is helpful in decision making. F(E)NO measurements complement the use of other tests in asthma, but more work is required to determine reference values and cut-points for appropriate interpretation...
  10. doi request reprint Biomarkers in the assessment and management of airways diseases
    D R Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Postgrad Med J 84:628-34; quiz 633. 2008
    ..They also have a potential role in monitoring disease activity and predicting future clinical outcomes for asthma and chronic obstructive pulmonary disease. Current evidence in relation to these issues is explored in this review...
  11. doi request reprint Risk assessment in asthma and COPD: a potential role for biomarkers?
    D R Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Thorax 64:261-4. 2009
    ..The well-tried model used in cardiovascular disease to assess absolute risk might possibly be adapted for use in COPD, and this should be actively explored...
  12. ncbi request reprint Bronchodilator response in relation to beta2-adrenoceptor haplotype in patients with asthma
    D Robin Taylor
    Otago Respiratory Research Unit and Department of Preventive and Social Medicine, Dunedin School of Medicine, New Zealand
    Am J Respir Crit Care Med 172:700-3. 2005
    ..Whether these features are related to single nucleotide polymorphisms or to combinations (haplotypes) is unclear...
  13. ncbi request reprint Asthma in remission: can relapse in early adulthood be predicted at 18 years of age?
    D Robin Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Chest 127:845-50. 2005
    ..To determine the frequency of relapse of asthma in young adults in remission at 18 years of age, during a follow-up period of 8 years, and to identify possible prognostic markers for relapse...
  14. ncbi request reprint beta-Adrenergic receptor polymorphisms: relationship to the beta-agonist controversy and clinical implications
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Expert Opin Pharmacother 8:3195-203. 2007
    ..ADRB2 genotyping of patients with severe or difficult-to-control asthma may shed light on a possible contributor to their clinical instability...
  15. ncbi request reprint A longitudinal study of the effects of tobacco and cannabis exposure on lung function in young adults
    D Robin Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Addiction 97:1055-61. 2002
    ..To assess the possible effects of tobacco and cannabis smoking on lung function in young adults between the ages of 18 and 26...
  16. pmc Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism
    D R Taylor
    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Thorax 55:762-7. 2000
    ..Polymorphisms of the beta(2) adrenoceptor influence receptor function in vitro and asthma phenotypes in vivo. However, their importance in determining responses to inhaled beta agonist treatment has not been clearly defined...
  17. ncbi request reprint Genetic variation of the beta(2)-adrenoceptor: its functional and clinical importance in bronchial asthma
    D R Taylor
    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Am J Pharmacogenomics 1:165-74. 2001
    ..Future studies will be required to clarify the pharmacodynamic effects of ADRB2haplotypes both in vitro and in vivo...
  18. ncbi request reprint The influence of polymorphism at position 16 of the beta2-adrenoceptor on the development of tolerance to beta-agonist
    D R Taylor
    Dunedin School of Medicine, University of Otago, New Zealand
    J Asthma 37:691-700. 2000
    ..Thus, although tolerance is influenced in vitro by polymorphism of the beta2-adrenoceptor, the magnitude of between-genotype differences in vivo is unlikely to be significant...
  19. ncbi request reprint The respiratory effects of cannabis dependence in young adults
    D R Taylor
    Department of Medicine, Dunedin School of Medicine, University of Otago Medical School, Dunedin, New Zealand
    Addiction 95:1669-77. 2000
    ..To evaluate the relationship between cannabis dependence and respiratory symptoms and lung function in young adults, while controlling for the effects of tobacco smoking...
  20. ncbi request reprint Beta-adrenergic receptor polymorphisms and drug responses in asthma
    D Robin Taylor
    Department of Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Pharmacogenomics 3:173-84. 2002
    ..The results of prospective studies based on selection by ADRB2 haplotype will be necessary before a more general application of this knowledge can be encouraged...
  21. doi request reprint Using biomarkers in the assessment of airways disease
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    J Allergy Clin Immunol 128:927-34; quiz 935-6. 2011
    ....
  22. ncbi request reprint ADRB2 polymorphisms and beta2 agonists
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Lancet 370:2075-6. 2007
  23. pmc Associations between respiratory symptoms, lung function and gastro-oesophageal reflux symptoms in a population-based birth cohort
    Robert J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respir Res 7:142. 2006
    ..The role of obesity in mediating this association is also unclear. We explored the associations between respiratory symptoms, lung function, and gastro-oesophageal reflux symptoms in a birth cohort of approximately 1000 individuals...
  24. doi request reprint Predicting corticosteroid response in chronic obstructive pulmonary disease using exhaled nitric oxide
    Jack F Dummer
    Dunedin and Christchurch Schools of Medicine, University of Otago, Dunedin, New Zealand
    Am J Respir Crit Care Med 180:846-52. 2009
    ..Response is more likely to occur in association with eosinophilic airway inflammation, for which the fraction of exhaled nitric oxide (Fe(NO)) is a good surrogate marker...
  25. ncbi request reprint Association between exhaled nitric oxide and systemic inflammatory markers
    Tim J T Sutherland
    Dunedin Multidisciplinary Health and Development Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Ann Allergy Asthma Immunol 99:334-9. 2007
    ..Exhaled nitric oxide is a noninvasive measure of asthmatic airway inflammation...
  26. doi request reprint Effects of steroid therapy on inflammatory cell subtypes in asthma
    Douglas C Cowan
    Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    Thorax 65:384-90. 2010
    ..ICS use led to phenotype misclassification. Steroid responsiveness was greater in EA, but the absence of eosinophilia did not indicate the absence of a steroid response. In NEA this was best predicted by baseline exhaled nitric oxide...
  27. ncbi request reprint Association between exhaled nitric oxide and systemic inflammatory markers
    Tim J T Sutherland
    Dunedin Multidisciplinary Health and Development Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Ann Allergy Asthma Immunol 99:534-9. 2007
    ..Exhaled nitric oxide is a noninvasive measure of asthmatic airway inflammation...
  28. doi request reprint Asthma phenotypes: consistency of classification using induced sputum
    Robert J Hancox
    Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, UK
    Respirology 17:461-6. 2012
    ..This classification can help determine whether corticosteroid treatment is indicated. We assessed the stability of these phenotypes over time and with different treatment regimens...
  29. doi request reprint Outcomes using exhaled nitric oxide measurements as an adjunct to primary care asthma management
    Richard S Hewitt
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Prim Care Respir J 18:320-7. 2009
    ..This is often difficult to judge. Our aim was to evaluate a decision-support algorithm incorporating FENO measurements in a nurse-led asthma clinic...
  30. doi request reprint Exercise-induced wheeze: Fraction of exhaled nitric oxide-directed management
    Douglas C Cowan
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respirology 15:683-90. 2010
    ..We assessed: the efficacy of cromoglycate, formoterol and montelukast in patients with EIW and low F(E)NO (<35 ppb) in a randomized cross-over trial, and the efficacy of inhaled corticosteroid in a high F(E)NO (>35 ppb) group...
  31. ncbi request reprint Sex differences in the relation between body mass index and asthma and atopy in a birth cohort
    Robert J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand
    Am J Respir Crit Care Med 171:440-5. 2005
    ..It remains unclear if this association is due to genuine asthma or to symptoms caused by overweight, at what age the association develops, and whether it is confined to females...
  32. ncbi request reprint Use of exhaled nitric oxide measurements to guide treatment in chronic asthma
    Andrew D Smith
    Respiratory Research Unit, Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    N Engl J Med 352:2163-73. 2005
    ..Measurements of the fraction of exhaled nitric oxide (FE(NO)) constitute a noninvasive marker that may be a useful alternative for the adjustment of inhaled-corticosteroid treatment...
  33. ncbi request reprint Effect of caffeine ingestion on exhaled nitric oxide measurements in patients with asthma
    Elizabeth S Taylor
    Otago Respiratory Research Unit, Dunedin School of Medicine, University of Otago Medical School, Dunedin, New Zealand
    Am J Respir Crit Care Med 169:1019-21. 2004
    ..We conclude that caffeinated foods and beverages are unlikely to acutely influence FENO in subjects with asthma, and protocols for laboratory measurement do not need to take this factor into account...
  34. pmc Systemic inflammation and lung function in young adults
    Robert J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Thorax 62:1064-8. 2007
    ..We explored the association between the forced expiratory volume in one second (FEV(1)) and the systemic inflammatory marker C-reactive protein (CRP) in young adults...
  35. ncbi request reprint Cigarette smoking and allergic sensitization: a 32-year population-based cohort study
    Robert J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    J Allergy Clin Immunol 121:38-42.e3. 2008
    ..Cigarette smoke has immunosuppressant effects, but its effect on allergic sensitization is unclear...
  36. doi request reprint The association between obesity and asthma: interactions between systemic and airway inflammation
    Tim J T Sutherland
    Respiratory Research Unit, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Am J Respir Crit Care Med 178:469-75. 2008
    ..However, clear evidence for either an additive or a synergistic pathologic interaction between obesity and asthma is lacking in humans...
  37. doi request reprint Exhaled nitric oxide levels in asthma: Personal best versus reference values
    Andrew D Smith
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    J Allergy Clin Immunol 124:714-8.e4. 2009
    ..Factors affecting the fraction of nitric oxide in exhaled air (FE(NO)) are multiple. Interpreting values when assessing airways disease may be problematic. Clinically optimum levels have not been defined...
  38. ncbi request reprint Adverse effects of short-acting beta-agonists: potential impact when anti-inflammatory therapy is inadequate
    Jonathan M Wraight
    Respiratory Research Unit, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respirology 9:215-21. 2004
    ..Our aim was to establish whether adverse effects of SABAs are greater at higher than normal doses and after withdrawing inhaled corticosteroid (ICS) therapy...
  39. ncbi request reprint The role of sleep-disordered breathing, daytime sleepiness, and impaired performance in motor vehicle crashes-a case control study
    Ruth N Kingshott
    Department of Respiratory Research, University of Otago, Dunedin, New Zealand
    Sleep Breath 8:61-72. 2004
    ..To examine levels of sleep-disordered breathing, daytime sleepiness, and impaired performance in 60 motor vehicle crash drivers and 60 controls matched for age, gender, and body mass index...
  40. ncbi request reprint Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests
    Andrew D Smith
    Dunedin School of Medicine, University of Otago Medical School, Dunedin, New Zealand
    Am J Respir Crit Care Med 169:473-8. 2004
    ..We conclude that FE(NO) measurements and induced sputum analysis are superior to conventional approaches, with exhaled nitric oxide being most advantageous because the test is quick and easy to perform...
  41. doi request reprint Simvastatin in the treatment of asthma: lack of steroid-sparing effect
    Douglas C Cowan
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Thorax 65:891-6. 2010
    ..Small trials have failed to show a significant benefit, but a systematic study to evaluate the steroid-sparing effect of statin treatment has not been carried out...
  42. ncbi request reprint Elevated posture for the management of obstructive sleep apnea
    Margot A Skinner
    Respiratory Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Sleep Breath 8:193-200. 2004
    ..However, no relationships could be identified between baseline data, including the identification of positional OSA, and objective outcomes that might predict patients who are likely to benefit from treatment in an elevated position...
  43. doi request reprint Biomarkers of inflammation in asthma: a clinical perspective
    D Robin Taylor
    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Semin Respir Crit Care Med 33:620-9. 2012
    ..At the very least, existing techniques should have a regular place in severe asthma clinics, if not more widely, where heterogeneity is the norm and not all asthma is what it seems...
  44. ncbi request reprint Eosinophils and eosinophilic cationic protein in induced sputum and blood: effects of budesonide and terbutaline treatment
    Ruth E Aldridge
    Canterbury Respiratory Research Unit, Christchurch School of Medicine, University of Otago, Christchurch Hospital, Christchurch, New Zealand
    Ann Allergy Asthma Immunol 89:492-7. 2002
    ..Eosinophilic cationic protein (ECP) levels in sputum and blood correlate with clinical severity, and serial measurements of ECP have been proposed as a suitable candidate...
  45. doi request reprint Serial exhaled nitric oxide measurements in the assessment of laboratory animal allergy
    Richard S Hewitt
    Respiratory Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    J Asthma 45:101-7. 2008
    ..METHODS. Fifty laboratory animal workers participated. Measurements of FE(NO) and spirometry were obtained at baseline (Friday) and twice-daily following a weekend with no animal contact...
  46. doi request reprint Supporting the diagnosis of non-specific respiratory symptoms in primary care: the role of exhaled nitric oxide measurement and spirometry
    Richard S Hewitt
    Research Fellow, Respiratory Research Department, Dunedin School of Medicine, Dunedin, New Zealand
    Prim Care Respir J 17:97-103. 2008
    ..To assess whether exhaled nitric oxide (FENO) measurements improve management and clinician confidence in patients presenting with non-specific respiratory symptoms...
  47. ncbi request reprint Bronchodilator tolerance: the impact of increasing bronchoconstriction
    J M Wraight
    Dept of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Eur Respir J 21:810-5. 2003
    ..Increasing bronchoconstriction conferred greater susceptibility to the effects of bronchodilator tolerance...
  48. doi request reprint Dynamic hyperinflation with bronchoconstriction: differences between obese and nonobese women with asthma
    Tim J T Sutherland
    Respiratory Research Unit, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Am J Respir Crit Care Med 177:970-5. 2008
    ..It is unclear whether the dynamic changes that occur during bronchoconstriction differ between obese versus nonobese patients with asthma...
  49. doi request reprint Efficacy of the 'tennis ball technique' versus nCPAP in the management of position-dependent obstructive sleep apnoea syndrome
    Margot A Skinner
    Respiratory Research Unit, Dunedin School of Medicine, School of Physiotherapy, University of Otago, Dunedin, New Zealand
    Respirology 13:708-15. 2008
    ..Our aim was to evaluate the efficacy of a thoracic anti-supine band (TASB), designed to mimic the so-called 'tennis ball technique', compared with nasal CPAP (nCPAP)...
  50. ncbi request reprint Lack of efficacy for a cervicomandibular support collar in the management of obstructive sleep apnea
    Margot A Skinner
    Respiratory Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Chest 125:118-26. 2004
    ..The effect of therapy using a cervicomandibular support collar (CMSC) to manage obstructive sleep apnea (OSA) was compared with standard therapy, nasal continuous positive airway pressure (nCPAP)...
  51. ncbi request reprint Adiposity, asthma, and airway inflammation
    Christene R McLachlan
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    J Allergy Clin Immunol 119:634-9. 2007
    ..One possible explanation might be that these studies have used body mass index to identify adiposity, which might be a less reliable measure of body fat in men than in women...
  52. ncbi request reprint Determination of beta2-adrenergic receptor (ADRB2) haplotypes by a multiplexed polymerase chain reaction assay
    Mathew D Littlejohn
    Gene Structure and Function Laboratory, Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, P O Box 4345, Christchurch, New Zealand
    Hum Mutat 20:479. 2002
    ..This assay will facilitate studies of ADRB2haplotypes in phenotypes such as patient responses to beta2-agonists, bronchial hyper-responsiveness, and cardiovascular conditions...
  53. ncbi request reprint Accuracy of monitoring for sleep-related breathing disorders in the coronary care unit
    Margot A Skinner
    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Chest 127:66-71. 2005
    ..To evaluate the frequency of sleep-disordered breathing (SDB) in patients presenting with acute cardiovascular events...
  54. ncbi request reprint Is exhaled nitric oxide measurement a useful clinical test in asthma?
    Andrew D Smith
    Respiratory Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Curr Opin Allergy Clin Immunol 5:49-56. 2005
    ..This review highlights recent advances in applying this technology to the diagnosis and ongoing assessment of asthma in the clinical and epidemiological settings...
  55. ncbi request reprint Reversing acute bronchoconstriction in asthma: the effect of bronchodilator tolerance after treatment with formoterol
    S L Jones
    Dept of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, New Zealand
    Eur Respir J 17:368-73. 2001
    ..This bronchodilator tolerance is evident in circumstances of acute bronchconstriction...
  56. doi request reprint Advances in the clinical applications of exhaled nitric oxide measurements
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    J Breath Res 6:047102. 2012
    ..Exhaled NO is potentially relevant in the assessment of occupational asthma (serial measurements) and also in diagnosing bronchiolitis obliterans in lung transplant patients...
  57. ncbi request reprint The efficacy of a mandibular advancement splint in relation to cephalometric variables
    Margot A Skinner
    Respiratory Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Sleep Breath 6:115-24. 2002
    ..Improvements in AHI may be explained by the MAS maintaining the new or existing relationship of the hyoid and its surrounding structures, thus preventing obstruction in the upper airway during sleep...
  58. pmc Relationship between socioeconomic status and asthma: a longitudinal cohort study
    R J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Thorax 59:376-80. 2004
    ..Most of these studies have been cross sectional in design and have relied on subjective markers of asthma such as symptoms of wheeze. Many have been unable to control adequately for potential confounding factors...
  59. ncbi request reprint Exhaled NO and assessment of anti-inflammatory effects of inhaled steroid: dose-response relationship
    S L Jones
    Dept of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, New Zealand
    Eur Respir J 20:601-8. 2002
    ..The relationship found in this study was linear over the dose range 0-500 microg x day(-1) soon after commencing therapy and continued over time...
  60. pmc Effects of cannabis on lung function: a population-based cohort study
    R J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Eur Respir J 35:42-7. 2010
    ..Cannabis use was associated with higher lung volumes, suggesting hyperinflation and increased large-airways resistance, but there was little evidence for airflow obstruction or impairment of gas transfer...
  61. ncbi request reprint Long-acting beta-agonist treatment in patients with persistent asthma already receiving inhaled corticosteroids
    R J Hancox
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    BioDrugs 15:11-24. 2001
    ..Guidelines for the management of patients with chronic persistent asthma are likely to require modification to reflect these developments...
  62. ncbi request reprint Interaction between corticosteroid and beta-agonist drugs. Biochemical and cardiovascular effects in normal subjects
    D R Taylor
    Department of Medicine, University of Otago Medical School, Dunedin, New Zealand
    Chest 102:519-24. 1992
    ..However, the degree of hypokalemia noted as a result of this drug interaction may be of clinical significance in the hypoxic conditions of acute airways obstruction...
  63. ncbi request reprint The efficacy of a novel tongue-stabilizing device on polysomnographic variables in sleep-disordered breathing: a pilot study
    Ruth N Kingshott
    Respiratory Research Unit, Dunedin School of Medicine, New Zealand
    Sleep Breath 6:69-76. 2002
    ..Additional larger prospective studies are required to identify suitable candidates for TSD use in the treatment of snoring and SDB...
  64. ncbi request reprint Adherence to asthma self-management plans with inhaled corticosteroid and oral prednisone: A descriptive analysis
    Jonathan M Wraight
    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Respirology 7:133-9. 2002
    ..The aim of the present study was to perform a descriptive analysis of patient responses to worsening asthma with regard to using individualized SMP...
  65. ncbi request reprint Craniofacial form and obstructive sleep apnea in Polynesian and Caucasian men
    R Coltman
    University of Otago, Dunedin, New Zealand
    Sleep 23:943-50. 2000
    ....
  66. ncbi request reprint The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control
    S L Jones
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Am J Respir Crit Care Med 164:738-43. 2001
    ..We conclude that eNO measurements are as useful as induced sputum analysis and AHR in assessing airway inflammation, with the advantage that they are easy to perform...
  67. ncbi request reprint Care plans for acutely deteriorating COPD: a randomized controlled trial
    I R Martin
    Department of General Practice, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Chron Respir Dis 1:191-5. 2004
    ..Acute exacerbations of chronic obstructive pulmonary disease (COPD) are a frequent reason for admission to hospital and are responsible for the majority of the direct economic costs of treating COPD...
  68. doi request reprint The effect of adiposity measured by dual-energy X-ray absorptiometry on lung function
    T J T Sutherland
    Respiratory Research Unit, Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    Eur Respir J 32:85-91. 2008
    ..This disappeared after adjustment in females but remained in males. The effects of thoracic and abdominal body fat on respiratory function are comparable but cannot be separated from one another...
  69. ncbi request reprint Exhaled NO: forward, backward, or sideways?
    D Robin Taylor
    Am J Respir Crit Care Med 176:221-2. 2007
  70. doi request reprint Inflammometry to assess airway diseases
    Ian D Pavord
    Department of Respiratory Medicine, Allergy and Thoracic Surgery, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester LE3 9QP, UK
    Lancet 372:1017-9. 2008
  71. ncbi request reprint Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1/vital capacity ratio: a longitudinal population study from childhood to adulthood
    Finn Rasmussen
    Firestone Institute for Respiratory Health, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 165:1480-8. 2002
    ..These data suggest that airway remodeling in asthma, as manifested by impaired lung function, begins in childhood and continues into adult life...
  72. ncbi request reprint Salamol and asthma in New Zealand
    D Robin Taylor
    N Z Med J 119:U2328; author reply U2328; discussion U2328. 2006
  73. ncbi request reprint Risk factors for hospital admission for asthma from childhood to young adulthood: a longitudinal population study
    Finn Rasmussen
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and McMaster University, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    J Allergy Clin Immunol 110:220-7. 2002
    ..Predictors of hospital admissions for asthma in children and young adults in a general population are not well defined, because most studies have used selected subpopulations...
  74. ncbi request reprint Outcome in adulthood of asymptomatic airway hyperresponsiveness in childhood: a longitudinal population study
    Finn Rasmussen
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    Pediatr Pulmonol 34:164-71. 2002
    ..We suggest that rather than considering AHR as a marker of asthma, it should be regarded as a parallel pathological process that may lead to subsequent symptoms and clinical evidence of asthma...
  75. ncbi request reprint Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study
    Malcolm R Sears
    Department of Medicine, McMaster University, Ontario, Hamilton, Canada
    Lancet 360:901-7. 2002
    ..Breastfeeding is widely advocated to reduce risk of atopy and asthma, but the evidence for such an effect is conflicting. We aimed to assess long-term outcomes of asthma and atopy related to breastfeeding in a New Zealand birth cohort...
  76. ncbi request reprint Risk of severe asthma episodes predicted from fluctuation analysis of airway function
    Urs Frey
    Paediatric Respiratory Medicine, Department of Paediatrics, University Hospital of Berne, Inselspital 3010 Berne, Switzerland
    Nature 438:667-70. 2005
    ..The characterization of fluctuations in airway function provides a quantitative basis for objective risk prediction of asthma episodes and for evaluating the effectiveness of therapy...
  77. pmc Sex differences in factors associated with childhood- and adolescent-onset wheeze
    Piush J Mandhane
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Am J Respir Crit Care Med 172:45-54. 2005
    ..Factors predicting the development of wheeze may differ between sexes and between childhood and adolescence...
  78. ncbi request reprint A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
    Malcolm R Sears
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ont, Canada
    N Engl J Med 349:1414-22. 2003
    ..The outcome of childhood asthma in adults has been described in high-risk cohorts, but few population-based studies have reported the risk factors for persistence and relapse...
  79. ncbi request reprint A randomized crossover efficacy trial of oral CPAP (Oracle) compared with nasal CPAP in the management of obstructive sleep apnea
    Fiona E Anderson
    Fisher and Paykel Healthcare, Auckland, New Zealand
    Sleep 26:721-6. 2003
    ..To determine the therapeutic efficacy and viability of a novel oral interface for continuous positive airway pressure (CPAP) compared with conventional nasal interfaces...