J R Tagg

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. pmc Mode of action of a lysostaphin-like bacteriolytic agent produced by Streptococcus zooepidemicus 4881
    R S Simmonds
    Department of Microbiology, University of Otago, Dunedin, New Zealand
    Appl Environ Microbiol 62:4536-41. 1996
  2. pmc Relatedness between the two-component lantibiotics lacticin 3147 and staphylococcin C55 based on structure, genetics and biological activity
    Eileen B O'Connor
    Moorepark Food Research Centre, Teagasc, Fermoy, CO, Cork, Ireland
    BMC Microbiol 7:24. 2007
  3. pmc Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners
    Ellen De Backer
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, UGent, Ghent, Belgium
    BMC Microbiol 7:115. 2007
  4. ncbi request reprint Prevention of streptococcal pharyngitis by anti-Streptococcus pyogenes bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivarius
    J R Tagg
    Department of Microbiology, University of Otago, P O Box 56, Dunedin, New Zealand
    Indian J Med Res 119:13-6. 2004
  5. ncbi request reprint Bacterial replacement therapy: adapting 'germ warfare' to infection prevention
    John R Tagg
    Department of Microbiology, University of Otago, P O Box 56, Dunedin, New Zealand
    Trends Biotechnol 21:217-23. 2003
  6. ncbi request reprint Beneficial microbes for the oral cavity: time to harness the oral streptococci?
    J P Burton
    BLIS Technologies Ltd, Centre for Innovation, University of Otago, Dunedin, New Zealand
    Benef Microbes 2:93-101. 2011
  7. doi request reprint Preliminary investigations of the colonisation of upper respiratory tract tissues of infants using a paediatric formulation of the oral probiotic Streptococcus salivarius K12
    D A Power
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    Eur J Clin Microbiol Infect Dis 27:1261-3. 2008
  8. ncbi request reprint A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters
    J P Burton
    BLIS Technologies, Center for Innovation, University of Otago, Dunedin, New Zealand
    J Appl Microbiol 100:754-64. 2006
  9. doi request reprint Salivaricin 9, a new lantibiotic produced by Streptococcus salivarius
    P A Wescombe
    BLIS Technologies Ltd, Dunedin, New Zealand
    Microbiology 157:1290-9. 2011
  10. doi request reprint Evaluation of safety and human tolerance of the oral probiotic Streptococcus salivarius K12: a randomized, placebo-controlled, double-blind study
    J P Burton
    BLIS Technologies Ltd, Centre for Innovation, University of Otago, Dunedin, New Zealand
    Food Chem Toxicol 49:2356-64. 2011

Collaborators

  • J P Burton
  • R S Simmonds
  • P Renault
  • Nicholas C K Heng
  • Andreas Tauch
  • Heather J L Brooks
  • HOWARD JENKINSON
  • R Paul Ross
  • G Reid
  • Philip A Wescombe
  • Ruth E Wirawan
  • Ralph W Jack
  • Otto Hyink
  • John D F Hale
  • Karen P Dierksen
  • Nikolai A Klesse
  • Chris N Chilcott
  • P A Wescombe
  • C N Chilcott
  • D A Power
  • Eileen B O'Connor
  • Cynthia L Robson
  • Ellen De Backer
  • Pearl M Swe
  • Chris J Moore
  • Mathew Upton
  • M Al-Qumber
  • Yi Tian Ting
  • Daniel A Power
  • J D F Hale
  • M Balakrishnan
  • M Upton
  • D Power
  • R E Wirawan
  • M A Navaratna
  • P J Dawes
  • Hans Verstraelen
  • Torsten Kleffmann
  • Megan Inglis
  • Colin Hill
  • Mario Vaneechoutte
  • Hayley J Baird
  • Rita Verhelst
  • Marleen Temmerman
  • Alan Carne
  • Nancy Ragland
  • Paul D Cotter
  • Kara M Swanson
  • Paula O'Connor
  • Mohammed A Alqumber
  • Orla O'Sullivan
  • Nancy L Ragland
  • Megan A Inglis
  • Peter A Cadieux
  • Glenn V Walker
  • Senthuran Sivabalan
  • Patrick J Dawes
  • Mayooran Balakrishnan
  • Balakrishnan Balakrishnan
  • M Kilian
  • H G Sahl
  • K W Frisken
  • A J Laws
  • M B Orr

Detail Information

Publications36

  1. pmc Mode of action of a lysostaphin-like bacteriolytic agent produced by Streptococcus zooepidemicus 4881
    R S Simmonds
    Department of Microbiology, University of Otago, Dunedin, New Zealand
    Appl Environ Microbiol 62:4536-41. 1996
    ..S. pyogenes, Streptococcus gordonii, Streptococcus oralis, S. mutans, and Streptococcus rattus has been evaluated...
  2. pmc Relatedness between the two-component lantibiotics lacticin 3147 and staphylococcin C55 based on structure, genetics and biological activity
    Eileen B O'Connor
    Moorepark Food Research Centre, Teagasc, Fermoy, CO, Cork, Ireland
    BMC Microbiol 7:24. 2007
    ..The aim of this study was to investigate, for the first time for any two component bacteriocins, the significance of the relatedness between these two systems...
  3. pmc Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners
    Ellen De Backer
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, UGent, Ghent, Belgium
    BMC Microbiol 7:115. 2007
    ..iners and L. jensenii to obtain a quantitative non culture-based determination of these species in 71 vaginal samples from 32 pregnant and 28 non-pregnant women aged between 18 and 45 years...
  4. ncbi request reprint Prevention of streptococcal pharyngitis by anti-Streptococcus pyogenes bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivarius
    J R Tagg
    Department of Microbiology, University of Otago, P O Box 56, Dunedin, New Zealand
    Indian J Med Res 119:13-6. 2004
    ..Amongst the other BLIS P-types detected were a number of strongly-inhibitory (P-type 777) S. salivarius. In the present study the inhibitory agents produced by prototype strains of P-types 226, 677 and 777 S. salivarius are compared...
  5. ncbi request reprint Bacterial replacement therapy: adapting 'germ warfare' to infection prevention
    John R Tagg
    Department of Microbiology, University of Otago, P O Box 56, Dunedin, New Zealand
    Trends Biotechnol 21:217-23. 2003
    ....
  6. ncbi request reprint Beneficial microbes for the oral cavity: time to harness the oral streptococci?
    J P Burton
    BLIS Technologies Ltd, Centre for Innovation, University of Otago, Dunedin, New Zealand
    Benef Microbes 2:93-101. 2011
    ....
  7. doi request reprint Preliminary investigations of the colonisation of upper respiratory tract tissues of infants using a paediatric formulation of the oral probiotic Streptococcus salivarius K12
    D A Power
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    Eur J Clin Microbiol Infect Dis 27:1261-3. 2008
    ..The relatively low proportion (33%) of subjects that colonised was attributed to failure of the amoxicillin pre-treatment to sufficiently reduce the indigenous S. salivarius populations prior to dosing with strain K12 powder...
  8. ncbi request reprint A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters
    J P Burton
    BLIS Technologies, Center for Innovation, University of Otago, Dunedin, New Zealand
    J Appl Microbiol 100:754-64. 2006
    ..To determine whether dosing with bacteriocin-producing Streptococcus salivarius following an antimicrobial mouthwash effects a change in oral malodour parameters and in the composition of the oral microbiota of subjects with halitosis...
  9. doi request reprint Salivaricin 9, a new lantibiotic produced by Streptococcus salivarius
    P A Wescombe
    BLIS Technologies Ltd, Dunedin, New Zealand
    Microbiology 157:1290-9. 2011
    ..pyogenes strains it appears to have potential as an important component of the bacteriocin armoury of S. salivarius probiotics intended to control S. pyogenes infections of the human oral cavity...
  10. doi request reprint Evaluation of safety and human tolerance of the oral probiotic Streptococcus salivarius K12: a randomized, placebo-controlled, double-blind study
    J P Burton
    BLIS Technologies Ltd, Centre for Innovation, University of Otago, Dunedin, New Zealand
    Food Chem Toxicol 49:2356-64. 2011
    ..This data demonstrates that the daily ingestion of S. salivarius K12 over a 28-day period does not adversely affect the human host and supports the safety of its oral delivery in a food-based carrier...
  11. ncbi request reprint Commensal bacilli inhibitory to mastitis pathogens isolated from the udder microbiota of healthy cows
    M Al-Qumber
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    J Appl Microbiol 101:1152-60. 2006
    ..To isolate from the microbiota of the healthy cow udder commensal bacteria having antimicrobial activity against bovine mastitis pathogens, with a long-term view to their potential application as antimastitis probiotics...
  12. pmc Identification of genes encoding two-component lantibiotic production in Staphylococcus aureus C55 and other phage group II S. aureus strains and demonstration of an association with the exfoliative toxin B gene
    M A Navaratna
    Department of Microbiology, University of Otago, Dunedin, New Zealand
    Infect Immun 67:4268-71. 1999
    ..Irreversible loss of both ET-B and two-component lantibiotic production occurs during laboratory passage of ET-B-positive S. aureus strains, particularly at elevated temperatures...
  13. ncbi request reprint Different bacteriocin activities of Streptococcus mutans reflect distinct phylogenetic lineages
    M Balakrishnan
    Department of Microbiology, University of Otago, Dunedin, New Zealand
    J Med Microbiol 51:941-8. 2002
    ..Phylogenetic analysis of the strains by several genotypic and phenotypic characteristics revealed that the mutacin groups were associated with distinct evolutionary lineages of S. mutans...
  14. ncbi request reprint Suspected periodontopathic microorganisms and their oral habitats in young children
    K W Frisken
    Department of Periodontology, School of Dentistry, University of Otago, Dunedin, New Zealand
    Oral Microbiol Immunol 2:60-4. 1987
    ..3%), whereas other BPB species were present in fewer than 5% of children. Fusobacterium nucleatum and Capnocytophaga species were isolated most frequently from plaque but were also commonly detected in the various other oral sites...
  15. ncbi request reprint Genetic basis for mutacin N and of its relationship to mutacin I
    J D F Hale
    Department of Microbiology, University of Otago, Dunedin, New Zealand
    Indian J Med Res 119:247-51. 2004
    ..In the present study the mutacin N structural gene (mutN) was cloned and compared with the mutacin I structural gene (mutA)...
  16. ncbi request reprint The rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics
    J P Burton
    BLIS Technologies, Center for Innovation University of Otago, Dunedin, New Zealand
    Oral Dis 11:29-31. 2005
    ..We conclude that probiotic bacterial strains originally sourced from the indigenous oral microbiotas of healthy humans may have potential application as adjuncts for the prevention and treatment of halitosis...
  17. ncbi request reprint The effect of ingestion of milk supplemented with salivaricin A-producing Streptococcus salivarius on the bacteriocin-like inhibitory activity of streptococcal populations on the tongue
    Karen P Dierksen
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    FEMS Microbiol Ecol 59:584-91. 2007
    ..salivarius could potentially help to effect a sustained increase in SalA-mediated protection against S. pyogenes infection...
  18. pmc Salivaricin A2 and the novel lantibiotic salivaricin B are encoded at adjacent loci on a 190-kilobase transmissible megaplasmid in the oral probiotic strain Streptococcus salivarius K12
    Otto Hyink
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    Appl Environ Microbiol 73:1107-13. 2007
    ..This is the first report of a single streptococcus strain producing two distinct lantibiotics...
  19. ncbi request reprint Sequence analysis of pDN571, a plasmid encoding novel bacteriocin production in M-type 57 Streptococcus pyogenes
    Nicholas C K Heng
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    Plasmid 52:225-9. 2004
    ..The SSO of pDN571 is of the ssoA type. SA-M57 (encoded by scnM57) is synthesized as a secreted 179-amino acid polypeptide with a 27-residue secretion signal peptide and has no homology to proteins of known function...
  20. ncbi request reprint Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis
    Ruth E Wirawan
    Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin, New Zealand
    Microbiology 153:1619-30. 2007
    ..Thus, uberolysin is a unique cyclic bacteriocin, belonging to the same family of bacteriocins as enterocin AS-48 and circularin A...
  21. ncbi request reprint Isolation and partial characterization of the Streptococcus mutans type AII lantibiotic mutacin K8
    Cynthia L Robson
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    Microbiology 153:1631-41. 2007
    ..1813 and SMU.1812) and then the ORFs mukF (SMU.1811), mukE (SMU.1810) and mukG (SMU.1809), thought to encode putative immunity peptides. Strains such as UA159 having incomplete loci did not produce detectable levels of mutacin K8...
  22. ncbi request reprint ef1097 and ypkK encode enterococcin V583 and corynicin JK, members of a new family of antimicrobial proteins (bacteriocins) with modular structure from Gram-positive bacteria
    Pearl M Swe
    Department of Microbiology and Immunology, Otago School of Medical Sciences, The University of Otago, PO Box 56, Dunedin, New Zealand
    Microbiology 153:3218-27. 2007
    ..jeikeium. Finally, we determined that the proteins kill sensitive bacteria without lysis, a feature that distinguishes them from known murolytic proteins...
  23. pmc Purification and characterization of streptin, a type A1 lantibiotic produced by Streptococcus pyogenes
    Philip A Wescombe
    Department of Microbiology, University of Otago, Dunedin, New Zealand
    Appl Environ Microbiol 69:2737-47. 2003
    ..In other strains, srtA transcription appeared to be defective. No direct association could be detected between the production of streptin and the production of the lantibiotic-like hemolysin streptolysin S in strain M25...
  24. pmc Competence-dependent bacteriocin production by Streptococcus gordonii DL1 (Challis)
    Nicholas C K Heng
    Department of Oral Sciences, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    J Bacteriol 189:1468-72. 2007
    ..The streptocin (sth) locus comprises two functional genes, sthA and sthB. Whereas STH(1) activity requires sthA alone, STH(2) activity depends on both genes...
  25. ncbi request reprint Megaplasmids encode differing combinations of lantibiotics in Streptococcus salivarius
    Philip A Wescombe
    BLIS Technologies Ltd, Centre for Innovation, University of Otago, PO Box 56, Dunedin, 9001, New Zealand
    Antonie Van Leeuwenhoek 90:269-80. 2006
    ..Since all bacteriocin-producing strains of S. salivarius tested to date appear to harbour plasmids, it appears that they may function as mobile repositories for bacteriocin loci, especially those of the lantibiotic class...
  26. ncbi request reprint Dysgalacticin: a novel, plasmid-encoded antimicrobial protein (bacteriocin) produced by Streptococcus dysgalactiae subsp. equisimilis
    Nicholas C K Heng
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Microbiology 152:1991-2001. 2006
    ..pyogenes, indicating that dysgalacticin represents a prototype of a new class of antimicrobial proteins...
  27. ncbi request reprint Identification and characterization of the loci encoding the competence-associated alternative sigma factor of Streptococcus gordonii
    Nicholas C K Heng
    Department of Oral Sciences, University of Otago School of Dentistry, Dunedin, New Zealand
    FEMS Microbiol Lett 259:27-34. 2006
    ..Our findings suggest that alternative regulatory elements, under overall control of the ComDE pathway, may influence expression of the comR loci...
  28. pmc Production of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva
    Philip A Wescombe
    BLIS Technologies Ltd, Dunedin, New Zealand
    Appl Environ Microbiol 72:1459-66. 2006
    ..salivarius or who have been colonized with the SalA2-producing probiotic S. salivarius K12...
  29. pmc Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis
    Ruth E Wirawan
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    Appl Environ Microbiol 72:1148-56. 2006
    ..To our knowledge, this is the first report both of characterization of a bacteriocin by S. uberis, as well as of a member of the nisin family of peptides in a species other than L. lactis...
  30. ncbi request reprint Streptococcus rattus strain BHT produces both a class I two-component lantibiotic and a class II bacteriocin
    Otto Hyink
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    FEMS Microbiol Lett 252:235-41. 2005
    ..BHT-B is a non-modified 5195Da peptide with some similarity to the tryptophan-rich Staphylococcus aureus bacteriocin, aureocin A53. Six S. rattus and two S. mutans strains were found to contain both the BHT-A and BHT-B genetic loci...
  31. pmc Ubericin A, a class IIa bacteriocin produced by Streptococcus uberis
    Nicholas C K Heng
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin 9054, New Zealand
    Appl Environ Microbiol 73:7763-6. 2007
    ..The uba locus comprises two overlapping genes: ubaA (ubericin A precursor peptide) and ubaI (putative immunity protein). Ubericin A is the first streptococcal class IIa bacteriocin to be characterized...
  32. ncbi request reprint A preliminary survey of Atopobium vaginae in women attending the Dunedin gynaecology out-patients clinic: is the contribution of the hard-to-culture microbiota overlooked in gynaecological disorders?
    Jeremy P Burton
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Aust N Z J Obstet Gynaecol 45:450-2. 2005
    ..vaginae-positive cases. Due to the high detection rate of A. vaginae we believe that it is important to determine whether this and other hard-to-culture microorganisms have a role in gynaecological disorders...
  33. pmc Identification of nlmTE, the locus encoding the ABC transport system required for export of nonlantibiotic mutacins in Streptococcus mutans
    John D F Hale
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    J Bacteriol 187:5036-9. 2005
    ..In this study, we have combined bioinformatic and mutational analyses to identify the ABC transporter designated NlmTE, which is required for mutacin biogenesis in strain UA159 as well as in another mutacin producer, S. mutans N...
  34. pmc Non-culture-based analysis of bacterial populations from patients with chronic rhinosinusitis
    Daniel A Power
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    J Clin Microbiol 43:5822-4. 2005
    ..Although resistance to antibiotics was low, there was evidence of changes in the composition of the bacterial microbiota over time, and the presence of noncultured bacteria was demonstrated...
  35. pmc Bacteriocin (mutacin) production by Streptococcus mutans genome sequence reference strain UA159: elucidation of the antimicrobial repertoire by genetic dissection
    John D F Hale
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    Appl Environ Microbiol 71:7613-7. 2005
    ..1914c)...
  36. pmc Safety assessment of the oral cavity probiotic Streptococcus salivarius K12
    Jeremy P Burton
    BLIS Technologies, Centre for Innovation, University of Otago, P O Box 56, Dunedin, New Zealand
    Appl Environ Microbiol 72:3050-3. 2006
    ..salivarius K12, including assessment of its antibiogram, metabolic profiles, and virulence determinants, and we examine the microbial composition of saliva following the dosing of subjects with K12...