Sato T, Keelan J, Mitchell M. Regulation of prostaglandin production in an immortalized human myometrial cell line by cytokines and non-steroidal anti-inflammatory drugs. Eur J Obstet Gynecol Reprod Biol. 2002;100:158-62 pubmed
..5) and indomethacin (2.7). DFU was not as selective in TNF-alpha stimulated cells (ratio 99.5). PGHS-II-selective inhibitors may be effective in the prevention of cytokine-driven myometrial PG production associated with preterm labor. ..
Sato T, Keelan J, Mitchell M. Critical paracrine interactions between TNF-alpha and IL-10 regulate lipopolysaccharide-stimulated human choriodecidual cytokine and prostaglandin E2 production. J Immunol. 2003;170:158-66 pubmed
..In the setting of an infection of the intrauterine, TNF-alpha may be a potential target for treatment intervention; IL-10 could be one such therapeutic. ..