Research Topics
| J A RoydsSummaryAffiliation: University of Otago Country: New Zealand Publications
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Detail Information
Publications
Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein levelDonia P Macartney-Coxson
1Wakefield Gastroenterology Research Institute, Wellington, New Zealand
BMC Cancer 8:187. 2008..We therefore examined 8p for genes involved in colorectal cancer progression...
p53 promotes adenoviral replication and increases late viral gene expressionJ A Royds
Department of Pathology, University of Otago, Dunedin, New Zealand
Oncogene 25:1509-20. 2006..These results have implications for the use of Ad mutants that are defective in p53 degradation, such as ONYX-015, as agents for the treatment of cancers...
p53 and disease: when the guardian angel failsJ A Royds
Department of Pathology, University of Otago, Dunedin, New Zealand
Cell Death Differ 13:1017-26. 2006..Finally, we outline some evidence that abnormalities in p53 function contribute to the etiology of other non-neoplastic diseases...
Exploitation of cell cycle and cell death controls by adenoviruses: the road to a productive infectionI Alasdair Russell
Cell Transformation Group, Department of Pathology, Dunedin School of Medicine, University of Otago, Box 913, Dunedin, New Zealand
Prog Mol Subcell Biol 36:207-43. 2004
p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumorsT L Slatter
Department of Pathology, School of Medicine, University of Otago, Dunedin, New Zealand
Cell Death Differ 17:540-50. 2010..We predict that by keeping B-cell populations in check, p53-dependent apoptosis prevents irregular B cells from eventuating in lymphomas...
Alternative lengthening of telomeres and survival in patients with glioblastoma multiformeV Hakin-Smith
Institute for Cancer Studies, Medical School, Sheffield, UK
Lancet 361:836-8. 2003..In patients with non-ALT tumours, telomerase activity did not affect survival (median 287 [199-375] vs 236 [230-242] days, p=0.275). We conclude that ALT is a prognostic indicator for patients with glioblastoma multiforme...
Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosisZ E Winters
Imperial Cancer Research Fund Molecular Oncology Laboratory, University of Oxford Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
Eur J Cancer 37:2405-12. 2001..Investigation of the subcellular distribution of cell cycle regulatory proteins, particularly p21(WAF1/CIP1), could provide valuable prognostic markers in breast cancer...
Comparative genomic hybridization and pathological findings in atypical teratoid/rhabdoid tumour of the central nervous systemS B Wharton
Academic Unit of Pathology, University of Sheffield, Medical School, Sheffield, UK
Neuropathol Appl Neurobiol 29:254-61. 2003....
Correlation of VEGF production with IL1 alpha and IL6 secretion by human pituitary adenoma cellsS A Borg
Hormone and Vascular Group, Academic Unit of Endocrinology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK
Eur J Endocrinol 152:293-300. 2005..We have also looked at the relationship of tumour volume and invasive status to VEGF secretion...
