I M Morison

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. ncbi Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia
    Robert J Weeks
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Mol Cancer 9:163. 2010
  2. ncbi The imprinted gene and parent-of-origin effect database
    I M Morison
    Cancer Genetics Laboratory, University of Otago, PO Box 56, Dunedin, New Zealand
    Nucleic Acids Res 29:275-6. 2001
  3. ncbi A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia
    Ian M Morison
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Nat Genet 40:387-9. 2008
  4. ncbi Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia
    Ian M Morison
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Blood 99:375-7. 2002
  5. ncbi A census of mammalian imprinting
    Ian M Morison
    Cancer Genetics Laboratory, Department of Biochemistry and National Research Centre for Growth and Development, University of Otago, PO Box 56, Dunedin, New Zealand
    Trends Genet 21:457-65. 2005
  6. ncbi Canonical WNT signalling determines lineage specificity in Wilms tumour
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Oncogene 28:1063-75. 2009
  7. ncbi Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pathol 215:377-87. 2008
  8. ncbi Imprinting of insulin-like growth factor 2 is modulated during hematopoiesis
    I M Morison
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Blood 96:3023-8. 2000
  9. ncbi Imprinting, expression, and localisation of DLK1 in Wilms tumours
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    J Clin Pathol 58:145-50. 2005
  10. ncbi Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms' tumour and gigantism
    O Ogawa
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Nat Genet 5:408-12. 1993

Collaborators

Detail Information

Publications26

  1. ncbi Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia
    Robert J Weeks
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Mol Cancer 9:163. 2010
    ..By screening candidate genes, we have detected frequent and dense methylation of the TESTIN (TES) promoter...
  2. ncbi The imprinted gene and parent-of-origin effect database
    I M Morison
    Cancer Genetics Laboratory, University of Otago, PO Box 56, Dunedin, New Zealand
    Nucleic Acids Res 29:275-6. 2001
    ..Data are accessed through a search engine and references are hyperlinked to PubMed...
  3. ncbi A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia
    Ian M Morison
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Nat Genet 40:387-9. 2008
    ..Notably, the family has no other phenotypic indication of abnormal apoptosis, implying that cytochrome c activity is not a critical regulator of most physiological apoptosis...
  4. ncbi Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia
    Ian M Morison
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Blood 99:375-7. 2002
    ..Of these cases, 9 showed loss of the maternally derived allele, suggesting that a germ-line event involving a 9p gene may play a role in the onset of childhood ALL...
  5. ncbi A census of mammalian imprinting
    Ian M Morison
    Cancer Genetics Laboratory, Department of Biochemistry and National Research Centre for Growth and Development, University of Otago, PO Box 56, Dunedin, New Zealand
    Trends Genet 21:457-65. 2005
    ..Accumulation of functional and comparative data for these genes will improve our understanding of imprinting and its contribution to mammalian evolution...
  6. ncbi Canonical WNT signalling determines lineage specificity in Wilms tumour
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Oncogene 28:1063-75. 2009
    ....
  7. ncbi Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pathol 215:377-87. 2008
    ....
  8. ncbi Imprinting of insulin-like growth factor 2 is modulated during hematopoiesis
    I M Morison
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Blood 96:3023-8. 2000
    ..These results suggest that transcriptional recognition of the IGF-2 imprint can be modulated during hematopoiesis and may facilitate the development of in vitro model systems to study the transcriptional recognition of a genomic imprint...
  9. ncbi Imprinting, expression, and localisation of DLK1 in Wilms tumours
    R Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    J Clin Pathol 58:145-50. 2005
    ..The GTL2/DLK1 domain is also imprinted and is structurally similar to H19/IGF2. The question arises as to whether DLK1 also undergoes LOI in Wilms tumour, or whether the LOI mechanism is restricted to the H19/IGF2 domain...
  10. ncbi Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms' tumour and gigantism
    O Ogawa
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Nat Genet 5:408-12. 1993
    ..These findings suggest that a defect in genomic imprinting can occur constitutionally, leading to growth abnormalities and predisposition to Wilms' tumour...
  11. ncbi Dietary iron intakes and biochemical iron status of 15-49 year old women in New Zealand: is there a cause for concern?
    E L Ferguson
    Department of Human Nutrition, University of Otago, Dunedin
    N Z Med J 114:134-8. 2001
    ..To assess dietary iron intakes and biochemical iron status of a nationally representative sample of nonpregnant 15-49 year old women (n=1,751) in New Zealand...
  12. ncbi Detailed methylation analysis of CpG islands on human chromosome region 9p21
    Robert J Weeks
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Genes Chromosomes Cancer 45:357-64. 2006
    ..Our data, which showed heterogeneous and low-level methylation of CpG islands, have obvious implications for methylation studies...
  13. ncbi Targeting the apoptosome for cancer therapy
    Elizabeth C Ledgerwood
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Clin Cancer Res 15:420-4. 2009
    ....
  14. ncbi A catalogue of imprinted genes and parent-of-origin effects in humans and animals
    I M Morison
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    Hum Mol Genet 7:1599-609. 1998
    ....
  15. ncbi Epigenetic differences between Wilms' tumours in white and east-Asian children
    Ryuji Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Lancet 363:446-51. 2004
    ..Variation in frequency of this epigenetic mechanism provides one explanation for the difference in incidence of Wilms' tumour between populations...
  16. ncbi Human insulin-like growth factor type I and type II receptors are not imprinted
    O Ogawa
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Hum Mol Genet 2:2163-5. 1993
    ..That the imprinting of the insulin-like growth factor type II receptor is not conserved between mouse and humans suggests that the physiological role of the IGF2 receptor may differ between these two species...
  17. ncbi Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia
    Tania L Slatter
    Department of Biochemistry, University of Otago, P.O. Box 56, 710 Cumberland St, Dunedin 9001, Otago, New Zealand
    Atherosclerosis 187:393-400. 2006
    ..In contrast, the maternal 1068H allele has less effect and is associated with a relatively normal HDL level. We conclude that haplotypes of mutant ABCA1 alleles may contribute to the phenotypic variance shown between FHA individuals...
  18. ncbi Myogenesis in Wilms' tumors is associated with mutations of the WT1 gene and activation of Bcl-2 and the Wnt signaling pathway
    Ryuji Fukuzawa
    Department of Biochemistry, Cancer Genetics Laboratory, University of Otago, P.O. Box 56, Dunedin, New Zealand
    Pediatr Dev Pathol 7:125-37. 2004
    ....
  19. ncbi Insulin-like growth factor-II imprinting in cancer
    Anthony E Reeve
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Lancet 359:2050-1. 2002
  20. ncbi Random monoallelic expression: making a choice
    Christel Krueger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
    Trends Genet 24:257-9. 2008
    ..This raises important questions about why, when and how cells choose and tolerate monoallelism and whether functional hemizygosity might provide an unappreciated advantage...
  21. ncbi Correct usage of "loss of imprinting"
    Ryuji Fukuzawa
    Am J Med Genet A 138:412; author reply 413-4. 2005
  22. ncbi Could epigenetics play a role in the developmental origins of health and disease?
    Wayne S Cutfield
    Liggins Institute, National Research Centre for Growth and Development, University of Auckland, Department of Pediatrics, New Zealand
    Pediatr Res 61:68R-75R. 2007
    ..The relevance of these animal studies to IVF, SGA, and very premature children are discussed as are potential candidate genes that may have undergone epigenetic modification to alter growth and metabolism...
  23. ncbi The imprinted gene and parent-of-origin effect database now includes parental origin of de novo mutations
    Rivka L Glaser
    Department of Biology, Massachusetts College of Liberal Arts, North Adams, MA 01247, USA
    Nucleic Acids Res 34:D29-31. 2006
    ..The 85 imprinted genes are described in 152 entries from several mammalian species. In addition, >300 other entries describe a range of reported parent-of-origin effects in animals...
  24. ncbi Physiological functions of imprinted genes
    Benjamin Tycko
    Institute for Cancer Genetics, Columbia University, New York, New York, USA
    J Cell Physiol 192:245-58. 2002
    ..otago.ac.nz/IGC) containing a comprehensive database of imprinted genes. Ultimately, these data will answer the long-debated question of whether there is a coherent biological rationale for imprinting...
  25. ncbi Reassessment of loss of heterozygosity within MLL in childhood acute lymphoblastic leukemia
    Carina J M van Schooten
    Blood 101:4222; author reply 4222-3. 2003
  26. ncbi Re: Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor
    Ian M Morison
    J Natl Cancer Inst 94:1809; author reply 1809-10. 2002