Research Topics
Genomes and Genes
| Tony R MerrimanSummaryAffiliation: University of Otago Country: New Zealand Publications
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Detail Information
Publications
Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseasesT R Merriman
Wellcome Trust Centre for Molecular Mechanisms in Disease, University of Cambridge, UK
Diabetes 50:184-94. 2001..Collectively, these data suggest that a locus (or loci) exists on human chromosome 18q12-q21 that influences multiple autoimmune diseases and that this association might be conserved between species...- Colocalization of mouse autoimmune diabetes loci Idd21.1 and Idd21.2 with IDDM6 (human) and Iddm3 (rat)Jade E Hollis-Moffatt
University of Otago, Department of Biochemistry, Box 56, Dunedin, New Zealand
Diabetes 54:2820-5. 2005..1-21.2 in mouse. Further genetic localization of Idd21.1 and Idd21.2 could expedite characterization of the human IDDM6 region... - Risk-taking: behind the warrior gene storyTony Merriman
Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin
N Z Med J 120:U2440. 2007..Insufficient rigour in interpreting and applying the relevant literature, and in generating new data, has (in conjunction with a lack of scientific investigative journalism) done science and Māori a disservice... 
The genetic basis of hyperuricaemia and goutTony R Merriman
Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
Joint Bone Spine 78:35-40. 2011..Ongoing genetic association studies are identifying and confirming other genes controlling serum urate concentrations; although genome-wide association studies in gout per se await recruitment of suitable case sample sets...- Type 1 diabetes, the A1 milk hypothesis and vitamin D deficiencyTony R Merriman
Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
Diabetes Res Clin Pract 83:149-56. 2009..Ecological and biological evidence convincingly implicate vitamin D deficiency in T1D. Latitude is a confounder of the ecological data that underpin the hypothesis that A1 beta-casein in cow's milk is a causative factor in T1D... - Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample setsJade E Hollis-Moffatt
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Arthritis Rheum 60:3485-92. 2009.... - A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Māori, case and control sample setsAmanda J Phipps-Green
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Hum Mol Genet 19:4813-9. 2010.... 
Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significanceJade E Hollis-Moffatt
Department of Biochemistry, 710 Cumberland Street, University of Otago, Dunedin 9054, New Zealand
Arthritis Res Ther 12:R116. 2010..Here we aimed to: one, confirm at a genome-wide level of significance association of rs6822844 with RA and, two, evaluate whether or not there were effects independent of rs6822844 on RA at the KIAA1109-TENR-IL2-IL21 locus...- The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample setsJade E Hollis-Moffatt
Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9054, New Zealand
Arthritis Res Ther 11:R152. 2009..We therefore tested this association in an independent study using New Zealand (NZ) and Oxford (UK) RA case control samples... - The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severityJade E Hollis-Moffatt
Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9012, New Zealand
Arthritis Res Ther 13:R85. 2011..There is no evidence for an association with gout in Caucasian populations. In the present study, we tested rs3733591 for association with gout in New Zealand (NZ) Māori, Pacific Island and Caucasian samples... - Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samplesCushla McKinney
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Ann Rheum Dis 69:1711-6. 2010.... - The PTPN22 locus and rheumatoid arthritis: no evidence for an effect on risk independent of Arg620TrpWan R Wan Taib
Department of Biochemistry, University of Otago, Dunedin, New Zealand
PLoS ONE 5:e13544. 2010..Our aim was to further investigate this possibility... - Association of higher DEFB4 genomic copy number with Crohn's diseaseRobert W Bentley
Department of Pathology, University of Otago, Christchurch, New Zealand
Am J Gastroenterol 105:354-9. 2010..Here, we analyze association of DEFB4 copy number with CD in a New Zealand case-control cohort of European origin... - Independent replication of an association of CNVR7113.6 with Crohn's disease in CaucasiansRebecca L Roberts
Department of Biochemistry, University of Otago, New Zealand
Inflamm Bowel Dis 18:305-11. 2012..0018). The aim of our study was to confirm the CNVR7113.6 association by genotyping two independent inflammatory bowel disease (IBD) cohorts and by conducting a subsequent meta-analysis... - Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancerBostjan Humar
Cancer Genetics Laboratory, University of Otago, Dunedin, Aotearoa, New Zealand
Oncogene 21:8192-5. 2002..004). However, this analysis suggested the -160C-->A CDH1 promoter polymorphism may be in linkage disequilibrium with a distinct aetiological locus or acts in combination with other functional variants in or near the CDH1 region... - An autoimmune diabetes locus (Idd21) on mouse chromosome 18Richard J Hall
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Mamm Genome 14:335-9. 2003..The chromosome substitution strain (NOD.ABH-Chr18) had reduced diabetes incidence compared with NOD mice (P < 0.0001). We have named the Chr 18 diabetes locus Idd21... - The deleted in colorectal carcinoma (DCC) gene 201 R --> G polymorphism: no evidence for genetic association with autoimmune diseaseRichard J Hall
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Eur J Hum Genet 11:840-4. 2003..Thus, the DCC 201 R --> G polymorphism does not appreciably influence risk of developing the autoimmune diseases tested... - Smad2: a candidate gene for the murine autoimmune diabetes locus Idd21.1Sarah M Hook
School of Pharmacy, University of Otago, Dunedin, New Zealand
J Clin Endocrinol Metab 96:E2072-7. 2011..1 from diabetes-resistant Biozzi/ABH mice, have a lower frequency of diabetes compared with the parental nonobese diabetic (NOD) strain, possibly due to reduced pathogenicity of β-islet-infiltrating immune cells... - Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysmsRebecca L Roberts
Department of Biochemistry, University of Otago, P O Box 56, Dunedin 9054, New Zealand
Atherosclerosis 218:123-6. 2011.... - Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohortHelen M A Simkins
University of Otago, Dunedin, New Zealand
Arthritis Rheum 52:2222-5. 2005 - IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel diseaseRebecca L Roberts
Department of Pathology, University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
Am J Gastroenterol 102:2754-61. 2007..The aim of our study was to test whether these SNPs are associated with CD in a population-based cohort of New Zealand Caucasian inflammatory bowel disease (IBD) patients... - Meta-analysis confirms a role for deletion in FCGR3B in autoimmune phenotypesCushla McKinney
Department of Biochemistry, University of Otago, Box 56, Dunedin, New Zealand
Hum Mol Genet 21:2370-6. 2012..44 (1.28-1.62), P(meta)= 2.9 × 10(-9)]. This meta-analysis implicates the clearance of immune complex in the etiology of non-organ-specific autoimmune disease... - The renal urate transporter SLC17A1 locus: confirmation of association with goutJade E Hollis-Moffatt
Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9054, New Zealand
Arthritis Res Ther 14:R92. 2012..However, evidence for association with gout is equivocal. We investigated the association of the SLC17A1 locus with gout in New Zealand sample sets... - A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian populationSoroush Nasri
Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin 9054, Aotearoa New Zealand
BMC Cancer 8:138. 2008..Recently, a new regulatory region essential for CDH1 transcription has been identified in CDH1 intron 2... - Population heterogeneity in the genetic control of serum urateTony R Merriman
Biochemistry Department, University of Otago, Dunedin, New Zealand
Semin Nephrol 31:420-5. 2011..A more complete picture will be revealed by very large meta-analyses of genome-wide association scans in Caucasian and in other populations with less genetic heterogeneity than Caucasians... - Novel germline CDH1 mutations in hereditary diffuse gastric cancer familiesBostjan Humar
Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
Hum Mutat 19:518-25. 2002..We, however, found this polymorphism to be common in a control population, suggesting that a major role for this polymorphism in gastric cancer susceptibility is unlikely... - Maternal psychological reaction to newborn genetic screening for type 1 diabetesNicola J Kerruish
Department of Women s and Children s Health, Otago Medical School, University of Otago, PO Box 913, Dunedin, New Zealand
Pediatrics 120:e324-35. 2007..The purpose of this work was to describe levels of maternal anxiety, depressive symptoms, and perceptions of infant vulnerability associated with newborn genetic screening for susceptibility to type 1 diabetes... - Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetesJeffrey C Barrett
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Nat Genet 41:703-7. 2009..01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27... - IL4, IL10, IL16, and TNF polymorphisms in New Zealand Caucasian Crohn's disease patientsJiwon Hong
Int J Colorectal Dis 23:335-7. 2008 - Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohortEuphemia Leung
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Immunol Cell Biol 84:233-6. 2006..0007) of ileocolonic involvement. The population-attributable risk for the SLC22A-TC haplotype is 15.1%. Thus, SLC22A-TC is associated with an increased risk of CD and disease phenotype in our New Zealand CD cohort... - Polymorphisms in NFKBIA and ICAM-1 genes in New Zealand Caucasian Crohn's disease patientsJiwon Hong
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
J Gastroenterol Hepatol 22:1666-70. 2007..Here we examined whether the NFKBIA 2758G/A and ICAM-1 K469E variants, recently shown to be CD susceptibility genes in Caucasian populations in Germany and the United Kingdom, are associated with CD in Caucasian patients in New Zealand... - TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohortJiwon Hong
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
J Gastroenterol Hepatol 22:1760-6. 2007..Here we examined the association between candidate disease-susceptibility polymorphisms in the TLR2, TLR4 and TLR9 genes and CD in a New Zealand Caucasian population... - Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease associationCatherine J Owen
Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
J Clin Endocrinol Metab 92:1106-11. 2007..These findings raise the possibility that this locus may influence autoimmune disease susceptibility across many populations... - Peroxisome proliferator-activated receptor-gamma gene polymorphisms and Crohn's diseaseEuphemia Leung
Int J Colorectal Dis 22:453-4. 2007 - Polymorphisms of CARD15/NOD2 and CD14 genes in New Zealand Crohn's disease patientsEuphemia Leung
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Immunol Cell Biol 83:498-503. 2005.... - Colony-stimulating factor-1 receptor gene polymorphisms and Crohn's diseaseEuphemia Leung
Int J Colorectal Dis 22:995-6. 2007