Tony R Merriman

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. ncbi request reprint Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases
    T R Merriman
    Wellcome Trust Centre for Molecular Mechanisms in Disease, University of Cambridge, UK
    Diabetes 50:184-94. 2001
  2. doi request reprint Type 1 diabetes, the A1 milk hypothesis and vitamin D deficiency
    Tony R Merriman
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    Diabetes Res Clin Pract 83:149-56. 2009
  3. doi request reprint The genetic basis of hyperuricaemia and gout
    Tony R Merriman
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    Joint Bone Spine 78:35-40. 2011
  4. ncbi request reprint Colocalization of mouse autoimmune diabetes loci Idd21.1 and Idd21.2 with IDDM6 (human) and Iddm3 (rat)
    Jade E Hollis-Moffatt
    University of Otago, Department of Biochemistry, Box 56, Dunedin, New Zealand
    Diabetes 54:2820-5. 2005
  5. ncbi request reprint Risk-taking: behind the warrior gene story
    Tony Merriman
    Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin
    N Z Med J 120:U2440. 2007
  6. doi request reprint Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Arthritis Rheum 60:3485-92. 2009
  7. doi request reprint A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Māori, case and control sample sets
    Amanda J Phipps-Green
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Hum Mol Genet 19:4813-9. 2010
  8. pmc Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance
    Jade E Hollis-Moffatt
    Department of Biochemistry, 710 Cumberland Street, University of Otago, Dunedin 9054, New Zealand
    Arthritis Res Ther 12:R116. 2010
  9. pmc The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9054, New Zealand
    Arthritis Res Ther 11:R152. 2009
  10. pmc The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9012, New Zealand
    Arthritis Res Ther 13:R85. 2011

Detail Information

Publications42

  1. ncbi request reprint Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases
    T R Merriman
    Wellcome Trust Centre for Molecular Mechanisms in Disease, University of Cambridge, UK
    Diabetes 50:184-94. 2001
    ..Collectively, these data suggest that a locus (or loci) exists on human chromosome 18q12-q21 that influences multiple autoimmune diseases and that this association might be conserved between species...
  2. doi request reprint Type 1 diabetes, the A1 milk hypothesis and vitamin D deficiency
    Tony R Merriman
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    Diabetes Res Clin Pract 83:149-56. 2009
    ..Ecological and biological evidence convincingly implicate vitamin D deficiency in T1D. Latitude is a confounder of the ecological data that underpin the hypothesis that A1 beta-casein in cow's milk is a causative factor in T1D...
  3. doi request reprint The genetic basis of hyperuricaemia and gout
    Tony R Merriman
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    Joint Bone Spine 78:35-40. 2011
    ..Ongoing genetic association studies are identifying and confirming other genes controlling serum urate concentrations; although genome-wide association studies in gout per se await recruitment of suitable case sample sets...
  4. ncbi request reprint Colocalization of mouse autoimmune diabetes loci Idd21.1 and Idd21.2 with IDDM6 (human) and Iddm3 (rat)
    Jade E Hollis-Moffatt
    University of Otago, Department of Biochemistry, Box 56, Dunedin, New Zealand
    Diabetes 54:2820-5. 2005
    ..1-21.2 in mouse. Further genetic localization of Idd21.1 and Idd21.2 could expedite characterization of the human IDDM6 region...
  5. ncbi request reprint Risk-taking: behind the warrior gene story
    Tony Merriman
    Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin
    N Z Med J 120:U2440. 2007
    ..Insufficient rigour in interpreting and applying the relevant literature, and in generating new data, has (in conjunction with a lack of scientific investigative journalism) done science and Māori a disservice...
  6. doi request reprint Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Arthritis Rheum 60:3485-92. 2009
    ....
  7. doi request reprint A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Māori, case and control sample sets
    Amanda J Phipps-Green
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Hum Mol Genet 19:4813-9. 2010
    ....
  8. pmc Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance
    Jade E Hollis-Moffatt
    Department of Biochemistry, 710 Cumberland Street, University of Otago, Dunedin 9054, New Zealand
    Arthritis Res Ther 12:R116. 2010
    ..Here we aimed to: one, confirm at a genome-wide level of significance association of rs6822844 with RA and, two, evaluate whether or not there were effects independent of rs6822844 on RA at the KIAA1109-TENR-IL2-IL21 locus...
  9. pmc The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9054, New Zealand
    Arthritis Res Ther 11:R152. 2009
    ..We therefore tested this association in an independent study using New Zealand (NZ) and Oxford (UK) RA case control samples...
  10. pmc The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9012, New Zealand
    Arthritis Res Ther 13:R85. 2011
    ..There is no evidence for an association with gout in Caucasian populations. In the present study, we tested rs3733591 for association with gout in New Zealand (NZ) Māori, Pacific Island and Caucasian samples...
  11. pmc Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: an association study in New Zealand Caucasians and meta-analysis
    James D Falvey
    James D Falvey, Robert W Bentley, Richard B Gearry, Murray L Barclay, Department of Medicine, University of Otago, Christchurch 8011, New Zealand
    World J Gastroenterol 19:6656-64. 2013
    ..To investigate the association of macrophage migration inhibitory factor (MIF) promoter polymorphisms with inflammatory bowel disease (IBD) risk...
  12. pmc Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples
    Cushla McKinney
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Ann Rheum Dis 69:1711-6. 2010
    ....
  13. pmc The PTPN22 locus and rheumatoid arthritis: no evidence for an effect on risk independent of Arg620Trp
    Wan R Wan Taib
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    PLoS ONE 5:e13544. 2010
    ..Our aim was to further investigate this possibility...
  14. doi request reprint Association of higher DEFB4 genomic copy number with Crohn's disease
    Robert W Bentley
    Department of Pathology, University of Otago, Christchurch, New Zealand
    Am J Gastroenterol 105:354-9. 2010
    ..Here, we analyze association of DEFB4 copy number with CD in a New Zealand case-control cohort of European origin...
  15. doi request reprint Independent replication of an association of CNVR7113.6 with Crohn's disease in Caucasians
    Rebecca L Roberts
    Department of Biochemistry, University of Otago, New Zealand
    Inflamm Bowel Dis 18:305-11. 2012
    ..0018). The aim of our study was to confirm the CNVR7113.6 association by genotyping two independent inflammatory bowel disease (IBD) cohorts and by conducting a subsequent meta-analysis...
  16. ncbi request reprint Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer
    Bostjan Humar
    Cancer Genetics Laboratory, University of Otago, Dunedin, Aotearoa, New Zealand
    Oncogene 21:8192-5. 2002
    ..004). However, this analysis suggested the -160C-->A CDH1 promoter polymorphism may be in linkage disequilibrium with a distinct aetiological locus or acts in combination with other functional variants in or near the CDH1 region...
  17. pmc The renal urate transporter SLC17A1 locus: confirmation of association with gout
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9054, New Zealand
    Arthritis Res Ther 14:R92. 2012
    ..However, evidence for association with gout is equivocal. We investigated the association of the SLC17A1 locus with gout in New Zealand sample sets...
  18. ncbi request reprint The deleted in colorectal carcinoma (DCC) gene 201 R --> G polymorphism: no evidence for genetic association with autoimmune disease
    Richard J Hall
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Eur J Hum Genet 11:840-4. 2003
    ..Thus, the DCC 201 R --> G polymorphism does not appreciably influence risk of developing the autoimmune diseases tested...
  19. ncbi request reprint An autoimmune diabetes locus (Idd21) on mouse chromosome 18
    Richard J Hall
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Mamm Genome 14:335-9. 2003
    ..The chromosome substitution strain (NOD.ABH-Chr18) had reduced diabetes incidence compared with NOD mice (P < 0.0001). We have named the Chr 18 diabetes locus Idd21...
  20. doi request reprint Smad2: a candidate gene for the murine autoimmune diabetes locus Idd21.1
    Sarah M Hook
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    J Clin Endocrinol Metab 96:E2072-7. 2011
    ..1 from diabetes-resistant Biozzi/ABH mice, have a lower frequency of diabetes compared with the parental nonobese diabetic (NOD) strain, possibly due to reduced pathogenicity of β-islet-infiltrating immune cells...
  21. doi request reprint Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms
    Rebecca L Roberts
    Department of Biochemistry, University of Otago, P O Box 56, Dunedin 9054, New Zealand
    Atherosclerosis 218:123-6. 2011
    ....
  22. ncbi request reprint IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease
    Rebecca L Roberts
    Department of Pathology, University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Am J Gastroenterol 102:2754-61. 2007
    ..The aim of our study was to test whether these SNPs are associated with CD in a population-based cohort of New Zealand Caucasian inflammatory bowel disease (IBD) patients...
  23. ncbi request reprint Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort
    Helen M A Simkins
    University of Otago, Dunedin, New Zealand
    Arthritis Rheum 52:2222-5. 2005
  24. doi request reprint Meta-analysis confirms a role for deletion in FCGR3B in autoimmune phenotypes
    Cushla McKinney
    Department of Biochemistry, University of Otago, Box 56, Dunedin, New Zealand
    Hum Mol Genet 21:2370-6. 2012
    ..44 (1.28-1.62), P(meta)= 2.9 × 10(-9)]. This meta-analysis implicates the clearance of immune complex in the etiology of non-organ-specific autoimmune disease...
  25. doi request reprint The population pharmacokinetics of allopurinol and oxypurinol in patients with gout
    Daniel F B Wright
    School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand
    Eur J Clin Pharmacol 69:1411-21. 2013
    ..The aims of this study were to develop a population pharmacokinetic model for allopurinol and oxypurinol and to explore the influence of patient characteristics on allopurinol and oxypurinol pharmacokinetics...
  26. pmc A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population
    Soroush Nasri
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin 9054, Aotearoa New Zealand
    BMC Cancer 8:138. 2008
    ..Recently, a new regulatory region essential for CDH1 transcription has been identified in CDH1 intron 2...
  27. doi request reprint Population heterogeneity in the genetic control of serum urate
    Tony R Merriman
    Biochemistry Department, University of Otago, Dunedin, New Zealand
    Semin Nephrol 31:420-5. 2011
    ..A more complete picture will be revealed by very large meta-analyses of genome-wide association scans in Caucasian and in other populations with less genetic heterogeneity than Caucasians...
  28. pmc A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm
    Gregory T Jones
    Department of Surgery, University of Otago, Dunedin 9054, New Zealand
    Hum Mol Genet 22:2941-7. 2013
    ....
  29. pmc CNVrd, a read-depth algorithm for assigning copy-number at the FCGR locus: population-specific tagging of copy number variation at FCGR3B
    Hoang tan Nguyen
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    PLoS ONE 8:e63219. 2013
    ..We conclude that it is possible to tag CNV at the FCGR locus, but CN and SNPs have to be characterized and correlated on a population-specific basis...
  30. ncbi request reprint Novel germline CDH1 mutations in hereditary diffuse gastric cancer families
    Bostjan Humar
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Hum Mutat 19:518-25. 2002
    ..We, however, found this polymorphism to be common in a control population, suggesting that a major role for this polymorphism in gastric cancer susceptibility is unlikely...
  31. doi request reprint Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function
    Kim Hughes
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Kidney Int 85:344-51. 2014
    ..Further studies are required to understand the mechanism of the potential renal function protection mediated by xanthine oxidase inhibitors. ..
  32. ncbi request reprint The genetic basis of gout
    Tony R Merriman
    Department of Biochemistry, University of Otago, Dunedin 9012, New Zealand Electronic address
    Rheum Dis Clin North Am 40:279-90. 2014
    ..Extending knowledge in this area depends on recruitment of large, clinically ascertained gout sample sets suitable for GWAS. ..
  33. ncbi request reprint Maternal psychological reaction to newborn genetic screening for type 1 diabetes
    Nicola J Kerruish
    Department of Women s and Children s Health, Otago Medical School, University of Otago, PO Box 913, Dunedin, New Zealand
    Pediatrics 120:e324-35. 2007
    ..The purpose of this work was to describe levels of maternal anxiety, depressive symptoms, and perceptions of infant vulnerability associated with newborn genetic screening for susceptibility to type 1 diabetes...
  34. pmc Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    Jeffrey C Barrett
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:703-7. 2009
    ..01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27...
  35. ncbi request reprint Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohort
    Euphemia Leung
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Immunol Cell Biol 84:233-6. 2006
    ..0007) of ileocolonic involvement. The population-attributable risk for the SLC22A-TC haplotype is 15.1%. Thus, SLC22A-TC is associated with an increased risk of CD and disease phenotype in our New Zealand CD cohort...
  36. ncbi request reprint TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort
    Jiwon Hong
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Gastroenterol Hepatol 22:1760-6. 2007
    ..Here we examined the association between candidate disease-susceptibility polymorphisms in the TLR2, TLR4 and TLR9 genes and CD in a New Zealand Caucasian population...
  37. ncbi request reprint Polymorphisms in NFKBIA and ICAM-1 genes in New Zealand Caucasian Crohn's disease patients
    Jiwon Hong
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Gastroenterol Hepatol 22:1666-70. 2007
    ..Here we examined whether the NFKBIA 2758G/A and ICAM-1 K469E variants, recently shown to be CD susceptibility genes in Caucasian populations in Germany and the United Kingdom, are associated with CD in Caucasian patients in New Zealand...
  38. ncbi request reprint IL4, IL10, IL16, and TNF polymorphisms in New Zealand Caucasian Crohn's disease patients
    Jiwon Hong
    Int J Colorectal Dis 23:335-7. 2008
  39. ncbi request reprint Polymorphisms of CARD15/NOD2 and CD14 genes in New Zealand Crohn's disease patients
    Euphemia Leung
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Immunol Cell Biol 83:498-503. 2005
    ....
  40. ncbi request reprint Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association
    Catherine J Owen
    Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    J Clin Endocrinol Metab 92:1106-11. 2007
    ..These findings raise the possibility that this locus may influence autoimmune disease susceptibility across many populations...
  41. ncbi request reprint Colony-stimulating factor-1 receptor gene polymorphisms and Crohn's disease
    Euphemia Leung
    Int J Colorectal Dis 22:995-6. 2007
  42. ncbi request reprint Peroxisome proliferator-activated receptor-gamma gene polymorphisms and Crohn's disease
    Euphemia Leung
    Int J Colorectal Dis 22:453-4. 2007